Laboratory

Laboratory of Embryonic and Genetic Engineering

To overcome intractable diseases through analyses of model animals
Research Theme
Development of the treatment for genetic disorders based on the use of model animals
Research Keywords

neurodegenrative disease, poly-glutamine disease, autophagy, model mice, embryonic engineering

Staff

Overview of Research and Education

Research Contents: Gene functions and mechanisms of disease process, at the level of live organisms, can be analyzed by using model animals. We create genetically modified experimental model mice to investigate genetic diseases.

Charge

Contact

Address
〒001-0021
N21, W11, Kita-ku, Sapporo, Hokkaido
Phone
011-706-9062
Fax
011-706-9210
Email
t-koda*sci.hokudai.ac.jp (Please replace * with @ when sending e-mail.)

Representative Publications

Shigeko Kijimoto-Ochiai, Keiko Kamimura, Toshiaki Koda, Neu-medullocytes, sialidase-positive B cells in the thymus, express autoimmune regulator (AIRE)., Sci. Rep. 9(1): 858 (2019)

Kan Yaguchi, Takahiro Yamamoto, Ryo Matsui, Yuki Tsukada, Atsuko Shibanuma, Keiko Kamimura, Toshiaki Koda, Ryota Uehara, Uncoordinated centrosome cycle underlies the instability of non-diploid somatic cells in mammals., J. Cell Biol. 217(7): 2463-2483 (2018)

Shigeko Kijimoto-Ochiai, Tokuko Matsumoto-Mizuno, Daisuke Kamimura, Masaaki Murakami, Miwako Kobayashi, Ichiro Matsuoka, Hiroshi Ochiai, Hideharu Ishida, Makoto Kiso, Keiko Kamimura, Toshiaki Koda, Existence of NEU1 sialidase on mouse thymocytes whose natural substrate is CD5., Glycobiology 28, 306-317 (2018)

Solomon T. Gizaw, Toshiaki Koda, Maho Amano, Keiko Kamimura, Tetsu Ohashi, Hiroshi Hinou, Shin-Ichiro Nishimura, A comprehensive glycome profiling of Huntington’s disease transgenic mice., Biochim. Biophys. Acta 1850(9): 1704-1718 (2015)

Refer to HOKKAIDO UNIVERSITY RESEARCHERS DIRECTORY
(https://researchers.general.hokudai.ac.jp/profile/en.Xm.hV9Kzr8YZsyMzPZ0e9A==.html)