Laboratory of Embryonic and Genetic Engineering

To overcome intractable diseases through analyses of model animals

Research Theme: Development of the treatment for genetic disorders based on the use of model animals
Research Keywords: neurodegenrative disease, poly-glutamine disease, autophagy, model mice, embryonic engineering

Overview of Research and Education

Research Contents: Gene functions and mechanisms of disease process, at the level of live organisms, can be analyzed by using model animals. We create genetically modified experimental model mice to investigate genetic diseases.

Charge

Charge (US):
School of Science, Biological Science course (Macromolecular Functions), Collaborative Laboratories
Charge (GS):
Graduate School of Life Science, Division of Life Science, Transdisciplinary Life Science Course, Biosystem and Biomolecule Control Science

Contact

Address: 〒001-0021
N21, W11, Kita-ku, Sapporo, Hokkaido
Phone: 011-706-9062
Fax: 011-706-9210
Email: t-koda*sci.hokudai.ac.jp (Please replace * with @ when sending e-mail.)

Laboratory Website

Representative Publications

Nobutaka Hanagata, Taro Takemura, Keiko Kamimura, Toshiaki Koda, Effect of immunosuppressants on a mouse model of osteogenesis imperfecta type V harboring a heterozygous Ifitm5 c.-14C > T mutation., Sci. Rep. 10(1): 21197 (2020)

Shigeko Kijimoto-Ochiai, Keiko Kamimura, Toshiaki Koda, Neu-medullocytes, sialidase-positive B cells in the thymus, express autoimmune regulator (AIRE)., Sci. Rep. 9(1): 858 (2019)

Kan Yaguchi, Takahiro Yamamoto, Ryo Matsui, Yuki Tsukada, Atsuko Shibanuma, Keiko Kamimura, Toshiaki Koda, Ryota Uehara, Uncoordinated centrosome cycle underlies the instability of non-diploid somatic cells in mammals., J. Cell Biol. 217(7): 2463-2483 (2018)

Shigeko Kijimoto-Ochiai, Tokuko Matsumoto-Mizuno, Daisuke Kamimura, Masaaki Murakami, Miwako Kobayashi, Ichiro Matsuoka, Hiroshi Ochiai, Hideharu Ishida, Makoto Kiso, Keiko Kamimura, Toshiaki Koda, Existence of NEU1 sialidase on mouse thymocytes whose natural substrate is CD5., Glycobiology 28, 306-317 (2018)

Refer to HOKKAIDO UNIVERSITY RESEARCHERS DIRECTORY
(https://researchers.general.hokudai.ac.jp/profile/en.Xm.hV9Kzr8YZsyMzPZ0e9A==.html)