HANAGATA NobutakaVisiting Professor

Laboratory of Frontier Biomaterials Science
Research Theme
Development of nucleic acid nanomedicines for the tratment of infectious diseases, allergy, and osteogeneisis imperfecta type V
Research Keywords

Nanomedicine, nucleic acid drugs, immunology, bone disease

Overview of Research

1. Immune cells recognize pathogen’s DNA and RNA, and induce immune responses. We develop nucleic acid nanomedicines that are complexes of synthesized nucleic acids with nanoparticles for the prevention and treatment of infectious diseases and allergy.

2. We found bone-restricted Ifitm5 that is a novel gene for bone formation. Recently, it is reported that mutation of this gene causes osteogenesis imperfecta type V. We develop nucleic acid nanomedicines that target this gene for the treatment of this bone disease.


  • School of Science:
  • Graduate School of Life Science:
    Division of Life Science, Transdisciplinary Life Science Course, Frontier Biomaterials Science (Inter-field Cooperation with NIMS)


Frontier biomaterials science is a novel field of research that integrates biotechnology with nanotechnology and materials science. We aim to development of nanomedicines for the treatment of infectious diseases, allergy, and bone disease.

Representative Publications

Hongxin Wang, Han Zhang, Bo Da, Dabao Lu, Ryo Tamura, Kenta Goto, Ikumu Watanabe, Daisuke Fujita, Nobutaka Hanagata, Junko Kano, Tomoki Nakagawa, and Masayuki Noguchi. Mechanics biomarker for cancer cells unidentifiable through morphology and elastic modulus. Nano Letter 21 (2021) 1538-1545

Nobutaka Hanagata, Taro Takemura, Keiko Kamimura, Toshiaki Koda. Effect of immunosuppressants on a mouse model of osteogenesis imperfecta type V harboring a heterozygeous Ifitm5 c.-14C>T mutation. Scientifc Reports 10[1] (2020) 21197

Shanmugavel Chinnathambi, Subramani Karthikeyan, Nobutaka Hanagata, Naoto Shirahata. Molecular interaction of silicon quantum dot micelles with plasma proteins: hemoglobin and thrombin. RSC Advances. 9 [26] (2019) 14928-14936

Nobutaka Hanagata, Xianglan Li, Min-Hua Chen, Jie Li, Shinya Hattori. Double-stranded phosphodiester cytosine-guanine oligodeoxynucleotide complexed with calcium phosphate as a potent vaccine adjuvant for activating cellular and Th1-type humoral immunities. International Journal of Nanomedicine 13, (2018) 43-62

Xia Li, Xiupeng Wang, Jun Zhang, Nobutaka Hanagata, Xuebin Wang, Qunhong Weng, Atsuo Ito, Yoshio Bando & Dmitri Golberg. Hollow boron nitride nanospheres as boron reservoir for prostate cancer treatment. Nature Communications 8 (2017) 13936


  • National Institute for Materials Science, Research Network and Facility Services Division