KODA ToshiakiSpecially Appointed Professor
- Laboratory
- Laboratory of Embryonic and Genetic Engineering
- Research Theme
- Development of the therapeutic method for genetic diseases through examination of model mice.
- Research Keywords
Transgenic mouse, knockout mouse, embryonic stem cells, disease model, triplet repeat disease, CRISPR/Cas9
Overview of Research
Improvement of genetic engineering
To improve methods for genetic modification of mice, we are establishing new embryonic stem cells and vector systems including CRISPR/Cas9.
Development of therapy for genetic diseases
We are examining therapeutic methods for diseases caused by genetic changes. Especially, we are interested in the instability of triplet repeats. Our approach is to investigate repeat instability in transgenic model mice.
Charge
- School of Science:
Biological Science course (Macromolecular Functions), Collaborative Laboratories - Graduate School of Life Science:
Division of Life Science, Transdisciplinary Life Science Course, Biosystem and Biomolecule Control Science
Message
We try to develop novel methods for therapy against intractable diseases.
Representative Publications
Shigeko Kijimoto-Ochiai, Keiko Kamimura, Toshiaki Koda, Neu-medullocytes, sialidase-positive B cells in the thymus, express autoimmune regulator (AIRE)., Sci. Rep. 9(1): 858 (2019)
Kan Yaguchi, Takahiro Yamamoto, Ryo Matsui, Yuki Tsukada, Atsuko Shibanuma, Keiko Kamimura, Toshiaki Koda, Ryota Uehara, Uncoordinated centrosome cycle underlies the instability of non-diploid somatic cells in mammals., J. Cell Biol. 217(7): 2463-2483 (2018)
Shigeko Kijimoto-Ochiai, Tokuko Matsumoto-Mizuno, Daisuke Kamimura, Masaaki Murakami, Miwako Kobayashi, Ichiro Matsuoka, Hiroshi Ochiai, Hideharu Ishida, Makoto Kiso, Keiko Kamimura, Toshiaki Koda, Existence of NEU1 sialidase on mouse thymocytes whose natural substrate is CD5., Glycobiology 28, 306-317 (2018)
Solomon T. Gizaw, Toshiaki Koda, Maho Amano, Keiko Kamimura, Tetsu Ohashi, Hiroshi Hinou, Shin-Ichiro Nishimura, A comprehensive glycome profiling of Huntington’s disease transgenic mice., Biochim. Biophys. Acta 1850(9): 1704-1718 (2015)
Refer to HOKKAIDO UNIVERSITY RESEARCHERS DIRECTORY
(https://researchers.general.hokudai.ac.jp/profile/en.Xm.hV9Kzr8YZsyMzPZ0e9A==.html)
Note
<Office Hour>
– Time: Anytime during the lecture period
– Place: Center for Promotion of Platform for Research on Biofunctional Molecules, CRIS, 3F
Please contact in advance by E-mail.
E-mail: t-koda[at]sci.hokudai.ac.jp
Affiliation
- Faculty of Advanced Life Science, Department of Functional Life Sciences, Embryonic and Genetic Engineering
- Frontier Research Center for Advanced Material and Life Science, Advanced Facility Unit