MURAI YutaAssistant Professor
- Laboratory
- Laboratory of Molecular Chemical Biology
- Research Theme
- Chemical biology using photocapture
- Research Keywords
Chemical biology, Photoaffinity labeling, Bioorganic chemistry
Overview of Research
Bioactive functions are caused by the interaction between biologically active molecules (drug, enzyme or messenger) and a protein. It is necessary to elucidation the mechanism such as where the protein exists, what kind of shape the protein has and ligand-binding domains with the protein directly for developing new drugs. Structural elucidation as well as identification of the target protein is a crucial matter in the field of life sciences for understanding and regulating complex biological processes. Whereas X-ray crystallography and NMR methods are useful for analyzing proteins, it is difficult for GPCR (G-protein-coupled receptor etc.) to apply the methods. The photoaffinity labeling is a valuable chemical method for studying the interactions of biologically active molecules with their target protein by photo-irradiation, and has been applied for the protein imaging or profiling. In particular, this approach is useful for elucidating proteins which are difficult to analyz e by X-ray crystallography and NMR methods. We are researching unexplained proteins using the photoaffinity labeling.
Charge
- School of Science:
Biological Science course (Macromolecular Functions), Core Laboratories - Graduate School of Life Science:
Division of Life Science, Transdisciplinary Life Science Course, Biomaterials Science
Representative Publications
Refer to HOKKAIDO UNIVERSITY RESEARCHERS DIRECTORY
(https://researchers.general.hokudai.ac.jp/profile/en.4XpaLVvuVtru4ElxEfUk1A==.html)
Note
<Office Hour>
– Time: Anytime during the lecture period
– Place: Frontier-AMLS, 4F
Please contact in advance by E-mail.
E-mail: ymurai[at]sci.hokudai.ac.jp
Affiliation
- Faculty of Advanced Life Science, Department of Advanced Transdisciplinary Sciences, Chemical Biology
- Frontier Research Center for Advanced Material and Life Science, Advanced Facility Unit