YU JianSpecially Appointed Assistant Professor
- Laboratory of X-Ray Structural Biology
- Research Theme
- Research concerning structure-based drug design, automated Native-SAD analysis method for X-ray crystal structure
- Research Keywords
Structural biology, strucuture-base drug desing, algorithm and software development, Native-SAD
Overview of Research
Protein molecules perform their various biological functions based on their different structures. Our group mainly focus on determinging and analyzing protien structure which is usually the key to revealing the reaction mechanisms of living organisms. Furthermore, we apply protien structures to further reaserch such as drug design, enzyme design and so on.
Structure-based drug design with AI
Structure-based drug design (SBDD) is a well-established tool in the rational drug design toolbox for modern drug discovery. SBDD uses the known 3D geometrical structure of proteins, which are most often derived from X-ray crystallography at an atomic resolution, to assist in the development of new drug compounds. Recently, artificial intelligence(AI) shows its reamarkable power in SBDD against a huge amount of data. Our group now focus on the development of new algorithm and software for SBDD with the AI techniques.
Native S-SAD method for X-ray crystallography
Native-SAD method use the anomalous scattering signal form sulfur atom in protien to solve the phase problem in X-ray crystallograph. The challenge of this method is to find the optimum parameters for data collection and data analysis. Our group now focus on developing an automated data collection and ananlysis system for Natve S-SAD with deep learning technique.
- School of Science:
Biological Science course (Macromolecular Functions), Core Laboratories
- Graduate School of Life Science:
Division of Life Science, Transdisciplinary Life Science Course, Bioinformation and Molecular Sciences
Refer to HOKKAIDO UNIVERSITY RESEARCHERS DIRECTORY
– Time: Anytime during the lecture period
– Place: Science Bldg. No.5, 3F, #5-313
Please contact in advance by E-mail.
- Faculty of Advanced Life Science, Department of Advanced Transdisciplinary Sciences, X-Ray Structural Biology
- Frontier Research Center for Advanced Material and Life Science, Advanced Facility Unit