タン ロジャー サルバシオン助教 (TAN Roger S.)
- 研究室
- 先端生体制御科学研究室
- 研究テーマ
- Design and Synthesis of Nanoparticle-glycoconjugate Drug Delivery Systems.
- 研究キーワード
Nanoparticle-based Delivery Systems, Glyconanotechnology, Glycoimmunology, Glycopeptide Synthesis, Glycan Synthesis, Drug Delivery, Drug Discovery.
研究内容
Glycans mediate virtually all biological processes, such as cell-pathogen interaction, disease progression, and immune response modulation. Delivering therapeutic agents to alter these processes has been very challenging due to the exquisitely complex nature of the biological systems. Our focus is on Glycoimmunology and Nanoparticle-based Drug Delivery Systems (NDDS) to find the most suitable and efficient way of delivering these therapeutic agents, with minimal adverse effects and perturbation on the biological systems, by taking advantage of these mediator glycans. We have established a delivery platform that enabled us to evade endolysosomal sequestration during intracellular delivery and successfully allowed glycan-guided organelle targeting. Coupled with this platform, we aim to fine-tune this technique and design a unique and comprehensive delivery system using a ‘bottom-up’ approach (from intracellular to systemic delivery).
担当学部・大学院
- 理学部担当:
生物科学科（高分子機能学），基幹講座 - 大学院生命科学院担当:
生命科学専攻，生命融合科学コース，生命機能制御科学
メッセージ
Join us in exploring Glycoscience for Drug Discovery and Drug Delivery!
代表的な研究業績
・Roger S. Tan, Glycosylated and non-glycosylated quantum dot-displayed peptides trafficked indiscriminately inside lung cancer cells but discriminately sorted in normal lung cells: An indispensable part in nanoparticle-based intracellular drug delivery, Asian J Pharm. Sci. 13 (3), 197-211 (2018).
・Roger S. Tan, Modulation of Cancer Cell Proliferation by unusually produced β(1-6) linked Mannan-oligosaccharides and β(1-6) linked Galacto-oligosaccharides using β–galactosidase from Aspergillus oryzae. International Journal of Advanced and Applied Sciences, 5(4): 30-41 (2018).
・Roger S. Tan, Hinou H., Nishimura S-I., Novel β-galactosynthase–β-mannosynthase dual activity of β-galactosidase from Aspergillus oryzae uncovered using monomer sugar substrates, RSC Adv., 6, 50833-50836 (2016).
・Roger S. Tan, Naruchi K., Amano M., Hinou H., Nishimura S-I., Rapid Endolysosomal Escape and Controlled Intracellular Trafficking of Cell Surface Mimetic Quantum-Dots-Anchored Peptides and Glycopeptides, ACS Chem. Biol. 10, 2073-2086 (2015).
備考
＜オフィスアワー＞
・訪問受け入れ日時：講義期間中はいつでも
・居室：次世代棟６階
※不在の場合があるため下記メールアドレスへ事前連絡の上来室してください。
roger.tan[at]sci.hokudai.ac.jp
所属
- 大学院先端生命科学研究院，先端融合科学研究部門，新薬探索研究分野
- 次世代物質生命科学研究センター，産学連携ユニット