Staff

HINOU HiroshiProfessor

Laboratory
Laboratory of Advanced Chemical Biology
Research Theme
Matrix life-chemistry research based on glycotyping technology and rapid synthesis of carbohydrates
Research Keywords

organic chemistry, glycotechnology, glycomedicine, chemical biology, inhibitor, synthetic probe, mass spectrometry, microarray, infection, immunity, cancer, lectin, glycotyping

Overview of Research

Carbohydrates (glycans) are indispensable to living matter not only as essential energy sources but also as signal molecules of intra- and intercellular systems. Our interests are focused on glycotechnology to elucidate and utilize the function of carbohydrates as signal molecules, and on chemical biology towards a new age of medicinal science.
To achieve these targets, we are developing innovative synthetic methods and structural&functional analytical methods for glycoconjugates such as glycopeptides, glycolipids, and oligosaccharides. Development of probing systems using these glycoconjugates is also in progress to elucidate and apply the functions of glycans in living matter.
Inhibitors of glycosidases and glycosyltransferases are also an exciting research area. Development of ultra-rapid glycotyping technologies “Glycotyping” is in progress.

Charge

Message

I’m focusing on the study of chemistry and biological function of glycoconjugates as a key probe to next-generation life sciences.

Representative Publications

Bryan M. Montalban, Hiroshi Hinou* “Glycoblotting-Based Ovo-Sulphoglycomics Reveals Phosphorylated N-Glycans as a Possible Host Factor of AIV Prevalence in Waterfowls” ACS Infectious Diseases, 10, 650-661, 2024. https://doi.org/10.1021/acsinfecdis.3c00520

Bryan M. Montalban, Hiroshi Hinou* “Glycoblotting Enables Seamless and Straightforward Workflow for MALDI-TOF/MS-based Sulphoglycomics of N- and O-glycans” Proteomics, 23, 2300012, 2023. https://doi.org/10.1002/pmic.202300012

Shogo Urakami, Hiroshi Hinou* “Sodium-Doped 3-Amino-4-Hydroxybenzoic Acid: Rediscovered Matrix for Direct MALDI Glycotyping of O-linked Glycopeptides and Intact Mucins” Int. J. Mol. Sci. 24, 16836, 2023. https://doi.org/10.3390/ijms242316836

Lareno L. Villones Jr., Anna-Kristin Ludwig, Hiroyuki Kumeta, Seiya Kikuchi, Rika Ochi, Tomoyasu Aizawa, Shin-Ichiro Nishimura, Hans-Joachim Gabius, Herbert Kaltner,* Hiroshi Hinou* “Altering the Modular Architecture of Galectins Affects its Binding with Synthetic α-Dystroglycan O-Mannosylated Core M1 Glycoconjugates In situ” ChemBioChem, e202200783, 2023. https://doi.org/10.1002/cbic.202200783

Refer to HOKKAIDO UNIVERSITY RESEARCHERS DIRECTORY

Note

<Office Hour>
– Time: Anytime during the lecture period
– Place: Frontier-AMLS, 6F
Please contact in advance by E-mail.
E-mail: hinou[at]sci.hokudai.ac.jp

<Research seeds>
https://seeds.mcip.hokudai.ac.jp/en/view/396/
https://seeds.mcip.hokudai.ac.jp/en/view/395/
https://seeds.mcip.hokudai.ac.jp/en/view/381/
https://seeds.mcip.hokudai.ac.jp/en/view/119/

<Research Group Homepage>
https://sites.google.com/eis.hokudai.ac.jp/hinou

Affiliation