2014年度：創薬科学基盤イノベーションハブ

発表論文

  1. Shibuta T., Sato S., Shibuya M., Kanoh N., Taniguchi T., Monde K., Iwabuchi Y.
    Enantioselective intramolecular aza-spiroannulation onto benzofurans using chiral rhodium catalysis
    Heterocycles, 89, 631-639 (2014)
  2. Hongen T., Taniguchi T., Nomura S., Kadokawa J., Monde K.
    In Depth Study on Solution-State Structure of Poly (lactic acid) by Vibrational Circular Dichroism
    Macromolecules, 47, 5313-5319 (2014)
  3. Salayová A., Kudličková Z., Baláž M., Budovská M., Pilátová M., Mojžiš J., Monde K., Petrovaj J., Gondová T.
    Stereoselective synthesis of 1-methoxyspiroindoline phytoalexins and their amino analogues
    Tetrahedron Asymmetry, 25, 1221-1233 (2014)
  4. Khandelwal P., Singh P., Taniguchi T., Monde K., Johmoto K., Uekusa H., Masubuti H., Fujimoto Y.
    Revision of the relative and absolute stereochemistry of 3-hydroxydehydroiso-α-lapachone and its derivatives.
    Phytochemistry Lett., 10, 224-229 (2014)
  5. Hashimoto M., Murai Y.
    Synthesis of Photoreactive Aromatic α-Amino Acids and Effective Hydrogen-Deuterium Exchange for Aromatic α-Amino Acids
    J. Syn. Org. Chem., 72, 360-369 (2014)
  6. Sakurai M., Masuda K., Wang L., Murai Y., Sakihama Y., Hashidoko Y., Hatanaka Y., Hashimoto M.
    Synthesis of Methoxy-Substituted Diazirinyl Phenylalanine – A Novel Photoreactive Aspartame Derivative for Functional Analysis of Sweet Receptors.
    Heterocycles, 88, 629-637 (2014)
  7. Wang L., Murai Y., Yoshida T., Okamoto M., Masuda K., Sakihama Y., Hashidoko Y., Hatanaka Y., Hashimoto M.
    Hydrogen/Deuterium Exchange of Cross-linkable α−Amino Acid Derivatives in Deuterated Triflic Acid.
    Biosci, Biotech, and Biochem., 78, 1129-1134 (2014)
  8. Sakurai M., Yoshida T., Wang L., Murai Y., Masuda K., Sakihama Y., Hashidoko Y., Hatanaka Y., Hashimoto M.
    Synthesis of Photoreactive Diazirinyl Salicin Derivative to Elucidate Functional Analysis of the Bitter Taste Receptor.
    Heterocycles, 90, 698-705 (2015)
  9. Wang L., Murai Y., Yoshida T., Ishida A., Masuda K., Sakihama Y., Hashidoko Y., Hatanaka Y., Hashimoto M.
    Alternative One-Pot Synthesis of (Trifluoromethyl) phenyldiazirines from Tosyloxime Derivatives: Application for New Synthesis of Optically Pure Diazirinylphenylalanines for Photoaffinity Labeling.
    Org. Lett., 17, 616-619 (2015)
  10. Yamasaki Y., Nouso K., Miyahara K., Wada N., Dohi C., Morimoto Y., Takeuchi Y., Yasunaka T., Kuwaki K., Onishi H., Ikeda F., Miyake Y., Nakamura S., Shiraha H., Takaki A., Amano M., Nishimura S-I., Yamamoto K.
    Use of noninvasive serum glycan markers to distinguish nonalcoholic steatohepatitis from simple steatosis
    J. Gastroen. Hepatol. 30, 528-534 (2015)
  11. Kimura K., Nishimura S-I., Miyoshi R., Hoque A., Miyoshi T., Watanabe Y.
    Application of glyco-blotting for identification of structures of polysaccharides causing membrane fouling in a pilot-scale membrane bioreactor treating municipal wastewater
    Bioresource Technol. 179, 180-186 (2015)
  12. Watanabe N., Hara Y., Kono A., Ohashi T., Amano M., Nishimura S-I.
    Nutriglycomics in Mice Fed High-Fat or Low-Protein Diets
    Journal of Nutrition & Metabolism 1(2), 4-8 (2014)
  13. Terashima M., Amano M., Onodera T., Nishimura S-I., Iwasaki N.
    Quantitative glycomics monitoring of induced pluripotent and embryonic stem cells during neuronal differentiation
    Stem. Cell Res. 13, 454-465 (2014)
  14. Filipa Marcelo, Fayna Garcia-Martin, Takahiko Matsuhsita, Joao Sardinha, Helena Coelho, Anneloes Qude-Vrielink, Christiane Koller, Sabine Andre, Eurico J. Cabrita, Hans-Joachim Gabius, Shin-Ichiro Nishimura, Jesus Jimenez-Barbero, and F. Javier Canada
    Delineating binding modes of Gal/GalNAc and structural elements of the molecular recognition of tumor-associated mucin glycopeptides by the human macrophage galactose-type lectin
    Chem. Euro. J. 20, 16147-16155 (2014)
  15. Garcia-Martin F., Matsushita T., Hinou H., Nishimura S-I.
    Fast epitope mapping for the anti-MUC1 monoclonal antibody by combining one-bead-one-glycopeptide library and microarray platform
    Chem. Eur. J. 20, 15891-15902 (2014)
  16. Ishibashi Y., Tobisawa Y., Hatakeyama S., Ohashi T., Tanaka M., Narita S., Koike T., Habuchi T., Nishimura S-I., Ohyama C., Yoneyama T.
    Serum tri- and tetra-antennary N-glycan is a potential predictive biomarker for castration-resistant prostate cancer
    The Prostate 74, 1521-1529 (2014)
  17. Inafuku S., Noda K., Amano M., Ohashi T., Yoshizawa C., Saito W., Kanda A., Nishimura S-I., Ishida S.
    A comparison of N-glycan profiles in human plasma and vitreous fluid
    Graefes Arch. Clin. Exp. Ophthalmol. 252, 1235-1243 (2014)
  18. Sunami H., Yokota I., Igarashi Y.
    Estimation of the angles migrating cells turn on three-dimensional micro-patterned scaffolds by live cell imaging with an inverted microscope
    e-Journal of Surface Science and Nanotechnology. 12, 289-298 (2014)
  19. Yuyama K., Sun H., Sakai S., Mitsutake S., Okada M., Tahara H., Furukawa JI., Fujitani N., Shinohara Y., Igarashi Y.
    Decreased Amyloid-β Pathologies by Intracerebral Loading of Glycosphingolipid-enriched Exosomes in Alzheimer Model Mice
    J. Biol. Chem. 289(35), 24488-24498 (2014)
  20. Hanamatsu H., Ohnishi S., Sakai S., Yuyama K., Mitsutake S., Takeda H., Hashino S., Igarashi Y.
    Altered levels of serum sphingomyelin and ceramide containing distinct acyl chains in young obese adults
    Nutrition and Diabetes. 4, e141 (2014)
  21. Usuki S., O’Brien D., Rivner MH., Yu RK.
    A new approach to ELISA-based anti-glycolipid antibody evaluation of highly adhesive serum samples
    Immunol Methods. 408, 52-63 (2014)
  22. Yamashima T., Mathivanan A., Dazortsava MY., Sakai S., Kurimoto S., Zhu H., Funaki N., Liang H., Hullin-Matsuda F., Kobayashi T., Akatsu H., Takahashi H., Minabe Y.
    Calpain-Mediated Hsp70.1 Cleavage in Monkey CA1 after Ischemia Induces Similar ‘Lysosomal Vesiculosis’ to Alzheimer Neurons
    Journal of Alzheimers Disease & Parkinsonism. 4(2), 139-147 (2014)
  23. Yuyama K., Sun H., Usuki S., Sakai S., Hanamatsu H., Mioka T., Kimura N., Okada M., Tahara H., Furukawa J., Fujitani N., Shinohara Y., Igarashi Y.
    A potential function for neuronal exosomes: sequestering intracerebral amyloid-β peptide
    FEBS Letters.589(1), 84-88 (2015)
  24. Yamagami K., Yamamoto T., Sasaki S., Mioka T., Sano T., Igarashi Y., Tanaka K.
    Inositol depletion restores vesicle transport in yeast phospholipid flippase mutants
    PLoS One. 10(3), e0120108 (2015)

著書・総説・解説等

  1. 門出健次
    日本合成化学協会　編
    有機合成実験法ハンドブック　第2版
    丸善出版
    24章第3節第4項　絶対立体配置　（印刷中）
  2. 谷口透
    簡単に溶液状態の分子の立体構造を解析：赤外円二色性キラル分光法
    現代化学, 518, 47-51 (2014)
  3. Maho Amano, Hiroshi Hinou, Risho Miyoshi, Shin-Ichiro Nishimura
    Potential Usage for In Vivo Lectin Screening in Live Animals Utilizing Cell Surface Mimetic Glyco- nanoparticles, Phosphorylcholine-Coated Quantum Dots (PC-QDs)
    Lectins: Methods and Prorocols, Methods in Molecular Biology, 1200, 361-369 (2014)
  4. Yuyama K., Mitsutake S., Igarashi Y.
    Pathological roles of ceramide and its metabolites in metabolic syndrome and Alzheimer’s disease.
    BBA – Molecular and Cell Biology of Lipids. 1841(5), 793-798 (2014)
  5. Yu RK., Usuki S.
    Human antiglycosphingolipids antibodies in Guillain-Barre syndrome.
    Autoantibodies, 3rd Edition, Chapter 69, 581-692 (2014)

国際学会

（招待講演）

  1. June 2014
    Munchen, Germany
    GLYCOPHARM meeting
    GLYCOPHARM at work with glycopeptide epitopes: promising targets uncovered by comprehensive glycomics and robust synthetic compound library
    Shin-Ichiro Nishimura
  2. July 2014
    Souel, Korea
    Korean Lipid Biology Symposium
    Roles of sphingolipid metabolites on metabolic syndrome, Altzheimer disease and skin health
    Igarashi Y.
  3. August 2014
    San Francisco, USA
    248th ACS National Meeting & Exposition
    Vibrational CD spectroscopy as a powerful tool for chiral analysis of flavor compounds
    Kenji Monde
  4. September 2014
    Ulaanbaatar, Mongolia
    Special Lecure in National University of Mongolia
    Introduction to Chirality and Chemical Biology
    Kenji Monde
  5. September 2014
    Sapporo, Japan
    CRC International Symposium
    Analysis and Applications of Chiral Biomolecules by Vibrational Circular Dichroism
    Kenji Monde
  6. October 2014
    Hebei, China
    Fourth International Conference on Vibrational Optical Activity (VOA-4)
    Chiral Analysis of Biologically Important Molecules by VCD with and without DFT Theoretical Calculations
    Kenji Monde
  7. October 2014
    Beijing, China
    Molecular Chirality Asia
    Solution-State Helical Structural Study of Poly-L-Lactic Acid by VCD
    Kenji Monde
  8. October 2014
    Beijing, China
    Sino-Japan Workshop on Chemical Biology
    Toward personalized medicine from glycan biomarkers discovered by glycoblotting-assisted high throughput serum glycomics
    Shin-Ichiro Nishimura
  9. October 2014
    Hebei, China
    Fourth International Conference on Vibrational Optical Activity (VOA-4)
    VCD calculation and the VCD exciton chirality method:Seeing what other methods can not see
    Tohru Taniguchi
  10. November 2014
    Hangzhou, China
    Asian Chemical Biology Initiative
    Development of a efficient methodology for the rapid isolation of bioactive sphingoid bases toward chemical library
    Kenji Monde
  11. December 2014
    Singapore
    8th Singapore International Chemistry Conference
    Easy access to molecular stereostructure by vibrational circular dichroism: from natural products to macromolecules
    Tohru Taniguchi
  12. February 2015
    Mysore, India
    International Symposium on Chemical Biology Approach to Metabiomics, Chemical genomics and Epigenomics
    Epitope-defined antibody as new class therapeutic and diagnostic reagents: Toward personalized medicine from chemical glycobiology
    Shin-Ichiro Nishimura
  13. March 2015
    2015 Queenstown Molecular Biology (Shanghai) Meetings
    Shanghai, China
    Epitope-defined antibody discovered by new glycotechnology
    Shin-Ichiro Nishimura
  14. March 2015
    Singapore, Singapore
    SLING Workshop: “Chemical diversity of sphingolipids and their potential biological functions”
    Diversity of sphingoid bases and their function toward the development of functional foods
    Sakai S.
  15. March 2015
    Singapore, Singapore
    SLING Workshop: “Chemical diversity of sphingolipids and their potential biological functions”
    Sphingolipid biology and drug and functional food development
    Igarashi Y.

（口頭発表）

  1. April 2014
    Rotterdam, Netherlands
    International Society for Extracellular Vesicles 2014
    Intracerebral administration of glycosphingolipid-enriched exosomes reduces Alzheimer’s pathologies in mouse brain
    Yuyama K., Hui S., Igarashi Y.
  2. July 2014
    Prague, Czech Republic
    CHIRALITY 2014
    Helical Nature of Polyester Studied by VCD
    Kenji Monde
  3. March 2015
    249th ACS National Meeting & Exposition
    Intracellular traffic of cell surface mimetic quantum dots-anchored glycopeptides
    Shin-Ichiro Nishimura

国内招待

  1. 2014年6月
    仙台市
    Symposium on Molecular Chirality 2014
    溶液中におけるポリ乳酸らせん構造のVCD解析
    門出　健次
  2. 2014年6月
    東大阪市
    第56回日本脂質生化学会
    シンポジウム１　スフィンゴ糖脂質研究とヘルスサイエンス-機能・動態・認識と応答-
    糖脂質エピトープの抗体認識の問題点とコレラトキシンエピトープ認識ペプチド
    臼杵　靖剛
  3. 2014年7月
    大阪市
    第33回（公財）篷庵社研究発表会
    赤外円二色性スペクトルによる分子キラル分析法の開発
    門出　健次
  4. 2014年7月
    倉敷市
    第49回天然物化学談話会
    キラル構造解析から拓く天然物化学
    谷口　透
  5. 2014年8月
    名古屋市
    第33回日本糖質学会
    アミロイドβ蛋白質代謝におけるスフィンゴ糖脂質含有細胞外顆粒エクソソームの役割
    湯山　耕平、孫　慧、古川　潤一、篠原　康郎、五十嵐　靖之
  6. 2014年9月
    札幌市
    平成26年度農芸化学会東北北海道支部合同若手シンポジウム
    赤外円二色性による天然有機化合物の三次元構造解析
    谷口　透
  7. 2014年10月
    豊中市
    新学術領域研究「天然物ケミカルバイオロジー：分子標的と活性制御」第６回若手研究者ワークショップ
    赤外円二色性キラル構造解析から拓く天然物化学
    谷口　透
  8. 2014年11月
    前橋市
    群馬Clinical Oncology Research勉強会
    糖鎖研究からの医薬品開発　- QuaDRADTMシステムの構築と抗体医薬の創出
    西村　紳一郎
  9. 2014年12月
    札幌市
    第10回アフリカ研究会兼第３回日本アフリカ学会北海道支部例会
    JSPS Core-to-Core project “Development of novel technology for disease prevention and diagnosis in East Africa and India”の紹介
    比能　洋
  10. 2015年1月
    札幌市
    北海道大学−NIMS連携10周年記念式典・ジョイントシンポジウム
    Auditorium, Collaboration Research Building (4th floor), Namiki, Tsukuba city Chiral Analysis by Vibrational Circular Dichroism with/without DFT Calculations
    門出　健次
  11. 2015年3月
    船橋市
    第95回日本化学会春季年会　進歩賞受賞講演
    赤外円二色性による立体配置・立体配座決定法の開発
    谷口　透

特許

  1. 2014/10/22（特許公開2014-215478）
    糖スフィンゴシン及びスフィンゴ塩基の製造方法
    発明者：門出健次、五十嵐靖之、臼杵靖剛、ボメゴウダ　シッダバサーブ　ゴウダ