研究業績

産学連携ユニット

原著論文
  1. Yamada K., Takahata M., Ito M., Nagahama K., Iwata A., Endo T., Sudo H., Ishiguro N., Iwasaki N.
    Risk factors of multidrug-resistant pyogenic spondylitis in thoraco-lumbar spine: a retrospective study of 122 cases
    J. Orthop Sci., 27(1):95-100 (2022)
    DOI: 10.1016/j.jos.2020.11.020
  2. Endo T, Kadoya K, Suzuki T, Suzuki Y, Terkawi MA, Kawamura D, Iwasaki N.
    Mature but not developing Schwann cells promote axon regeneration after peripheral nerve injury.
    NPJ Regenerative Medicine, 7:12 (2022)
    DOI: 10.1038/s41536-022-00205-y
  3. Miura S, Iwasaki K, Kondo E, Endo K, Matsubara S, Matsuoka M, Onodera T, Iwasaki N.
    Stress on the posteromedial region of the proximal tibia increased over time after anterior cruciate ligament injury.
    Knee Surg Sports Traumatol Arthrosc, 30:1744–1751 (2022)
    DOI: 10.1007/s00167-021-06731-4
  4. Matsubara S, Onodera T, Iwasaki K, Hishimura R, Matsuoka M, Kondo E, Iwasaki N.
    Discrepancy in the Distribution Patterns of Subchondral Bone Density Across the Ankle Joint After Medial Opening-Wedge and Lateral Closing-Wedge High Tibial Osteotomy.
    Am J Sports Med, 50(2):478-485 (2022)
    DOI: 10.1177/03635465211062235
  5. Kondo E, Kawaguchi Y, Yokota M, Onodera J, Iwasaki N, Yasuda K.
    Implantation of autogenous meniscal fragments wrapped with a fascia sheath induces fibrocartilage regeneration in a large meniscal defect even in sheep
    A histological and biomechanical study.
    Orthop Traumatol Surg Res, 103225 (2022)
    DOI: 10.1016/j.otsr.2022.103225
  6. 下田康平,河村太介,遠藤 健,松井雄一郎,芝山浩樹,岩崎倫政
    第 1 中手骨への短母指伸筋伳固定を併用した母指 CM 関節形成術による第 1 中手骨内転変形の矯正効果
    日本手外科学会雑誌, 38:1-5 (2022)
  7. Koike Y., Kotani Y., Terao H., Iwasaki N.
    Comparison of Outcomes of Oblique Lateral Interbody Fusion with Percutaneous Posterior Fixation in Lateral Position and Minimally Invasive Transforaminal Lumbar Interbody Fusion for Degenerative Spondylolisthesis
    Asian Spine J., 15(1), 97-106 (2021)
    DOI: 10.31616/asj.2019.0342
  8. Koike Y., Kotani Y., Terao H., Iwasaki N.
    Risk Factor Analysis of Proximal Junctional Kyphosis after Surgical Treatment of Adult Spinal Deformity with Oblique Lateral Interbody Fusion
    Asian Spine J., 15(1), 107-116 (2021)
    DOI: 10.31616/asj.2019.0341
  9. Motomiya M, Nishimoto N, Urita A, Kawamura D, Shimizu Y, Iwasaki N.
    Patient characteristics affecting knowledge of the possibility of surgical reconstruction for rheumatoid hand and wrist deformities
    Mod Rheumatol. 31(3), 614-620 (2021)
    DOI: 10.1080/14397595.2020.1790779
  10. Arima H., Ohba T., Kudo D., Shigematsu H., Kaito T., Saito W., Sudo H., Seki S., Yagi M., Ito M., Sakai D.
    Expert consensus on surgical treatment for adolescent idiopathic scoliosis in Japan
    J. Orthop. Sci., online ahead of print
    26(5), 765-773 (2021)
    DOI: 10.1016/j.jos.2020.08.002
  11. Kotani Y., Koike Y., Ikeura A., Tokunaga H., Saito T.
    Clinical and radiologic comparison of anterior-posterior single-position lateral surgery versus MIS-TLIF for degenerative lumbar spondylolisthesis
    J. Orthop Sci., 26(6):992-998 (2021)
    DOI: 10.1016/j.jos.2020.10.013
  12. Endo T., Imagama S., Kato S., Kaito T., Sakai H., Ikegawa S., Kawaguchi Y., Kanayama M., Hisada Y., Koike Y., Ando K., Kobayashi K., Oda I., Okada K., Takagi R., Iwasaki N., Takahata M.
    Association between vitamin A intake and disease severity in early-onset heterotopic ossification of the posterior longitudinal ligament of the spine
    Global Spine J., 25, 2192568221989300 (2021)
    DOI: 10.1177/2192568221989300
  13. Ura K., Yamada K., Tsujimoto T., Ukeba D., Iwasaki N., Sudo H.
    Ultra-purified alginate gel implantation decreases inflammatory cytokine levels, prevents intervertebral disc degeneration, and reduces acute pain after discectomy
    Sci Rep. 11(1), 638 (2021)
    DOI: 10.1038/s41598-020-79958-9
  14. Kataoka Y., Shimizu T., Takeda R., Tadano S., Saito Y., Osuka S., Ishida T., Samukawa M., Irie T., Takahashi D., Iwasaki N., Tohyama H.
    Effects of unweighting on gait kinematics during walking on a lower-body positive-pressure treadmill in patients with hip osteoarthritis
    BMC Musculoskelet Disord. 22(1), 46 (2021)
    DOI: 10.1186/s12891-020-03909-8
  15. Irie TY., Irie T., Orías AAE., Segami K., Iwasaki N., An HS MD., Inoue N.
    Three-dimensional distribution of CT attenuation in the lumbar spine pedicle wall
    Sci Rep. 11, 1709 (2021)
    DOI: 10.1038/s41598-020-80676-5
  16. Inose H., Kato T., Nakamura H., Hoshino M., Togawa D., Hirano T., Tokuhashi Y., Ohba T., Haro H., Tsuji T., Sato K., Sasao Y., Takahata M., Otani K., Momoshima S., Takahashi K., Yuasa M., Hirai T., Yoshii T., Okawa A.
    Predictors for quality of life improvement after acute osteoporotic vertebral fracture: results of post hoc analysis of a prospective randomized study
    Qual Life Res. 30(1), 129-135 (2021)
    DOI: 10.1007/s11136-020-02629-9
  17. Momma D, Onodera T, Kawamura D, Urita A, Matsui Y, Baba R, Funakoshi T, Kondo M, Endo T, Kondo E, Iwasaki N.
    Acellular Cartilage Repair Technique Based on Ultrapurified Alginate Gel Implantation for Advanced Capitellar Osteochondritis Dissecans
    Orthop J. Sports Med., 8(11), 2325967120962103 (2021)
    DOI: 10.1177/2325967121989676
  18. Hao W, Zhao W, Kimura T, Ukawa S, Kadoya K, Kondo K, Tamakoshi A.
    Association of gait with global cognitive function and cognitive domains detected by MoCA-J among community-dwelling older adults: a cross-sectional study.
    BMC Geriatrics, 2;21(1):523 (2021)
    DOI: 10.1186/s12877-021-02467-5
  19. Iwasaki K, Kondo E, Endo K, Matsubara S, Matsuoka M, Onodera T, Iwasaki N.
    Alteration of the distribution patterns of the subchondral bone density across the proximal tibia after anterior cruciate ligament injury over time.
    Am J Sports Med, 49(6):1561-1569 (2021)
    DOI: 10.1177/03635465211002537
  20. Matsubara S, Onodera T, Iwasaki K, Hishimura R, Matsuoka M, Kondo E, Iwasaki N.
    Hallux Valgus with Second Brachymetatarsia Discovered Accidentally A Case Report.
    J Foot Ankle Surg, 18:S1067-2516(21)00087-9 (2021)
    DOI: 10.1053/j.jfas.2020.11.008
  21. Matsuoka M, Okamoto M, Soma T, Yokota I, Arai R, Onodera T, Kondo E, Iwasaki N, Hiraga H.
    Impact of Smoking History on Pulmonary Metastasis-free Survival in Patients With Soft-tissue Sarcoma.
    Cancer Diagnosis & Prognosis, 1(2)89-94 (2021)
    DOI: 10.21873/cdp.10013
  22. Matsuoka M, Onodera T, Yokota I, Iwasaki K, Matsubara S, Hishimura R, Kondo E, Iwasaki N.
    Surgical Resection of Primary Tumor in the Extremities Improves Survival for Metastatic Soft-Tissue Sarcoma Patients: A Population-Based Study of the SEER Database.
    Clin Transl Oncol, 23(12):2474-2481 (2021)
    DOI: 10.1007/s12094-021-02646-1
  23. Itoga R, Matsuoka M, Onodera T, Shimizu A, Iwasaki K, Matsubara S, Hishimura R, Kondo E and Iwasaki N.
    Delayed Onset of Infectious Foreign Body Granuloma for Non-absorbable Sutures after Open Achilles Tendon Repair : A Case Report.
    J Foot Ankle Surg, 60(6):1297-1300 (2021)
    DOI: 10.1053/j.jfas.2021.04.025
  24. Kaibara T, Kondo E, Matsuoka M, Iwasaki K, Onodera T, Momma D, Iwasaki N.
    Medial closed-wedge distal femoral osteotomy with local bone grafts for large collapsed steroid-induced osteonecrosis of the lateral femoral condyle: A case report.
    J Orthop Sci, 4: S0949-2658(21)00213-X (2021)
    DOI: 10.1016/j.jos.2021.06.016
  25. Itoga R, Matsuoka M, Onodera T, Yokota I, Iwasaki K, Matsubara S, Hishimura R, Kondo E and Iwasaki N.
    Brain Metastasis in Soft Tissue Sarcoma at Initial Presentation.
    Anticancer Res, 41(11):5611-5616 (2021)
    DOI: 10.21873/anticanres.15376.
  26. Sato D, Inoue M, Sasaki T, Uchida J, Onodera T, Kondo E, Iwasaki N.
    No patella resurfacing total knee arthroplasty leads to reduction in the thickness of patellar cartilage to less than half within 5 years : a quantitative longitudinal evaluation using MRI.
    J Exp Orthop, 24;8(1):107 (2021)
    DOI: 10.1186/s40634-021-00425-z
  27. Liang D, Onodera T, Hamasaki M, Hishimura R, Homan K, Xu L, Tian Y, Kanai S, Iwasaki N.
    Quantification of Cartilage Surface Degeneration by Curvature Analysis Using 3D Scanning in a Rabbit Model.
    Cartilage, 13(2_suppl):1734S-1741S (2021)
    DOI: 10.1177/19476035211059597
  28. Momma D, Onodera T, Kawamura D, Urita A, Matsui Y, Baba R, Funakoshi T, Kondo M, Endo T, Kondo E, Iwasaki N.
    Acellular Cartilage Repair Technique Based on Ultrapurified Alginate Gel Implantation for Advanced Capitellar Osteochondritis Dissecans.
    Orthop J Sports Med, 11;9(3):2325967121989676 (2021)
    DOI: 10.1177/2325967121989676.
  29. Ebata T, Terkawi MA, Hamasaki M, Matsumae G, Onodera T, Aly MK, Yokota S, Alhasan H, Shimizu T, Takahashi D, Homan K, Kadoya K, Iwasaki N.
    Flightless I is a catabolic factor of chondrocytes that promotes hypertrophy and cartilage degeneration in osteoarthritis.
    iScience, 24;24(6):102643 (2021)
    DOI: 10.1016/j.isci.2021.102643
  30. Xu L, Urita A, Onodera T, Hishimura R, Nonoyama T, Hamasaki M, Liang D, Homan K, Gong JP, Iwasaki N.
    Ultrapurified Alginate Gel Containing Bone Marrow Aspirate Concentrate Enhances Cartilage and Bone Regeneration on Osteochondral Defects in a Rabbit Model.
    Am J Sports Med, 49(8):2199-2210 (2021)
    DOI: 10.1177/03635465211014186
  31. Kameda T, Kondo E, Onodera T, Iwasaki K, Onodera J, Yasuda K, Iwasaki N.
    Changes in the Contact Stress Distribution Pattern of the Patellofemoral Joint After Medial Open-Wedge High Tibial Osteotomy: An Evaluation Using Computed Tomography Osteoabsorptiometry.
    Orthop J Sports Med, 9(4): 2325967121998050 (2021)
    DOI: 10.1177/2325967121998050
  32. Matsubara S, Onodera T, Iwasaki K, Hishimura R, Matsuoka M, Kondo E, Iwasaki N.
    Hallux Valgus With Second Brachymetatarsia Discovered Accidentally A Case Report.
    J Foot Ankle Surg, 60(5):1060-1062 (2021)
    DOI: 10.1053/j.jfas.2020.11.008
  33. Tian Y, Onodera T, Terkawi MA, Iwasaki K, Hishimura R, Liang D, Miyazaki T, Iwasaki N.
    Local Administration of Low-Dose Nerve Growth Factor Antibody Reduced Pain in a Rat Osteoarthritis Model.
    Int J Mol Sci, 4;22(5):2552 (2021)
    DOI: 10.3390/ijms22052552
  34. Yokota S, Matsumae G, Shimizu T, Hasegawa T, Ebata T, Takahashi D, Heguo C, Tian Y, Alhasan H, Takahata M, Kadoya K, Terkawi MA, Iwasaki N.
    Cardiotrophin Like Cytokine Factor 1 (CLCF1) alleviates bone loss in osteoporosis mouse models by suppressing osteoclast differentiation through activating interferon signaling and repressing the nuclear factor-κB signaling pathway.
    Bone, 153:116140 (2021)
    DOI: 10.1016/j.bone.2021.116140
  35. Ishizu H, Arita K, Terkawi MA, Shimizu T, Iwasaki N.
    Risks vs. benefits of switching therapy in patients with postmenopausal osteoporosis.
    Expert Rev Endocrinol Metab, 16(5):217-228 (2021)
    DOI: 10.1080/17446651.2021.1956902
  36. Kobayashi H, Fujita R, Hiratsuka S, Shimizu T, Sato D, Hamano H, Iwasaki N, Takahata M.
    Differential effects of anti-RANKL monoclonal antibody and zoledronic acid on necrotic bone in a murine model of Staphylococcus aureus-induced osteomyelitis.
    J Orthop Res, 40(3):614-623 (2021)
    DOI: 10.1002/jor.25102
  37. Yamaguchi J, Yasuda K, Kondo E, Kaibara T, Ueda D, Yabuuchi K, Onodera J, Iwasaki N, Saito M, Yagi T.
    Extrusion of the medial meniscus is a potential predisposing factor for post-arthroscopy osteonecrosis of the knee.
    BMC Musculoskeletal Disorders, 22(a1);1-11 (2021)
    DOI: 10.1186/s12891-021-04730-7
  38. Yokota S, Sakamoto K, Shimizu Y, Asano T, Takahashi D, Kudo K, Iwasaki N, Shimizu T.
    Evaluation of whole-body modalities for diagnosis of multifocal osteonecrosis-a pilot study.
    Arthritis Res Ther, 11;23(1):83 (2021)
    DOI: 10.1186/s13075-021-02473-3
  39. Nakamura Y, Shimizu T, Asano T, Shimodan S, Ishizu H, Takahashi D, Takahata M, Iwasaki N.
    Short-term efficacy and safety of zoledronate acid or denosumab in Japanese patients with postmenopausal osteoporosis.
    J Bone Miner Metab, 39(5):824-832 (2021)
    DOI: 10.1007/s00774-021-01221-6
  40. Shimizu T, Arita K, Murota E, Hiratsuka S, Fujita R, Ishizu H, Asano T, Takahashi D, Takahata M, Iwasaki N.
    The twelve-month clinical efficacy of romosozumab or denosumab in a real-world setting in Japanese patients.
    J Bone Miner Metab, 39(5):868-875 (2021)
    DOI: 10.1007/s00774-021-01226-1
  41. Ebata T, Terkawi MA, Hamasaki M, Matsumae G, Onodera T, Aly MK, Yokota S, Alhasan H, Shimizu T, Takahashi D, Homan K, Kadoya K, Iwasaki N.
    Flightless I is a catabolic factor of chondrocytes that promotes hypertrophy and cartilage degeneration in osteoarthritis.
    iScience, 24;24(6):102643 (2021)
    DOI: 10.1016/j.isci.2021.102643.
  42. Matsumae G, Shimizu T, Yuan T, Takahashi D, Ebata T, Alhasan H, Yokota S, Kadoya K, Terkawi MA, Iwasaki N.
    Targeting thymidine phosphorylase as a potential therapy for bone loss associated periprosthetic osteolysis.
    Bioeng Transl Med, 8;6(3) (2021)
    DOI: 10.1002/btm2.10232
  43. Shimizu T, Arita K, Murota E, Hiratsuka S, Fujita R, Ishizu H, Asano T, Takahashi D, Takahata M, Iwasaki N.
    Effects after starting or switching from bisphosphonate to romosozumab or denosumab in Japanese postmenopausal patients.
    J Bone Miner Metab, 39(5):868-875 (2021)
    DOI: 10.1007/s00774-021-01226-1
  44. Ogawa T, Shimizu T, Asano T, Iwasaki N, Takahashi D.
    Radiological predictors associated with success of treatment for developmental dysplasia of hip using the Pavlik harness:A retrospective study.
    J Orthop Sci, 4:S0949-2658(21)00206-2 (2021)
    DOI: 10.1016/j.jos.2021.06.010
  45. Yokota S, Matsumae G, Shimizu T, Hasegawa T, Ebata T, Takahashi D, Heguo C, Tian Y, Alhasan H, Takahata M, Kadoya K, Terkawi MA, Iwasaki N.
    Cardiotrophin Like Cytokine Factor 1 (CLCF1) alleviates bone loss in osteoporosis mouse models by suppressing osteoclast differentiation through activating interferon signaling and repressing the nuclear factor-κB signaling pathway.
    Bone, 153:116140 (2021)
    DOI: 10.1016/j.bone.2021.116140
  46. Ukeba D, Yamada K, Tsujimoto T, Ura K, Nonoyama T, Iwasaki N, Sudo H.
    Bone Marrow Aspirate Concentrate Combined with in Situ Forming Bioresorbable Gel Enhances Intervertebral Disc Regeneration in Rabbits.
    J Bone Joint Surg Am, 21;103(8):e31 (2021)
    DOI: 10.2106/JBJS.20.00606
  47. Irie TY, Irie T, Orías AAE, Segami K, Iwasaki N,An HS, MD, Inoue N.
    Micro-computed tomography analysis of the lumbar pedicle wall.
    PLoS One, 8;16(7) (2021)
    DOI: 10.1371/journal.pone.0253019
  48. Yamamoto T, Hasegawa T, Fraitas PHL, Hongo H, Zhao S, Yamamoto T, Nasoori A, Abe M, Maruoka H, Kubota K, Morimoto Y, Haraguchi M, Shimizu T, Takahata M, Iwasaki N, Li M, Amizuka N.
    Histochemical characteristics on minimodeling-based bone formation induced by anabolic drugs for osteoporotic treatment.
    Biomed Res, 42(5):161-171 (2021)
    DOI: 10.2220/biomedres.42.161
  49. Hashimoto K, Hasegawa T, Yamamoto T, Hong H, Abe M, Nasooori A, Nakahishi K, Maruoka H, Morimoto Y, Kubota K, Shimizu T, Haraguchi M, Takahata, Iwasaki N, Li M, Fujisawa T, Amizuka N.
    Hisological observation on the initial stage of vascular invasion into the secondary ossification of murine femoral epiphyseal cartilage.
    Biomedical Research (Tokyo), 42(4):139-151 (2021)
    DOI: 10.2220/biomedres.42.139
  50. Ishizu H, Shimizu H, Shimizu T, Ebata T, Ogawa Y, Miyano M, Arita K, Ohashi Y, Iwasaki N.
    Rheumatoid arthritis is a risk factor for refracture in patients with fragility fractures.
    Modern Rheumatology, 3:roab109 (2021)
    DOI: 10.1093/mr/roab109
  51. Numaguch K, Momma D, Matsui Y, Yokota M, Oohinata J, Kondo E, Iwasaki N.
    Stress-Distribution Pattern Across the Glenohumeral Joint in Collegiate and Professional Baseball Players: A Computed Tomography Osteoabsorptiometry Study.
    Orthop J Sports Med, 3;9(6):23259671211009185 (2021)
    DOI: 10.1177/23259671211009185
  52. Numaguch K, Momma D, Matsui Y, Oohinata J, Yamaguchi T, Inoue N, Kondo E, Iwasaki N.
    Changes in elbow joint contact area in symptomatic valgus instability of the elbow in baseball players.
    Sci Rep, 11:19782 (2021)
    DOI: 10.1038/s41598-021-99193-0
  53. Momma D, Espinoza Orías AA, Irie T, Irie T, Kondo E, Iwasaki N, Inoue N.
    Four-dimensional computed tomography evaluation of shoulder joint motion in collegiate baseball pitchers.
    Sci Rep, 25;12(1):3231(2021)
    DOI: 10.1038/s41598-022-06464-5
  54. Irie TY, Irie T, Espinoza Orías AA, Segami K, Iwasaki N, An HS, Inoue N.
    Micro-computed tomography analysis of the lumbar pedicle wall.
    PLoS One, 8;16(7):e0253019 (2021)
    DOI: 10.1371/journal.pone.0253019
  55. Yamada K, Nagahama K, Abe Y, Murota E, Hiratsuka S, Takahata M, Iwasaki N.
    Unintentional fusion in preserved facet joints without bone grafting after percutaneous endoscopic transforaminal lumbar interbody fusion.
    Spine Surg Relat Res, 5(6)390-396 (2021)
    DOI: 10.22603/ssrr.2020-0232
  56. Yamada K, Maeda K, Ito MY, Inage F, Isoe T, Yokota N, Sugita O, Sato N, Tha KK, Iwasaki N, Arato T, Sudo H.
    Exploratory clinical trial on the safety and capability of dMD-001 in lumbar disc herniation:Study protocol for a first-in-human pilot study.
    Contemporary Clinical Trials Communications, 23:100805 (2021)
    DOI: 10.1016/j.conctc.2021.100805
  57. Yamada K, Nagahama K, Abe Y, Hyugaji Y, Takahata M, Iwasaki N.
    Morphological analysis of Kambin's triangle using 3D CT/MRI fusion imaging of lumbar nerve root created automatically with artificial intelligence.
    Eur Spine J, 30(8) (2021)
    DOI: 10.1007/s00586-021-06916-y
  58. Ura K, Yamada K, Tsujimoto T, Ukeba D, Iwasaki N, Sudo H.
    Ultra-purified alginate gel implantation decreases inflammatory cytokine levels,
    prevents intervertebral disc degeneration, and reduces acute pain after discectomy.
    Sci Rep, 11(1)638 (2021)
    DOI: 10.1038/s41598-020-79958-9
  59. Kokabu T, Abe Y, Yamada K, Iwasaki N, Sudo H.
    Impact of multilevel facetectomy on segmental spinal flexibility in patients with thoracic adolescent idiopathic scoliosis.
    Clinical Biomechanics, 83, 105296 (2021)
    DOI: 10.1016/j.clinbiomech.2021.105296
  60. Sudo H, Tachi H, Kokabu T, Yamada K, Iwata A, Endo T, Takahata M, Abe Y, Iwasaki N.
    In vivo deformation of anatomically pre-bent rods in thoracic adolescent idiopathic scoliosis.
    Sci Rep 11, 12622 (2021)
    DOI: 10.1038/s41598-021-92187-y
  61. Endo T, Koike Y, Hisada Y, Fujita R, Suzuki R, Tanaka M, Tsujimoto T, Shimamura Y, Hasegawa Y, Kanayama M, Yamada K, Iwata A, Sudo H, Ishii M, Iwasaki N, Takahata M
    Aggravation of ossified ligamentum flavum lesion is associated with the degree of obesity.
    Global spine J, 21925682211031514 (2021)
    DOI: 10.1177/21925682211031514
  62. Suzuki R, Koike Y, Ota M, Endo T, Hisada Y, Tsujimoto T, Kanayama M, Ito MY, Sudo H, Iwata A, Yamada K, Iwasaki N, Takahata M.
    Thrombocytopenia associated with unrecognized non-alcoholic fatty liver disease is an independent predictor of perioperative significant blood loss in cervical laminoplasty.
    World Neurosurgery, 155:e797-804 (2021)
    DOI: 10.1016/j.wneu.2021.09.012
  63. Tachi H, Kato K, Abe Y, Kokabu T, Yamada K, Iwasaki N, Sudo H.
    Surgical outcome prediction using a four-dimensional planning simulation system with finite element analysis incorporating pre-bent rods in adolescent idiopathic scoliosis
    Simulation for spatiotemporal anatomical correction technique.
    Frontiers Bioengineering, 12;9:746902 (2021)
    DOI: 10.3389/fbioe.2021.746902
  64. Kokabu T, Kanai S, Kawakami N, Uno K, Kotani T, Suzuki T, Tachi H, Abe Y, Iwasaki N, Sudo H.
    An algorithm for using deep learning convolutional neural networks with three dimensional depth sensor imaging in scoliosis detection.
    Spine J, 21(6):980-987 (2021)
    DOI: 10.1016/j.spinee.2021.01.022
  65. Iwasaki K, Kondo E, Endo K, Matsubara S, Matsuoka M, Onodera T, Iwasaki N.
    Effect of High Tibial Osteotomy on the Distribution of Subchondral Bone Density Across the Proximal Tibial Articular Surface of the Knee With Medial Compartment Osteoarthritis.
    Am J Sports Med, 49(6):1561-1569 (2021)
    DOI: 10.1177/03635465211002537
  66. Yamada K, Takahata M, Ito M, Nagahama K, Iwata A, Endo T, Sudo H, Ishiguro N, Iwasaki N.
    Risk factors of multidrug-resistant pyogenic spondylitis in thoraco-lumbar spine: A retrospective study of 122 cases.
    Journal of orthopaedic science, 27(1):95-100 (2021)
    DOI: 10.1016/j.jos.2020.11.020
  67. Ogawa T, Tsukuda Y, Suzuki Y, Hiratsuka S, Inoue R, Iwasaki N.
    Utility of thermal image scanning in screening for febrile patients in cold climates
    J Orthop Sci, 3;S0949-2658(21)00268-2 (2021)
    DOI: 10.1016/j.jos.2021.08.002
  68. Hontani K, Matsui Y, Kawamura D, Urita A, Momma D, Hamano H, Iwasaki N.
    Stress distribution pattern in the distal radioulnar joint before and after ulnar shortening osteotomy in patients with ulnar impaction syndrome.
    Sci Rep, 9;11(1):17891 (2021)
    DOI: 10.1038/s41598-021-97398-x
  69. Matsui Y, Horie T, Funakoshi T, Kawamura D, Nishida M, Iwasaki N.
    Dynamic Evaluation of Intraneural Microvascularity of the Ulnar Nerve Using Contrast-Enhanced Ultrasonography in Patients With Cubital Tunnel Syndrome.
    J Hand Surg Am, S0363-5023(21)00433-0 (2021)
    DOI: 10.1016/j.jhsa.2021.06.024
  70. Matsui Y, Horie T, Iwasaki N.
    Ulnar nerve morphology during elbow flexion in patients with and without cubital tunnel syndrome: a sonographic study.
    J Hand Surg Eur, 47(2):218-220 (2021)
    DOI: 10.1177/17531934211026108
  71. Tsujimoto F, Endo T, Menjo Y, Kanayama M, Oda I, Suda K, Fujita R, Koike Y, Hisada Y, Iwasaki N.
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  83. 岩崎 浩司, 葛原 凌大, 近藤 英司, 松原 新史, 松岡 正剛, 後藤 佳子, 小野寺 智洋, 岩崎 倫政
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  84. 岩崎 浩司, 三浦 宗也, 近藤 英司, 松原 新史, 松岡 正剛, 後藤 佳子, 小野寺 智洋, 岩崎 倫政
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  85. 松原 新史, 小野寺 智洋, 岩崎 浩司, 菱村 亮介, 松岡 正剛, 近藤 英司, 岩崎 倫政
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  86. 鈴木 久崇, 松原 新史, 岩崎 浩司, 亀田 敏明, 松岡 正剛, 後藤 佳子, 小野寺 智洋, 近藤 英司, 岩崎 倫政
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  87. 上徳 善太, 近藤 英司, 岩崎 浩司, 小野寺 智洋, 安田 和則, 岩崎 倫政
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  89. 宮野真博,浅野毅,清水智弘,高橋要,入江徹,髙橋大介,岩崎倫政
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  90. 福島瑛,清水智弘,清水寛和,高橋要,髙橋大介,岩崎倫政
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  91. 下段俊,髙橋大介,清水智弘,岩崎倫政
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  92. 小川裕生,清水智弘,浅野毅,高橋要,髙橋大介,岩崎倫政
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  93. 大橋佑介,清水智弘,清水寛和,高橋要,髙橋大介,岩崎倫政
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  100. 上千春, 青木喜満, 安田和則, 八木知徳, 井上雅之, 近藤英司, 遠山晴一, 金子 知
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    DOI: 10.1186/s13071-016-1518-1
  325. Tsuboi K., Hasegawa T., Yamamoto T., Sasaki M., Hongo H., de Freitas PH., Shimizu T., Takahata M., Oda K., Michigami T., Li M., Kitagawa Y., Amizuka N.
    Effects of drug discontinuation after short-term daily alendronate administration on osteoblasts and osteocytes in mice.
    Histochem Cell Biol., 146(3), 337-50, (2016)
    DOI: 10.1007/s00418-016-1450-7
  326. Sudo H., Abe Y., Kokabu T., Ito M., Abumi K., Ito YM., Iwasaki N.
    Correlation analysis between change in thoracic kyphosis and multilevel facetectomy and screw density in main thoracic adolescent idiopathic scoliosis surgery.
    Spine J., 16(9), 1049-54, (2016)
    DOI: 10.1016/j.spinee.2016.04.014
  327. Adjou Moumouni PF., Terkawi MA., Jirapattharasate C., Cao S., Liu M., Nakao R., Umemiya-Shirafuji R., Yokoyama N., Sugimoto C., Fujisaki K., Suzuki H., Xuan X.
    Molecular detection of spotted fever group rickettsiae in Amblyomma variegatum ticks from Benin.
    Ticks Tick Borne Dis., 7(5), 828-33, (2016)
    DOI: 10.1016/j.ttbdis.2016.03.016
  328. Sudo H., Mayer MM., Kaneda K., Núñez-Pereira S., Shono Y., Hitzl WH., Iwasaki N., Koller H.
    Maintenance of spontaneous lumbar curve correction following thoracic fusion of main thoracic curves in adolescent idiopathic scoliosis.
    Bone Joint J., 98-B(7), 997-1002, (2016)
    DOI: 10.1302/0301-620X.98B7.37587
  329. Urita A., Funakoshi T., Horie T., Nishida M., Iwasaki N.
    Difference in vascular patterns between transosseous-equivalent and transosseous rotator
    cuff repair.
    J Shoulder Elbow Surg., 26(1), 149-156, (2016)
    DOI: 10.1016/j.jse.2016.06.010
  330. Terkawi MA., Takano R., Kato K.
    Isolation and co-cultivation of human macrophages and neutrophils with Plasmodium falciparumparasitized erythrocytes: An optimized system to study the phagocytic activity to malarial parasites.
    Parasitol Int., 65(5 Pt B), 545-548, (2016)
    DOI: 10.1016/j.parint.2016.03.005
  331. Arai R., Takahashi D., Inoue M., Irie T., Asano T., Konno T., Terkawi MA., Onodera T., Kondo E., Iwasaki N.
    Efficacy of teriparatide in the treatment of nontraumatic osteonecrosis of the femoral head.
    A retrospective comparative study with alendronate.
    BMC Musculoskelet Disord., 18(1), 24, (2016)
    DOI: 10.1186/s12891-016-1379-y
  332. Mori N., Kimura S., Onodera T., Iwasaki N., Nakagawa I., Masuda T.
    Use of a pneumatic tourniquet in total knee arthroplasty increases the risk of distal deep vein thrombosis: A prospective, randomized study.
    Knee, 23(5), 887-9, (2016)
    DOI: 10.1016/j.knee.2016.02.007
  333. Tsujimoto T., Takahata M., Kokabu T., Matsuhashi M., Iwasaki N.
    Pyogenic spondylodiscitis following antiinterleukin-6 therapy in a patient with rheumatoid arthritis (implication of hematogenous infection risk in degenerative intervertebral discs):
    A case report and review of the literature.
    J Orthop Sci., 21(5), 694-7, (2016)
    DOI: 10.1016/j.jos.2015.06.018
  334. Komatsu M., Suda K., Takahata M., Matsumoto S., Ushiku C., Yamada K., Yamane J., Endo T., Iwasaki N., Minami A.
    Delayed bilateral vertebral artery occlusion after cervical spine injury: a case report.
    Spinal Cord Series and Cases, 2, 16031, (2016)
    DOI: 10.1038/scsandc.2016.31
著書・総説・解説など
  1. Sudo H.
    Four-dimensional anatomical spinal reconstruction in thoracic adolescent idiopathic scoliosis.
    JJBJS Essent Surg Tech. 12(1) e21.00038 (2022)
    DOI: 10.2106/JBJS.ST.21.00038
  2. 小野寺智洋、江畑拓、濱崎雅成、照川アラー、岩崎倫政
    変形性関節症の病態におけるマクロファージの役割、
    リウマチ科,67 (2): 216-220, (2022) 科学評論社
  3. Kokabu T., Kanai S., Kawakami N., Uno K., Kotani T., Suzuki T., Tachi H., Abe Y., Iwasaki N., Sudo H.
    An algorithm for using deep learning convolutional neural networks with three-dimensional depth sensor imaging in scoliosis detection
    Spine J., 1-8 (2021)
    DOI: 10.1016/j.spinee.2021.01.022
  4. 遠藤 健., 河村 太介., 松井 雄一郎., 瓜田 淳., 太田 光俊., 岩崎 倫政.
    手指DIP関節固定がMP・PIP関節の可動域に及ぼす影響 ―Cadaverを用いた検討-
    日本手外科学会誌, 37(5), 1-3 (2021)
  5. Takeuchi R, Kondo E, Akiyama T, Yonekura A, Nakamura R, Nakayama H.
    Osteotomies around the knee for older active patients. Advances in Knee Ligament and Knee Preservation Surgery. Nakamura N, Marx RG, Musahl V, Getgood A, Sherman SL, Verdonk P (ed.)
    Springer, Cham p425-436, (2021)
  6. 小野寺智洋
    足の腫瘍性病変・小児疾患の診かた,
    巻き趾、明日の足診療シリーズII 301-304, (2021) 全日本病院出版会
  7. 髙橋大介,清水智弘,宮崎拓自,中村夢志郎,岩崎倫政
    大腿骨頭軟骨下脆弱性骨折の特徴と治療方針
    関節外科 基礎と臨床 Vol.40 No.12 2021.12,43-47(2021) メジカルビュー社
  8. 太田 光俊, 田中 勇希, 岩崎 倫政, 村上 正晃
    関節リウマチにおける軟骨細胞の新たな役割 IL-6アンプとTMEM147.
    リウマチ科66(4),393-403,(2021) 化学評論社
  9. 近藤英司
    治療法の再整理とアップデートのために 専門家による私の治療 
    膝靱帯損傷(解説) 第4版 (0385-9215)5085号 Page43-44(2021) 日本医事新報社
  10. 近藤英司
    誌上シンポジウム 北海道における膝前十字靱帯再建手術の現状と課題 
    膝前十字靱帯のバイオロジーとバイオメカニクス
    北海道整形災害外科学会雑誌(2021)
  11. 近藤英司
    特集 ACL再断裂に対する治療戦略 再再建方法(ハムストリング)
    臨床整形外科56(6):773-778,(2021) 医学書院
  12. 近藤英司
    特集 膝膝周囲骨切り術を成功に導く基礎知識. 歴史の学ぶ膝周囲骨切り術を成功に導くためのコツ
    臨床整形外科 56(9):1115-1124,(2021) 医学書院
  13. 門間太輔、近藤英司、岩崎倫政
    特集:エキスパートが伝えたい肩関節診断の奥義、投球肩の診断~四次元CTの可能性 
    Monthly Book Orthopaedics 34(11)13-19,(2021) 全日本病院出版会
  14. 大越 康充, 馬場 力哉, 岩崎 浩司, 前田 龍智, 岩館 茜, 小野寺 智洋, 近藤 英司, 岩崎 倫政
    【UKAの適応と手技の最前線】内側脛骨大腿関節症および膝蓋大腿関節症に対する組み合わせ式二顆置換術(BiKA)の適応と臨床成績(解説/特集).
    関節外科 (0286-5394)40巻9号 Page959-965(2021)メジカルビュー社
  15. 近藤英司
    ハムストリング腱を用いる遺残組織温存ACL再建術, 出家正隆編
    ビジュアル・サージカルテクニック膝関節鏡視下手術 p68-72, (2021) 文光堂
  16. 近藤英司
    II各論 1.外傷・障害 A.靱帯損傷 
    3)内側支持機構損傷、津村 弘、三浦裕正、松田秀一、岡崎 賢編
    膝関節外科学 p200-206,(2021) 南江堂
  17. 近藤英司
    II各論 1.外傷・障害 A.靱帯損傷 4)後外側支持機構損傷、津村 弘、三浦裕正、松田秀一、岡崎 賢編
    膝関節外科学 p207-212,(2021)南江堂
  18. 近藤英司
    遠山晴一、安田和則:前十字靱帯損傷、松本秀男、近藤英司、池上博泰、
    西良浩一編 講座 スポーツ整形外科学, 2章スポーツによる膝関節の外傷・障害  p28-38,(2021) 中山書店
  19. 近藤英司,安田和則
    Case 1内側楔状開大式高位脛骨骨切り術後の骨癒合遷延、偽関節. 1. Open wedge high tibial osteotomy (OWHTO)
    竹内良平編 症例から学ぶ膝周囲骨切り術ピットフォール―陥らないために!抜け出すために !
    p2-6,(2021) 全日本病院出版会
  20. 近藤英司,小野寺純, 安田和則, 八木知徳
    Case 2内側楔状開大式高位脛骨骨切り術後の外反変形. 1. Open wedge high tibial osteotomy (OWHTO).
    竹内良平編:症例から学ぶ膝周囲骨切り術ピットフォール―陥らないために!抜け出すために !
    p7-10,(2021) 全日本病院出版会
  21. 近藤英司,安田和則
    Case 1高度内反変形に対する逆V字型高位脛骨骨切り術. 3. 逆V字型高位脛骨骨切り術. 
    竹内良平編:症例から学ぶ膝周囲骨切り術ピットフォール―陥らないために!抜け出すために !
    p50-54,(2021) 全日本病院出版会
  22. 近藤英司、安田和則
    II脛骨の骨切り術、内側楔状開大式高位けいこつ骨切り術
    岡崎 賢編:膝周囲骨切り術のすべて p50-63,(2021) メジカルビュー社
  23. 辻本 武尊., 須藤 英毅., 東藤 正浩., 山田 勝久., 岩崎 浩司., 大西 貴士., 筌場 大介., 浦 勝郎., 岩崎 倫政.
    高純度硬化性ゲルによる無細胞移植椎間板組織自然再生誘導法の検討
    北海道整形災害外科学会誌, 62(1), 1-15 (2020)
  24. 上徳 善太., 松原 新史., 近藤 英司., 岩崎 浩司., 小野寺 智洋., 安田 和則., 岩崎 倫政.
    膝重度複合靱帯損傷に対する自家腱ハイブリッド代用材料を用いた一期的および二期的再建術の臨床成績
    日本関節鏡・膝・スポーツ整形外科学会雑誌, 45(1), 120-121 (2020)
  25. 西田 善郎., 近藤 英司., 岩崎 浩司., 林 睦., 上徳 善太., 小野寺 智洋., 河村 太介., 八木 知徳., 安田 和則., 岩崎 倫政.
    膝屈筋腱ハイブリッド代用材料を用いた解剖学的二束後十字靱帯再建術の臨床成績:一束再建術との比較
    日本関節鏡・膝・スポーツ整形外科学会雑誌, 45(1), 140-141 (2020)
  26. 上田 大輔., 安田 和則., 薮内 康史., 小野寺 純., 小野寺 伸., 八木 知徳., 近藤 英司., 岩崎 浩司., 岩崎 倫政.
    高位脛骨骨切り術のための腓骨強斜位骨切り手技:術後の骨癒合に関する放射線医学的評価を中心に
    日本関節鏡・膝・スポーツ整形外科学会雑誌, 45(1), 156-157 (2020)
  27. 岩崎 浩司., 近藤 英司., 亀田 敏明., 小野寺 智洋., 上徳 善太., 安田 和則., 八木 知徳., 岩崎 倫政.
    高位脛骨骨切り術後の脛骨関節面における軟骨下骨骨密度分布の変化―CT absorptiometry法を用いて―
    日本関節鏡・膝・スポーツ整形外科学会雑誌, 45(1), 178-179 (2020)
  28. 清水 寛和., 岩崎 浩司., 近藤 英司., 小野寺 智洋., 上徳 善太., 安田 和則., 八木 知徳., 岩崎 倫政.
    膝十字靱帯不全を合併した内側型変形性膝関節症に対する膝十字靱帯再建術と高位脛骨骨切り術の二期的手術の短期成績
    日本関節鏡・膝・スポーツ整形外科学会雑誌, 45(1), 206-207 (2020)
  29. 細川 吉暁., 近藤 英司., 岩崎 浩司., 小野寺 智洋., 八木 知徳., 安田 和則., 岩崎 倫政.
    高位脛骨骨切り術が膝蓋骨高位に与える影響―内側楔状開大式と逆V字型の比較―
    日本関節鏡・膝・スポーツ整形外科学会雑誌, 45(1), 208-209 (2020)
  30. 三浦 宗也., 岩崎 浩司., 近藤 英司., 岩崎 倫政.
    膝前十字靭帯損傷膝の脛骨関節面における軟骨下骨の骨密度分布:CT osteoabsorptiometry法を用いて
    臨床バイオメカニクス, 41, 149-154 (2020)
  31. 太田 光俊., 河村 太介., 瓜田 淳., 松井 雄一郎., 遠藤 健., 岩崎 倫政.
    CT横断像を用いた手根骨アライメントの検討
    日本手外科学会雑誌, 37, 175-178 (2020)
  32. 佃 幸憲., 瓜田 淳., 松居 祐樹., 岩崎 倫政.
    リバース型人工肩関節置換術後上腕骨ステム周囲の単純X線評価
    肩関節, 44(1), 205-208 (2020)
  33. 山口 哲也., 瓜田 淳., 松居 祐樹., 倉茂 秀星., 岩崎 倫政.
    On-lay型リバース型人工肩関節置換術後の外旋筋力評価
    肩関節, 44(2), 434-437 (2020)
  34. 山田 勝久., 長濱 賢., 室田 栄宏笠., 平塚 重人., 岩崎 倫政.
    新コンセプトの低侵襲腰椎椎体間固定術である全内視鏡下経椎間孔腰椎椎体間固定術の手術手技と腰椎変性すべり症に対する術後2年の臨床成績
    別冊整形外科, 77, 2-5 (2020)
  35. 濱野 博基., 河村 太介., 本宮 真., 松井 雄一郎., 瓜田 淳., 岩崎 倫政.
    関節リウマチに対する術中の人工肘関節周囲骨折の背景とその臨床成績
    日本手外科学会雑誌, 36, 545-548 (2020)
  36. 太田 光俊., 河村 太介., 瓜田 淳., 松井 雄一郎., 遠藤 健., 岩崎 倫政.
    CT横断像を用いた手根骨アライメントの検討
    日本手外科学会雑誌, 37, 175-178 (2020)
  37. 本宮 真., 渡辺 直也., 亀田 裕亮., 河村 太介., 岩崎 倫政.
    指部軟部欠損創に対する遊離皮弁の治療成績 ―静脈吻合における顕微鏡下parachute 端側吻合法の有用性
    日本手外科学会雑誌, 37, 128-132 (2020)
  38. 横田 隼一., 小野寺 智洋., 亀田 敏明., 林 晴久., 加藤 琢磨., 近藤 英司., 岩崎 倫政.
    当科における血友病生膝関節症に対する人工膝関節置換術の臨床成績
    北海道整形災害外科学会雑誌, 61, 101-104 (2020)
  39. 濵野 博基., 河村 太介.,  本宮 真.,  松井 雄一郎.,  瓜田 淳., 岩崎 倫政.
    関節リウマチに対する術中の人工肘関節周囲骨折の背景とその臨床成績
    日手会誌, 36, 545-548 (2020)
  40. 山口 純., 安田 和則., 上田 大輔., 小野寺 純., 小野寺 伸., 薮内 康史., 八木 知徳., 近藤 英司., 岩崎 倫政., 丸毛 啓史., 斎藤 充. 
    当院において発生した10例の膝関節鏡視下手術後骨壊死の病態
    関節病学会雑誌, 39, 410-418 (2020)
  41. 花松 久寿、古川 潤一
    糖鎖一時構造解析の開発要素
    生化学 特集「Human Glycomeがもたらす未来」の企画にあたって, vol 92. No. 3 (2020)
  42. 近藤 英司、安田 和則
    遺残組織を温存した再建術
    パーフェクト 前十字靭帯再建術(ACL), 145-151 (2020) 
  43. 近藤 英司
    【新任教授寄稿】北海道大学病院 スポーツ医学診療センターの運営に関する抱負
    北海道医学雑誌95(1), 47-48 (2020)
  44. 近藤 英司
    治療法の再整理とアップデートのために 専門家による私の治療 膝靭帯損傷
    日本医事新報5020, 45-46 (2020)
  45. 近藤 英司
    連載 私の整形外科診療のコツ 第11回 膝前十字靭帯損傷
    関節外科39(11), 1258-1261 (2020)
  46. 佐藤 大、高畑 雅彦
    Vocabulary Siglec-15(解説)
    整形外科 71巻2号, 159 (2020) 
  47. 高畑 雅彦
    【骨粗鬆症性椎体骨折治療の最新知見】骨粗鬆症性椎体骨折受傷時の骨粗鬆症治療薬剤の考え方(解説/特集)
    整形・災害外科 63巻2号, 141-146 (2020)
  48. 高畑 雅彦、石井 賢
    骨粗鬆症に対する薬物療法の最近のトピックについて ストラテジー(treat to target)についての議論が進んでいる
    日本医事新報 5002号, 51 (2020) 
  49. 須藤 英毅
    整形外科X人工知能 情報処理技術(IT)を用いた側弯症手術の解剖学的4D矯正と人工知能に対する展望
    臨床整形外科55, 913-918
  50. 岩崎 倫政
    末梢神経損傷
    標準整形外科学 第14版 862-875 (2020)
  51. 門間 太輔,岩崎 倫政
    ②治療編 Ⅱ手・肘の特徴的な疾患 1肘の関節症・炎症性疾患④肘離断性骨軟骨炎(Panner病も含む)、⑤リトルリーグ肘
    手・肘の診療
  52. 小野寺 智洋
    明日の足診療シリーズI
    足の変性疾患・後天性変形の診かたII章8) 関節固定術(直視下), 99-104 (2020)
  53. 角家 健
    末梢神経修復・再生のメカニズム
    OS NEXUS 17末梢神経障害・損傷の修復と再建術,
    2-7 (2019)
  54. 高畑 雅彦
    北海道の脊椎外科と国際貢献 脊椎脊髄外科のグローバル化(解説)
    北海道整形災害外科学会雑誌, 61(1), 24-25 (2019)
  55. 高畑 雅彦、佐藤 大、岩崎 倫政
    新しい医療技術.Siglec-15分子標的治療の有用性
    整形災害外科, 62(4), 405-409 (2019)
  56. 角家 健
    脊髄損傷後の神経回路再生
    ブレインサイエンス・レビュー2019, 129-143 (2019)
  57. 角家 健
    末梢神経修復・再生のメカニズム
    OS NEXUS 17末梢神経障害・損傷の修復と再建術, 2-7 (2019)
  58. 角家 健
    国際経験-脊椎外科医の米国での留学経験の実際とその後
    北海道整形災害外科学会雑誌, 61(1), 40-43 (2019)
  59. 須藤 英毅、小甲 晃史、安倍 雄一郎、岩崎 倫政、金井 理
    側弯検診システムの研究開発
    臨床整形外科54, 306-310 (2019)
  60. 須藤 英毅、金井 理、小甲 晃史、安倍 雄一郎、岩崎 倫政、千葉 晶彦
    4D-有限要素解析シミュレーションによる術前計画と積層造形技術を含む脊柱変形矯正用カスタムメイドインプラントの開発
    別冊整形外科 整形外科診療における最先端技術75, 218-221 (2019)
  61. 須藤 英毅、小甲 晃史、安倍 雄一郎、岩田 玲、岩崎 倫政、金井 理
    3Dデプスセンサを用いた脊柱側弯症に対する自動診断支援技術の開発
    別冊整形外科 整形外科診療における最先端技術75, 88-90 (2019)
  62. Iwasaki N.
    Arthritis. Chapter 13 Glycans in Osseous Tissue and Articulation
    Glycoscience: Basic Science to Applications. (Ed. Naoyuki Taniguchi, Tamao Endo, Jun Hirabayashi, Shoko Nishimara, Kenji Kadomatsu, Kazunari Akiyoshi, Kiyoko F. Aoki-Kinoshita) (Springer Nature Singapore Pte Ltd.), 224-226 (2019)
  63. Sudo H., Abumi K.
    UPPER CERVICAL - C2 pedicle screw fixation technique (Heiko Koller / Yohan Robinson: Cervical Spine Surgery: Standard and Advanced Techniques, Springer)
    Chapter 37 - SURGICAL TECHNIQUES - , 259-264 (2019)
  64. 近藤 英司、安田 和則
    Ⅳ. 手術各論;A. Open wedge high tibial osteotomy (OWHTO) Trisプレート
    日本Knee Osteotomyフォーラム編:ゼロからはじめる! Knee Osteotomyアップデート, 58-63 (2018)
  65. 近藤 英司、安田 和則
    Ⅳ. 手術各論;D. その他の脛骨近位骨切り術 逆V字型高位脛骨骨切り術
    日本Knee Osteotomyフォーラム編:ゼロからはじめる! Knee Osteotomyアップデート, 154-159 (2018)
  66. 近藤 英司、安田 和則
    Ⅲ. 骨切り術 ロッキングプレートを用いた逆V字型高位脛骨骨切り術の落とし穴
    宗田大編:OS NEXUS 15 膝関節手術の落とし穴陥らないためのテクニック, 184-195 (2018)
  67. 近藤 英司
    シンポジウム 膝前十字靱帯のバイオメカニクス:2束前十字靱帯再建術の生体力学的評価 2つの1束再建術との比較
    臨床整形外科, 53, 589-594 (2018)
  68. 角家 健、近藤 英司、高畑 雅彦、須藤 英毅、古川潤一、小野寺 智洋、アラー テルカウイ、岩崎 倫政
    基礎研究体制と概要-北海道大学整形外科- 北海道整形災害外科学会誌 誌上シンポジウム,
    59(2), 197-204 (2018)
  69. 角家 健
    慢性期と急性期での脊髄損傷における神経回路の再生
    脊椎脊髄ジャーナル, 31(6), 579-587 (2018)
  70. 角家 健、Mark Tuszynski、岩崎 倫政
    亜急性期と慢性期脊髄損傷への神経幹細胞/前駆細胞移植が持つ解剖学的および機能学的再生効果
    日本整形外科学会雑誌, 92, 743-748 (2018)
  71. 高畑 雅彦
    北海道における整形外科基礎研究.骨代謝研究
    北海道整形災害外科学会雑誌, 59(2), 205-208 (2018)
  72. 須藤 英毅
    椎間板研究の最前線 椎間板変性治療 アポトーシス,
    臨床整形外科, 53, 971-974 (2018)
  73. 小野寺 智洋
    運動器の外科治療 -リング型創外固定器による治療 Ilizarov法 / Taylor Spatial Frame (TSF) を用いて-
    産業動物臨床医学雑誌, 9(3), 118-121 (2018)
  74. 小野寺 智洋、 岩崎 倫政
    軟骨再生研究
    北海道整形災害外科学会雑誌, 59(2), 209-212 (2018)
  75. 髙橋 大介、岩崎 倫政
    臨床各科難治症例から学ぶ診療のエッセンス -末期変形性股関節症を合併した非定型大腿骨骨折
    週刊日本医事新報, 4908, 12-13 (2018)
  76. 髙橋 大介、岩崎 倫政
    臨床各科難治症例から学ぶ診療のエッセンス -寛骨臼側の高度骨破壊を合併した急速破壊型股関節症
    週刊日本医事新報, 4923, 10-11 (2018)
  77. 瓜田 淳、岩崎 倫政
    一次修復可能な腱板断裂に対する鏡視下腱板修復術–北海道大学整形外科における腱板縫合および基礎的研究–
    北海道整形災害外科学会雑誌, 60(1), 20-24 (2018)
  78. 瓜田 淳、岩崎 倫政
    成長期の上肢スポーツ外傷・障害 –部位別の特徴および種目関連性について–
    Monthly Book Medical Rehabilitation, 228, 33-38 (2018)
  79. 松井 雄一郎、岩崎 倫政
    人工手関節症例登録.整形外科レジストリー
    Bone Joint Nerve, 8(3), 361-363 (2018)
  80. 小甲 晃史、須藤 英毅、安倍 雄一郎、伊東 学、岩崎 倫政
    学術奨励賞・受賞記念論文 思春期特発性側弯症における術中rod-deformationに影響を与える因子の検討
    北海道整形災害外科学会雑誌, 60, 6-11 (2018)
  81. 清水 智弘、岩崎 倫政、Xiaojuan Li
    関節リウマチの骨軟骨破壊病変 -HR-pQCT-画像解析, (38)7, 672-676 (2018)
  82. 門間 太輔、遠藤 香織、清水 智弘、船越 忠直、岩崎 倫政
    投球障害肩に対する治療
    北海道整形災害外科学会雑誌, 60(1), 48-51 (2018)
  83. 河村 太介、岩崎 倫政
    橈骨頭・頚部骨折に対する観血的整復固定術(ORIF)OS NEXUS 13 高齢者上肢骨折に対する手術,
    64-71 (2018)
  84. Terkawi MA., Takano R., Furukawa A., Murakoshi F., Kato K.
    Involvement of β-defensin 130 (DEFB130) in the macrophage microbicidal mechanisms for killing Plasmodium falciparum
    Sci Rep., 7, 41772 (2017)
    DOI: 10.1038/srep41772
  85. 高畑雅彦
    頚椎.関節リウマチ 進行期関節リウマチの画像診断
    メディカル・サイエンス・インターナショナル
    (2017)
  86. 須藤英毅
    思春期特発性側弯症に対する胸椎固定術後の腰椎
    カーブ自然矯正効果の長期的検討
    整形外科, 68, 1128-1129 (2017)
  87. 須藤英毅
    脊椎の手術:椎弓形成術(頸椎)
    整形外科看護2017秋季増刊号, 176-181 (2017)
  88. 角家健
    神経前駆細胞移植による脊髄損傷後の皮質脊髄路の再生
    北海道医療新聞, 6月号(2016)
  89. 高畑雅彦
    【ハイブリッド手術室とは−現状と将来−】脊椎外科手術におけるハイブリッド手術室の現状と将来
    (解説/特集)
    臨床麻酔, 40(9), 1258-62 (2016)
  90. 伊東学、高畑雅彦、須藤英毅、金田清志、佐藤栄修、岩崎倫政
    骨粗鬆症性椎体骨折後後彎症(OPK)の病態と治療戦略 骨粗鬆症性椎体圧潰による遅発性麻痺の病態と治療 前方法vs.後方法(解説)
    日本整形外科学会雑誌,90(9),577-83(2016)
  91. 入江徹、高橋大介、浅野毅、高橋要、新井隆太、亀田敏明、下段俊、岩崎倫政
    Modified Watson-Jones法とposterolateral法によるTHA術後深部静脈血栓症の発生率・発生部位の比較検討
    Hip Joint,42巻1号,536-9(2016)
  92. 浅野毅、高橋大介、入江徹、下段俊、新井隆太、岩崎倫政
    大腿骨転子間彎曲内反骨切り術後の内反進行例の検討
    Hip Joint,42巻1号,297-301(2016)
  93. 浅野毅、高橋大介、入江徹、下段俊、新井隆太、中野宏昭、深谷英昭、松本悠介、岩崎倫政
    著明な骨欠損を伴うTHA再置換術後感染性ゆるみに対しteriparatideを併用して二期的再置換術を施行した1例(原著論文)
    Hip Joint,42巻2号,790-4(2016)
  94. 岩田玲、角家健、須藤英毅、高畑雅彦、岩崎倫政
    【骨折(四肢・脊椎脊髄外傷)の診断と治療(その1)】 脊椎 脊椎椎体(頸椎・胸椎・腰椎) 
    脊椎外傷に対する手術的治療の適応と方法(解説/特集)
    別冊整形外科,70,152-8(2016)
  95. 下段俊、入江徹、高橋大介、浅野毅、新井隆太、亀田敏明、岩崎倫政
    人工股関節全置換術後における医師主導型評価と患者立脚型評価の相関性の検討
    Hip Joint,42巻1号,124-8(2016)
  96. 薮内康史、近藤英司、小野寺純、小野寺智洋、亀田敏明、北村信人、八木知徳、安田和則、岩崎倫政
    内側楔状開大式高位脛骨骨切り術後のスポーツ復帰に関する検討
    日本関節病学会誌,35,149-54(2016)
  97. 清水智弘、高畑雅彦、亀田裕亮、濱野博基、伊藤哲平、木村廣美[須田]、東藤正浩、但野茂、岩崎倫政
    ビタミンK依存性グラ化オステオカルシンは副甲状腺ホルモン製剤の骨治癒効果に影響する
    北海道整形災害外科学会雑誌,58(1),9-14(2016)
  98. 濵野博基、高畑雅彦、太田昌博、平塚重人、清水智弘、亀田裕亮、岩崎倫政
    脊椎骨増殖性病変と骨粗鬆症を併存するびまん性特発性骨増殖症に対するテリパラチドの治療効果-
    靭帯骨化石灰化症自然発症モデルマウス(twy/twy)を用いた検討-
    臨床整形外科,51(5),458-65(2016)
  99. 辻本武尊、小谷善久、上徳善太、益子竜哉、綛村俊之、岩崎倫政
    首下がり症状を呈する高度頚椎後弯症に対し手術療法を行った2症例
    北海道整形災害外科学会雑誌,57(2),269-74(2016)
  100. 鈴木裕貴、内田淳、笹沢史生、山崎修司、門司順一、小野寺智洋、岩崎倫政
    多数回の骨折を繰り返した糖尿病性足部シャルコー関節の治療経験
    日本足の外科学会雑誌,37(1),367-70(2016)
  101. 松前元、紺野拓也、高橋大介、入江徹、浅野毅、新井隆太、岩崎倫政
    前立腺癌の溶骨性骨転移を右寛骨臼に発症し股関節中心性脱臼をきたした一例
    Hip Joint,42巻1号,195-8(2016)
  102. 木田博朗、高畑雅彦、小甲晃史、三田真俊、安井啓悟、岩崎倫政
    髄核脱出を伴った小児頸椎椎間板石灰化症の1例
    北海道整形災害外科学会雑誌,57(2),283-5(2016)
  103. 小池良直、高畑雅彦、岩田玲、校條祐輔、小甲晃史、須藤英毅、岩崎倫政
    児童期に発症した腰椎椎間板ヘルニアの特徴
    北海道整形災害外科学会雑誌,57(2),279-82(2016)
  104. 細川吉暁、船越忠直、鈴木裕貴、松井雄一郎、河村太介、亀田裕亮、岩崎倫政
    陳旧性肘関節後方完全脱臼に対し、創外固定器を併用した観血的脱臼整復術を施行した1例
    日本肘関節学会雑誌 23 巻 2 号, 251-253 (2016)
  105. 細川吉暁、浅野毅、髙橋大介、入江徹、新井隆太、下段俊、岩崎倫政
    経過中にMRI所見が変化した大腿骨頭軟骨下脆弱性骨折の1例
    北海道整形災害外科学会雑誌, 58(2) , 280-281 (2017)
  106. 横田正司、小野寺純、近藤英司、北村信人、岩崎倫政、安田和則
    解剖学的2束ACL再建術における遺残組織の温存が移植腱の再構築過程に与える効果
    -MRIを用いた研究-
    日本関節鏡・膝・スポーツ整形外科学会雑誌,41(1),118-9(2016)
  107. 大羽文博、金山雅弘、橋本友幸、高畑雅彦、岩田玲、岩崎倫政
    腰部脊柱管狭窄症に対する保存療法の効果とその限界
    東北整形災害外科学会雑誌,59(1),5-8(2016)
国際学会(招待講演)
  1. October 2019
    Seoul, Korea
    The 63rd Annual Congress of the Korean Orthopaedic Associaton
    Inverted V-shaped high tibial osteotomy for medial osteoarthritis of the knee with severe varus deformity.
    Kondo E.
  2. July 2018
    Bankok, Thailand
    Osteotomies around the knee education course
    Open-wedge High Tibial Osteotomy using TriS Medial HTO Plate System
    Kondo E.
  3. July 2018
    Seoul, Korea
    International Cervical Conference 2018
    Surgical technique of cervical pedicle screw using special instrument
    Takahata M.
  4. October 2018
    Seoul, Korea
    The 62nd Annual Congress of the Korean
    Orthopaedic Association, International Symposium
    Effects of remnant tissue preservation on clinical outcome after double-bundle ACL reconstruction
    Kondo E.
  5. November 2018
    Gwangju, Korea
    The 10th Congress of Asia-Pacific Knee Society
    Clinical outcome of inverted V-shaped high tibial osteotomy for medial osteoarthritic knees with severe varus deformity
    Kondo E.
  6. November 2018
    Busan, Korea
    11th Murup hospital live surgery 2018
    Live surgery Ⅲ:Hybrid LCWHTO (Fibular Osteotomy)
    Kondo E.
  7. November 2018
    Xiamen, China
    China Orthopaedic Association
    Anterior cervical plate screw fixation. Short Plate to Prevent ALOD.
    Takahata M.
  8. November 2018
    Xiamen, China
    China Orthopaedic Association
    Surgical techniques of Laminoplasty to reduce postoperative axial pain
    Takahata M.
  9. July 2017
    Gwangju, Chonnam natinal university Bitgoeul hospital, Korea
    2017 Asia Pacific stem cells and cartilage repair symposium
    Effects of Intara-articular urtrapurified low endotoxin alginate administration on meniscal defects in rabbits.
    Kondo E., Woo Young Kim., Onodera T., Iwasaki N.
  10. October 2017
    Soeul, Korea
    The 61th Korean Orthopaedic Association International Symposium
    One or two stage revision ACL reconstruction.
    Kondo E.
  11. December 2016
    Sapporo, Japan
    RIES-Hokudai International symposium
    Axon regeneration by homologous tissue reconstitution.
    Kadoya K.
国際学会(口頭発表)
  1. February 2021
    Orthopedic Research Society 2021 Annual Meeting,
    Kinematics Of Varus Thrust In Patients With Medial Knee Osteoarthritis - Quantified By Three-dimensional Analysis
    Iwasaki K, Ohkoshi Y, Tateyama Y, Ukishiro K, Kawakami K, Suzuki S, Maeda T, Onodera T, Kondo E, Iwasaki N
  2. February 2021
    Orthopedic Research Society 2021 Annual Meeting,
    Annexin A1 (AnxA1) for potential therapeutic and translatable intervention in bone diseases typified by pathological bone resorption.
    Alhasan H, Terkawi MA, Matsumae G, Ebata T, Takahashi D, Shimizu T, Yokota S, Kadoya K, Iwasaki N
  3. February 2021
    Orthopedic Research Society 2021 Annual Meeting,
    Sclerotic Change of Cancellous Bone at Humeral Capitellum Predicts Unsuccessful Nonoperative Management of Capitellar.
    Long Beach, USA.
    Momma D, Matsui Y, Kawamura D, Urita A, Matsui Y, Kondo E, Iwasaki N
  4. February 2021
    The 67th Annual Meeting of the Orthopaedic Research Society,
    Oral administration of Saracatinib, a Src kinase family inhibitor, suppresses pathological bone resorption in wear debris-induced osteolysis murine model. Poster presentation.
    Matsumae G, Terkawi MA, Shimizu T, Ebata T, Takahashi D, Iwasaki N
  5. June 2021
    APSS-APPOS 2021
    Validation of parameters recommended for secondary screening for developmental dysplasia of the hip in Japan.
    Shimizu T, Takahashi D, Shimizu H, Suzuki H, Iwasaki N
  6. May 2021
    2020+1 World Congress of World Congress of Society for Tennis Medicine and Science
    Return to sports after joint preservation surgery.
    Kondo E
  7. June 2021
    13th combined meeting of APSS-APPOS
    Unintentional facet fusion without bone grafting after minimally invasive lumbar interbody fusion: A retrospective study of percutaneous endoscopic transforaminal lumbar interbody fusion.
    Yamada K, Nagahama K, Abe Y, Takahata M, Iwasaki N
  8. July 2021
    オンライン開催
    The 38th Annual Symposium of the National Neurotrauma Society,
    Novel High-throughput Screening Assay Identifies Berberine as Neuroprotection Drug for Spinal Cord Injury.
    Suzuki Y, Kadoya K, Endo T, Rufei Y, Asano T, Maenaka K, Nakagawa S, Iwasaki N.
  9. September 2021
    NASS (North American Spine Society)36th Annual Meeting
    An algorithm for using deep learning convolutional neural networks with three dimensional depth sensor imaging in scoliosis detection.
    Kokabu T, Kanai S, Kawakami N, Uno K, Kotani T, Suzuki T, Tachi H, Abe Y, Iwasaki N, Sudo H.
  10. September 2021
    SRS (Scoliosis Research Society)56th Annual Meeting
    An algorithm for using deep learning convolutional neural networks with three dimensional depth sensor imaging in scoliosis detection.
    Kokabu T, Kanai S, Kawakami N, Uno K, Kotani T, Suzuki T, Tachi H, Abe Y, Iwasaki N, Sudo H.
  11. November 2021
    7th world congress of minimally invasive spine surgery & techniques (WCMISST), Sponsored Symposium
    Percutaneous Endoscopic Transforaminal Lumbar Interbody Fusion (PETLIF) -A New Modified Technique for Treating Degenerative Lumbar Spondylolisthesis-
    Yamada K, Nagahama K, Abe Y, Hyugaji Y, Takahata M, Iwasaki N
  12. April 2019
    Chengdu, China
    2019 Asia-Pacific knee, arthroscopy and sports medicine society and the 16th International forum on orthopedics sports medicine and arthroscopy
    Inverted V-shaped high tibial osteotomy for osteoarthritic knees with severe varus deformity.
    Kondo E.
  13. May 2019
    Cancun, Mexico
    The 12th biennial Congress of International Society of Arhroscopy, Knee Surgery and Orthopaedic Sports Medicine
    ACLR with remnant preservation: So what?
    Kondo E.
  14. May 2019
    Cancun, Mexico
    The 12th biennial Congress of International Society of Arthroscopy, Knee Surgery and Orthopaedic Sports Medicine
    Inverted V-shaped high tibial osteotomy for medial osteoarthritic knees with severe varus deformity.
    Kondo E.
  15. July 2019
    Sapporo, Japan
    Asia Pacific Society for Biology and Medical Sciences (APSBMS)
    A double-edged sword in aseptic loosening of total joint arthroplasty.
    Terkawi MA.
  16. October 2019
    Vancouver, Canada
    The 19th Annual meeting of International Cartilage Regeneration and Joint Preservation Society (ICRS 2019)
    Inflamed macrophages by articular cartilage fragments elicits typical gene expression signature of endochondral ossification in co-cultured chondrocytes.
    Onodera T.
  17. October 2019
    Seoul, Korea
    The 63rd Annual Congress of the Korea Orthopaedic Association
    The Effect of the First Metatarsal Shortening in the Modified Lapidus procedure.
    Onodera T.
  18. November 2019
    Nice, France
    The 59th International Spinal Cord Society Annual Scientific Meeting
    Age is a critical factor for segmental motor recovery after severe cervical spinal cord injury: Analysis of complete paralysis cases at 72 hours after injury.
    Kadoya K.
  19. May 2018
    Glasgow, United Kingdom
    European Society for Sports Traumatology, Knee Surgery and Arthroscopy 2018
    Evaluation of the grafted tendon location in the femoral tunnel after anterior cruciate ligament reconstruction: A magnetic resonance imaging study
    Kondo E.
  20. May 2018
    Sydney, New South Wales, Australia
    Australian Orthopaedic Association (AOA)
    Continuing Orthopaedic Education and Asia Pacific Knee Arthroscopy and Sports Medicine Society (APKASS) Congress
    Evaluation of the grafted tendon location in the femoral tunnel after anterior cruciate ligament reconstruction: a magnetic resonance imaging study
    Kondo E.
  21. July 2018
    Otsu, Japan
    18th Japan-France Orthopedic Society Conference (SOFJO, Société Francco-Japonaise d’Orthopédie)
    Transcriptional profile of stimulated macrophages by ultra-high molecular weight polyethylene debris of orthopedic implants implies a novel mechanism of osteolysis
    Terkawi MA.
  22. August 2018
    Incheon, Korea
    The 5th KOREA-JAPAN Knee Ostotomy Symposium
    Inverted V-shaped high tibial osteotomy for medial osteoarthritic knees with severe varus deformity.
    Kondo E.
  23. September 2018
    Sydney, Australia
    The 57th International Spinal Cord Society Annual Scientific Meeting
    The influence of surgical timing on neurological recovery after severe cervical spinal cord injury.
    Analysis of complete paralysis cases.
    Kadoya K.
  24. November 2018
    Gwangju, Korea
    The 10th Congress of Asia-Pacific Knee Society Clinical outcome of medial open-wedge high tibial osteotomy using a novel fixation system:
    comparison with a conventional plate
    Kondo E.
国内招待講演
  1. 2022年2月
    第34回日本老年麻酔学会
    超高齢社会とロコモティブシンドローム
    岩崎 倫政
  2. 2021年1月
    Web講演
    Shiga Spine Web Conference
    頚椎手術を安全かつ確実に行うための工夫〜変形矯正から靭帯骨化、骨粗鬆症まで〜
    高畑 雅彦
  3. 2021年2月
    Web講演
    骨粗鬆症セミナーin小樽
    骨の研究からみえてくる脊椎脊髄疾患の病態と治療のピットフォール
    高畑 雅彦
  4. 2021年4月
    第16回佐賀県整形外科医会学術集会
    関節リウマチ(RA)および変形性関節症(OA)手関節に対する治療戦略ー薬物治療から手術治療まで
    岩崎 倫政
  5. 2021年4月
    第65回日本リウマチ学会
    関節リウマチ診療における手外科医の役割―RA手関節に対する手術成績のさらなる向上を目指して
    岩崎 倫政
  6. 2021年5月
    第94回日本整形外科学会学術総会
    肘軟骨損傷に対する治療の最前線―硝子様軟骨による修復・再生を目指して―
    岩崎 倫政
  7. 2021年9月
    第40回神奈川県西湘地区整形外科講演会
    軟骨損傷に対する治療の現況ー疼痛マネジメントから再生医療までー
    岩崎 倫政
  8. 2021年10月
    我汝会えにわ病院
    ロコモー現状と課題
    岩崎 倫政
  9. 2021年11月
    第12回東京手の外科手術手技研究会
    RA手関節に対する新規人工手関節の開発と臨床応用
    岩崎 倫政
  10. 2021年7月
    第46回九州膝関節研究会. 福岡市
    新しい膝関節周囲骨切り術
    近藤 英司
  11. 2021年5月
    第18回北海道関節疾患研究会
    特別講演I. 変形性膝関節症に対する膝周囲骨切り術の適応と課題~保存療法も含めて
    近藤 英司
  12. 2021年8月
    札幌スポーツ医科学セミナー2021
    スポーツ復帰のための膝関節温存手術
    近藤 英司
  13. 2021年9月
    第58回北海道膝関節研究会
    そうだったんだ!学べる最新膝治療講座 Up to 「Date Distal Femoral Osteotomy」
    近藤 英司
  14. 2021年12月
    第37回膝関節フォーラムいちからわかる膝周囲骨切り術
    膝周囲骨切り術の適応(内反膝、外販膝) 
    近藤 英司
  15. 2021年12月
    第37回膝関節フォーラムいちからわかる膝周囲骨切り術
    症例検討
    近藤 英司
  16. 2021年10月
    AMED/BINDSセミナー(大阪大学)
    血液脳脊髄関門機能保護を介した中枢神経保護薬の探索
    角家 健
  17. 2021年11月
    第94回日本生化学会大会
    ヒト血液の総合グライコミクス解析”について
    古川 潤一
  18. 2021年5月
    北海道骨粗鬆症セミナー
    個別化医療の時代へ向かう骨粗鬆症治療;多様な原因を把握し、適切な治療レシピを提案.【WEB開催】
    高畑 雅彦
  19. 2021年6月
    Web脊椎骨粗鬆症セミナー東京医科歯科大学
    重症骨粗鬆症患者の脊椎再建手術―どうしても手術が必要な場合の術式の工夫から原因探索,薬物治療まで
    高畑 雅彦
  20. 2021年6月
    十勝整形シンポジウム
    何かおかしい脆弱性骨折の鑑別診断と治療のピットフォール
    高畑 雅彦
  21. 2021年7月
    第20回北海道関節外科セミナー
    脆弱性骨折リスクの高い骨粗鬆症に対する実臨床に基づいた治療戦略
    高畑 雅彦
  22. 2021年7月
    札幌市整形外科疾患セミナー.ウェブセミナー
    脆弱性骨折の鑑別診断の秘訣
    高畑 雅彦
  23. 2021年9月
    Osteoporosis Diagnosis and Treatment Web Sympodium.
    知っているだけで差のつく臨床骨代謝学と脊椎外科診療
    高畑 雅彦
  24. 2020年6月-8月
    オンライン学術総会
    第93回日本整形外科学会学術総会
    手外科における新規治療法の開発と発展
    岩崎 倫政
  25. 2020年6月-8月
    オンライン学術総会
    第93回日本整形外科学会学術総会
    膝周囲骨切り術の現状と課題
    近藤 英司
  26. 2020年6月
    岡山市
    第40回日本骨形態計測学会
    病態から考える関節リウマチ患者の骨粗鬆症治療戦略.シンポジウム4「骨形態計測から見たRAの骨病変」
    高畑 雅彦
  27. 2020年8月 ハイブリッド開催
    京都市
    第57回日本リハビリテーション医学会学術集会
    手外科におけるリハビリテーション医療の重要性
    岩崎 倫政
  28. 2020年10月
    オンライン開催
    第135回中部日本整形外科災害外科学会・学術集会
    整形外科領域における実用化・産業化を目指した研究の現状と未来
    岩崎 倫政
  29. 2020年10月
    web配信
    e-casebook LIVE
    ココが知りたい、膝周囲骨切り術の手術手技:コツとピットフォール
    近藤 英司
  30. 2020年10月
    Live-Web形式
    第29回インストゥルメンテーション学会
    脊椎外傷に対するKaneda deviceを用いた前方支柱再建術
    高畑 雅彦
  31. 2020年10月
    Live-Web形式
    第29回 日本脊椎インストゥルメンテーション学会
    脊柱変形矯正用カスタムメイドインプラント4Dロッドの開発
    須藤 英毅
  32. 2020年11月
    オンライン開催
    第31回日本臨床スポーツ医学会学術集会
    中高年者のスポーツ障害後の関節温存手術の成績:膝関節を中心に
    近藤 英司
  33. 2020年11月
    札幌市
    第11回ベンチャー創設支援フォーラム~再生医療等製品からその周辺産業まで~
    外傷性神経疾患治療方法の開発-軸索細胞促進分子と神経保護薬-
    角家 健
  34. 2020年12月
    Web講演
    愛媛脊椎カンファレンス
    サージカルアナトミー頚椎手術のコツと落とし穴
    高畑 雅彦
  35. 2020年12月
    神戸市
    第12回日本関節鏡・膝・スポーツ医学会学術集会・第46回日本整形外科スポーツ医学会学術集会
    Latest surgical techniques and prevention of complications in around knee osteotomy. Inverted V-shaped high tibial osteotomy for medial osteoarthritis of the knee with severe varus deformity
    近藤 英司
  36. 2020年12月
    神戸市
    第12回日本関節鏡・膝・スポーツ医学会学術集会・第46回日本整形外科スポーツ医学会学術集会
    逆V字型高位脛骨骨切り術:手技の実際と臨床成績
    近藤 英司
  37. 2020年12月
    神戸市
    第12回日本関節鏡・膝・スポーツ整形外科学会
    肘離断性骨軟骨炎に対する手術治療の課題と展望
    岩崎 倫政
  38. 2020年12月
    Web講演
    AMED 再生・細胞医療・遺伝子治療プロジェクト研究開発交流会(分野融合/新技術の部屋)(シンポジウム)
    高純度同種間葉系幹細胞(REC)と硬化性ゲルを用いた腰部脊柱管狭窄症に対する細胞治療
    須藤 英毅
  39. 2019年4月
    札幌市
    第62回日本手外科学会会長講演
    手外科における基礎研究 ―基礎研究成果の具現化を目指して―
    岩崎 倫政
  40. 2019年4月
    札幌市
    第62回日本手外科学会学術集会
    米国における基礎研究 ―神経再生研究を通じて―
    角家 健
  41. 2019年4月
    札幌市
    痛み、しびれセミナー in 手稲
    神経障害性疼痛の診断と治療
    高畑 雅彦
  42. 2019年4月
    小樽市
    小樽後志運動器・神経疾患セミナー
    軟骨損傷に対する再生治療法の応用 ―現状と展望―
    岩崎 倫政
  43. 2019年4月
    釧路市
    釧路市整形外科医会学術講演会
    脊柱靱帯骨化症への挑戦
    高畑 雅彦
  44. 2019年5月
    函館市
    函館中央病院モーニングセミナー
    関節疾患への再生医療の応用 ―基礎から臨床へ―
    岩崎 倫政
  45. 2019年5月
    帯広市
    帯広厚生病院講演会
    関節疾患に対する再生医療の応用 ―基礎から臨床への展開―
    岩崎 倫政
  46. 2019年5月
    那覇市
    沖縄PTH研究会
    整形外科領域におけるPTH製剤の有用性と落とし穴
    高畑 雅彦
  47. 2019年6月
    札幌市
    第11回日本関節鏡・膝・スポーツ整形外科学会
    脊髄損傷に対する新規治療法の開発:神経前駆細胞移植とBBB保護薬
    角家 健
  48. 2019年6月
    松本市
    第17回Shinsyu Orthopaedic Seminar
    脊柱靱帯骨化症に挑む ~病態解明へのアプローチから治療のピットフォールまで~
    高畑 雅彦
  49. 2019年6月
    東京都
    第35回University of Tokyo Spine Group研究会
    頚椎手術の危機回避と手術成績を向上させるための工夫
    高畑 雅彦
  50. 2019年6月
    恵庭市
    我汝会えにわ病院講演会
    関節リウマチの治療 ―手関節手術の発展―
    岩崎 倫政
  51. 2019年7月
    北九州市
    第39回日本骨形態計測学会.スポンサードセミナー2
    骨粗鬆症性椎体骨折後早期に生じるドミノ骨折および椎体圧潰の病態
    高畑 雅彦
  52. 2019年7月
    名古屋市
    尾北整形外科連携懇話会
    骨の研究からみえてくる脊椎脊髄疾患の病態と治療のピットフォール
    高畑 雅彦
  53. 2019年7月
    札幌市
    北大脊椎脊髄外科セミナー
    将来のせき損治療
    角家 健
  54. 2019年7月
    札幌市
    北海道リウマチ医の会
    脆弱性椎体骨折の鑑別診断 ―何か見逃していませんか?―
    高畑 雅彦
  55. 2019年8月
    金沢市
    第30回日本末梢神経学会学術集会
    末梢神経損傷に対する新規治療法開発に向けた基礎研究
    岩崎 倫政
  56. 2019年8月
    岡山市
    2019年度岡山大学整形外科桃整会夏季セミナー
    移植細胞を用いない軟骨再生治療法の開発と臨床応用
    岩崎 倫政
  57. 2019年8月
    札幌市
    第32回東区北区生活習慣病セミナー
    生活習慣病と骨粗鬆症
    高畑 雅彦
  58. 2019年9月
    宇都宮市
    第61回獨整会公開学術講演会
    整形外科診療に役立つ骨代謝学
    高畑 雅彦
  59. 2019年9月
    横浜市
    第92回日本生化学会大会、シンポジウム(広がりゆく糖鎖科学の世界)
    複合糖質糖鎖の網羅的定量解析と構造解析
    古川 潤一
  60. 2019年10月
    東京都
    西新宿整形外科研究会オータムセミナー
    脆弱性骨折の鑑別診断 ―何かおかしい骨折の見分け方と治療上の注意―
    高畑 雅彦
  61. 2019年11月
    秋田市
    第54回日本脊椎脊髄障害医学会、ランチョンセミナー6
    何かおかしい脆弱性骨折の鑑別診断 ―それって普通の骨折ですか?―
    高畑 雅彦
  62. 2019年11月
    札幌市
    日本学術会議北海道地区会議学術講演会
    スポーツ障害を科学する ―野球肘の科学―
    岩崎 倫政
  63. 2019年11月
    神戸市
    第70回神戸整形外科セミナー
    骨代謝学から読み解く脊椎疾患の病態と治療
    高畑 雅彦
  64. 2019年11月
    新潟市
    第18回新潟運動器QOL研究会
    見逃してはいけない脆弱性椎体骨折の原因と骨粗鬆症治療の落とし穴
    高畑 雅彦
  65. 2019年12月
    札幌市
    痛みセミナー in Sapporo ~多診療科におけるPain Management~
    脊髄,末梢神経に由来する痛みの原因と治療
    高畑 雅彦
  66. 2019年12月
    東京都
    第36回膝関節フォーラム
    ACL移植腱のリモデリングの評価
    近藤 英司
  67. 2019年12月
    札幌市
    病院調剤連携懇話会
    いつのまにか進む骨粗鬆症 ~予防と治療の重要性~
    高畑 雅彦
  68. 2018年1月
    小樽市
    第23回グリアクラブ
    神経幹/前駆細胞を使用した脊髄損傷後神経回路形成
    角家 健
  69. 2018年3月
    金沢市
    第11回神経発生討論会
    神経幹/前駆細胞を使用した脊髄損傷後神経回路形成
    角家 健
  70. 2018年4月
    神戸市
    第47回日本脊椎脊髄病学会
    「脊椎手術で知っておくべき解剖学」
    高畑 雅彦
  71. 2018年5月
    神戸市
    第91回日本整形外科学会学術総会
    シンポジウム40 前十字靱帯再建術 -Update- 前十字靱帯再建術における遺残組織温存の効果
    近藤 英司
  72. 2018年5月
    神戸市
    第91回日本整形外科学会学術総会
    春期胸腰椎側弯症に対する前方矯正固定術の有用性
    須藤 英毅
  73. 2018年6月
    福岡市
    第10回日本関節鏡・膝・スポーツ整形外科学会
    Effects of remnant tissue preservation on clinical outcomes after anatomic double-bundle anterior cruciate ligament reconstruction
    Kondo E.
  74. 2018年6月
    福岡市
    第10回日本関節鏡・膝・スポーツ整形外科学会
    国際シンポジウム:1期的および2期的前十字靭帯再建術
    One and two-stage procedures for revision anterior cruciate ligament reconstruction
    Kondo E.
  75. 2018年7月
    札幌市
    第7回日本Knee Osteotomyフォーラム
    ビデオレクチャー1:膝周囲骨切り術の基本手技1 逆V字骨切り術
    近藤 英司
  76. 2018年10月
    奈良市
    第33回日本整形外科学会基礎学術集会
    パネルディスカッション2 問題解決に向けた膝前十字靱帯の基礎研究:移植腱の再構築過程の制御と促進
    近藤 英司
  77. 2017年4月
    札幌市
    第46回日本脊椎脊髄病学会学術集会 ランチョンセミナー
    最新の骨代謝学の知見を脊椎外科診療にどう活かすか?
    高畑 雅彦
  78. 2017年5月
    札幌市
    北海道大学第三内科医局会セミナー
    幹細胞を応用した神経再生:現状と将来
    角家 健
  79. 2017年6月
    大阪市
    第37回日本骨形態計測学会 ランチョンセミナー
    骨修復メカニズムに関する最近の知見と骨代謝改善薬の影響
    高畑 雅彦
  80. 2017年8月
    札幌市
    TEN TOPICS IN RHEUMATOLOGY 2017
    関節リウマチ脊椎病変
    高畑 雅彦
  81. 2017年9月
    札幌市
    第55回北海道膝関節研究会
    Ⅲ.そうだったんだ!学べる最新膝治療講座 Up to date「 培養軟骨移植について」
    近藤 英司
  82. 2017年9月
    宮崎市
    第43回日本整形外科スポーツ医学会学術集会 ランチョンセミナー8
    自家腱ハイブリッド代用材料を用いた膝靭帯再建術:基礎と臨床
    近藤 英司
  83. 2017年10月
    札幌市
    北海道整形外科イベント道民講座 市民公開講座
    こしの痛みの原因と治療、予防法.骨と関節の日
    高畑 雅彦
  84. 2017年12月
    東京都
    第34回膝関節フォーラム
    1重束vs2重束-バイオメカニクスの観点から
    近藤 英司
  85. 2017年12月
    神戸市
    2017年度生命科学系学会合同年次大会
    【ワークショップ】総合グライコミクスで幹細胞を記述する
    古川 潤一
  86. 2016年4月
    札幌市
    Monthly Orthopaedic Seminar
    脊髄損傷と末梢神経に関する最近の知見
    角家 健
  87. 2016年7月
    札幌市
    第29回日本臨床整形外科学会学術集会 ひぐまセミナー
    骨粗鬆症の予防と治療ガイドライン2015年版を踏まえた骨粗鬆症治療について
    高畑 雅彦
  88. 2016年8月
    札幌市
    第27回日本骨軟部放射線診断セミナー
    下肢画像と手術
    小野寺 智洋
  89. 2016年9月
    松本市
    第127回中部日本整形外科災害外科学会学術集会
    脊椎ナビゲーション手術・ハイブリット手術のコツとピットフォール
    高畑 雅彦
  90. 2016年10月
    福岡市
    第31回日本整形外科学会基礎学術集会
    神経幹細胞移植による脊髄損傷治療
    角家 健

先端基盤ユニット

国際学会(口頭発表)
  • July 2019
    The International Congress on Industrial and Applied Mathematics 2019 (Balencia, Spain)
    Derivation of potential energy function from quantitative cell survival data.

先端融合科学研究部門

産学連携ユニット

原著論文
  1. Koide R., Hirane N., Kambe D., Yokoi Y., Otaki M., Nishimura S-I.
    Antiadhesive nanosome elicits role of glycocalyx of tumor cell-derived exosomes in the organotropic cancer metastasis
    Biomaterials, 280, 121314 (2022)
    DOI: 10.1016/j.biomaterials.2021.121314
  2. Urakami S., Hinou H.
    Glycan Selective MALDI In-source Decay Analysis of Intact Glycoprotein
    Analysis & Sensing 2, e20210004s (2022)
    DOI: 10.1002/anse.202100040
  3. Bermejo I. A., Navo C. D., Castro-López J., Guerreiro A., Fernández E. M. S., García-Martín F., Hinou H., Nishimura S.-I., Fernández J. M. G., Mellet C. O., Avenoza A., Busto J. H., Bernardes G. J. L., Hurtado-Guerrero R., Peregrina J. M., Corzana F.
    Synthesis, conformational analysis and in vivo assays of an anti-cancer vaccine that features an unnatural antigen based on an sp2-iminosugar fragment
    Chem. Sci. 11, 3996-4006 (2020)
    DOI: 10.1039/c9sc06334j
  4. Hayakawa A., Matsushita T., Yokoi Y., Wakui H., Fayna Garcia-Martin, Hinou H., Matsuoka K., Nouso H., Kamiyama T., Taketomi A, Nishimura S-I.
    Impaired O-Glycosylation at Consecutive Threonine TTX Motifs in Mucins Generates Conformationally Restricted Cancer Neoepitopes
    Biochemistry 59, 1221-1241 (2020)
    DOI: 10.1021/acs.biochem.0c00007
  5. Soma O., Hatakeyama S., Yoneyama T., Saito M., Sasaki H., Tobisawa Y., Noro D., Suzuki Y., Tanaka M., Nishimura S-I., Harada H., Ishida H., Tanabe K., Satoh S., Ohyama C.
    Serum N-glycan profiling can predict biopsy-proven graft rejection after living kidney transplantation
    Clin. Exp. Nephrol. 24, 174-184 (2020)
    DOI: 10.1007/s10157-019-01820-8
  6. Takahashi H., Kamiyama T., Hirane N., Kobayashi N., Aiyama T., Nagatsu A., Shimada S., Orimo T., Kakisaka T., Fukai M., Yokoo H., Kamachi H., Nishimura S-I., Taketomi A.
    Analysis of the correlation between alterations in N‑glycans and invasiveness in liver cancer cell lines
    Oncol. Rep. 44, 2757-2769 (2020)
    DOI: 10.3892/or.2020.7795
  7. Pablo A. Guillen-Poza, Elena Matilde Sánchez-Fernández, Gerard Artigas, José Manuel García Fernández, Hinou H., Carmen Ortiz Mellet, Nishimura S-I., Fayna Garcia-Martin
    Amplified detection of breast cancer autoantibodies using MUC1-based Tn antigen mimics
    J. Med. Chem. 63, 8524-8533 (2020)
    DOI: 10.1021/acs.jmedchem.0c00908
  8. Yokoi Y., Nishimura S-I.
    Effect of Site‐specific O-Glycosylation on the Structural Behavior of NOTCH1 Receptor Extracellular EGF‐like Domains 11 and 10
    Chem. Eur. J. 26, 12363-12372 (2020)
    DOI: 10.1002/chem.202002652
  9. Wakui H., Tanaka Y., Ose T., Matsumoto I., Kato K., Yao M., Tachibana T., Sato M., Naruchi K., García-Martín F., Hinou H., Nishimura S-I.
    A straightforward approach to antibodies recognising cancer specific glycopeptidic neoepitopes
    Chem. Sci 11, 4999-5006 (2020)
    DOI: 10.1039/d0sc90254c
  10. Bermejo I. A., Navo C. D., Castro-López J., Guerreiro A., Fernández E. M. S., García-Martín F., Hinou H., Nishimura S.-I., Fernández J. M. G., Mellet C. O., Avenoza A., Busto J. H., Bernardes G. J. L., Hurtado-Guerrero R., Peregrina J. M., Corzana F.
    Synthesis, conformational analysis and in vivo assays of an anti-cancer vaccine that features an unnatural antigen based on an sp2-iminosugar fragment
    Chem. Sci. 11, 3996-4006 (2020)
    DOI: 10.1039/c9sc06334j
  11. Carbajo-Gordillo, Ana; Jimenez Blanco, Jose; Benito, Juan; Lana, Hugo; Marcelo, Gema; Di Giorgio, Christophe; Przybylski, Cédric; Hinou, Hiroshi; Ceña, Valentín; Ortiz Mellet, Carmen; Mendicuti, Francisco; Tros de ILarduya, Conchita; García Fernández, José
    “Click Synthesis of Size and Shape-Tunable Star Polymers with Functional Macrocyclic Cores for Synergistic DNA Complexation and Delivery”
    Biomacromolecules 21, 5173-5188 (2020)
    DOI: 10.1021/acs.biomac.0c01283
  12. Hinou H., Kikuchi S., Ochi R., Igarashi K., Takada W., Nishimura S-I.
    Synthetic glycopeptides reveal specific binding pattern and conformational change at O-mannosylated position of α-dystroglycan by POMGnT1 catalyzed GlcNAc modification
    Bioorgan. Med. Chem., 27, 2822-2831 (2019)
    DOI: 10.1016/j.bmc.2019.05.008
  13. Gebrehiwot Abrha G., Seifu Melka D., Mamo Kassaye Y., Gemechu T., Lako W., Hinou H., Nishimura S-I.
    Exploring serum and Immunoglobulin G N-glycome as diagnostic biomarkers for early detection of breast cancer in Ethiopian women
    BMC Cancer, 19, 588 (2019)
    DOI: 10.1186/s12885-019-5817-8
  14. Flechner A., Butschak G., Löffler A., Rühmann J., Nishimura S-I., Dölling R., Purfürst B., Goletz S., Danielczyk A., Karsten U.
    Cluster binding studies with two anti-Thomsen-Friedenreich (anti-core-1, CD176) antibodies: evidence for a quadruple epitope
    Int. Immunopharmacol. 72, 186-194 (2019)
    DOI: 10.1016/j.intimp.2019.03.058
  15. Sanes T. Jurgen, Hinou H., Lee YC, Nishimura S-I.
    Glycoblotting of Egg White Reveals Diverse N-glycan Expression in Quail Species
    J. Agr. Food Chem. 67, 531-540 (2019)
    DOI: 10.1021/acs.jafc.8b04782
  16. Matsumoto T., Hatakeyama S., Yoneyama T., Tobisawa Y., Ishibashi Y., Yamamoto H., Yoneyama T., Hashimoto Y., Ito H., Nishimura S-I., Ohyama C.
    Serum N-glycan profiling is a potential biomarker for castration-resistant prostate cancer
    Sci. Rep. 9, 168761 (2019)
    DOI: 10.1038/s41598-019-53384-y
  17. Koide R., Nishimura S-I.
    Antiadhesive nanosomes facilitate targeting of lysosomal GlcNAc salvage pathway through derailed cancer endocytosis
    Angew. Chem. Int. Ed. 58, 14513-14518 (2019)
    DOI: 10.1002/anie.201907778
  18. Hideshima S., Hayashi H., Hinou H., Nambuya S., Kuroiwa S., Nakanishi T., Momma T., Nishimura S-I., Sakoda Y., Osaka T.
    Glycan-immobilized dual-channel field effect transistor biosensor for the rapid identification of pandemic influenza viral particles
    Sci. Rep. 9, 11616 (2019)
    DOI: 10.1038/s41598-019-48076-6
  19. Hinou H.
    Aniline Derivative/DHB/Alkali Metal Matrices for Reflectron Mode MALDI-TOF and TOF/TOF MS Analysis of Unmodified Sialylated Oligosaccharides and Glycopeptides
    Int. J. Mass Specytom., 443, 109-115 (2019)
    DOI: 10.1016/j.ijms.2019.06.006
  20. Hinou H., Kikuchi S., Ochi R., Igarashi K., Takada W., Nishimura S-I.
    Synthetic glycopeptides reveal specific binding pattern and conformational change at O-mannosylated position of a-dystroglycan by POMGnT1 catalyzed GlcNAc modification.
    Bioorgan. Med. Chem. 27, 2822-2831 (2019)
    DOI: 10.1016/j.bmc.2019.05.008
  21. Gebrehiwot Abrha G., Seifu Melka D., Mamo Kassaye Y., Gemechu T., Lako W., Hinou H., Nishimura S-I.
    Exploring serum and Immunoglobulin G N-glycome as diagnostic biomarkers for early detection of breast cancer in Ethiopian women
    BMC Cancer 19, 588 (2019)
    DOI: 10.1186/s12885-019-5817-8
  22. Heger L., Balk S., Lühr J.J., Heidkamp G.F., Lehmann C.H., Purbojo A., Hartmann A., Garcia-MartinF., Nishimura S-I., Cesnjevar R., Nimmerjahn F., Dudziak D.
    CLEC10A is a specific marker for human CD1c+DCs and enhances their Toll-like receptor 7/8 induced cytokine secretion
    Front. Immunol., 9, 744 (2018)
    DOI: 10.3389/fimmu.2018.00744
  23. Gebrehiwot Abrha G., Seifu Melka D., Mamo Kassaye Y., Rehan F.I., Rangappa S., Hinou H., Kamiyama T., Nishimura S-I.
    Healthy human serum N-glycan profiling reveals the influence of ethnic variation on the identified cancer-relevant glycan biomarkers
    PLOS ONE 13, e0209515 (2018)
    DOI: 10.1371/journal.pone.0209515
  24. Ishihara S., Aoki K., Mizutani T., Amano M., Nishimura S-I., Haga H.
    Glycosphingolipid GM2 induces invasiveness in irradiation-tolerant lung cancer cells
    Cell Struct. Funct. 43, 177-185 (2018)
    DOI: 10.1247/csf.18026
  25. Hammura K., Ishikawa A., Ravi H.V., Miyoshi R., Yokoi Y., Tanaka M., Hinou H., Nishimura S-I.
    Synthetic glycopeptides allow for the quantitation of scarce non-fucosylated IgG Fc N-glycans of therapeutic antibody
    ACS Med. Chem. Lett. 9, 889-894 (2018)
    DOI: 10.1021/acsmedchemlett.8b00127
  26. Yogesh K.V., Kamiyama T., Ohyama C., Yoneyama T., Nouso K., Kimura S., Hinou H., Nishimura S-I.
    Synthetic glycopeptides as a designated standard in focused glycoproteomics to discover serum cancer biomarkers
    Med Chem Comm 9, 1351-1358 (2018)
    DOI: 10.1039/c8md00162f
  27. Heger L., Balk S., Lühr J.J., Heidkamp G.F., Lehmann C.H., Purbojo A., Hartmann A., Garcia-Martin F., Nishimura S-I., Cesnjevar R., Nimmerjahn F., Dudziak D.
    CLEC10A is a specific marker for human CD1c+DCs and enhances their Toll-like receptor 7/8 induced cytokine secretion
    Front. Immunol. 9, 744 (2018)
    DOI: 10.3389/fimmu.2018.00744
  28. Swamy M., Murai Y., Ohno Y., Jojima K., Kihara A., Mitsutake S., Igarashi Y., Yu J., Yao M., Suga Y., Anetai M., Monde K.
    Structure-inspired design of a sphingolipid mimic sphingosine-1-phosphate receptor agonist from a naturally occurring sphingomyelin synthase inhibitor
    Chem. Commun., 54, 12758-12761 (2018)
    DOI: 10.1039/c8cc05595e
  29. Nagaraja B., Nishimura S-I., Sosalegowda A.
    Comparative Glycomics of Fat Globule Membrane Glycoconjugates from Buffalo (Bubalus bubalis)
    Milk & Colostrum
    J. Agr. Food chem. 65, 1496-1506 (2017)
    DOI: 10.1021/acs.jafc.6b03330
  30. Artigas G., Hinou H., Garcia-Martin F., Hans-Joachim G., Nishimura S-I.
    Synthetic Mucin-like Glycopeptides as Versatile Tools to Measure Effects of Glycan Structure/ Density/Position on Interaction with Adhesion/
    Growth-regulatory Galectins in Arrays
    Chem-Asian J. 12, 159-167 (2017)
    DOI: 10.1002/asia.201601420
  31. Tanaka T., Yoneyama T., Noro D., Imanishi K., Kojima Y., Hatakeyama S., Tobisawa Y., Mori K., Yamamoto H., Imai A., Yoneyama T., Hashimoto Y., Koie T., Tanaka M., Nishimura S-I., Kurauchi S., Takahashi I., Ohyama C.
    Aberrant N-Glycosylation Profile of Serum Immunoglobulins is a Diagnostic Biomarker of Urothelial Carcinomas
    Int. J. Mol. Sci., 18, 2632 (2017)
    DOI: 10.3390/ijms18122632
  32. Somovilla V.J., Bermeijo I.A., Albuquerque I.S., Martínez-S. N., Castro-Lopez J., Garcia-Martin F., Companon I., Hinou H., Nishimura S-I., Jimenez-Barbero J., Asensio J.L., Avenoza G., Busto J.H., Hurtado-Guerrero. R., Peregrina J.M., Bernardes G.J.L., Corzana F.
    The use of fluoroproline in MUC1 antigen enables efficient detection of antibodies in patients with prostate cancer
    J. Am. Chem. Soc., 139, 18255-18261 (2017)
    DOI: 10.1021/jacs.7b09447
  33. Artigas G., Monteiro J.T., Hinou H., Nishimura S-I., Lepenies B., Garcia-Martin F.
    Glycopeptides as Targets for Dendritic Cells: Exploring MUC1 Glycopeptides Binding Profile toward Macrophage Galactose-Type Lectin (MGL) Orthologs
    J.Med.Chem., 60, 9012-9021 (2017)
    DOI: 10.1021/acs.jmedchem.7b01242
  34. Naito S., Takahashi T., Onoda J., Uemura S., Ohyabu N., Takemoto H., Yamane S., Fujii I., Nishimura S-I., Numata Y.
    Generation of Novel Anti-MUC1 Monoclonal Antibodies with Designed Carbohydrate Specificities Using MUC1 Glycopeptide Library
    ACS Omega, 2, 7493-7505 (2017)
    DOI: 10.1021/acsomega.7b00708
  35. Noro D., Yoneyama T., Hatakeyama S., Tobisawa Y., Mori K., Hashimoto Y., Koie T., Tanaka M., Nishimura S-I., Sasaki H., Saito M., Harada H., Chikaraishi T., Ishida H., Tanabe K., Satoh S., Ohyama C.,
    Serum Aberrant N-Glycan Profile as a Marker Associated with Early Antibody-Mediated Rejection in Patients Receiving a Living Donor Kidney Transplant
    Int. J. Mol. Sci., 18, 1731 (2017)
    DOI: 10.3390/ijms18081731
  36. Furukawa T., Hinou H., Takeda S., Chiba H., Nishimura S-I., Shu-Ping Hui,
    An efficient glycoblotting-based analysis of oxidized lipids in liposomes and a lipoprotein
    ChemBioChem, 18, 1903-1909 (2017)
    DOI: 10.1002/cbic.201700384
  37. Hayakawa S., Yokoi Y., Hinou H., Nishimura S-I.
    Chemical synthesis demonstrates dynamic O-glycosylation regulates folding and functional conformation of a pivotal EGF12 domain of human NOTCH1 receptor
    Biochemistry, 56, 4379-4391 (2017)
    DOI: 10.1021/acs.biochem.7b00372
  38. Ohyabu N., Kakiya K., Yokoi Y., Hinou H., Nishimura S-I.
    Convergent solid-phase synthesis of macromolecular MUC1 models truly mimicking serum glycoprotein biomarkers of interstitial lung diseases
    J. Am. Chem. Soc. 138, 8392-8395 (2016)
    DOI: 10.1021/jacs.6b04973
  39. Roger S. Tan, Hinou H., and Nishimura S-I.
    Novel β-galactosynthase-β-mannosynthase dual activity of β-galactosidase from Aspergillus oryzae uncovered using monomer sugar substrates
    RSC Adv. 6, 50833-50836 (2016)
    DOI: 10.1039/c6ra08060j
  40. Kaneko K., Takamatsu T., Inomata T., Oikawa K., Itoh K., Hirose K., Amano M., Nishimura S-I., Toyooka K., Matsuoka K., Pozueta-Romero J., Mitsui T.
    N-glycomic and microscopic subcellular localization analyses of NPP1, 2 and 6 strongly indicate that trans-Golgi compartments participate in the Golgito-plastid traffic of nucleotide pyrophosphatase/phosphodiesterases in rice
    Plant Cell Physiol. 57, 1610-1628 (2016)
    DOI: 10.1093/pcp/pcw089
著書・総説・解説など
  1. 西村紳一郎、涌井初、横井康広
    スパイクタンパク質の「動的エピトープ」は新型コロナウイルスの弱点?
    臨床化学 第50巻第4号 392-393 (2021) 日本臨床化学会
  2. 比能 洋
    ペプチド・糖ペプチド環化技術 –水素結合制御により環化効率を飛躍的に向上–
    北海道大学研究シーズ集, Vol.5, p39 (2018)
  3. 比能 洋
    未修飾シアリル化糖鎖および複合糖質の高感度・高分解能構造解析を実現するMALDIマトリックス
    北海道大学研究シーズ集Web版
  4. Nishimura S-I., Ishihara T., Iwasaki N.
    Differentiation Biomarkers of Osteoarthritis Determined by Glycoblotting
    Biomarkers in Bone Disease, 647-669 (2017)
    DOI: 10.1007/978-94-007-7693-7_50
国際学会(招待講演)
  1. December 2021
    The 2021 International Chemical Congress of Pacific Basin Societies (Pacifichem2021)
    Antibodies recognizing dynamic neoepitopes generated by cancer-specific truncated immature O-glycosylation
    Shin-Ichiro Nishimura
  2. January 2020
    Bagalore, INDIA
    107th Indian Science Congress
    Chemical Glycobiology (Starting from Glycoconjugate Syntheses)
    Hinou H.
  3. July 2019
    Sapporo, JAPAN
    APSBMS 2019 Annual Meeting
    Mid-sized drugs based on peptides & glycopeptides: from the chemical synthesis to the biological evaluation
    Garcia Martin Fayna Maria
  4. August 2019
    San Diego, USA
    Japanese-American Symposium on Applied & Translational Glycosciences, ACS Fall 2019 National Meeting
    Novel matrix system for reflectron mode MALDI-TOF and TOF/TOF MS analysis of unmodified sialylated oligosaccharides and glycopeptides
    Hinou H.
  5. March 2018
    Siem Reap, Cambodia
    International Congress on Pure and Applied Chemistry 2018
    Microarray and NMR Study of Core M1 Glycan Modified α-Dystroglycan Fragments
    Hinou H.
  6. April 2017
    San Francisco, USA
    253rd ACS National Meeting (Carbohydrate Division)
    New glycotechnology platform interfacing chemistry and biology
    Nishimura S.
  7. July 2016
    Madrid, Spain
    GLYCOPHARM Final Conference
    New trends in glycodrug discovery: Molecular targets unveiled by chemical synthesis and nanotechnology
    Nishimura S-I.
国際学会(口頭発表)
  1. May 2019
    San Sebastian, Spain
    XXVIII Biennial Meeting of the Spanish Royal Association of Chemistry
    Probing the Effect of Iminosugars on Mucin 1 Glycopeptide–Antibody Recognition
    Garcia Martin Fayna Maria
  2. June 2017
    West Dover, USA
    Gordon Research Conference (GRC) on Carbohydrate Nanomedicine targeting intracellular glycoenzymes
    Nishimura S.
国内招待講演
  1. 2021年2月
    札幌(Online)
    質量分析学会第29回北海道談話会
    MALDI-TOFMSによる糖質解析 ~前処理工程をどれだけ簡素化できるか~
    比能 洋
  2. 2021年9月
    オンライン開催
    第70回高分子討論会
    動的エピトープ理論-翻訳後糖鎖修飾が惹起するタンパク質の脆弱性 / The dynamic epitope theory-Vulnerability of proteins induced by posttranslational glycosylation
    西村 紳一郎
  3. 2021年8月
    東京
    LIFE SCIENCE CONEECT 2021
    動的エピトープ理論による革新的創薬
    西村 紳一郎
  4. 2021年7月
    オンライン開催
    官民研究開発投資拡大プログラム(PRISM)令和二年度成果報告会
    ヒト組織由来エクソソームの糖鎖プロファイリングによる新しいバイオマーカーの探索
    西村 紳一郎
  5. 2021年9月
    出張授業(オンライン)札幌市開成高校
    (生物多様性・気候変動) 糖と生命
    比能 洋
  6. 2021年9月
    北海道大学オープンキャンパスSDGs特集(録画)
    生命をつなぐ曖昧な情報「糖」の謎に挑戦する
    比能 洋
  7. 2021年9月
    北海道大学理学部生物科学科(高分子機能学)ホームカミングデー(Online)
    糖と私
    比能 洋
  8. 2021年11月
    職業人へのインタビュー活動、札幌市立啓明中学校(オンライン)
    大学職員
    比能 洋
  9. 2020年12月
    札幌(Online)
    異分野meetup week2020☆研究者コミュニティサロン☆“糖鎖研究について語ろう!”
    化学者から見た糖鎖研究
    比能 洋
  10. 2019年11月
    さいたま市
    GlycoTOKYO2019
    ローマは一日にして成らず。されど、すべての道は?
    西村 紳一郎
  11. 2018年3月
    大阪府
    医薬基盤・健康・栄養研究所セミナー
    独創的なシステム糖鎖工学プラットフォームからの創薬イノベーション
    西村 紳一郎
  12. 2017年1月
    札幌市
    SUMOシンポジウム
    質量分析装置を活用した糖鎖研究
    比能 洋
  13. 2017年7月
    大阪市
    第36回公益財団法人蓬庵社研究助成発表会
    筋ジストロフィー、多発性硬化症などの神経疾患に関するO -マンノース型糖鎖修飾の合成化学的機能解明
    比能 洋
  14. 2017年10月
    札幌市
    第57回日本臨床化学会年次学術集会
    動的エピトープ理論:タンパク質のダイナミックな翻訳後修飾が創出する疾患特異的抗原構造
    西村 紳一郎
  15. 2016年6月
    札幌市
    北大クロスロード
    私の競争的資金獲得法
    比能 洋
  16. 2016年7月
    大阪府
    ペプチド研究所研究講演会
    糖ペプチド合成システムの開発と展開
    比能 洋
  17. 2016年8月
    東京都
    イノベーションジャパン2016~大学見本市&ビジネスマッチング~
    糖鎖情報の解読・利用技術−グライコーム分析・合成・集積・利用技術−
    比能 洋
  18. 2016年9月
    横浜市
    第65回高分子討論会
    Glycoblotting型マイクロアレイによる合成糖ペプチドの相互作用解析
    比能 洋

国際連携ユニット

原著論文
  1. Guo Y.Z., Nakajima T., Mredha T.I., Guo H.L., Cui K., Zheng Y., Cui W., Kurokawa T., Gong J.P.
    Facile Preparation of Cellulose Hydrogel with Achilles Tendon-like Super Strength through Aligning Hierarchical Fibrous Structure
    Chemical Engineering Journal, 428, 132040 (2022)
    DOI: 10.1016/j.cej.2021.132040
  2. Kaibara T., Wang L., Tsuda M., Nonoyama T., Kurokawa T., Iwasaki N., Gong J.P., Tanaka S., Yasuda K.
    Hydroxyapatite-hybridized Double-network Hydrogel Surface Enhances Differentiation of Bone Marrow-derived Mesenchymal Stem Cells to Osteogenic Cells
    Journal of Biomedical Materials Research: Part A, 110(4), 747-760 (2022)
    DOI: 10.1002/jbm.a.37324
  3. Zhang Y., Fukao K., Matsuda T., Nakajima T., Tsunoda K., Kurokawa T., Gong J.P.
    Unique Crack Propagation of Double Network Hydrogels under High Stretch
    Extreme Mechanics Letters, 51, 101588 (2022)
    DOI: 10.1016/j.eml.2021.101588
  4. Zhu R., Yang H., Cui W., Fadillah L., Huang T., Xiong Z., Tang C., Kowalski D., Kitano S., Zhu C., King D.R., Kurokawa T., Aoki Y., Habazaki H.
    High strength hydrogels enable dendrite-free Zn metal anodes and high-capacity Zn-MnO2 batteries via a modified mechanical suppression effect
    Journal of Materials Chemistry A, 10(6), 3122-3133 (2022)
    DOI: 10.1039/D1TA10079C
  5. Ukeba D., Yamada K., Suyama T., Lebl D.R., Tsujimoto T., Nonoyama T., Sugino H., Iwasaki N., Watanabe M., Matsuzaki Y., Sudo H.
    Combination of ultra-purified stem cells with an in situ forming bioresorbable gel enhances intervertebral disc regeneration
    eBioMedicine, 76, 103845 (2022)
    DOI: 10.1016/j.ebiom.2022.103845
  6. Wnag Z.J., Jiang J., Mu Q., Maeda S., Nakajima T., Gong J.P.
    Azo-crosslinked Double Network Hydrogels Enabling Highly Efficient Mechanoradical Generation
    Journal of the American Chemical Society, 144(7), 3154-3161 (2022)
    DOI: 10.1021/jacs.1c12539
  7. Fan H., Guo H., Kurokawa T., Gong J.P.
    Quantitative Determination of Cation-π Interaction between Metal Ions and Aromatic Groups in Aqueous Media by A Hydrogel Donnan Potential Method
    Physical Chemistry Chemical Physics, 24(10), 6126-6132 (2022)
    DOI: 10.1039/D1CP05622K
  8. Matsumae G., Terkawi M.A., Nonoyama T,, Kuroakwa T., Takahashi D., Shimizu T., Kadoya K., Gong J.P., Yasuda K., Iwasaki N.
    Evaluation of Biological Responses to Micro-particles Derived from a Double Network Hydrogel
    Biomaterials Science, published online (2022) 
    DOI: 10.1039/D1BM01777B
  9. Sato Y., Wang Y., Song Y., Geng W., Yan S., Nakamura K., Kikukawa T., Demura M., Ayabe T., Aizawa T.
    Potent bactericidal activity of reduced cryptdin-4 derived from its hydrophobicity and mediated by bacterial membrane disruption.
    Amino Acids, 54, 289-297 (2022)
    DOI: 10.1007/s00726-021-03115-3
  10. Ishihara S. and Haga H.
    Matrix Stiffness Contributes to Cancer Progression by Regulating Transcription Factors
    Cancers, 14, 1049 (2022)
    DOI: 10.3390/cancers14041049
  11. Nonoyama T., Wang L., Tsuda M., Suzuki Y., Kiyama R., Yasuda K., Tanaka S., Nagata K., Fujita R., Sakamoto N., Kawasaki N., Yurimoto H., Gong J.P.
    Isotope Microscopic Observation of Osteogenesis Process Forming Robust Bonding of Double Network Hydrogel to Bone
    Advanced Healthcare Materials, 10(3), 2001731 (2021)
    DOI: 10.1002/adhm.202001731
  12. Xiao R. Mai T.T., Urayama K., Gong J.P., Qu S.
    Micromechanical Modeling of the Multi-axial Deformation Behavior in Double Network Hydrogels
    International Journal of Plasticity, 137, 102901-102919 (2021)
    DOI: 10.1016/j.ijplas.2020.102901
  13. Fan H., Wang J., Gong J.P.
    Barnacle Cement Proteins‐Inspired Tough Hydrogels with Robust, Long‐Lasting, and Repeatable Underwater Adhesion
    Advanced Functional Materials, 31(11), 2009334-2009341 (2021)
    DOI: 10.1002/adfm.202009334
  14. Venkata S.P., Cui K., Guo J., Zehnder A.T., Gong J.P., Hui C.Y.
    Constitutive Modeling of Bond Breaking and Healing Kinetics of Physical Polyampholyte (PA) Gel
    Extreme Mechanics Letters, 43, 101184-101196 (2021)
    DOI: 10.1016/j.eml.2021.101184
  15. Ye Y.N., Cui K., Hong W., Li X., Yu C., Hourdet D., Nakajima T., Kurokawa T., Gong J.P.
    Molecular Mechanism of Abnormally Large Nonsoftening Deformation in a Tough Hydrogel
    Proceedings of the National Academy of Sciences, 118(14), e2014694118 (2021)
    DOI: 10.1073/pnas.2014694118
  16. Xu L., Urita A., Onodera T., Hishimura R., Nonoyama T., Hamasakiari M., Liang D., Homan K., Gong J.P., Iwasaki N.
    Ultrapurified Alginate Gel Containing Bone Marrow Aspirate Concentrate Enhances Cartilage and Bone Regeneration on Osteochondral Defects in a Rabbit Model
    The American Journal of Sports Medicine, 49(8), 2199-2210 (2021) 
    DOI: 10.1177/03635465211014186
  17. Yue Y., Nrikane Y., Gong J.P.
    Ultrahigh-Water-Content Photonic Hydrogels with Large Electro-optic Responses in Visible to Near-infrared Region
    Advanced Optical Materials, 9(9), 20022198 (2021)
    DOI: 10.1002/adom.202002198
  18. Suzuka J., Tsuda M., Wang L., Kohsaka S., Kshida K., Semba S., Aburatani S., Frauenlob M., Kurokawa T., Kojima S., Ueno T., Ohmiya Y., Mano H., Yasuda K, Gong J.P., Tanaka S.
    Rapid Reprogramming of Tumour Cells into Cancer Stem Cells on Double-Network Hydrogels
    Nature Biomedical Engineering, 5, 914-925 (2021)
    DOI: 10.1038/s41551-021-00692-2
  19. Li X., Cui K., Kuroakawa T., Ye Y.N., Sun T.L., Yu C., Creton C, Gong J.P.
    Effect of Mesoscale Phase Contrast on Fatigue-Delaying Behavior of Self-Healing Hydrogels
    Science Advances, 7(16), eabe8210 (2021)
    DOI: 10.1126/sciadv.abe8210
  20. Venkata S.P., Cui K., Guo J., Zehnder A.T., Gong J.P., Hui C.Y.
    Constitutive Modeling of Strain-Dependent Bond Breaking and Healing Kinetics of Chemical Polyampholyte (PA) Gel
    Soft Matter, 17(15), 4161-4169 (2021)
    DOI: 10.1039/D1SM00110H
  21. Ukeba D., Yamada K., Tsujimoto T., Ura K., Nonoyama T., Iwasaki N., Sudo H.
    Bone Marrow Aspirate Concentrate Combined with in Situ Forming Bioresorbable Gel Enhances Intervertebral Disc Regeneration in Rabbits
    The Journal of Bone and Joint Surgery, 103(8), e31 (11 pages) (2021)
    DOI: 10.2106/JBJS.20.00606
  22. Nakajima T., Hoshino K., Guo H., Kurokawa T., Gong J.P.
    Experimental Verification of the Balance between Elastic Pressure and Ionic Osmotic Pressure of Highly Swollen Charged Gels
    Gels, Special Issue: Stimuli-Responsive Gels 2.0, 7(2), 39 (2021)
    DOI: 10.3390/gels7020039
  23. Zheng Y., Kiyama R., Matsuda T., Cui K., Li X., Cui W., Guo Y., Nakajima T., Kurokawa T., Gong J.P.
    Nanophase Separation in Immiscible Double Network Elastomers Induces Synergetic Strengthening, Toughening, and Fatigue Resistance
    Chemistry of Materials, 33(9), 3321-3334 (2021)
    DOI: 10.1021/acs.chemmater.1c00512
  24. Fan H., Cai Y., Gong J.P.
    Facile Tuning of Hydrogel Properties by Manipulating Cationic-Aromatic Monomer Sequences
    SCIENCE CHINA Chemistry, 64(9), 1560-1568 (2021)
    DOI: 10.1007/s11426-021-1010-3
  25. Yamamoto J., Matsui A., Gan F., Oura M., Ando R., Matsuda T., Gong J.P., Kinjo M.
    Quantitative Evaluation of Macromolecular Crowding Environment Based on Translational and Rotational Diffusion Using Polarization Dependent Fluorescence Correlation Spectroscopy
    Scientific Reports, 11, 10594 (2021)
    DOI: 10.1038/s41598-021-89987-7
  26. Ye Y.N., Haque M.A., Inoue A., Katsuyama Y., Kurokawa T., Gong J.P.
    Flower-like Photonic Hydrogel with Superstructure Induced via Gradient Shear Field
    ACS Macro Letters, 10(6), 708-713, (2021)
    DOI: 10.1021/acsmacrolett.1c00178
  27. Okumura T., Takahashi R., hagita K., King D.R., Gong J.P.
    Improving the Strength and Toughness of Macroscale Double Networks by Exploiting Poisson’s Ratio Mismatch
    Scientific Reports, 11, 13280 (2021)
    DOI: 10.1038/s41598-021-92773-0
  28. Nonoyama T., Wang L., Kiyama R., Kashimura N., Yasuda K., Tanaka S., Kurokawa T., Gong J.P.
    Fast In Vivo Fixation of Double Network Hydrogel to Bone by Monetite Surface Hybridization
    Journal of the Ceramic Society of Japan, 129(9), 584-589 (2021)
    DOI: 10.2109/jcersj2.21084
  29. Liu Z., Hui C.Y., Jagota A., Gong J.P., Kiyama R.
    A Surface Flattening Method for Characterizing the Surface Stress, Drained Poisson’s Ratio and Diffusivity of Poroelastic Gels
    Soft Matter, 17(31), 7332-7340 (2021)
    DOI: 10.1039/D1SM00513H
  30. Cui W., Huang Y., Chen L., Saruwatari Y., Hui C.Y., Zheng Y., Kurokawa T., King D.R., Gong J.P.
    Tiny Yet Tough: Maximizing the Toughness of Fiber-Reinforced Soft Composites in the Absence of a Fiber-Fracture Mechanism
    Matter, 4(11), 3646-3661 (2021)
    DOI: 10.1016/j.matt.2021.08.013
  31. Wang Z., Zheng X., Ouchi T., Kouznetsova T.B., Beech H.K., Av-Ron S., Matsuda T., Bowser B.H., Wang S., Johnson J.A, Kalow J.A., Olsen B.D., Gong J.P., Rubinstein M., Craig S.L.
    Toughening Hydrogels Through Force-triggered Chemical Reactions that Lengthen Polymer Strands
    Science, 374(6564), 193-196 (2021)
    DOI: 10.1126/science.abg2689
  32. Matsuda T., Kawakami R., Nakajima T., Hane Y., Gong J.P.
    Revisiting the Origins of the Fracture Energy of Tough Double-Network Hydrogels with Quantitative Mechanochemical Characterization of the Damage Zone
    Macromolecules, 54(22), 10331-10339 (2021)
    DOI: 10.1021/acs.macromol.1c01214
  33. Yu C., Cui K., Guo H., Ye Y.N., Li X., Gong J.P.
    Structure Frustration Enables Thermal History-Dependent Responsive Behavior in Self-Healing Hydrogels
    Macromolecules, 54(21), 9927-9936 (2021)
    DOI: 10.1021/acs.macromol.1c01461
  34. Zheng Y., Matsuda T., Nakajima T., Cui W., Zhang Ye,, Hui C.Y., Kurokawa T., Gong J.P.
    How Chain Dynamics Affects Crack Initiation in Double Network Gels
    Proceedings of the National Academy of Sciences, 118(49), e2111880118 (2021)
    DOI: 10.1073/pnas.2111880118
  35. Nishimura T., Guo H., Kiyama R., Katsuyama Y., Gong J.P., Kurokawa T.
    In Situ Evaluation of the Polymer Concentration Distribution of Microphase-Separated Polyelectrolyte Hydrogels by the Microelectrode Technique
    Macromolecules, 54(23), 10776-10785 (2021)
    DOI: 10.1021/acs.macromol.1c01435
  36. Iizuka T., Takei M., Saito Y., Rumi F., Zheng J., Lu X., Chafey P., Broussard C., Guilloux-Assalet L., Charpin D., Ebisawa M., Sénéchal H., Aizawa T., Poncet P.
    Gibberellin-regulated protein sensitization in Japanese cedar (Cryptomeria japonica) pollen allergic Japanese cohorts.
    Allergy, 76, 2297-2302 (2021)
    DOI: 10.1111/all.14816.
  37. Suzuki K., Nakamura K., Shimizu Y., Yokoi Y., Ohira S., Hagiwara M., Wang Y., Song Y., Aizawa T., Ayabe T.
    Decrease of α-defensin impairs intestinal metabolite homeostasis via dysbiosis in mouse chronic social defeat stress model.
    Scientific Reports, 11, 9915 (2021)
    DOI: 10.1038/s41598-021-89308-y
  38. Nishiyama R., Ojima T., Ohnishi Y., Kumaki Y., Aizawa T., Inoue A.
    An oxidative metabolic pathway of 4-deoxy-L-erythro-5-hexoseulose uronic acid (DEHU) from alginate in an alginate-assimilating bacterium.
    Communications Biology, 4, 1254 (2021)
    DOI: 10.1038/s42003-021-02786-8
  39. Komatsu Y., Kumakura D., Seto N., Izumi H., Takeda Y., Ohnishi Y., Nakaoka S, Aizawa T.
    Dynamic Associations of Milk Components With the Infant Gut Microbiome and Fecal Metabolites in a Mother–Infant Model by Microbiome, NMR Metabolomic, and Time-Series Clustering Analyses
    Frontiers in Nutrition, 8, 813690 (2021)
    DOI: 10.3389/fnut.2021.813690
  40. Oyama H., Nukuda A., Ishihara S., Haga
    Soft Surfaces Promote Astrocytic Differentiation of Mouse Embryonic Neural Stem Cells via Dephosphorylation of MRLC in the Absence of Serum
    Scientific Reports, 11, 19574, 1-11 (2021)
    DOI: 10.1038/s41598-021-99059-5
  41. Yasuda S., Akiyama T., Nemoto S., Hayashi T., Ueta T., Kojima K., Tsukamoto T., Nagatoishi S., Tsumoto K., Sudo Y., Kinoshita M., Murata T.
    Methodology for Further Thermostabilization of an Intrinsically Thermostable Membrane Protein Using Amino Acid Mutations with Its Original Function Being Retained
    J. Chem. Inf. and Model., 60(3), 1709-1716, (2020)
    DOI: 10.1021/acs.jcim.0c00063
  42. Yamamura R., Nakamura K., Kitada N., Aizawa T., Shimizu Y., Nakamura K., Ayabe T., Kimura T., Tamakoshi A.
    Associations of gut microbiota, dietary intake, and serum short-chain fatty acids with fecal short-chain fatty acids.
    Biosci Microbiota Food Health., 39(1), 11-17, (2020)
    DOI: 10.12938/bmfh.19-010
  43. Hirabayashi Y., Nakamura K., Sonehara T., Suzuki D., Hanzawa S., Shimizu Y., Aizawa T., Nakamura K., Tamakoshi A., Ayabe T.
    Analysis of Serotonin in Human Feces Using Solid Phase Extraction and Column-switching LC-MS/MS
    Mass Spectrometry, 8, A0081, (2020)
    DOI: 10.5702/massspectrometry.a0081
  44. Response surface method for polyhydroxybutyrate (PHB) bioplastic accumulation in Bacillus drentensis BP17 using pineapple peel.
    Penkhrue W., Jendrossek D., Khanongnuch C., Pathom-Aree W., Aizawa T., Behrens R.L., Lumyong S.
    PLoS One., 15(3), e0230443, (2020)
    DOI: 10.1371/journal.pone.0230443
  45. Nonoyama T., Lee Y.W., Ota K., Fujioka K., Hong W., Gong J.P.
    Instant Thermal Switching from Soft Hydrogel to Rigid Plastics Inspired by Thermophile Proteins
    Advanced Materials, 32(4), 1905878 (7 pages) (2020)
    DOI: 10.1002/adma.201905878
  46. Guo H., Uehara Y., Matsuda T., Kiyama R., Li L., Ahmed J., Katsuyama Y., Nonoyama T., Kurokawa T.
    Surface charges dominated protein adsorption on hydrogels
    Soft Matter, 16(7), 1897-1907 (2020)
    DOI: 10.1039/c9sm01999e
  47. Fukao K., Nakajima T., Nonoyama T., Kurokawa T., Kawai T., Gong J.P.
    Effect of Relative Strength of Two Networks on Internal Fracture Process of Double Network Hydrogels as Revealed by in situ Small-Angle X-ray Scattering
    Macromolecules, 53(4), 1154-1163 (2020)
    DOI: 10.1021/acs.macromol.9b02562
  48. Hui C.Y., Liu Z., Phoenix S.L., King D.R., Cui W., Huang Y., Gong J.P.
    Mechanical Behavior of Unidirectional Fiber Reinforced Soft Composites
    Extreme Mechanics Letters, 35, 100642 (13 pages) (2020)
    DOI: 10.1016/j.eml.2020.100642
  49. Hirayama S., Kurokawa T., Gong J.P.
    Non-Linear Rheological Study of Hydrogel Sliding Friction in Water and Concentrated Hyaluronan Solution
    Tribology International, 147, 106270 (7 pages) (2020)
    DOI: 10.1016/j.triboint.2020.106270
  50. Aizawa T., Demura M., Gohara K., Haga H., Ishimori K., Kinjo M., Komatsuzaki T., Maenaka K., Yao M.
    Biophysical Research in Hokkaido University, Japan
    Biophys Rev, 12, 233-236 (2020)
    DOI: 10.1007/s12551-020-00649-w
  51. Shibata Y., Kurokawa T., Aizawa T., Gong JP.
    Bactericidal effect of cationic hydrogels prepared from hydrophilic polymers.
    J Appl Polym Sci., 137, e49583 (2020)
    DOI: 10.1002/app.49583
  52. Komatsu Y., Wada Y., Izumi H., Shimizu T., Takeda Y., Aizawa T.
    1H NMR metabolomic and transcriptomic analyses reveal urinary metabolites as biomarker candidates in response to protein undernutrition in adult rats.
    Br J Nutr, 125, 633-643 (2020)
    DOI: 10.1017/S0007114520003281
  53. Kusama K, Miyagawa M, Ota K, Kuwabara N, Saeki K, Ohnishi Y, Kumaki Y, Aizawa T, Nakasone T, Okamatsu S, Miyaoka H, Tamura K.
    Cordyceps militaris Fruit Body Extract Decreases Testosterone Catabolism and Testosterone-Stimulated Prostate Hypertrophy.
    Nutrients, 13, e50 (2020)
    DOI: 10.3390/nu13010050
  54. Hirayama S., Kurokawa T., Gong J.P.
    Non-Linear Rheological Study of Hydrogel Sliding Friction in Water and Concentrated Hyaluronan Solution
    Tribology International, 147, 106270-106276 (2020)
    DOI: 10.1016/j.triboint.2020.106270
  55. Li X., Cui K., Sun T.L., Meng L., Yu C., Li L., Creton C., Kurokawa T., Gong J.P.
    Mesoscale Bicontinuous Networks in Self-healing Hydrogels Delay Fatigue Fracture
    Proceedings of the National Academy of Sciences, 117(14), 7606-7612 (2020)
    DOI: 10.1073/pnas.2000189117
  56. Semba, S. Kitamura N., Tsuda M., Goto K., Kurono S., Ohmiya Y., Kurokawa T., Gong J.P., Yasuda K., Tanaka S.
    Synthetic Synthetic Poly(2‐acrylamido‐2‐methylpropanesulfonic acid) Gel Induces Chondrogenic Differentiation of ATDC5 Cells via a Novel Protein Reservoir Function
    Journal of Biomedical Materials Research Part A, 109(3), 354-364 (2020)
    DOI: 10.1002/jbm.a.37028
  57. Fan H., Guo H., Wang J., Gong J.P.
    Competitive Cation−π Interactions Between Small Cations and Polycations with Phenyl Groups in Poly(Cation−π) Hydrogels
    Giant, Volume 1, 100005 (2020)
    DOI: 10.1016/j.giant.2020.100005
  58. Fukao K., Tanaka K., Kiyama R., Nonoyama T., Gong J.P.
    Hydrogels Toughened by Biominerals as Energy-Dissipative Sacrificial Bonds
    Journal of Materials Chemistry B, 8(24), 5184-5188 (2020)
    DOI: 10.1039/d0tb00833h
  59. Hashimoto D., Semba S., Tsuda M., Kurokawa T., Kitamura N., Yasuda K., Gong J.P., Tanaka S.
    Integrin α4 Mediates ATDC5 Cell Adhesion to Negatively Charged Synthetic Polymer Hydrogel Leading to Chondrogenic Differentiation
    Biochemical and Biophysical Research Communications, 528(1), 120-126 (2020)
    DOI: 10.1016/j.bbrc.2020.05.071
  60. Nakajima T., Chida T., Mito K., Kurokawa T., Gong J.P.
    Double-Network Gels as Polyelectrolyte Gels with Salt-Insensitive Swelling Properties
    Soft Matter, 16(23), 5487-5496 (2020)
    DOI: 10.1039/d0sm00605j
  61. King D.R., Takahashi R., Ikai T., Fukao K., Kurokawa T., Gong J.P.
    Anisotropic Double Network Hydrogels via Controlled Orientation of a Physical Sacrificial Network
    ACS Applied Polymer Materials, 2(6), 2350-2358 (2020)
    DOI: 10.1021/acsapm.0c00290
  62. Haque M.A., Cui K., Ilyas M., Kurokawa T., Marcellan A., Brûlet A., Takahashi R., Nakajima T., Gong J.P.
    Lamellar Bilayer to Fibril Structure Transformation of Tough Photonic Hydrogel under Elongation
    Macromolecules, 53(12), 4711-4721 (2020)
    DOI: 10.1021/acs.macromol.0c00878
  63. Cui W., King D.R., Huang Y., Chen L., Sun T.L., Guo Y., Saruwatari Y., Hui C.Y., Kurokawa T., Gong J.P.
    Fiber-reinforced Viscoelastomers Show Extraordinary Crack Resistance that Exceeds MetalsAdvanced Materials, 32(31), 1907180-1907188 (2020) 
    DOI: 10.1002/adma.201907180
  64. Shibata Y., Kurokawa T., Aizawa T., Gong J.P.
    Bactericidal effect of Cationic Hydrogels Prepared from Hydrophilic Polymers
    Journal of Applied Polymer Science, 137(48), 49583 (2020)
    DOI: 10.1002/app.49583
  65. Cui K., Ye Y.N., Sun T.L., Yu C., Li X., Kurokawa T., Gong J.P.
    Phase Separation Behavior in Tough and Self-Healing Polyampholyte Hydrogels
    Macromolecules, 53(13), 5116-5126 (2020)
    DOI: 10.1021/acs.macromol.0c00577
  66. Yu C., Guo H., Cui K., Li X., Ye Y.N., Kurokawa T., Gong J.P.
    Hydrogels as Dynamic Memory with Forgetting Ability
    Proceedings of the National Academy of Sciences, 117(32), 18962-18968 (2020)
    DOI: 10.1073/pnas.2006842117
  67. Nakajima T., Kurokawa T., Furukawa H., Gong J.P.
    Effect of the Constituent Networks of Double-Network Gels on their Mechanical Properties and Energy Dissipation Process
    Soft Matter, 16(37), 8618-8627 (2020)
    DOI: 10.1039/d0sm01057j
  68. Delgado D.E., King D.R., Cui K., Gong, J.P., Shull K.R.
    High-Fidelity Hydrogel Thin-Films Processed from Deep Eutectic Solvents
    ACS Applied Materials & Interfaces, 12(38), 43191-43200 (2020)
    DOI: 10.1021/acsami.0c09618
  69. Sedlačík T., Nonoyama T., Guo H., Nakajima T., Takeda Y., Kurokawa T., Gong J.P.
    Preparation of Tough Double- and Triple-Network Supermacroporous Hydrogels through Repeated Cryogelation
    Chemistry of Materials, 32(19), 8576-8586 (2020)
    DOI: 10.1021/acs.chemmater.0c02911
  70. Matsuda T., Kawakami R., Nakajima T., Gong J.P.
    Crack Tip Field of a Double-Network Gel: Visualization of Covalent Bond Scission through Mechanoradical Polymerization
    Macromolecules, 53(20), 8787-8795 (2020)
    DOI: 10.1021/acs.macromol.0c01485
  71. Jhuang J., Frauenlob M., Shibata Y., Wang L., Nakajima T., Nonoyama T., Tsuda M., Tanaka S., Kurokawa T., Gong J.P.
    Chitin-Based Double-Network Hydrogel as Potential Superficial Soft-Tissue-Repairing Materials
    Biomacromolecules, 21(10), 4220-4230 (2020)
    DOI: 10.1021/acs.biomac.0c01003
  72. Yin H., King D.R., Sun T.L., Saruwatari Y., Nakajima T., Kurokawa T., Gong J.P.
    Polyzwitterions as a Versatile Building Block of Tough Hydrogels: From Polyelectrolyte Complex Gels to Double-Network Gels
    ACS Applied Materials & Interfaces, 12(44), 50068-50076 (2020)
    DOI: 10.1021/acsami.0c15269
  73. Cui K., Ye Y.N., Yu C., Li X., Kurokawa T., Gong J.P.
    Stress Relaxation and Underlying Structure Evolution in Tough and Self-Healing Hydrogels
    ACS Applied Materials & Interfaces, 12(44), 50068-50076 (2020)
    DOI: 10.1021/acsami.0c15269
  74. Hui C.Y., Liu Z., Bain N., Jagota A., Dufresne E.R., Style R.W., Kiyama R., Gong J.P.
    How Surface Stress Transforms Surface Profiles and Adhesion of Rough Elastic Bodies
    Proceedings of the Royal Society A, 476(2243), 20200477 (2020)
    DOI: 10.1098/rspa.2020.0477
  75. S. Ishida-Ishihara., M. Akiyama., K. Furusawa., I. Naguro., H. Ryuno., T. Sushida., S. Ishihara., H. Haga.
    Osmotic Gradients Induce Stable Dome Morphogenesis on Extracellular Matrix
    Journal of Cell Science, 133, jcs243865 (2020)
    DOI: 10.1242/jcs.243865
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    Fabrication of Tough and Stretchable Hybrid Double-Network Elastomers Using Ionic Dissociation of Polyelectrolyte in Nonaqueous Media
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    Double Network Hydrogels Based on Semi-rigid Polyelectrolyte Physical Networks
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    Tough Triblock Copolymer Hydrogels with Different Micromorphologies for Medical and Sensory Materials
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    A Multi-axial Theory of Double Network Hydrogels
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    Tough Double Network Elastomers Reinforced by the Amorphous Cellulose Network
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  93. Murakawa K., King D.R., Sun T.L., Guo H., Kurokawa T., Gong J.P.
    Polyelectrolyte Complexation via Viscoelastic Phase Separation Results in Tough and Self-Recovering Porous Hydrogel
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    Programmed Diffusion Induces Anisotropic Superstructure in Hydrogel with High Mechano-Optical Sensitivity
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    ACS Applied Materials & Interfaces, 11(38), 35343-35353 (2019)
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    Internal Damage Evolution in Double-Network Hydrogels Studied by Microelectrode Technique
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    Fabrication of Tough Hydrogels Composites from Photo-responsive Polymers to Show Double Network Effect
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    ACS Macro Letters, 8(11), 1407-1412 (2019)
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    Macromolecules, 52(22), 8651-8661 (2019)
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    Nature Communications, 10, 5127 (2019)
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    The intercellular expression of type-XVII collagen, laminin-332, and integrin-β1 promote contact following during the collective invasion of a cancer cell population.
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    Meflin-Positive Cancer-Associated Fibroblasts Inhibit Pancreatic Carcinogenesis.
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    Girdin/GIV Regulates Collective Cancer Cell Migration by Controlling Cell Adhesion and Cytoskeletal Organization
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    Long-term Culture of Human iPS Cell-derived Telencephalic Neuron Aggregates on Collagen Gel
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    Micro Patterning of Hydroxyapatite by Soft Lithography on Hydrogels for Selective Osteoconduction
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    Network Elasticity of a Model Hydrogel as a Function of Swelling Ratio: From Shrinking to Extreme Swelling State
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    A new allergen family involved in pollen foodassociated syndrome: Snakin/gibberellin-regulated proteins.
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    R-Spondin1 expands Paneth cells and prevents dysbiosis induced by graft-versus-host disease.
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    Anisotropic Tough Double Network Hydrogel from Fish Collagen and its Spontaneous In Vivo Bonding to Bone
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  134. Higa K., Kitamura N., Goto K., Kurokawa T., Gong J. P., Kanaya F., Yasuda K.
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  140. Ishihara S., Ponik S. M., Haga H.
    Mesenchymal Stem Cells in Breast Cancer: Response to Chemical and Mechanical Stimuli
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  152. Wada S., Kitamura N., Nonoyama T., Kiyama R., Kurokawa T., Gong J. P., Yasuda K.
    Hydroxyapatite-Coated Double Network Hydrogel Directly Bondable to the Bone: Biological and Biomechanical Evaluations of the Bonding Property in an Osteochondral Defect
    Acta Biomaterialia, 44, 125-134 (2016)
    DOI: 10.1016/j.actbio.2016.08.016
  153. Cui K., Sun, T.L., Kurokawa, T., Nakajima, T., Nonoyama T., Chen, L., Gong, J.P.
    Stretching-Induced Ion Complexation in Physical Polyampholyte Hydrogels
    Soft Matter, 12, 8833-8840 (2016)
    DOI: 10.1039/c6sm01833e
  154. Huang Y., King D.R., Sun T.L., Nonoyama T., Kurokawa T., Nakajima T., Gong J.P.
    Energy-Dissipative Materices Enable Synergistic Toughening in Fiber Reinforced Soft Composites
    Adv. Funct. Mater., 27, 1605350 (2016)
    DOI: 10.1002/adfm.201605350
  155. Nukuda A., Endoh H., Yasuda M., Mizutani T., Kawabata K., Haga H.
    Role of ATF5 in the Invasive Potential of Diverse Human Cancer Cell Lines
    Biochem. Biophys. Res. Commun. 474, 509–514 (2016)
    DOI: 10.1016/j.bbrc.2016.04.131
  156. Yamada T., Tsuda M., Wagatsuma T., Fujioka Y., Fujioka M., Satoh A. O., Horiuchi K., Nishide S., Nanbo A., Totsuka Y., Haga H., Tanaka S., Shindoh M., Ohba Y.
    Receptor Activator of NF-κB Ligand Induces Cell Adhesion and Integrin α2 Expression via NF-κB in Head and Neck Cancers
    Scientific Reports. 6, 23545, 1-16 (2016)
    DOI: 10.1038/srep23545
  157. Mizutani T., Haga H., Kawabata K.
    Data Set for Comparison of Cellular Dynamics between Human AAVS1 Locus-modified and Wild-type Cells
    Data in Brief. 6, 793–798 (2016)
    DOI: 10.1016/j.dib.2015.12.053
  158. Ishihara S., Mizutani T., Kawabata K., Haga H.
    An Improved Method for Western Blotting When Extracting Proteins from Mammalian Cells Cultured on a Collagen Gel under Serum-free Conditions
    Cytotechnology. 68, 25-32 (2016)
    DOI: 10.1007/s10616-014-9766-4
  159. Mizutani T., Furusawa K., Haga H., Kawabata K.
    Heterogeneous Filament Network Formation by Myosin Light Chain Isoforms Effects on Contractile Energy Output of Single Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells
    Regenerative Therapy, 3, 90-96 (2016)
    DOI: 10.1016/j.reth.2016.02.009
  160. Teshima T., Onoe H., Tottori S., Aonuma H., Mizutani T., Kamiya K., Ishihara H., Kanuka H., Takeuchi S.
    High-Resolution Vertical Observation of Intracellular Structure using Magnetically Responsive Microplates
    Small, 12(25), 3366-3373 (2016)
    DOI: 10.1002/smll.201600339
  161. Sasaki N., Saitoh Y., Sharma R.K., Furusawa K.
    Determination of the elastic modulus of b-lactoglobulin amyloid fibrils by measuring the Debye-Waller factor
    International Journal of Biological Macromolecules, 92, 240-245, (2016)
    DOI: 10.1016/j.ijbiomac.2016.07.011
  162. Furusawa K., Mizutani T., Sasaki N.
    Development of the evaluation system for barrier functions of engineered epithelial lumens
    Regenerative Therapy, 3, 82-89, (2016)
    DOI: 10.1016/j.reth.2016.02.010
  163. Ossai E.C., Tomimori Y., Ohki S., Okada K., Yonekura T., Furusawa K., Sasaki N.
    Morphology and Properties of Globular Polymeric Materials in the Solid State: A Composite Material of DNA with a Cationic Surfactant
    Journal of Polymer Science: Part B: Polymer Physics, 54, 730-738, (2016)
    DOI: 10.1002/polb.23968
著書・総説・解説など
  1. Cui K., Gong J.P.,
    How Double Dynamics Affects Large Deformation and Fracture of Soft Materials
    Journal of Rheology, 66(3), (2022)
  2. Cui K., Gong J.P.,
    Tough Hydrogels Based on Sacrificial Bond Principle
    Macromolecular Engineering: From Precise Synthesis to Macroscopic Materials and Applications, Wiley-VCH, (2022)
  3. Zheng Y, Gong J.P.,
    Double-Network Gels: Strong and Tough Interpenetrating Networks
    Online Encyclopedia of Polymers, Polymeric Materials, and Polymer Technology: Polymer Materials Section, CRC Press, (2022) 
  4. 相沢 智康
    花粉食物アレルギー症候群原因抗原GRPファミリー
    アレルギーの臨床, 553, 85-88 (2021)
  5. Long R., Hui C.Y., Gong J.P., Bouchbinder E.
    The Fracture of Highly Deformable Soft Materials: A Tale of Two Length Scales
    Annual Review of Condensed Matter Physics, 12(1), 71-94 (2021)
    DOI: 10.1146/annurev-conmatphys-042020-023937
  6. 中島 祐、龔 剣萍
    新陳代謝して成長するゲル新陳代謝して成長するゲル
    化学と教育、69巻3号、94-97(2021)
  7. Cui K., Gong J.P.
    Aggregated Structures and Their Functionalities in Hydrogels
    Aggregate, published online (2021)
  8. 崔 昆朋、龔 剣萍
    忘却能力を持つ動的記憶素子の構築~人間の脳の動的な記憶・忘却挙動に触発されて~
    超分子研究会アニュアルレビュー、No.41、12-13 (2021)
  9. Nonoyama T., Gong J.P.
    Tough Double Network Hydrogel and Its Biomedical Applications
    Annual Review of Chemical and Biomolecular Engineering, 12, 393-410 (2021)
    DOI: 10.1146/annurev-chembioeng-101220-080338
  10. Cui K., Gong J.P.,
    Aggregated Structures and Their Functionalities in Hydrogels
    Aggregate, 2(2), e33 (2021)
  11. Nonoyama T., Gong J.P.,
    Tough Double Network Hydrogel and Its Biomedical Applications
    Annual Review of Chemical and Biomolecular Engineering, 12(1), 393-410 (2021)
  12. King D.R., Gong J.P.,
    Hierarchical Toughening: A Step toward Matching the Complexity of Biological Materials,
    Chem, 7(5), 1153-1155 (2021)
  13. Fan H., Gong J.P.,
    Bioinspired Underwater Adhesives
    Advanced Materials, 33(44), 2102983 (2021)
  14. Yue Y., Gong J.P.,
    Structure and Unique Functions of Anisotropic Hydrogels Comprising Uniaxially Aligned Lamellar Bilayers
    Bulletin of the Chemical Society of Japan (BCSJ), 94(9), 2221-2234 (2021)
  15. 田中伸哉、鈴鹿淳、王磊、津田真寿美、龔 剣萍、高阪真路、間野博行
    ハープ現象の発見:DNゲルでがん幹細胞を創り出す(Rapid reprogramming of tumour cells into cancer stem cells on double-network hydrogel)
    実験医学 9月号 39(14)、2255-2259 (2021) 羊土社
  16. 樫村 尚宏、野々山貴行、龔 剣萍
    骨リモデリングプロセスを利用したハイドロゲルの骨への高強度接着-人工軟骨への応用に向けて
    バイオミメティクス(生体模倣技術)の医療応用 生物の神秘を医療に活かす(別冊「医学のあゆみ」)(2021) 医歯薬出版
  17. 野々山 貴行、木山 竜二、深尾 一城、安田 和則、黒川 孝幸、龔 剣萍
    人工軟骨への応用を目指した高強度ハイドロゲル-リン酸カルシウム複合体
    セラミックス、第55巻3月号、166-170 (2020)
  18. Nonoyama T., Gong J.P.
    Meet the phase-separation polymeric gel
    The Innovation Platform, Issue 1, 73-74 (2020)
  19. 相沢 智康
    ヒノキ科樹種由来新規花粉食物アレルギー症候群原因抗原Cup s 7
    アレルギーの臨床, 548, 82-85 (2020)
  20. Nonoyama T.
    Robust hydrogel–bioceramics composite and its osteoconductive properties
    Polymer Journal, Focus Review, 52(7), 709-716 (2020)
    DOI: 10.1038/s41428-020-0332-y
  21. Fan H., Gong J.P.
    Fabrication of Bioinspired Hydrogels: Challenges and Opportunities
    Macromolecules, Perspective, 53(8), 2769-2782 (2020)
    DOI: 10.1021/acs.macromol.0c00238
  22. 樫村 尚宏、野々山 貴行、龔 剣萍
    骨リモデリングプロセスを利用したハイドロゲルの骨への高強度接着―人工軟骨への応用に向けて
    医学のあゆみ、75巻11号、1203-1209(2020)
  23. 中島 祐
    「栄養」を取り込んで成長するゲル
    高分子、Vol.69 No.4、146-147 (2020)
  24. 中島 祐、深尾 一城、龔 剣萍
    第2編第2章第1節 「高靱性ゲルの創製と破壊機構の解明」
    ポリマーの強靭化技術最前線~破壊機構、分子結合制御、しなやかタフポリマーの開発~,
    149-160 (2020)
  25. Chanthad C., King D.R.
    Adhesive binders for nanosilicon anodes in lithium-ion batteries
    Handbook of Nanotechnology Applications, 279-299 (2020)
  26. 石原 誠一郎、芳賀 永
    組織の「硬さ」から迫る線維症研究の新展開
    実験医学 増刊『線維化 慢性疾患のキープロセス』, 第4章 第4節 (2020)
  27. 芳賀 永
    上皮細胞シートの折り返しによる管腔形成と細胞極性
    医学のあゆみ, 268(6), 507-511 (2019)
  28. 崔 昆朋、孫 桃林、龔 剣萍
    Tough and Self-healing Supramolecular Hydrogels Composed of Polyampholytes
    高分子通報(Polymer Bulletin)創刊30周年記念号, 3, 1-16 (2019)
  29. 相沢 智康
    遺伝子組換え微生物による抗菌ペプチドの生産技術
    天然系抗菌・防カビ剤の開発と応用, 【第Ⅳ編 生産・技術】第4章, (2019)
  30. 相沢 智康
    ヒノキ科樹種由来PFAS原因抗原BP14
    アレルギーの臨床, No.529, (2019)
  31. 相沢 智康
    ヒノキ科樹種由来花粉関連食物アレルギー症候群原因抗原の解析
    アレルギーの臨床, No.531, (2019)
  32. 相沢 智康
    ペプチドの立体構造解析手法
    医薬品開発における中分子領域(核酸医薬・ペプチド医薬)の開発戦略, 第3章ペプチド医薬品の創薬開発におけるポイント 第2節, (2019)
  33. 相沢 智康
    ホソイトスギ由来花粉関連食物アレルギー症候群原因抗原Cup s 7の解析
    アレルギーの臨床, No.538, (2019)
  34. 木山 竜二、龔 剣萍
    ダブルネットワークゲルのタフ化機構とその最新の研究動向/ Toughening Mechanism of Double Network Gels and New Research Trends
    日本ゴム協会誌/Journal of Society of Rubber Science and Technology, Japan,「ImPACT しなやかなタフポリマー」特集号、第92巻、第9号、352-356 (2019)
  35. 松田 昂大、中島 祐、龔 剣萍
    鍛えて成長するゲル―破壊による創造の材料科学―
    現代化学、2019年8月号、No.581、53-57 (2019)
  36. 安田 和則、田邉 芳江、龔 剣萍
    ダブルネットワークゲルを用いた硝子軟骨自然再生への挑戦
    関節・軟骨の再生医療, 149-160 (2019)
  37. 芳賀 永、石原 誠一郎
    三次元培養における培養手法と周辺技術動向
  38. 相沢智康
    第II編 ペプチド 第8章「ペプチドの遺伝子組換え微生物を用いた高効率生産技術」
    抗菌ペプチドの機能解明と利用技術, 79-88 (2018)
  39. 野々山貴行、黒川孝幸、安田和則、龔剣萍
    硬くて柔らかくてよく伸びるダブルネットワークゲルの開発と生体との関わり
    ゲル化・増粘剤の使い方、選び方 事例集, 596-604 (2018)
  40. 古澤和也
    第6章「刺激応答性」ゲルを作製するには? 第3節 異方性ゲルの作成技術
    ゲル化・増粘剤の使い方、選び方 事例集, 313-322 (2018)
  41. 芳賀 永
    基質の軟らかさが誘引する上皮細胞の集団運動と3次元形態形成
    生物物理, 58, 196-199 (2018)
  42. 黒川 孝幸
    高分子ゲルの新たな機能と医療への応用
    月刊ソフトマター, 16-18 (2018)
  43. 野々山 貴行、龔 剣萍、安田 和則
    高強度・高靭性ダブルネットワークゲルの開発とソフト人工軟骨への応用
    月刊機能材料, Vol. 38, No. 5, 51-59 (2018)
  44. 堀端 修人、中島 祐、龔 剣萍
    刺激応答性発色ゲル
    応用物理学会・有機分子・バイオエレクトロニクス分科会 会誌, 29(4), 232-235 (2018)
  45. 姚 閔、陳 美容
    tRNA依存的アミノ酸システインの生合成複合体の分子機構
    生化学, 第90巻, 第4号, 512-518 (2018)
  46. Sun T. L., Cui K., Gong J. P.
    Tough, Self-Recovery and Self-healing Polyampholyte Hydrogels
    Polymer Science Ser. C, 59, 11-17 (2017)
    DOI: 10.1134/S1811238217010118
  47. Nakajima T.
    Generalization of the Sacrificial Bond Principle for Gel and Elastomer Toughening
    Polymer J., 49, 477-485 (2017)
    DOI: 10.1038/pj.2017.12
  48. 野々山貴行、中島祐、黒川孝幸、北村信人、安田和則、龔剣萍
    ダブルネットワークゲル(DN ゲル)の軟骨応用に向けた検討
    FC Report, 35, 148-152 (2017)
  49. 中島祐,龔剣萍
    刺激応答性構造色と異方的物性を示すリオトロピック液晶ゲル
    液晶,20,212-217 (2016)
  50. 水谷武臣
    3次元化細胞の力学
    細胞社会学,50-62 (2016)
  51. 新井健生編(古澤和也 第3.8節 分担執筆)
    マルチチャネルコラーゲンゲルを用いた三次元再生組織の構築
    組織工学ライブラリ2マイクロロボティクスとバイオの融合 三次元細胞システム設計論 新井健生編, 141-156
国際学会(招待講演)
  1. February 2022
    San Diego, USA
    The Adhesion Society 45th Annual Meeting
    Optimizing Adhesion at Internal and External Interfaces in Hydrogel Systems
    King D.R.
  2. March 2022
    Bethlehem, USA
    Bioengineering Seminar Series
    From Micro to Macro: Extending the “Double Network Concept” to Large Length Scales
    King D.R.
  3. March 2022
    iCANX Talks, (WEB)
    Bioinspired Soft Materials: Challenges and Opportunities
    Gong J.P.
  4. March 2021
    オンライン開催
    ACS Macro Letters 10th Anniversary Webinar Series: Polymer Physics/Physical Chemistry
    Hydrogels: Challenges and Opportunities
    Gong J.P.
  5. April 2021
    ACS Spring 2021 National Meeting: Macromolecular Chemistry, (WEB)
    Self-growing of double network hydrogels by mechanical training
    Gong J.P.
  6. April 2021
    Spring ACS 2021 National Meeting: Fundamentals of Polymer Mechanics Symposium, (WEB)
    Fatigue fracture of self-healing polyampholyte hydrogels with hierarchical structure
    Gong J.P.
  7. April 2021
    Spring ACS 2021 National Meeting: Fundamentals of Polymer Mechanics Symposium, (WEB)
    From Micro to Macro: Extending the ‘Double Network Concept’ to Large Length Scales
    King D.R.
  8. April 2021
    Biohydrogels 2021, (WEB)
    Double Network Hydrogels for Biological Applications
    Gong J.P.
  9. April 2021
    Pohang University of Science and Technology, (WEB)
    From Micro to Macro: Extending the ‘Double Network Concept’ to Large Length Scales
    King D.R.
  10. May 2021
    The 48th World Polymer Congress (IUPAC-MACRO2020+), (WEB)
    Rapid Thermal Switching from Hydrogel to Plastic
    Gong J.P.
  11. May 2021
    The 48th World Polymer Congress (IUPAC-MACRO2020+), (WEB)
    Dynamic Hydrogels
    Gong J.P.
  12. May 2021
    IUTAM Symposium on Mechanics of Smart and Tough Gels, (WEB)
    Tough and self-healing physical hydrogels composed of polyampholytes
    Gong J.P.
  13. June 2021
    The 13th International Symposium on Polyelectrolytes (ISP2020), (WEB)
    Dynamic Hydrogels
    Gong J.P.
  14. September 2021
    International Webinar on Gels and Networks, (WEB)
    Scaling the Toughness of Soft Composites to New Heights through Fiber Reinforcement
    King D.R.
  15. October 2021
    Duke Soft Matter Symposium on Polymer Networks, (WEB)
    Unique functions of anisotropic hydrogels intercalated by lamellar bilayer membranes
    Gong J.P.
  16. October 2021
    Taiwan-Japan Bilateral Polymer Symposium, (WEB)
    Self-Growing Gels Inspired by Metabolism
    Nakajima T.
  17. November 2021
    The 13th International IUPAC Conference on Polymer-solvent Complexes and Intercalates (Polysolvat-13), (WEB)
    Poly(cation-π) Hydrogels as Super Glues in Sea water
    Gong J.P.
  18. December 2021
    Polymer Physics & Polymer Spectroscopy Webinar, (WEB)
    Yielding Criterion of Double Network Hydrogels
    Gong J.P.
  19. December 2021
    Pacifichem 2021: Materials Symposium “The Many Flavors of Mechanochemistry”, (WEB)
    Self-growing hydrogels learnt from muscle training
    Gong J.P.
  20. December 2021
    Pacifichem 2021: Macromolecular Symposium “Tough and Toughend Polymers”, (WEB)
    Fatigue fracture of self-healing hydrogels with hierarchical structure
    Gong J.P.
  21. January 2020
    Ventura, USA
    2020 Gordon Research Conference on Multifunctional Materials and Structures
    Self-Growing Hydrogels Inspired by Biological Metabolism
    Nakajima T.
  22. August 2020
    オンライン開催
    EASF (Engineering and Applied Science Forum) Young Webinar
    Double Networks: From Molecular-scale to Macro-scale
    King.D.R.
  23. December 2020
    オンライン開催
    Extreme Mechanics Letter (EML) Webinar
    Self-Growing and Strengthening of Double Network Hydrogels by Mechanical Training
    Gong.J.P.
  24. May 2019
    Budapest, Hungary
    Frontiers in Polymer Science 2019
    Self-growing double network hydrogels by repetitive mechanical training
    Gong J.P.
  25. June 2019
    Xi'an, China
    The 3nd International Symposium for Advanced Gel Materials & Soft Matters
    Self-growing hydrogels by repetitive mechanical training
    Gong J.P.
  26. June 2019
    Shenzhen, China
    Joint Meeting of the 5th International Symposium of Flexible and Stretchable Electronics 2019 (ISFSE 2019) and the 5th International Workshop on Soft Machines and Mechanics 2019 (IWSMM 2019)
    Macroscale Double Networks: Design Criteria for Optimizing Strength and Toughness
    King D.R.
  27. June 2019
    Shenzhen, China
    Joint Meeting of the 5th International Symposium of Flexible and Stretchable Electronics 2019 (ISFSE 2019) and the 5th International Workshop on Soft Machines and Mechanics 2019 (IWSMM 2019)
    Bone-Inspired Soft Composite Possessing Osteo-Activity
    Nonoyama T.
  28. July 2019
    Guangzhou, China
    Seminar at South China University of Technology
    Macroscale Double Networks: A Universal Method for Improving the Strength and Toughness of Soft Materials
    King D.R.
  29. July 2019
    Guangzhou, China
    Seminar at South China University of Technology
    Bone-Inspired Soft Ceramics Possessing Osteo-Activity
    Nonoyama T.
  30. July 2019
    Kashiwa, Japan
    Seminar at the University of Tokyo
    Macroscale Double Networks: Extending the “Double Network Concept” to Large Length-Scales
    King D.R.
  31. July 2019
    Cork, Ireland
    ECI Colloidal, Macromolecular and Biological Gels II
    Macroscale Double Networks: Expanding the “Sacrificial Bond Concept” to Large Length-Scales
    King D.R.
  32. July 2019
    Capri, Italy
    DoDyNet Summer School
    Molecular design of self-growing hydrogels in response to mechanical training
    Gong J.P.
  33. July 2019
    Sapporo, Japan
    International Symposium on Biopolymer Synthesis and Degradation
    Quick & Reversible Thermo-Robustizing Hydrogels Exhibiting 1000 Times Modulus Jump
    Nonoyama T.
  34. August 2019
    Yangon, Myanmar
    International Congress on Pure & Applied Chemistry (ICPAC Yangon 2019)
    Activity Measurement of Polyelectrolyte in Hydrogels by Microelectrode Technique
    Kurokawa T.
  35. September 2019
    Beijing, China
    7th Asian Symposium on Advanced Materials (ASAM-7)
    Self-Growing Hydrogels by Mechanical Training
    Gong J.P.
  36. September 2019
    Fukui, Japan
    第68回高分子討論会(日韓ジョイントセッション)
    Self-growong gels inspired by metabolism
    Nakajima T.
  37. October 2019
    Tokyo, Japan
    JST CREST International Workshop : New Developments toward Wearable Photonics: From Materials to Devices CREST (「次世代フォトニクス」国際シンポジウム~ウェアラブルフォトニクスに向けた新しい展開:マテリアルからデバイスへ~)
    Self-growing materials under mechanical training
    Gong J.P.
  38. October 2019
    Xi’an, China
    2019 National Polymer Congress of CHINA / 2019年全国高分子学術論文報告会China-Japan Joint Symposium for Young Polymer Scientists
    Hydrogel Possessing Rubbery-to-Glassy Transition at Elevated Temperature
    Nonoyama T.
  39. October 2019
    Xi’an, China
    Seminar at Shaanxi University of Science & Technology, Shaanxi University of Science & Technology
    Robust Phase-Separation Induced Rubbery-to-Glassy Transition at Elevated Temperature
    Nonoyama T.
  40. November 2019
    Tokyo, Japan
    Millennium Science Forum (MSF)
    Strengthening materials using weak bonds-A novel strategy
    Gong J.P.
  41. November 2019
    Paris, France
    Seminar at ESPCI
    Self-Growing Hydrogels by Mechanical Training
    Gong J.P.
  42. December 2019
    Hyderabad, India
    2nd India-Japan Workshop on Magnetic Resonance
    Development and application of novel overexpression systems for NMR analysis of antimicrobial peptides
    Aizawa T.
  43. December 2019
    Tokyo, Japan
    CEMS International Symposium on Supramolecular Chemistry and Functional Materials 2019 (CEMSupra2019) (理化学研究所 創発物性科学研究センター 国際会議)
    Self-growing hydrogels by repetitive mechanical training
    Gong J.P.
  44. December 2019
    Yokohama, Japan
    Materials Research Meeting 2019 (MRM2019)
    Fiber Reinforced Hydrogels With Extra-Ordinarily High Toughness
    Gong J.P.
  45. December 2019
    Philadelphia, USA
    Seminar at University of Pennsylvania, University of Pennsylvania
    Macroscale Double Networks: Extending the “Double Network Concept” to Large Length-Scales
    King D.R.
  46. February 2018
    Hat Yai, Thailand
    Pure and Applied Chemistry International Conference 2018 (PACCON2018)
    Fusion of Double Network Tough Hydrogel and Bioceramics
    Nonoyama T.
  47. March 2018
    San Diego, USA
    The Adhesion Society 41st Annual Meeting and 6th World Congress on Adhesion and Related Phenomena (WCARP)
    Hydrogels with Reversible Sacrificial Bonds-From Toughness to Bioadhesion to Soft Composites
    Gong J. P.
  48. March 2018
    Kerkrade, The Nethrlands
    17th International Conference on Deformation, Yield and Fracture of Polymers Repeatable under water adhesion of hydrogels
    Gong J. P.
  49. July 2018
    Tronto, Canada
    Japan-Toronto Morphogenesis Symposium
    Collective Movement and 3D Morphogenesis of Epithelial Cells Responding to Viscoelastic Substrates
    Haga H.
  50. June 2018
    Raleigh, USA
    Special Seminar at North Carolina State University
    Applying the Double Network Concept on the Macroscale
    King D.R.
  51. June 2018
    Shaanxi Province, China
    The 13th International Symposium on Polymer Physics (PP’2018)
    Tough physical double network hydrogels based on tri-block copolymers
    Gong J.P.
  52. June 2018
    Shaanxi Province, China
    The 4th International Workshop on Soft Machines and Mechanics
    Deformation of 1D photonic hydrogels with lipid bilayers
    Gong J.P.
  53. June 2018
    Prague, Czech
    82nd Prague Meeting on Macromolecules - Polymer Networks and Gels 2018 and 24th Polymer Network Group Meeting (PNG2018)
    Autonomous Mechanical Remodelling of Double Network Hydrogels
    Gong J.P.
  54. July 2018
    Cairns, Australia
    MACRO2018
    In vivo robust bonding of double network hydrogels to bones
    Gong J.P.
  55. July 2018
    Beijing, China
    International Symposium on Soft Matter: Interface and Active Materials
    Applying the Double Network Principle on the Macroscale
    King D.R.
  56. July 2018
    Sapporo, Japan
    Japan-Korea Joint Symposium on Polymer Science 2018 (JKJS2018)
    Novel Hydrogels with Reversible Sacrificial Bonds-From Toughness to Wet Adhesion to Composites -
    Gong J.P.
  57. August 2018
    Yamagata, Japan
    First International Conference on 4D Materials and Systems (M01 Gel Symposium 2018)
    Effect of Anisotropic compliance on Adhesion in Water
    Kurokawa T.
  58. August 2018
    Yamagata, Japan
    First International Conference on 4D Materials and Systems (M01 Gel Symposium 2018)
    Creating “double network” composites via macroscale reinforcement
    King D.R.
  59. October 2018
    Dhaka, Bangladesh
    Bangladesh Chemical Congress 2018
    Thermoresponsive Hydrogel Possessing Reversible Super Modulus Jumping
    Nonoyama T.
  60. October 2018
    Osaka, Japan
    The 9th International Conference on Multiscale Materials Modeling (MMM2018)
    Hydrogels with Dynamic Sacrificial Bonds - From Toughness to Adhesion to Composites -
    Gong J.P.
  61. October 2018
    Langkawi, Malaysia
    INTERNATIONAL CONGRESS ON PURE & APPLIED CHEMISTRY (ICPAC) 2018
    Effect of Inhomogeneous Compliance induced by Fiber Orientation in Polyampholyte Hydrogel on Adhesion in Water
    Kurokawa T.
  62. November 2018
    Boston, USA
    MRS Fall 2018 Meeting: The Future of Materials Science Academia—Preparing for a career in Higher Education Embracing Internationality: Becoming a Faculty Member Abroad
    King D.R.
  63. February 2017
    Bangkok, Thailand
    Pure and Applied Chemistry International Conference (PACCON) 2017
    Taking inspirations from Nature to design“ green” composites
    King D.R.
  64. March 2017
    Narashino, Japan
    The 11th International Gel Symposium (GelSympo2017)
    Self-healing and Self-Adjustable Adhesion of Polyampholyte Hydrogels
    Gong J.P.
  65. April 2017
    San Francisco, USA
    253rd ACS National Meeting
    Toughening soft materials with sacrificial bonds
    Gong J. P.
  66. May 2017
    Beijing, China
    Seminar at Beijing University of Chemical Technology
    Taking Inspirations from Nature to Design Functional Composite Materials
    King D. R.
  67. June 2017
    Telluride, USA
    2017 Telluride Science Research Conference(TSRC) on Polymer Physics
    Could we observe the single chain behavior at ultimate extension via double network gel?
    Gong J. P.
  68. July 2017
    Sapporo, Japan
    HU-KSMCB Joint Symposium
    Substrate stiffness enhances cancer progression through transcription factor YAP and ATF5 activations
    Haga H.
  69. July 2017
    Irvine, USA
    Japan-UCI Meeting on 3D Morphogenesis
    Collective movement and 3D morphogenesis of epithelial cells induced by viscoelasticity of the extracellular matrix
    Haga H.
  70. August 2017
    Guiyang, China
    The 2nd International Symposium for Advanced Gel Materials & Soft Matters (ISAGMSM)
    Tough soft composites based on sacrificial bond mechanism
    Gong J. P.
  71. August 2017
    Changchun, China
    International Symposium on Advanced Polymeric Materials 2017 (ISAPM 2017)
    Hydrogels with Reversible Sacrificial Bonds: Tough, Self-healing, Adhesion
    Gong J. P.
  72. August 2017
    Changchun, China
    Seminar at Changchun Applied Chemistry Institute
    Hydrogels with Reversible Sacrificial Bonds: Tough, Self-healing, Adhesion
    Gong J. P.
  73. September 2017
    Crete, Greece SUPOLEN
    Hydrogels based on polymer association: Toughness, self-healing, and adhesion
    Gong J. P.
  74. September 2017
    Hanoi, Vietnam
    ASAM-6 Soft Ceramics -Double Network Tough Hydrogels Meet Bioceramics
    Nonoyama T.
  75. November 2017
    Paris, France
    French National Conference on Polymers
    Hydrogels with sacrificial bonds: tough, selfhealing, and self-adjustable adhesion
    Gong J. P.
  76. November 2017
    Sapporo, Japan
    The 18th RIES-HOKUDAI International Symposium
    Epithelial cell polarity essential for collective migration and 3D morphogenesis of cell sheets
    Haga H.
  77. June 2016
    Moscow, Russia
    1th International Symposium “Polyelectrolytes 2016”
    Polyampholyte hydrogels: tough, self-healing, and self-adjustable adhesion
    Gong J.P.
  78. August 2016
    Kyoto, Japan
    The XVIIth International Conference on Rheology (ICR2016)
    Study on Deformation Kinetics of Engineered Tissues
    Furusawa K.
  79. October 2016
    Beijing, China
    Seminar at Beihang University
    Effect of Skeleton at Clingfish Suction Pad
    Kurokawa T.
  80. October 2016
    Beijing, China
    The 1st International Symposium for Advanced
    Gel Materials & Soft Matters
    Tough soft materials with sacrificial bonds
    Gong J.P.
  81. October 2016
    Kitakyushu, Japan
    The International Rubber Conference (IRC) “Gels and Related Soft Materials” Session
    Toughening of soft materials with sacrificial bonds
    Gong J.P.
  82. December 2016
    Fukuoka, Japan
    IPC2016 (The 11th SPSJ International Polymer Conference)
    Effect of Fibrous Skeleton in Polyampholyte Hydrogel on Adhesion in Water
    Kurokawa T.
国際学会(口頭発表)
  1. February 2022
    San Diego, USA
    The Adhesion Society 45th Annual Meeting
    Predicting the fracture toughness of fiber-reinforced soft composites in the absence of a fiber-fracture mechanism
    King D.R.
  2. February 2021
    オンライン開催
    3rd ICReDD International Symposium
    Self-Evolving Hydrogels by Mechanical Training
    Gong J.P.
  3. February 2021
    オンライン開催
    3rd ICReDD International Symposium
    Mechanical force initiates radical reactions in double-network gels
    Nakajima T.
  4. February 2021
    オンライン開催
    The Adhesion Society Annual Meeting
    Improving the Strength and Toughness of Macroscale Double Networks via Poisson’s Ratio Mismatch
    King D.R.
  5. December 2021
    オンライン開催
    Pacifichem2020
    Tough composite hydrogel utilizing ionic bond between poly(acrylic acid) and hydroxyapatite
    Nonoyama T.
  6. February 2020
    Charleston, USA
    The Adhesion Society 43rd Annual Meeting
    Double network gels from semi-rigid polyelectrolyte physical networks with controlled anisotropy
    King D.R.
  7. November–December 2020
    オンライン開催
    2020 Virtual MRS Spring/Fall Meeting,
    Anisotropic Double Network Hydrogels based on Semi-Rigid Polyelectrolyte Physical Networks
    King D.R.
  8. February 2019
    Hilton Head Island, USA
    The Adhesion Society 42nd Annual Meeting
    Synergistic Toughening in Fabric Reinforced Hydrogel Systems and their Applications
    King D.R.
  9. July 2019
    Montreal, Canada
    The 2nd Conference on Multiscale Mechanochemistry and Mechanobiology
    Self-growing hydrogels through a metabolic-like mechanochemical process
    Nakajima T.
  10. October 2019
    Okinawa, Japan
    The 13th Pacific Rim Conference of Ceramic Societies (PACRIM13)
    Bioceramics Toughening Soft & Wet Materials
    Nonoyama T.
  11. November 2019
    Sapporo, Japan
    2nd ICReDD International Symposium
    Stress Responsive Disulfide Bond Reduction in Tough Double Network Hydrogels
    Nakajima T.
  12. December 2019
    Boston, USA
    2019 MRS Fall Meetings & Exhibits
    Macroscale Double Networks: A Universal Method for Improving the Strength and Toughness of Soft Materials
    King D.R.
  13. February 2018
    San Diego, USA
    The Adhesion Society 41st Annual Meeting and 6th World Congress on Adhesion and Related Phenomena (WCARP)
    Effect of Fibrous Skeleton in Polyampholyte Hydrogel on Adhesion in Water
    Kurokawa T.
  14. February 2018
    San Diego, USA
    The Adhesion Society 41st Annual Meeting and 6th World Congress on Adhesion and Related Phenomena (WCARP)
    Scaling Toughness with Macroscale Double Network Composites
    King D. R.
  15. March 2018
    New Orleans, USA
    The 255th ACS National Meeting & Exposition Creating Tough and Healable Macroscale Double Network hydrogels
    King D. R.
  16. September 2018
    Hockley Vallay Resort (Mono, CANADA)
    18th International Conference on Retinal Proteins
    Functional importance of trimer formation of lightdriven H+ pump Gloeobacter rhodopsin
    Kikukawa T.
  17. May 2018
    Fukuoka, Japan
    MIRAI Materials Science Workshop 2018 Spring
    Effect of Fibrous Skeleton in Polyampholyte Hydrogel on Adhesion in Water
    Kurokawa T.
  18. June 2018
    Prague, Czech
    82nd Prague Meeting on Macromolecules - Polymer Networks and Gels 2018 and 24th Polymer Network Group Meeting (PNG2018)
    Hydrogel Possessing Thermo Reversible Robustizing
    Nonoyama T.
  19. October 2018
    Tokyo, Japan
    MIRAI Scientific Session – MATERIALS SCIENCE
    Microelectrode technique for measuring electric potential of polyelectrolyte hydrogels
    Kurokawa T.
  20. October 2018
    Nagoya, Japan
    30th Symposium and Annual Meeting of the International Society for Ceramics in Medicine (Bioceramics30)
    Area-selective Osteoconduction of Hap-patterned Tough Hydrogel by Acidic Gel Stamping
    Nonoyama T.
  21. November 2018
    Boston, USA
    MRS Fall 2018 Meeting
    Fabric Reinforced Hydrogel/Elastomer Composites for Stimuli-Responsive Actuators
    King D.R.
  22. March 2017
    Narashino, Japan
    The 11th International Gel Symposium (GelSympo2017)
    Tough hydrogels with H-bonds as reversible sacrificial bonds
    Sun T.L.
  23. March 2017
    New Orleans, USA
    APS March Meeting 2017
    The role of reinforcement geometry in toughening hydrogel composites
    King D.R.
  24. March 2017
    New Orleans, USA
    APS March Meeting 2017
    Study on requirements of the first network for tough double network gels
    Nakajima T.
  25. August 2017
    Guiyang, China
    The 2nd International Symposium for Advanced Gel Materials & Soft Matters (ISAGMSM)
    Hydrogels with Multi-Cylindrical Lamellar Bilayers: Swelling-Induced Contraction and Anisotropic Molecular Diffusion
    Nakajima T.
  26. August 2017
    Kyoto, Japan
    IUMRS-ICAM 2017, The 15th International Conference on Advanced Materials Construction of Engineered Bone Tissues with Complex Hierarchical Structures
    Furusawa K., Yahata S.
  27. August 2017
    Kyoto, Japan
    IUMRS-ICAM 2017, The 15th International Conference on Advanced Materials Phase Behaviors of Collagen Solution
    Furusawa K., Sugiyama K.
  28. November 2017
    Tainan, Taiwan
    Japan-Taiwan Bilateral Symposium on Polymeric Materials for Future Vehicles
    Toughening of Soft Materials Based on Sacrificial Bond Principle
    Nakajima T.
  29. November 2017
    Boston, USA
    2017 MRS Fall Meeting
    Scaling Toughness with Macro-Scale “Double Network” Composites
    King D. R.
  30. August 2016
    Kyoto, Japan
    The XVIIth International Congress on Rheology (ICR2016)
    Time-temperature Superposition Principle to Fracture Behavior of Tough and Self-healing Polyampholyte Hydrogels
    Sun T.L.
  31. October 2016
    Beijing, China
    The 1st International Symposium for Advanced Gel Materials & Soft Matters
    Adhesion gain by fibrous skeleton based on fish suction pad
    Kurokawa T.
  32. October 2016
    Beijing, China
    The 1st International Symposium for Advanced Gel Materials & Soft Matters
    Time-dependent mechanical behavior of tough and self-healing polyampholyte hydrogels
    Sun T.L.
  33. October 2016
    Nagoya, Japan
    5th Nagoya Biomimetics International Symposium (NaBIS)
    Effect of Fibrous Skeleton at Clingfish Suction Pad
    Kurokawa T.
  34. November 2016
    Klosterneuburg, Austria
    Japan-Austria joint meeting “Understanding the logic behind developmental dynamics”
    3D morphogensis of epithelial cells responding to viscoelasticity of the extracellular matrix
    Haga H.
  35. December 2016
    Fukuoka, Japan
    IPC2016 (The 11th SPSJ International Polymer Conference)
    Developing Extremely Tough Hydrogel Composites
    King D.R.
国内招待講演
  1. 2022年3月
    オンライン開催
    北海道大学大学院医学研究院 第10回消化器内科セミナー
    ハイドロゲルの各種機能性
    黒川 孝幸
  2. 2022年3月
    オンライン開催
    セラミックス協会2022年年会
    生体無機-高分子ゲル融合体をモデル材料とした骨構造・形成機序の研究
    野々山 貴行
  3. 2022年3月
    オンライン開催
    第5回 東工大応用化学系 次世代を担う若手シンポジウム
    新陳代謝によって成⻑するゲル
    中島 祐
  4. 2022年3月
    オンライン開催
    日本化学会第102春季年会 
    犠牲結合原理の確立による多様な高靭性ソフトマテリアルの創出
    龔 剣萍
  5. 2022年2月5日
    オンライン開催
    第23回日本亜鉛栄養治療研究会学術集会
    膵がんにおいて圧縮ストレスが駆動する亜鉛シグナルと悪性化
    二瓶 達也, 石原 誠一郎, 榎本 篤, 芳賀 永
  6. 2021年3月
    オンライン開催
    情報機構セミナー
    ダブルネットワークゲルをはじめとした各種機能性高分子ゲルの作製技術と特性制御及び応用展開
    黒川 孝幸
  7. 2021年5月
    オンライン開催
    東京大学医学部集中講義 医用生体工学入門
    高分子ゲルが拓くソフトマターの世界
    龔 剣萍
  8. 2021年5月
    オンライン開催
    第70回高分子学会年次大会
    強い相分離を利用した昇温過程におけるゴム-ガラス転移を示すソフトマテリアル
    野々山 貴行
  9. 2021年6月
    オンライン開催
    2021年繊維学会年次大会
    生物のように栄養を取り込んで成長するゲル
    中島 祐
  10. 2021年6月
    オンライン開催
    高分子学会精密ネットワークポリマー研究会講演会
    ソフトフォトニッククリスタルゲルの創製
    龔 剣萍
  11. 2021年7月
    オンライン開催
    2021とどけWPIの最新研究シリーズ
    身近な最先端化学
    中島 祐
  12. 2021年7月
    オンライン開催
    生体機能関連化学部会若手の会 第32回サマースクール
    生物のように栄養を取り込んで成長するゲル
    中島 祐
  13. 2021年8月
    オンライン開催
    R&Dリサーチセンター高分子ゲルWEBセミナー
    各種機能性高分子ゲルの作製技術と特性制御及び応用展開
    黒川 孝幸
  14. 2021年11月
    オンライン開催
    接着界面科学研究会PartⅦ第8回例会 ~接着界面科学シンポジウム~
    逆のガラス転移を示すソフトマテリアル
    野々山 貴行
  15. 2021年11月
    オンライン開催
    高分子学会高分子表面研究会
    高分子ゲルの表面摩擦
    黒川 孝幸
  16. 2021年11月
    オンライン開催
    富士フィルム講演会
    ハイドロゲルの各種機能性の検討
    黒川 孝幸
  17. 2021年11月
    オンライン開催
    高分子学会関東支部 茨城地区講演会
    ダブルネットワーク原理による高靭性複合材料の設計と創製
    野々山 貴行
  18. 2021年11月
    オンライン開催
    日本セラミックス協会東北北海道支部 第29回北海道地区セミナー2021
    骨の犠牲結合に習う高分子ゲル材料の強靭化
    野々山 貴行
  19. 2021年11月
    オンライン開催
    名古屋大学機械システム工学専攻 固体力学セミナー
    網目鎖が極度に伸長されたゲルの力学特性:実験的アプローチ
    中島 祐
  20. 2021年11月
    名古屋市
    第43回日本バイオマテリアル学会大会
    ハイドロゲル−バイオセラミックス複合材料系からみる骨の犠牲結合
    野々山 貴行
  21. 2021年12月
    オンライン開催
    大阪大学工業会 産学高分子塾10周年記念公開セミナー2
    生物のように、新陳代謝によって成長するゲル材料の創製
    中島 祐
  22. 2021年12月
    オンライン開催
    第31回日本MRS年次大会
    Soft Matter Possessing Reverse Glass Transition with Elevating Temperature(昇温過程で逆のガラス転移を示すソフトマテリアル)
    野々山 貴行
  23. 2021年12月
    オンライン開催
    日本バイオマテリアル学会 第10 回北陸信越ブロック若手研究発表会
    超高強度ダブルネットワークゲルの最新動向
    中島 祐
  24. 2021年11月
    オンライン開催
    第59回日本生物物理学会年会
    Application of novel overexpression systems of recombinant antimicrobial peptides for NMR analysis
    Tomoyasu AIZAWA
  25. 2021年9月6日
    オンライン開催
    2021年度先端モデル動物支援プラットホーム若手支援技術講習会
    がんのメカノバイオロジー:転写因子を介したがん進行の制御
    石原 誠一郎, 芳賀 永
  26. 2020年9月
    オンライン
    第58回日本生物物理学会年会
    遺伝子組換え抗菌ペプチドの生産技術の開発と応用(Development and application of novel overexpression systems of antimicrobial peptides)
    相沢 智康
  27. 2020年5月(コロナ感染症の懸念のため中止、発表は有効)
    福岡市
    第69回高分子学会年次大会
    高分子ゲルの摩擦
    黒川 孝幸
  28. 2020年9月
    盛岡市 オンライン開催
    第69回高分子討論会
    高分子ゲル研究のチュートリアル
    黒川 孝幸
  29. 2020年10月
    東京都 オンライン開催第10回 CSJ化学フェスタ
    ハイドロゲル表面摩擦のダイナミクス
    黒川 孝幸
  30. 2020年10月
    東京都 オンライン開催
    第10回 CSJ化学フェスタ「Let’s enjoy chemistry in Japan! / 日本で化学を楽しもう!」セッション
    There and Back Again: How an Internship in Japan Sparked a New Journey
    King.D.R.
  31. 2020年11月
    オンライン開催
    第95回高分子若手研究会[関西]
    Dynamic hydrogels inspired from nature
    龔 剣萍
  32. 2020年11月
    東京都 オンライン開催
    第29回ポリマー材料フォーラム
    高靭性複合材料の設計と創製
    龔 剣萍
  33. 2020年12月
    オンライン開催
    第176回東海高分子研究会講演会
    まるで生き物!高機能複合ゲルの世界
    中島 祐
  34. 2019年2月
    札幌市
    第6回北海道大学オープンファシリティシンポジウム
    WPI-ICReDDの取り組みとグローバルファシリティセンターへの期待
    中島 祐
  35. 2019年3月
    つくば市
    北大-KEK第9回連携シンポジウム
    強靭なダブルネットワークゲルの大変形構造解析と自己強靭化
    中島 祐
  36. 2019年6月
    札幌市
    第61回北大祭公開講義
    まるで生き物!? ソフト&ウェットな材料「ゲル」
    中島 祐
  37. 2019年7月
    札幌市
    北大道新アカデミー2019年度前期
    機械と生きものの「構造」の違い
    黒川 孝幸
  38. 2019年8月
    札幌市
    2019年度34th Summer University in Hokkaido&北海道高分子若手研究会
    高分子ゲルの摩擦挙動に影響をおよぼす階層的要因
    黒川 孝幸
  39. 2019年8月
    札幌市
    2019年度34th Summer University in Hokkaido&北海道高分子若手研究会
    Double Networks: From Molecular-scale to Macro-scale (二重網目構造を取り入れた材料設計:分子スケールからマクロスケールへ)
    キング ダニエル
  40. 2019年9月
    札幌市
    北海道大学ライフサイエンスフォーラム2019
    まるで生き物! 機能性ゲルの最新動向
    中島 祐
  41. 2019年11月
    彦根市
    第2回やわらかいものづくり研究会・ゲル部会
    高強度ゲルの人工軟結合組織への応用と固定化技術
    野々山 貴行
  42. 2019年11月
    金沢市
    第2回腫瘍細胞生物学セミナー
    足場の硬さに応答した細胞たちが織り成すがん悪性化メカニズム
    石原 誠一郎、 芳賀 永
  43. 2019年12月
    横浜市
    第18回生体医歯工学公開セミナー
    鍛えて成長するゲル ―破壊による創造の材料科学―
    龔 剣萍
  44. 2018年2月
    東京都
    帝人21世紀フォーラム
    細胞集団に自発的な3次元形態形成を促す培養技術の開発
    芳賀 永、古澤 和也
  45. 2018年2月
    金沢市
    AIMaP研究会「反応拡散系と実験の融合」
    細胞の集団運動と3次元形態形成
    芳賀 永
  46. 2018年3月
    名古屋市
    日本農芸化学会 2018年度大会
    遺伝子組換え抗菌ペプチドの高効率生産技術とその応用
    相沢 智康
  47. 2018年3月
    京都市
    The 33rd Biomechanics Seminar
    Mechanosensitive Response of Cancer and Epithelial Cells Induced by in/on Viscoelastic Substrates
    芳賀 永
  48. 2018年3月
    高松市
    第95回日本生理学会大会
    細胞の基質牽引力と基質の粘弾性がもたらす上皮細胞の集団運動と3D形態形成
    Collective migration and 3D morphogenesis of epithelial cells induced by cellular contractile forces on a viscoelastic substrate
    芳賀 永
  49. 2018年10月
    東京都
    CSJ化学フェスタ
    多細胞系のメカノバイオロジー
    芳賀 永
  50. 2018年6月
    北九州市
    九州地区高分子若手研究会・夏の講演会
    生物に学ぶ水中吸着の工夫
    黒川 孝幸
  51. 2018年7月
    和光市
    理研セミナー
    Polyampholyte hydrogel with toughness and strong adhesion
    黒川 孝幸
  52. 2018年7月
    東京都
    18-1高分子学会講演会
    高強度高分子ゲル開発指針の転換
    黒川 孝幸
  53. 2018年7月
    札幌市
    APSBMS 2018 Annual Meeting
    Spontaneous Osteogenesis Penetration into Soft Material:
    A Simple & Natural Approach to Fix Materials in Body
    Nonoyama T.
  54. 2018年10月
    川崎市
    進化する高分子材料 表面・界面制御コース
    高分子ゲルの摩擦と吸着
    黒川 孝幸
  55. 2018年11月
    東京都
    “未来へのバイオ技術” 勉強会バイオ素材百花繚乱13
    鋼鉄の5倍丈夫な繊維強化ハイドロゲル
    黒川 孝幸
  56. 2017年1月
    吹田市
    関西大学先端科学技術シンポジウム
    ダブルネットワークゲルとその高靱性原理
    龔 剣萍
  57. 2017年1月
    名古屋市
    日本機械学会 第29回バイオエンジニアリング講演会
    基質の粘弾性と細胞の基質牽引力がもたらす上皮細胞シートの3D形態形成
    芳賀 永
  58. 2017年1月
    大阪市
    第21回関西大学先端科学技術シンポジウム
    再生組織の形態形成レオロジー
    古澤 和也
  59. 2017年3月
    東京都
    第67回医用高分子研究会
    高強度ダブルネットワークゲルとその軟骨治療への
    応用
    龔 剣萍
  60. 2017年3月
    横浜市
    日本化学会第97春季年会(2017)
    フォトニックソフトマターの創成と機能制御
    龔 剣萍
  61. 2017年7月
    東京都
    17-1高分子学会講演会
    金属を凌駕する繊維強化ゲルコンポジットのデザインと創製
    龔 剣萍
  62. 2017年9月
    登別市
    2017年度北海道高分子若手研究会
    生体融合型ゲルーバイオセラミックス複合マテリアルの創製
    野々山 貴行
  63. 2017年11月
    横浜市
    マテリアルゲノム時代の材料設計支援技術発表会
    「顕微インデンテーション法とは~新規な力学物性評価技術~」
    バイオセラミックス-高強度ゲル複合によるバイオ・メカニカルアドバンテージ
    野々山 貴行
  64. 2017年11月
    市原市
    第30回アイオノマーシンポジウム in 千葉
    ネットワーク形成制御によるゲル材料特性の自在制御
    黒川 孝幸
  65. 2017年11月
    札幌市
    The 18th RIES-HOKUDAI International Symposium on 極[Kyoku]
    Soft Ceramics : Fusion of Tough gel and Bioceramics
    野々山 貴行
  66. 2017年12月
    神戸市
    2017年度生命科学系学会合同年次大会
    メカニカルなストレスによって促進されるがん細胞の悪性化
    芳賀 永
  67. 2016年4月
    沖縄県国頭郡恩納村
    Seminar at Okinawa Institute of Science and Technology
    Build Tough Hydrogels with Sacrificial Bonds
    龔 剣萍
  68. 2016年7月
    鹿児島市
    第54回高分子材料自由討論会
    Polyampholyte hydrogels: tough, self-healing, and self-adjustable adhesion
    龔 剣萍
  69. 2016年8月
    札幌市
    北大若手研究者の会第16回研究交流会
    Effect of salt on the swelling behaviour of tough and self-healing polyampholyte hydrogels
    孫 桃林
  70. 2016年8月
    札幌市
    31st Summer University in Hokkaido・2016 年度北海道高分子若手研究会
    ハイドロゲル高強度化手法の一般化
    中島 祐
  71. 2016年9月
    東広島市
    日本セラミックス協会第29回秋季シンポジウム
    可逆的犠牲結合による高靭性・自己修復性ゲル
    龔 剣萍
  72. 2016年9月
    横浜市
    第65回高分子討論会
    高靱性ゲルの新展開
    龔 剣萍
  73. 2016年9月
    旭川市
    水和ゲルの表面摩擦と潤滑−生体低摩擦の謎に迫る
    龔 剣萍
  74. 2016年10月
    東京都
    第9回 ChemBioハイブリッドレクチャー
    犠牲結合原理による高靱性ソフトマテリアルの創製
    龔 剣萍
  75. 2016年11月
    福井市
    高分子学会北陸支部研究発表会
    高靱性ゲルの創製とその応用展開
    龔 剣萍
  76. 2016年11月
    京都市
    京都大学再生研セミナー
    Collective Migration and 3D Morphogenesis of Epithelial Cells Induced by Cellular Contractile Forces on a Viscoelastic Substrate
    芳賀 永
  77. 2016年11月
    つくば市
    第54回日本生物物理学会年会
    Collective Movement and 3D Morphogenesis of Epithelial Cells Responding to Viscoelasticity of the Extracellular Matrix
    芳賀 永

先端基盤ユニット

原著論文
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    Dynamic control of microbial movement by photoswitchable ATP antagonists
    Chemistry A European Journal, e202200807 (2022)
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    Structural snapshot of a glycoside hydrolase family 8 endo-β-1,4-glucanase capturing the state after cleavage of the scissile bond
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    Structural insights reveal the second base catalyst of isomaltose glucohydrolase
    The FEBS Journal, 289(4)1118-1134 (2022)
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  5. Zubir M.Z.M., Maulida N.F., Abe Y., Nakamura Y., Abdelrasoul M., Taniguchi T., Monde K.
    Deuterium labelling to extract local stereochemical information by VCD spectroscopy in the C-D stretching region: a case study of sugars
    Org. Biomol. Chem., 20, 1067-1072 (2022)
    DOI: 10.1039/d1ob02317a
  6. Murai Y., Sekiguchi A., Hirakawa T., Usuki S., Igarashi Y., Monde K.
    Evaluation of Chiral N,N-Dimethyl-Sphingosine for the interaction between NGF and trkA
    Chirality, 34, 807-812 (2022)
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  7. Mondal S., Aher R.D., Bethi V., Lin Y.J., Taniguchi T., Monde K., Tanaka F.
    Control of Reactions of Pyruvates by Catalysts: Direct Enantioselective Mannich Reactions of Pyruvates Catalyzed by Amine-based Catalyst Systems
    Org. Lett., 24, 1853-1858 (2022)
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    Penta-deuterium-labeled 4E, 8Z-sphingadienine for rapid analysis in sphingolipidomics study
    Chem. Phys. Lipids, 245, 105202-105210 (2022)
    DOI: 10.1016/j.chemphyslip.2022.105202
  9. Komatsu Y., Kumakura D., Seto N., Izumi H., Takeda Y., Ohnishi Y., Nakaoka S. and Aizawa T.
    Dynamic Associations of Milk Components With the Infant Gut Microbiome and Fecal Metabolites in a Mother–Infant Model by Microbiome, NMR Metabolomic,and Time-Series Clustering Analyses.
    frontiers in Nutrition 07 January (2022)
    DOI: 10.3389/fnut.2021.813690
  10. Baba H.,Watanabe Y., Miura K., Okada K., Kondo M., Ozaki K., Hasebe A., Ayabe T., Nakamura K., Aizawa T., Nakaoka S., Ogasawara K., Suzuki T., Saito H., Kimura T., Tamakoshi A., Yamazaki Y.
    Oral frailty and carriage oral Candida in community-dwelling older adults. (Checkup to discover Health with Energy for senior Residents in Iwamizawa;CHEER Iwamizawa),
    Gerodontology, 39(1)1 49-58 (2022)
    DOI: 10.1111/ger.12621
  11. Suzuki K., Abe S.M. , Kumakura D., Nakaoka S., Fujiwara F., Miyamoto H., Nakaguma T.,Okada M., Sakurai K., Shimizu S., Iwata H., Masuya H., Nihei N., Ichihashi Y.
    Chemical-mediated microbial interactions can reduce the ef-fectiveness of time-series-based inference of ecological interac-tion networks,
    Int. J. Environ. Res. Public Health, 19,1228 (2022)
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  12. Yamaguchi R., Iwasa Y., Tachiki Y.
    Recurrent speciation rates on islands decline with species number.
    Proceedings of the Royal Society B, (2021)
    DOI: 10.1098/rspb.2021.0255
  13. Swamy M.M., Murai Y., Monde K., Tsuboi S., Jin T.
    Shortwave-Infrared Fluorescent Molecular Imaging Probes Based on π-Conjugation Extended Indocyanine Green
    Bioconjugate Chem., 32, 1541-1547 (2021)
    DOI: 10.1021/acs.bioconjchem.1c00253
  14. Koshino S., Taniguchi T., Monde K., Kwon E., Hayashi Y.
    Enantiodivergent One-Pot Synthesis of Axially Chiral Biaryls Using Organocatalyst-Mediated Enantioselective Domino Reaction and Central-to-Axial Chirality Conversion
    Chem. Eur. J., 27, 15786-15794 (2021)
    DOI: 10.1002/chem.202102797
  15. Umekubo N., Taniguchi T., Monde K., Hayashi Y.
    Synthesis of Bicyclo[2.2.2]octanes with a Quaternary Bridgehead Carbon by Diphenylprolinol Silyl Ether-mediated Domino Reaction
    Asian J. Org. Chem., 10, 3261-3265 (2021)
    DOI: 10.1002/ajoc.202100573
  16. Taniguchi T., Zubir M.Z.M., Harada N., Monde K.
    Exploration of chromophores for a VCD couplet in a spectrally transparent infrared region for biomolecules
    Phys. Chem. Chem. Phys., 23, 27525-27532 (2021)
    DOI: 10.1039/d1cp04074j
  17. 江口 晃一、向井 克之、湯山 耕平、栗本 成敬、田中 藍子、勝山(鏡) 豊代、西平 順、門出 健次、五十嵐 靖之
    こんにゃく由来グルコシルセラミド摂取による脳内アミロイドβ蓄積に対する抑制効果の探索的試験-プラセボ対照
    ランダム化二重盲検並行群間比較試験-
    薬理と治療, 49(8), 1225-1239 (2021)
  18. Iwanami S., EjimaK., Kim K. S., Noshita K., Fujita Y.,Miyazaki T., Kohno S., Miyazaki Y., Morimoto S., Nakaoka S., Koizumi Y., Asai Y., Aihara K., Watashi K., Thompson N.R., Shibuya K., Fujiu K., Perelson S.A., Iwami S., Wakita T.
    Detection of significant antiviral drug effects on COVID-19 with reasonable sample sizes in randomized controlled trials: a modeling study combined with clinical data,
    PLoS Medicine, 8(7): e1003660 (2021)
    DOI: 10.1371/journal.pmed.1003660.
  19. Koolath S., Murai, Y., Suga, Y., Monde, K.
    Chiral Combinatorial Preparation and Biological Evaluation of Unique Ceramides for Inhibition of Sphingomyelin Synthase
    Chirality, 32, 308-313 (2020)
    DOI: 10.1002/chir.23179
  20. Lkhamkhuu E., Zikihara K., Katsura H., Tokutomi S., Hosokawa T., Usami Y., Ichihashi M., Yamaguchi J., Monde K.
    Effect of Circularly Polarized Light on Germination, Hypocotyl Elongation and Biomass Production of Arabidopsis and Lettuce
    Involvement of Phytochrome B
    Plant Biotechnology, 37, 57-67 (2020)
    DOI: 10.5511/plantbiotechnology.19.1219a
  21. Koshino S., Takikawa A., Ishida K., Taniguchi T., Monde K., Kwon E., Umemiya S., Hayashi Y.
    Inversion of the axial information during oxidative aromatization in the synthesis of axially chiral biaryls using organocatalyst as a key step
    Chem. Eur. J., 26, 4524-4530 (2020)
    DOI: 10.1002/chem.201905814
  22. Sun X., Ye Y., Sakurai N., Kato K., Yuasa K., Tsuji A., Yao M.
    Crystallographic analysis of Eisenia hydrolysis-enhancing protein using a long wavelength for native-SAD phasing.
    Acta Crystallographica Section F Structural Biology Communications, 76, 20-24, (2020)
    DOI: 10.1107/S2053230X19016716
  23. Wang H., Yu J., Satoh Y., Nakagawa Y., Tanaka R., Kato K., Yao M.
    Crystal structures clarify cofactor binding of plant tyrosine decarboxylase
    Biochemical and Biophysical Research Communications, 523(2)500-505, (2020)
    DOI: 10.1016/j.bbrc.2019.12.077
  24. Goshima Y., Nakaoka S., Ohashi K., Sakamaki H., Shibuya K., Shibuya A.
    A mathematical model for dynamics of soluble form of DNAM-1 as a biomarker for graft-versus-host disease
    PLoS ONE, 15, e0228508 (2020)
    DOI: 10.1371/journal.pone.0228508
  25. Deepak H.V., Swamy M.M.M., Murai Y., Suga Y., Anetai M., Yo T., Kuragano M., Uwai K., Tokuraku K., Monde K.
    Daurichromenic Acid from the Chinese Traditional Medicinal Plant Rhododendron dauricum Inhibits Sphingomyelin Synthase and Aβ Aggregation
    Molecules, 25, 4077-4088 (2020)
    DOI: 10.3390/molecules25184077
  26. Uto T., Ikeda Y., Sunagawa N., Tajima K., Yao M., and Yui T.
    Molecular Dynamics Simulation of Cellulose Synthase Subunit D Octamer with Cellulose Chains from Acetic Acid Bacteria: Insight into Dynamic Behaviors and Thermodynamics on Substrate Recognition
    J. Chem. Theory Comput., 17, 488−496 (2020)
    DOI: 10.1021/acs.jctc.0c01027
  27. Yu J., Shinoda A., Kato K., Tanaka I., and Yao M.
    A solution-free crystal-mounting platform for native SAD
    Acta Cryst., D76, 938-945 (2020)
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  28. Chen M., Gai Z., Okada C., Ye Y., Yu J and Yao M.
    Flexible NAD+ Binding in Deoxyhypusine Synthase Reflects the Dynamic Hypusine Modification of Translation Factor IF5A
    Int. J. Mol. Sci., 21(15), 5509 (2020)
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  29. Nagano Y., Sugiyama A., Kimoto M., Wakahara T., Noguchi Y., Jiang X., Saijo S., Shimizu N., Yabuno N., Yao M., Gooley P., Moseley C., Tadokoro T., Maenaka K., Ose T.
    The measles virus V protein binding site to STAT2 overlaps with that of IRF9
    J. Virol, 94, e01169-20 (2020)
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  30. Sugiyama A., Nomai T., Jiang X., Minami M., Yao M., Maenaka K., Ito N., Gooley Paul R., Moseley Gregory W., Ose T.,
    Structural comparison of the C-terminal domain of functionally divergent lyssavirus P proteins
    Biochem. Biophys. Res. Commun, 529, 507-512 (2020)
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  31. Wakui H., Tanaka Y., Ose T., Matsumoto I., Kato K., Yao M., Tachibana T., Sato M., Naruchi K, Martin Fayna Garucia., Hinou H., Nishimura S.
    A straightforward approach to antibodies recognising cancer specific glycopeptidic neoepitopes.
    Chemical Science, 11, 4999-5006, (2020)
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    Molecular Basis for the Biosynthesis of an Unusual Chain-Fused Polyketide, Gregatin A
    J. Am. Chem. Soc, 142, 8464-8472 (2020)
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    The [4Fe-4S] cluster of sulfurtransferase TtuA desulfurizes TtuB during tRNA modification in Thermus thermophiles.
    Communications biology, 3(1), 168 – 168, (2020)
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    Chapter 2 - An information and statistical analysis pipeline for microbial metagenomic sequencing data
    Handbook of Statistics Vol.43, 67-80 (2020)
    DOI: 10.1016/bs.host.2020.01.001
  35. Goshima Y., Nakaoka S., Ohashi K., Sakamaki H., Shibuya K., Shibuya A.
    A mathematical model for dynamics of soluble form of DNAM-1 as a biomarker for graft-versus-host disease
    PLoS ONE, 15(2):e0228508 (2020)
    DOI: 10.1371/journal.pone.0228508
  36. Costa P., Debebe B., Razavi M., Nakaoka S., Worth A., Wallace D., Beverley P., Macallan D., Asquith B.,
    The rules of human T cell fate in vivo
    Frontiers in Immunology, 11:573 (2020)
    DOI: 10.3389/fimmu.2020.00573
  37. Kurusu T., Kim K., Koizumi Y., Nakaoka S., Ejima K., Misawa N., Koyanagi Y., Sato K., Iwami S.,
    Quantifying the antiviral effect of APOBEC3 on HIV-1 infection in humanized mouse model
    Journal of Theoretical Biology, 498 (2020) 110295
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  38. Aso H., Nagaoka S., Kawakami E., Ito J., Islam S., Tan B., Nakaoka S., Ashizaki K., Shiroguchi K., Suzuki Y., Satou Y., Koyanagi Y., Sato K.
    Multi-omics investigation revealing the characteristics of HIV--infected cells in vivo
    Cell Reports, Volume 32, Issue 2 (2020) 107887
    DOI: 10.1016/j.celrep.2020.107887
  39. Iwanami S., Kitagawa K., Asai Y., Ohashi H., Nishioka K., Inaba H., Nakaoka S., Wakita T., Diekmann O., Iwami S.
    Should a viral genome stay in the host cell or leave? A quantitative dynamics study of how hepatitis C virus deals with this dilemma
    PLoS Biology, 18(7) (2020) e3000562
    DOI: 10.1371/journal.pbio.3000562
  40. Kim K., Yamamoto Y., Nakaoka S., Tomonaga K., Iwami S., Honda T.
    Modeling Borna disease virus in virto spread reveals the mode of antiviral effect conferred by an endogenous bornavirus-like element
    Journal of Virology, Volume 94 Issue 21 e01204-20 (2020)
    DOI: 10.1128/JVI.01204-20
  41. Yamaguchi R., Otto P. S.
    Insights from Fisher’s geometric model on the likelihood of speciation under different histories of environmental change
    Evolution 74: 1603-1619 (2020)
    DOI: 10.1111/evo.14032
  42. Lee J. H., Yamaguchi R., Yokomizo H., Nakamaru, M.
    Preservation of the value of rice paddy fields: Investigating how to prevent farmers from abandoning the fields by means of evolutionary game theory
    Journal of Theoretical Biology 110247 (2020)
    DOI: 10.1016/j.jtbi.2020.110247
  43. Nakahara T., Horita J., Booton R. D., Yamaguchi, R.
    Extra molting, cannibalism and pupal diapause under unfavorable growth conditions in Atrophaneura alcinous (Lepidoptera: Papilionidae)
    Entomological Science 23: 57-65 (2020)
    DOI: 10.1111/ens.12399
  44. Kiske C., Riegel A., Hopf R., Kvindt A., Poplacean I., Taniguchi T., Swamy M., Monde K., Eisenreich W., Engel K.
    Determination of the Absolute Configurations and the Sensory Properties of the Enantiomers of a Homologous Series (C6-C10) of 2-Mercapto-4-alkanones
    J. Agric. Food Chem., 67, 1187-1196 (2019)
    DOI: 10.1021/acs.jafc.8b06599
  45. Sasaki R., Tainaka R., Ando Y., Hashi Y., Virupaksha D., Suga Y., Murai Y., Anetai M., Monde K., Ota K., Ito I., Kikuchi H., Oshima Y., Endo Y., Nakao H., Sakono M., Uwai K., Tokuraku K.
    An automated microliter-scale high-throughput screening system (MSHTS) for real-time monitoring of protein aggregation using quantumdot nanoprobes
    Sci. Rep., 9, 2587 (2019)
    DOI: 10.1038/s41598-019-38958-0
  46. Othman MA., Yuyama K., Murai Y., Igarashi Y., Mikami D., Sivasothy Y., Awang K., Monde K.
    Malabaricone C as natural sphingomyelin synthase inhibitor against diet-induced obesity and its lipid metabolism in mice
    ACS Medicinal Chemistry Letters, 10(8), 1154-1158 (2019)
    DOI: 10.1021/acsmedchemlett.9b00171
  47. Okamura, H., Fujioka, T., Mori, N., Taniguchi, T., Monde, K., Watanabe, H., Takikawa, H.
    First enantioselective synthesis of salinipostin A, a marine cyclic enol-phosphotriester isolated from Salinispora sp
    Tetrahedron Lett., 60, 150917-150919 (2019)
    DOI: 10.1016/j.tetlet.2019.07.008
  48. Saaidin S. A., Murai, Y., Ishikawa, T., Monde, K.
    Design and Synthesis of Ligand‐Tag Exchangeable Photoaffinity Probe Utilizing Nosyl Chemistry.
    Eur. J. Org. Chem., 46, 7563-7567 (2019)
    DOI: 10.1002/ejoc.201901348
  49. Morishita Y., Okazaki Y., Yi Yi Luo, Nunoki J., Taniguchi T., Oshima Y., Asai T.
    Use of plant hormones to activate silent polyketide biosynthetic pathways in Arthrinium sacchari, a fungus isolated from a spider.
    Org. Biomol. Chem. 2019, 17, 780-784 (2019)
    DOI: 10.1039/c8ob02837k
  50. Christiane Kiske, Anja Devenie Riegel, Ronja Hopf, Anna Kvindt, Iulia Poplacean, Tohru Taniguchi, Mahadeva M. M. Swamy, Kenji Monde, Wolfgang Eisenreich, Karl-Heinz Engel;
    Determination of the Absolute Configurations and Sensory Properties of the Enantiomers of a Homologous Series (C6-C10) of 2-Mercapto-4-alkanones.
    J. Agric. Food Chem. 2019, 67, 1187-1196 (2019)
    DOI: 10.1021/acs.jafc.8b06599
  51. Ye Y., Meirong C., Kato K., Yao M.
    The pH-dependent conformational change of eukaryotic translation initiation factor 5: Insights into partner-binding manner.
    Biochemical and Biophysical Research Communications, 519, 186-191, (2019)
    DOI: 10.1016/j.bbrc.2019.08.128
  52. Li L., Adachi M., Yu J., Kato K., Shinoda A., Ostermann A., E.Schrader T., Ose T., and Yao M.
    Neutron crystallographic study of heterotrimeric glutamine amidotransferase CAB
    Acta Crystallogr F Struct Biol Commun., 75, 193-196, (2019)
    DOI: 10.1107/S2053230X19000220
  53. Hashimoto T., Ye Y., Matsuno A.,Ohnishi Y., Kitamura A., Kinjo M., Abe S., Ueno T., Yao M., Ogawa T., Matsui T., and Tanaka, Y.
    Encapsulation of biomacromolecules by soaking and co-crystallization into porous protein crystals of hemocyanin
    Biochem. Biophys. Res. Commun., 509, 577-584, (2019)
    DOI: 10.1016/j.bbrc.2018.12.096
  54. Kumar Sasmal S., Takeuchi Y., Nakaoka S.
    T-cell mediated adaptive immunity and antibody-dependent enhancement in secondary dengue infection
    Journal of Theoretical Biology, 470, 50-63 (2019)
    DOI: 10.1016/j.jtbi.2019.03.010
  55. Hongen T., Taniguchi T., Monde K.
    Modifying Oligoalanine Conformation by Replacement of Amide to Ester Linkage Chirality
    Chirality, 30, 396-401 (2018)
    DOI: 10.1002/chir.22823
  56. Gowda S. B., Nakahashi A., Yamane K., Nakahashi S., Murai Y., C. Siddegowda A. K., Hammam M. A. S., Monde K.
    Facile Chemoselective Strategy toward Capturing Sphingoid Bases by Unique Glutaraldehyde Functionalized Resin
    ACS Omega, 3, 753-759 (2018)
    DOI: 10.1021/acsomega.7b01440
  57. Tanzawa T., Kato K., Dylan G., Ose T., Kumakura Y., Hans W., Uchiumi T., Tanaka I., Yao M.
    The C-terminal helix of ribosomal P stalk recognizes a hydrophobic groove of elongation factor 2 in a novel fashion
    Nucleic Acids Res., 46(6), 3232-3244 (2018)
    DOI: 10.1093/nar/gky115
  58. Tanzawa T., Kato K., Girodat D., Ose T., Kumakura Y., Wieden H., Uchiumi T., Tanaka I., Yao M.
    The C-terminal helix of ribosomal P stalk recognizes a hydrophobic groove of elongation factor 2 in a novel fashion
    Nucleic Acids Research, 46, 3232-3244 (2018)
    DOI: 10.1093/nar/gky115
  59. Auiewiriyanukul W., Saburi W., Kato K., Yao M., Mori H.
    Function and structure of GH13_31 α-glucosidase with high α-(1→4)-glucosidic linkage specificity and transglucosylation activity.
    FEBS Letters., 592, (13), 2268-2281 (2018)
    DOI: 10.1002/1873-3468.13126
  60. Saburi W., Jaito N., Kato K., Tanaka Y., Yao M., Mori H.
    Biochemical and structural characterization of Marinomonas mediterranead-mannose isomerase Marme_2490 phylogenetically distant from known enzymes.
    Biochimie, 144, 63-73 (2018)
    DOI: 10.1016/j.biochi.2017.10.016
  61. Swamy M., Murai Y., Ohno Y., Jojima K., Kihara A., Mitsutake S., Igarashi Y., Yu J., Yao M., Suga Y., Anetai M., Monde K.
    Structure-inspired design of a sphingolipid mimic sphingosine-1-phosphate receptor agonist from a naturally occurring sphingomyelin synthase inhibitor
    Chemical Communication. 54, 12758-12761 (2018)
    DOI: 10.1039/c8cc05595e
  62. Kawauchi G., Umemiya S., Taniguchi T., Monde K., Hayashi Y.
    Enantio- and Diastereoselective Synthesis of Latanoprost using an Organocatalyst
    Chem. Eur. J., 24, 8409-8414 (2018)
    DOI: 10.1002/chem.201800829
  63. Murakami R., Sano K., Iwai T., Taniguchi T., Monde K., Sawamura M.
    Palladium-Catalyzed Asymmetric C(sp³)-H Allylation of 2-Alkylpyridines
    Angew. Chem., Int. Ed., 57, 9465-9469 (2018)
    DOI: 10.1002/anie.201802821
  64. Katakami C., Kamo S., Torii A., Hara N., Imai Y., Taniguchi T., Monde K., Okabayashi Y., Hosokai T., Kuramochi K., Tsubaki K.
    Synthesis and Photochemical Properties of Axially Chiral Bis (dinaphthofuran)
    J. Org Chem., 83, 14610-14616 (2018)
    DOI: 10.1021/acs.joc.8b02424
  65. Taniguchi T., Suzuki T., Satoh H., Shichibu Y., Konishi K., Monde K.
    Preparation of Carbodiimides with One-Handed Axial Chirality
    J. Am. Chem. Soc., 140, 15577-15581 (2018)
    DOI: 10.1021/jacs.8b08969
  66. Saito S., Murai Y., Usuki S., Yoshida M., Hammam M.A.S., Mitsutake S., Yuyama K., Igarashi Y., Monde K.
    Synthesis of Nontoxic Fluorous Sphingolipids as Molecular Probes of Exogenous Metabolic Studies for Rapid Enrichment by FSPE
    Eur. J. Org. Chem., 2017, 1045-1051 (2017)
    DOI: 10.1002/ejoc.201601302
  67. Kasamatsu K., Yoshimura T., Mandi A., Taniguchi T., Monde K., Furuta T., Kawabata T.
    α-Arylation of α-Amino Acid Derivatives with Arynes via Memory of Chirality: Asymmetric Synthesis of Benzocy-clobutenones with Tetrasubstituted Carbon
    Org. Lett., 19, 352-355 (2017)
    DOI: 10.1021/acs.orglett.6b03533
  68. Taniguchi T., Nakano K., Baba R., Monde K.
    Analysis of Configuration and Conformation of Furanose Ring in Carbohydrate and Nucleoside by Vibrational Circular Dichroism
    Org. Lett., 19, 404-407 (2017)
    DOI: 10.1021/acs.orglett.6b03626
  69. Tachrim Z. P., Wang L., Murai Y., Yoshida T., Kurokawa N., Ohashi F., Hashidoko Y., Hashimoto M.
    Triflouromethanesulfonic Acid as Acylation Catalyst : Special Feature for C- and/ or O-Acylation Reactions
    Catalysts, 7, 40 (2017)
    DOI: 10.3390/catal7020040
  70. Suzuki K.T., Suzuki M., Shigeta M., Fortriede J.D., Takahashi S., Mawaribuchi S., Yamamoto T., Taira M., Fukui A.
    Clustered Xenopus keratin genes: A genomic, transcriptomic, and proteomic analysis
    Dev. Biol., 2, 384-392 (2017)
    DOI: 10.1016/j.ydbio.2016.10.018
  71. Watanabe M., Yasuoka Y., Mawaribuchi S., Kuretani A., Ito M., Kondo M., Ochi H., Ogino H., Fukui A., Taira M., Kinoshita T.
    Conservatism and variability of gene expression profiles among homeologous transcription factors in Xenopus laevis
    Dev. Biol., 426, 301-324 (2017)
    DOI: 10.1016/j.ydbio.2016.09.017
  72. Mawaribuchi S., Takahashi S., Wada M., Uno Y., Matsuda Y., Kondo M., Fukui A., Takamatsu N., Taira M., Ito M.
    Sex chromosome differentiation and the W- and Z-specific loci in Xenopus laevis
    Dev. Biol. 426, 393-400 (2017)
    DOI: 10.1016/j.ydbio.2016.06.015
  73. Yao J., Sugawara M., Obara H., Mizutani T., Takei M.
    Distinct Motion of GFP-Tagged Histone Expressing Cells Under AC Electrokinetics in Electrode-Multilayered Microfluidic Device
    IEEE Transactions on Biomedical Circuits and Systems, 11(6), 1450-1458 (2017)
    DOI: 10.1109/TBCAS.2017.2729584
  74. Huang J.-R., Sohail M., Taniguchi T., Monde K., Tanaka F.
    Formal (4+1) Cycloaddition and Enantioselective Michael?Henry Cascade Reactions To Synthesize Spiro[4,5]decanes and Spirooxindole Polycycles
    Angew. Chem., Int. Ed., 56, 5853-5857 (2017)
    DOI: 10.1002/anie.201701049
  75. Takayama Y., Ishii T., Ohmiya H., Iwai T., Schwarzer M. C., Mori S., Taniguchi T., Monde K., Sawamura M.
    Asymmetric Synthesis of β-Lactams through Copper-Catalyzed Alkyne-Nitrone Coupling with Prolinol-Phosphine Chiral Ligand
    Chem., Eur. J., 23, 8400-8404 (2017)
    DOI: 10.1002/chem.201702070
  76. Taniguchi T.
    Analysis of Molecular Configuration and Conformation by Electronic and Vibrational Circular Dichroism: Theoretical Calculation and Exciton Chirality Method.
    Bull. Chem. Soc. Jpn.,90, 1005-1016 (2017)
    DOI: 10.1246/bcsj.20170113
  77. Reyes R. L., Harada T., Taniguchi T., Monde K., Iwai T., Sawamura M.
    Enantioselective Rh- or Ir-Catalyzed Directed C(sp3)‒H Borylation with Phosphoramidite Chiral Ligands
    Chem. Lett., 46, 1747-1750 (2017)
    DOI: 10.1246/cl.170853
  78. Narita K., Sato H., Minami A., Kudo K., Gao L., Liu C., Ozaki T., Kodama M., Lei X., Taniguchi T., Monde K., Yamazaki M., Uchiyama M., Oikawa H.
    Focused genome mining of structurally related sesterterpenes: enzymatic formation of enantiomeric and diastereomeric products
    Org. Lett., 19, 6696-6699 (2017)
    DOI: 10.1021/acs.orglett.7b03418
  79. Chen M., Kato K., Kubo Y., Tanaka Y., Liu Y., Long F., Whitman B. W., Lill P., Gatsogiannis C., Raunser S., Shimizu N., Shinoda A., Nakamura A., Tanaka I., Yao M.
    Structural basis for tRNA-dependent cysteine biosynthesis
    Nat. Commun., 8, 1521 (2017)
    DOI: 10.1038/s41467-017-01543-y
  80. Nojima S., Fujishima A., Kato K., Ohuchi K., Shimizu N., Yonezawa K., Kenji T., Yao M.
    Crystal structure of the flexible tandem repeat domain of bacterial cellulose synthesis subunit C
    Sci. Rep., 7, 13018 (2017)
    DOI: 10.1038/s41598-017-12530-0
  81. Kunthic T., Watanabe H., Kawano R., Tanaka Y., Promdonkoy B., Yao M., Boonserm P.
    pH Regulates Pore Formation of a Protease Activated Vip3Aa from Bacillus thuringiensis
    BBA-Biomembranes., 1859, 2234-2241 (2017)
    DOI: 10.1016/j.bbamem.2017.08.018
  82. Komoda K., Narita M., Yamashita K., Tanaka I., Yao M.
    The Asymmetric Trimeric Ring Structure of the Nucleocapsid Protein of Tospovirus
    J. Virol., 91, e01002-17 (2017)
    DOI: 10.1128/JVI.01002-17
  83. Kikuchi A., Okuyama M., Kato K., Osaki S., Ma M., Kumagai Y., Matsunaga K., Klahan P., Tagami T., Yao M., Kimura A.,
    A novel glycoside hydrolase family 97 enzyme: bifunctional β-l-arabinopyranosidase/α-galactosidase from Bacteroides thetaiotaomicron
    Biochimie., 142, 41-50 (2017)
    DOI: 10.1016/j.biochi.2017.08.003
  84. Chen M., Asai S., Narai S., Nambu S., Omura N., Sakaguchi Y., Suzuki T., Ikeda-Saito M., Watanabe K., Yao M., Shigi N., Tanaka Y.
    Biochemical and structural characterization of oxygen-sensitive 2-thiouridine synthesis catalyzed by an iron-sulfur protein TtuA
    Proc. Natl. Acad. Sci. USA., 114, 4954-4959 (2017)
    DOI: 10.1073/pnas.1615585114
  85. Okuyama M., Matsunaga K., Watanabe K., Yamashita K., Tagami T., Kikuchi A., Ma M., Klahan P., Mori H., Yao M., Kimura A.
    Efficient synthesis of α-galactosyl oligosaccharides using a mutant Bacteroides thetaiotaomicron retaining α-galactosidase (BtGH97b)
    FEBS J., 284, 766-783 (2017)
    DOI: 10.1111/febs.14018
  86. Mandi A., Swamy M. M. M., Taniguchi T., Anetai M., Monde K.
    Reducing Molecular Flexibility by Cyclization for Elucidation of Absolute Configuration by CD Calculations: Daurichromenic Acid
    Chirality, 28, 453-459 (2016)
    DOI: 10.1002/chir.22606
  87. Taniguchi T., Asahata M., Nasu A., Shichibu Y., Konishi K., Monde K.
    Facile Diastereoseparation of Glycosyl Sulfoxides by Chiral Stationary Phase
    Chirality, 28, 534-539 (2016)
    DOI: 10.1002/chir.22610
  88. Nakahashi A., C. Siddegowda A. K., Hammam M. A. S., Gowda S. G. B., Murai Y., Monde K.
    Stereochemical study of sphingosine by vibrational circular dichroism
    Org. Lett., 18, 2327-2330 (2016)
    DOI: 10.1021/acs.orglett.6b00477
  89. Mizutani S., Komori K., Taniguchi T., Monde K., Kuramochi K., Tsubak K.
    A Bioinspired Synthesis of (±)-Rubrobramide, (±)-Flavipucine, and Isoflavipucine
    Angew. Chem., Int. Ed., 55, 9553-9556 (2016)
    DOI: 10.1002/anie.201602910
  90. Taniguchi T., Hongen T., Monde K.
    Studying the stereostructures of biomolecules and their analogs by vibrational circular dichroism.
    Polym. J., 48, 925–931 (2016)
    DOI: 10.1038/pj.2016.61
  91. Hayashi Y., Bondzic B. P., Yamazaki T., Gupta Y., Ogasawara S., Taniguchi T., Monde K.
    Asymmetric Diels–Alder Reaction of α-Substituted and β, β-Disubstituted α, β-Enals via Diarylprolinol Silyl Ether for the Construction of All-Carbon Quaternary Stereocenters
    Chem., Eur. J., 22, 15874-15880 (2016)
    DOI: 10.1002/chem.201602345
  92. Kiske C., Noerenberg S., Ecker M., Ma X., Taniguchi T., Monde K., Eisenreich W., Engel K.-H.
    Reinvestigation of the Absolute Configurations of Chiral s-Mercaptoalkanones Using Vibrational Circular Dichroism and 1H NMR Analysis
    J. Agric. Food Chem., 64, 8563-8571 (2016)
    DOI: 10.1021/acs.jafc.6b03670
  93. Kimura S., Suzuki T., Chen M., Kato K., Yu J., Nakamura A., Tanaka I., Yao M.
    Template-dependent nucleotide addition in the reverse (3'-5') direction by Thg1-like protein
    Science Advances., 2, e1501397 (2016)
    DOI: 10.1126/sciadv.1501397
  94. Okada C., Wakabayashi H., Kobayashi M., Shinoda A., Tanaka I., Yao M.
    Crystal structures of the UDP-diacylglucosamine pyrophosphohydrase LpxH from Pseudomonas aeruginosa
    Scientific Reports., 6, 32822 (2016)
    DOI: 10.1038/srep32822
  95. Ye Y., Saburi W., Odaka R., Kato K., Sakurai N., Komoda K., Nishimoto M., Kitaoka M., Mori H., Yao M.
    Structural insights into the difference in substrate recognition of two mannoside phosphorylases from two GH130 subfamilies
    FEBS Lett., 590, 828-837 (2016)
    DOI: 10.1002/1873-3468.12105
  96. Oshima K., Kakiuchi Y., Tanaka Y., Ueda T., Nakashima T., Kimura M., Yao M.
    Structural basis for recognition of a kink-turn motif by an archaeal homologue of human Rnase P protein Rpp38
    Biochem. Biophys. Res. Commun., 474, 541-546 (2016)
    DOI: 10.1016/j.bbrc.2016.04.118
  97. Sekine Y., Tanzawa T., Tanaka Y., Ishimori K., Uchida T.
    Cytoplasmic Heme-Binding Protein (HutX) from Vibrio cholerae Is an Intracellular Heme Transport Protein for the Heme-Degrading Enzyme, HutZ
    Biochemistry., 55, 884-893 (2016)
    DOI: 10.1021/acs.biochem.5b01273
  98. Chen M., Nakazawa Y., Kubo Y., Asano N., Kato K., Tanaka I., Yao M.
    Crystallographic analysis of a subcomplex of the transsulfursome with tRNA for Cys-tRNA (Cys) synthesis
    Acta Cryst. F., 72, 569-572 (2016)
    DOI: 10.1107/S2053230X16009559
  99. Chen M., Narai A., Omura N., Shigi N., Chimnaronk S., Tanaka Y., Yao M.
    Crystallographic study of the 2-thioribothymidinesynthetic complex TtuA-TtuB from Thermus thermophilus
    Acta Cryst. F., 72, 777-781 (2016)
    DOI: 10.1107/S2053230X16014242
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    Shu S., Carlson J., Kinoshita T., Ohta Y., Mawaribuchi S., Jenkins J., Grimwood J., Schmutz J., Mitros T., Mozaffari S., Suzuki Y., Haramoto Y., Yamamoto T.S., Takagi C., Heald R., Miller K., Haudenschild C., Kitzman J., Nakayama T., Izutsu Y., Robert J., Fortriede J., Burns K., Lotay V., Karimi K., Yasuoka Y., Dichmann D.S., Flajnik M.F., Houston D.W., Shendure J., DuPasquier L., Vize P.D., Zorn A.M., Ito M., Marcotte E., Wallingford J.B., Ito Y., Asashima M., Ueno N., Matsuda Y., Veenstra G.C., Fujiyama A., Harland R.M., Taira M., Rokhsar D.S.
    (75) Genome evolution in the allotetraploid frog Xenopus laevis
    Nature, 538(7625): 336-343 (2016)
    DOI: 10.1038/nature19840
著書・総説・解説など
  1. Tajima K, Imai T, Yui T, Yao M and Saxena I.
    Cellulose-synthesizing machinery in bacteria, Cellulose 29, 2755–277 (2021)
    DOI: 10.1007/s10570-021-04225-7
  2. 菊川峰志,尾瀬農之,金城政孝
    蛍光偏光測定
    実験医学別冊
    創薬研究のための相互作用解析パーフェクト低中分子・抗体創薬におけるスクリーニング戦略と実例、in silico解析、一歩進んだ分析技術まで, 74-85 (2021) 羊土社
  3. 門出 健次、村井 勇太
    ケモエンザイマティカルな長鎖塩基の調製と樹脂固定型グルタルアルデヒドによる効率的精製法
    生化学, 92 (2), 272-277 (2020)
  4. 門出 健次
    分光学的性質 ―生体物質の円二色性―
    日本化学会 編 化学便覧 基礎編 改訂6版15章 97-98 (2020) 丸善出版(株)
  5. 門出 健次、前田 耕治、安川 智之、床波 志保 編
    旋光度と円偏光二色法(CD)
    機器分析ハンドブック2 -高分子・分析技術編-10章 140-153 (2020) 化学同人
  6. Monde K.,
    VCD Exciton Chirality Method. In: Hung-Wen (Ben) Liu, Tadhg P. Begley (eds.)
    Comprehensive Natural Products III: Chemistry and Biology. vol. 7, 344-352. Elsevier. (2020)
  7. 中岡 慎治、熊倉 大騎
    腸内環境を保全するうえでの数理科学の役割
    実験医学 2020年11月号 Vol.38 No.18. 3078-3084.
  8. 谷口 透
    「赤外円二色性分光法で見る溶液中分子の世界」化学と教育 2019, 66, 825.
  9. 村井 勇太、門出 健次
    セラミド研究会 編 セラミド研究の新展開 ~基礎から応用へ~
    第33章 278-285(2019) ”天然物を利用したセラミド関連物質の化学合成戦略”
    食品化学新聞社 ISBN978-4-916143-35-8
  10. 石坂 優人、陳 明皓、奈良井 峻、堀谷 正樹、田中 良和、姚 閔
    鉄硫黄クラスターが関与するtRNAチオ化修飾酵素の詳細な反応機構解明を目指した研究
    Photon Factory News, 第37巻, 第3号, 20-24 (2019)
  11. Nakaoka S., Matsuyama K.
    Information and statistical analysis pipeline for high-throughput RNA sequencing data
    Springer protocol Epidermis, 1-10 (2019)
  12. 谷口透、門出健次
    円二色性(CD)・赤外円二色性(VCD)による立体構造解析~実践例と注意点~
    有機合成化学協会誌, 75, 522-529 (2017)
  13. 門出健次、村井勇太
    化学プローブは求愛タンパク質の心をどう射留めるのか?-生命現象解明・創薬に小分子の視点から
    化学, 72, 70-71 (2017)
  14. 門出健次、谷口透
    VCD励起子キラリティー法
    分光研究,65, 137-144 (2016)
  15. 村井勇太
    光でターゲット分子を捕まえるトリフルオロメチルフェニルジアジリン
    (生体機序の解明に役立つ光反応性芳香族アミノ酸の簡易的合成)
    化学と生物,54, 243-245 (2016)
  16. 谷口透
    鏡の国の核酸医薬? D-microRNA を標的とするL-RNA アプタマー
    化学,71(8), 59-60 (2016)
  17. Min Yao
    (Chapter16) Structure Determination Software for Macromolecular X-Ray Crystallography
    『Advanced Methods in Structural Biolog』,
    Springer, 293-314 (2016)
  18. 田中良和
    第2章 タンパク質のドメイン
    『Essentialタンパク質科学』,南江堂,59-94 (2016)
  19. 松野明日香,田中良和
    超巨大タンパク質会合体ヘモシアニンのX線結晶構造解析
    日本結晶学会誌,58(2), 91-95 (2016)
  20. 田中良和
    D5対称
    日本結晶学会誌, 58(2), 107 (2016)
国際学会(招待講演)
  1. August 2021
    Asian Symposium on Medicinal Plants and Spices XVII (2021)Contextualizing Natural Product Science for Societal Relevance, (online),
    Discovering sphingomyelin synthase (SMS) inhibitors from natural plants toward development of lipid chemical biology ,
    Monde K.
  2. November 2020
    Molecular Chirality Asia 2020, (WEB)
    Chirality of Sphingolipids - How to Detect its Small Chirality and How Affects its Biological Activity –
    Monde K.
  3. November 2020
    Trends in Chemical Science: Challenges and Opportunities (IWTCSCO-2020)
    Department of Chemistry, St. Philomena's College (Autonomous), Mysuru , India (WEB)
    Natural and Synthetic inhibitors of Lipid related Enzyme, Targeting Metabolic Syndrome, Cancer and Alzheimer’s disease
    Monde K.
  4. 2020年10月
    オンライン開催
    Establishing International Research Network of Mathematical Oncology
    A computational method to detect key factors associated with critical transition of gene expression profile
    中岡 慎治
  5. 2020年12月
    オンライン開催
    THE 21st RIES-HOKUDAI INTERNATIONAL SYMPOSIUM
    A computational method to detect key factors associated with critical transition of health condition
    中岡 慎治
  6. January 2019
    Yangon, Myanmar
    Asian Chemical Biology Initiative (ACBI) 2019 Yangon Meeting
    Study on the efficient synthesis of acylceramides including ω-9 unsaturated ultra-long-chain fatty acids towards skin barrier care
    Monde K.
  7. July 2019
    A3 symposium (Sendai, Japan)
    Application of energy landscape analysis for cellular differentiation process
    Nakaoka S.
  8. October 2019
    Hunter Collage Seminor
    New York, NY
    Sphingosine Chemical Biology
    Monde K.
  9. November 2019
    The Fourth A3 Roundtable Meeting
    on Asia Chemical Probe Research Hub
    Sendai, Japan,
    Naturally Occurring Sphingomyelin Synthase Inhibitors against
    Diet-Induced Obesity and their Action Mechanism
    Monde K.
  10. December 2019
    Adichunchanagiri Univerisy, Nagara, India
    Symposium “Recent Trends in Medicinal Chemistry”
    Sphingolipid Chemical Biology toward Drug Discovery from Nature
    Monde K.
  11. December 2019
    2nd Chemical Biology Workshop (ChemBiol Workshop)
    Nampo Hound Premier Hotel, Busan, Korea
    Naturally Occurring Sphingomyelin Synthase Inhibitors against
    Diet-Induced Obesity and their Action Mechanism
    Monde K.
  12. July 2018
    Harbin, China
    4th Molecular Chirality Asia (MCAsia 2018)
    Axial Chirality of Twisted Carbodiimide
    Monde K.
  13. December 2018
    Singapore, Singapore
    10th Singapore International Chemistry Conference
    VCD Studies on Three-Dimensional Structures of Flexible Molecules in Solution State
    Taniguchi T.
  14. November 2018
    Jeju Island, Korea
    A3 Roundtable Meeting on Asia Chemical Probe Research
    Discovering sphingomyelin synthase (SMS) inhibitors from natural resources and synthetic and semi synthetic library
    Monde K.
  15. January 2017
    Ho Chi Minh, Vietnam
    Asian Chemical Biology Initiative (ACBI) 2017 Hochi Minh Meeting
    What can we do using Circularly Polarized Light ?
    Monde K.
  16. March 2017
    Damai Laut, Perak, Malaysia.
    The International Conference on Natural Products 2017 (ICNP2017)
    Non-empirical Determination of Absolute Configurations for Natural Products by Vibrational Circular Dichroism
    Monde K.
  17. June 2017
    Gif-sur-Yvette, France
    Organic Seminar at Departement SNCM (Substances Naturelles et Chimie Médicinale)
    ICSN-CNRS, LabEx LERMIT
    Non-empirical Determination of Absolute Configurations for Natural Products by Vibrational Circular Dichroism
    Monde K.
  18. July 2017
    Tokyo, Japan
    Chirality 2017
    Difference effect between left and right CPL toward Arabidopsis thaliana
    Monde K.
  19. August 2017
    Changchun, China
    第15回中国生化学と薬理学学会年会
    Nucleotide elongation in the reverse (3’‒5’) direction by TLP (Thg1-Like Protein)
    Yao M.
  20. August 2017
    Luoyang, China
    第15回中国河南省薬理学学会年会
    Building a biosynthesis pathway of non-natural adrenergic drug
    Yao M.
  21. November 2017
    GuangZhou, China
    International Nonthermal Food Processing Symposium
    Studies on the synthesis mechanism of bacterial cellulose
    Yao M.
  22. May 2016
    Beijing, China
    Peking University & Hokkaido University Joint Seminar on Organic Chemistry and Chemical Biology
    Vibrational Circular Dichroism (VCD) Exciton Chirality Method: Powerful Tool for Stereochemical Analysis of Small, Medium, and Large Molecules
    Monde K.
  23. June 2016
    Shiga, Japan
    12th International Workshop on Supramolecular Nanoscience of Chemically Programmed Pigments (SNCPP16)
    Efficient supply and synthesis of unique sphingoids contained in natural resources
    Murai Y.
  24. June 2016
    Sapporo, Japan
    2016 Taiwan-Japan Joint Symposium of Crystallography Frontier of Protein Crystallography-Molecular base of transsulfursome for synthesizing Cys-tRNA (Cys) by indirect pathway
    Yao M.
  25. July 2016
    Kuala Lumpur, Malaysia
    FSG Colloquium Universiti Teknologi MARA (UiTM)
    Chiral Chemical Biology utilizing Vibrational Circular Dichroism (VCD) and Sphingosine Chemical Biology
    Monde K.
  26. September 2016
    Ulanbator, Mongolia
    Special Seminar, National University of Mongolia
    Introduction to Chirality and Chemical Biology
    Monde K.
  27. September 2016
    Fukuoka, Japan
    The First A3Roundtable Meeting on Chemical Probe Research Hub
    Chirality via Vibrational Circular Dichroism (VCD) and Sphingosine Chemical Biology
    Monde K.
  28. November 2016
    Honolulu, Hawaii, USA
    8th US-Japan Symposium 21st Century Innovations in Natural Products
    Determination of Absolute Configuration by Vibrational Circular Dichroism With/Without DFT Calculation
    Monde K.
国際学会(口頭発表)
  1. December 2021
    オンライン開催
    PACIFICHEM2021
    Chemical Communications through Natural and Synthetic Bioactive Compounds (#79)
    Oral administration of natural sphingomyelin synthase inhibitor against high fat diet-induced obesity and its lipid metabolism in mice
    Monde K.
  2. December 2021
    オンライン開催
    PACIFICHEM2021
    Drug-Discovery Based on Natural Products Chemistry (#361)
    Structure-inspired design of a sphingolipid mimic sphingosine-1-phosphate receptor agonist from a naturally occurring sphingomyelin synthase inhibitor
    Monde K.
  3. October 2019
    4th Workshop on Virus Dynamics (Paris, France)
    A computational method to detect key factors associated with critical transition of gene expression profile in viral infection
    Nakaoka S.
  4. December 2019
    National Univ. of Singapore (シンガポール)
    アジア結晶学会
    Dynamic structure is requited for transslufursome on the Cys-tRNA(Cys) synthesis in indirect pathway
    Yao M.
  5. December 2019
    The 2019 International Symposium on Nonlinear Theory and Its Applications (Kuala Lumpur, Malaysia)
    Investigation of possible coherent metabolic modes in auxotrophic bacterial community
    Nakaoka S.
  6. June 2017
    Rennes, France
    the 16th International Conference on Chiroptical Spectroscopy
    Can plant recognize left and right circular polarization light?
    Monde K.
  7. September 2017
    Ulaanbaatar, Mongolia
    Asian Chemical Biology Initiative (ACBI) 2017 Ulaanbaatar Meeting
    Naturally occurring sphingomyelin synthase inhibitor inspiring sphingo-mimic
    Monde K.
  8. September 2017
    Tokyo, Japan
    the 2nd Asian Conference on Oleo Science (ACOS 2017)
    Chiral Analysis of Lipids by Vibrational Circular Dichroism
    Monde K.
  9. November 2017
    Hangzhou, China
    A3 Roundtable Meeting on Asia Chemical Probe Research
    Naturally occurring sphingomyelin synthase inhibitor inspiring sphingo-mimic
    Monde K.
国内招待講演
  1. 2022年3月
    オンライン開催
    第26回HiSOR研究会
    ~生体分子の構造機能研究におけるキラル分光の新しい可能性~
    特性吸収に着目した赤外円二色性スペクトルによる機能性分子の立体化学研究
    門出 健次
  2. 2021年3月
    オンライン開催
    特別シンポジウム~渡邉信久先生を偲んで~
    北海道大学でX線発生装置を使ったS-SAD法に取り組んでいた頃
    姚 閔、北郷 悠、田中 勲
  3. 2021年3月
    オンライン開催
    日本化学会 第101春季年会 (2021) 特別企画
    ⾃然から学ぶ最先端生命化学 -中西香爾先生が生命化学に遺したもの -
    生命分子の立体構造―エキサイトンキラリティー
    門出 健次
  4. 2021年7月
    オンライン開催
    「化学コミュニケーションのフロンティア」第8回公開シンポジウム
    食品由来マラバリコーンCの多様な生理活性とその機構解明
    門出 健次
  5. 2020年12月
    オンライン開催
    量子生命科学会 第2回大会 ~量子による生命フロンティアへの挑戦~
    生体分子中のアンモニアを可視化する試み
    横溝 太一,李 龍,姚 閔, 尾瀬 農之
  6. 2019年3月
    東広島市
    第23回HiSOR研究会
    ~分子キラリティの計測・理論技術の革新から迫る 生命機能研究の新展開~
    赤外円二色性スペクトルによる生命分子のキラリティ解明
    門出 健次
  7. 2019年6月
    仙台国際センター、仙台市
    第30回万有仙台シンポジウム 主催:MSD生命科学財団
    赤外円二色性スペクトルによる生命分子のキラリティ解明
    門出 健次
  8. 2019年8月
    富山市
    第36回和漢医薬学会学術大会
    エネルギー地形を利用した腸内細菌叢データの数理解析
    中岡 慎治
  9. 2019年9月
    北海道大学ライフサイエンスフォーラム2019
    ―新たなるフロンティアへの序章―
    北海道大学、理学部大講堂、札幌市
    高分子学科設立60周年を迎えて
    ―北大・理学部・高分子学科のこれまでの歩みと現状―
    門出 健次
  10. 2019年12月
    札幌市
    2019年度北大道新アカデミー理系講座
    細胞中の分子が相手を見分ける方法
    尾瀬 農之
  11. 2019年12月
    福岡市
    分子生物学会
    疑似細胞分化過程からデータ駆動型数理モデルを導出する試み
    中岡 慎治
  12. 2018年3月
    静岡市
    静岡県立大学薬学院講演会
    円二色性(CD)と赤外円二色性(VCD)によるキラル分子の構造解明~基礎と実践例~
    谷口 透
  13. 2018年3月
    千葉市
    第98回日本化学会春季年会 中西シンポジウム
    アジド基・シアノ基の特異なVCDスペクトル特性の研究~キラル分子の新規構造解析法の開発に向けて
    谷口 透
  14. 2018年3月
    水戸市
    2017年度量子ビームサイエンスフェスタ
    狂犬病ウイルスP蛋白質変異体の結晶および機能解析
    尾瀬 農之
  15. 2018年10月
    熱海市
    第1回水和ナノ構造研究会
    アンモニア輸送機構を理解するためのGatCAB中性子構造解析の現状
    姚 閔
  16. 2018年9月
    東京都
    平成30年度第1回構造生物学研究会
    中性子回折によるアミド基転移酵素GatCABのアンモニア輸送機構解明の試み
    姚 閔
  17. 2018年5月
    千葉市
    シンポジウム モレキュラー・キラリティー2018
    モレキュラー・キラリティーアワード受賞講演
    赤外円二色性(VCD)法による絶対配置決定法の開発
    門出 健次
  18. 2017年5月
    東京都
    北海道大学次世代物質生命科学研究センター
    「脂質機能性解明研究部門」設置記念シンポジウム
    ケミカルバイオロジーによるSMS阻害剤の開発
    門出 健次
  19. 2017年7月
    つくば市
    VCD and ROA Application/Study Meeting 2017
    VCD測定の実際と、北大オープンファシリティの紹介
    谷口 透
  20. 2017年11月
    東京都
    シンポジウム「キラル振動分光法の基礎と最新技術」
    赤外円二色性(VCD)による生体分子の立体構造解析
    門出 健次
  21. 2017年11月
    高知市
    超分子化学特論特別セミナー
    キラル分光法で合成分子・生理活性分子の立体配置と溶液中立体配座を観る
    谷口 透
  22. 2017年12月
    つくば市
    第4回タンパク質X線溶液散乱講習会
    SAXS解析によるtranssulfursomeのダイナミクス研究の事例
    姚 閔
  23. 2017年12月
    野田市
    バイオインフォマティクス教育部門主催教育セミナー
    Viral and host factor relationships which determine host tropism; viral protein and host protein interactions on cell surface and inner cell
    尾瀬 農之
  24. 2016年5月
    東京都
    第4回慶応有機化学若手シンポジウム
    立体構造解析から拓く天然物化学
    谷口 透

生命機能科学研究部門

産学連携ユニット

原著論文
  1. Kamioka M, Goto Y, Nakamura K, Yokoi Y, Sugimoto R, Ohira S, Kurashima Y, Umemoto S, Sato S, Kunisawa J, Takahashi Y, Domino SE, Renauld JC, Nakae S, Iwakura Y, Ernst PB, Ayabe T, Kiyono H.
    Intestinal commensal microbiota and cytokines regulate Fut2+ Paneth cells for gut defense
    Proc Natl Acad Sci U.S.A. 119, e2115230119 (2022)
    DOI: 10.1073/pnas.2115230119
  2. Baba H, Watanabe Y, Miura K, Okada K, Kondo M, Ozaki K, Hasebe A, Ayabe T, Nakamura K, Aizawa T, Nakaoka S, Ogasawara K, Suzuki T, Saito H, Kimura T, Tamakoshi A, Yamazaki Y.
    Oral frailty and carriage of oral Candida in community-dwelling older adults (Checkup to discover Health with Energy for senior Residents in Iwamizawa; CHEER Iwamizawa)
    Gerodontology, 39(1)49-58 (2022)
    DOI: 10.1111/ger.12621
  3. Yokoi Y, Adachi T, Sugimoto R, Kikuchi M, Ayabe T, Nakamura K
    Simultaneous real-time analysis of Paneth cell and intestinal stem cell response to interferon-γ by a novel stem cell niche tracking method
    Biochem Biophys Res Commun 545, 14-19 (2021)
    DOI: 10.1016/j.bbrc.2021.01.050
  4. Kotake K, Kumazawa T, Nakamura K, Shimuzu Y, Ayabe T, Adachi T.
    Ingestion of miso regulates immunological robustness in mice
    PLOS ONE 17, e0261680 (2021)
    DOI: 10.1371/journal.pone.0261680
  5. Sato Y, Wang Y, Song Y, Geng W, Yan S, Nakamura K, Kikukawa T, Demura M, Ayabe T, Aizawa T.
    Potent bactericidal activity of reduced cryptdin-4 derived from its hydrophobicity and mediated by bacterial membrane disruption
    Amino Acids, 54(2)289-297(2021)
    DOI: 10.1007/s00726-021-03115-3
  6. Shimizu Y, Nakamura K, Kikuchi M, Ukawa S, Nakamura K, Okada E, Imae A, Nakagawa T, Yamamura R, Tamakoshi A, Ayabe T.
    Lower human defensin 5 in elderly people compared to middle-aged is associated with differences in the intestinal microbiota composition: the DOSANCO Health Study
    GeroScience, Jun 8 (2021)
    DOI: 10.1007/s11357-021-00398-y
  7. Suzuki K, Nakamura K, Shimizu Y, Yokoi Y, Hagiwara M, Ohira S, Wang Y, Song Y, Aizawa T, Ayabe T.
    Decrease of alpha-defensin impairs intestinal metabolite homeostasis via dysbiosis in mouse chronic social defeat stress model
    Sci Rep 11, 9915 (2021)
    DOI: 10.1038/s41598-021-89308-y
  8. Yamamura R, Nakamura K, Kitada N, Aizawa T, Shimizu Y, Nakamura K, Ayabe T, Kimura T, Tamakoshi A.
    Associations of gut microbiota, dietary intake, and serum short-chain fatty acids with fecal short-chain fatty acids
    Biosci Microbiota Food Health 39, 11-17 (2020)
    DOI: 10.12938/bmfh.19-010
  9. Nakamura K, Yokoi Y, Fukaya R, Ohira S, Shinozaki R, Nishida T, Kikuchi M, Ayabe T
    Expression and localization of Paneth cells and their alpha-defensins in the small intestine of adult mouse
    Front Immunol 11, 570296 (2020)
    DOI: 10.3389/fimmu.2020.570296
  10. Hanyu H, Yokoi Y, Nakamura K, Ayabe T, Tanaka K, Uno K, Miyajima K, Saito Y, Iwatsuki K, Shimizu M, Tadaishi M, Kobayashi-Hattori K
    Mycotoxin deoxynivalenol has different impacts on intestinal barrier and stem cells by its route of exposure
    Toxins 12, 610 (2020)
    DOI: 10.3390/toxins12100610
  11. Shimizu Y, Nakamura K, Yoshii A, Yokoi Y, Kikuchi M, Shinozaki R, Nakamura S, Ohira S, Sugimoto R, Ayabe T
    Paneth cell alpha-defensin misfolding correlates with dysbiosis and ileitis in Crohn’s disease model mice
    Life Science Alliance 3, 6:e201900592 (2020)
    DOI: 10.26508/lsa.201900592
  12. Komatsu Y, Shimizu Y, Yamano M, Kikuchi M, Nakamura K, Ayabe T, Aizawa T
    Disease progression-associated alterations in fecal metabololies in SAMP1/YitFc mice, a Crohn’s disease model
    Metabolomics 16, 4:48 (2020)
    DOI: 10.1007/s11306-020-01671-5
  13. Hirabayashi Y, Nakamura K, Sonehara T, Suzuki D, Hanzawa S, Shimizu Y, Aizawa T, Nakamura K, Tamakoshi A, Ayabe T
    Analysis of serotonin in human feces using solid phase extraction and column-switching LC-MS/MS
    Mass Spectrometry 9, 1:A0081 (2020)
    DOI: 10.5702/massspectrometry.A0081
  14. Murabe K., Tsukamoto T., Aizawa T., Demura M., Kikukawa T.
    Direct Detection of the Substrate Uptake and Release Reactions of the Light-Driven Sodium-Pump Rhodopsin.
    J Am Chem Soc., 142, 16023-16030 (2020)
    DOI: 10.1021/jacs.0c07264
  15. Yokoi Y., Nakamura K., Yoneda T., Kikuchi M., Sugimoto R., Shimizu Y., Ayabe T.
    Paneth cell granule dynamics on secretory responses to bacterial stimuli in enteroids
    Sci Rep., 9:2710 (2019)
    DOI: 10.1038/s41598-019-39610-7
  16. Pillai MR, Mihi B., Ishiwata K., Nakamura K., Sakuragi N., Finkelstein DB, McGargill MA, Nakayama T., Ayabe T., Coleman ML, Bix M.
    Myc-induced nuclear antigen constrains a latent intestinal epithelial cell-intrinsic anthelmintic pathway
    PLOS ONE , 14(2): e0211244 (2019)
    DOI: 10.1371/journal.pone.0211244
  17. Takakuwa A, Nakamura K, Kikuchi M, Sugimoto R, Ohira S, Yokoi Y, Ayabe T
    Butyric acid and leucine induce a-defensin secretion from small intestinal Paneth cells
    Nutrients 11, 2817 (2019)
    DOI: 10.3390/nu11112817
  18. Shimizu Y, Sakuragi N, Nakamura K, Taira T, Ayabe T, Fukui A
    A simple culture method for liver and intestinal tissue-resident macrophages from neonatal mice
    In Vitro Cell Dev Biol – Animal 55, 436-444 (2019)
    DOI: 10.1007/s11626-019-00359-y
  19. Yokoi Y, Nakamura K, Yoneda T, Kikuchi M, Sugimoto R, Shimizu Y, Ayabe T
    Paneth cell granule dynamics on secretory responses to bacterial stimuli in enteroids
    Sci Rep 9, 2710 (2019)
    DOI: 10.1038/s41598-019-39610-7
  20. Pillai MR, Mihi B, Ishiwata K, Nakamura K, Sakuragi N, Finkelstein DB, McGargill MA, Nakayama T, Ayabe T, Coleman ML, Bix M
    Myc-induced nuclear antigen constrains a latent intestinal epithelial cell-intrinsic anthelmintic pathway
    PLOS ONE 14, e0211244 (2019)
    DOI: 10.1371/journal.pone.0211244
  21. Eriguchi Y., Nakamura K., Yokoi Y., Takahashi S., Hashimoto D., Teshima T., Ayabe T., Selsted ME, Ouellette AJ.
    Essential role of interferon-gamma in T cell-associated intestinal inflammation
    JCI Insight, 3(18): e121886 (2018)
    DOI: 10.1172/jci.insight.121886
  22. Yaguchi K., Yamamoto T., Shimada M., Sugimoto R., Nakamura K., Ayabe T., Uehara R.
    Ploidy-dependent change in cyclin D2 expression and sensitization to cdk4/6 inhibition in human somatic haploid cells
    Biochem Biophys Res Commun. 26;504(1):231-237 (2018)
    DOI: org/10.1016/j.bbrc.2018.08.160
  23. Cobo ER, Holani R., Moreau F., Nakamura K., Ayabe T., Mastroiannid JR, Ouellette AJ, Chadee K.
    Entamoeba histolytica alters ileal Paneth cell functions in intact and Muc2 mucin deficiency
    Infect Immun, 86(7) e00208-18 (2018)
    DOI: 10.1128/IAI.00208-18
  24. Hayase E., Hashimoto D., Nakamura K., Noizat C., Ogasawara R., Takahashi S., Ohigashi H., Yokoi Y., Sugimoto R., Matsuoka S., Ara T., Yokoyama E., Yamakawa T., Ebata K., Kondo T., Hiramine R., Aizawa T., Ogura Y., Hayashi T., Mori H., Kurokawa K., Tomizuka K., Ayabe T., Teshima T.
    R-Spondin1 expands Paneth cells and prevents dysbiosis induced by graft-versus-host disease.
    J. Exp. Med., 214, 3507-3518 (2017)
    DOI: 10.1084/jem.20170418
  25. Nakamura K., Sakuragi N., Takakuwa A., Ayabe T.
    Paneth cell α-defensins and enteric microbiota in health and disease.
    Biosci Microbiota Food Health 35: 57-67 (2016)
    DOI: 10.12938/bmfh.2015-019
  26. Nohara S., Kato K., Fujiwara D., Sakuragi N., Yanagihara K., Iwanuma Y., Kajiyama Y.
    Aminopeptidase N (APN/CD13) as a target molecule for scirrhous gastric cancer.
    Clin Res Hepatol Gastroenterol 40: 494-503 (2016)
    DOI: 10.1016/j.clinre.2015.11.003
著書・総説・解説など
  1. 綾部時芳
    パネート細胞
    腸内細菌学会用語集.(2022) 公益財団法人腸内細菌学会
  2. 綾部 時芳
    健康でいるための「腸活」
    医療と健康の今を伝える健康さっぽろ 45, 4-5 (2021)
  3. 綾部時芳
    消化管の内分泌系
    食品免疫学事典.日本食品免疫学会編. 2章 消化管の機能と健康.64-65 (2021) 朝倉書店
  4. 綾部時芳
    バクテリオシン
    食品免疫学事典.日本食品免疫学会編. 5章 腸内細菌と免疫.228-229 (2021) 朝倉書店
  5. 中村公則
    抗菌ペプチド/ディフェンシン
    食品免疫学事典.日本食品免疫学会編. 2章 消化管の機能と健康.70-71 (2021) 朝倉書店
  6. 中村 公則
    パネート細胞
    消化器病サイエンス, Vol.3, no.1, pp43 (2019)
  7. 綾部 時芳、中村 公則
    自然免疫と共生を紐解く小腸オルガノイド enteroid
    医学のあゆみ(企画:「腸と健康:腸オルガノイドが挑む次世代バイオモデル」)
    270:1059-1063 (2019)
  8. 中村 公則
    パネート細胞
    消化器病サイエンス.3:43 (2019)
  9. 中村 公則、菊池 摩仁、綾部 時芳
    抗菌ペプチドαディフェンシンによる腸内細菌叢の制御
    腸内細菌学会誌 33: 129-135 (2019)
  10. 綾部 時芳
    腸内環境のパラダイムシフトから健康と疾病を理解する
    腸内細菌学会誌, 32, 145-148 (2018)
  11. 綾部時芳、中村公則
    抗菌ペプチドによる自然免疫
    実験医学 増刊(生体バリア),35, 1078-1083 (2017)
  12. 綾部時芳
    自然免疫から迫る健康と病気―食品機能性と腸管―
    FOOD STYLE, 21, 41-43 (2017)
  13. 綾部時芳
    Paneth細胞が担う腸内細菌との共生と疾患
    日本潰瘍学会誌, 44, 33-37 (2017)
  14. 櫻木直也、綾部時芳
    自然免疫による腸内細菌叢の制御と共生 疾病との接点
    診断と治療 Vol.104, No.2, 227-232 (2016)
国際学会(招待講演)
  1. May 2019
    Los Angeles, USA
    Hokudai-USC Research Workshop “Gut-Organ Crosstalk”
    Paneth cell in health and disease – an overview from intestinal homeostasis and inter organ network
    Ayabe T
  2. May 2019
    Los Angeles, USA
    Hokudai-USC Research Workshop “Gut-Organ Crosstalk”
    Dynamics and mechanisms of Paneth cell granule secretory responses in enteroids
    Yokoi Y, Nakamura K, Sugimoto R, Ohira S, Kikuchi M, Ayabe T
  3. May 2019
    Los Angeles, USA
    Hokudai-USC Research Workshop “Gut-Organ Crosstalk”
    Paneth cell α-defensin misfolding leads to dysbiosis and subsequent ileitis in a murine model of Crohn's disease
    Shimizu Y, Nakamura K, Kikuchi M, Shinozaki R, Ayabe T
国際学会(口頭発表)
  1. June 2021
    オンライン開催
    World Microbe Forum. Host-Microbe Biology
    Dynamics of Paneth cell granule secretory responses to bacteria in innate enteric immunity
    Yokoi Y.    
  2. American Society for Cell Biology Annual Meeting 2019
    Acetylcholine-induced Paneth cell granule secretion via muscarinic M3 receptor in mouse small intestine
    Yokoi Y, Nakamura K, Sugimoto R, Ohira S, Kikuchi M, Ayabe T
  3. American Society for Cell Biology Annual Meeting 2019
    Paneth cell dysfunction in pathophysiology of nonalcoholic steatohepatitis
    Nakamura S, Nakamura K, Kikuchi M, Yokoi Y, Ohira S, Shimizu Y, Nishida T, Ayabe T
国内招待講演
  1. 2022年2月
    日本食品・機械研究会 特別講演
    抗菌ペプチドαディフェンシンによる腸内細菌制御と健康
    綾部 時芳、横井 友樹、清水 由宇、中村 公則
  2. 2021年7月
    第58回日本消化器免疫学会 若手入門編セミナー
    抗菌ペプチドから粘膜免疫を理解する
    綾部 時芳、横井 友樹、中村 公則
  3. 2021年8月
    オンライン開催
    第24回日本臨床腸内微生物学会学術集会 シンポジウム「免疫と細菌叢」
    Paneth細胞αディフェンシンが担う腸内細菌叢の形成からみた生体恒常性の維持機構
    中村 公則
  4. 2021年11月
    オンライン開催
    東洋大学 ライフイノベーション研究所2021年シンポジウム「免疫と健康維持・増進」
    Paneth細胞αディフェンシンによる腸内細菌形成からみた健康と病気
    中村 公則
  5. 2020年2月
    札幌市
    第20回COI参画機関会議
    健康ものさし αディフェンシン ―母子の腸内環境が拓く健康
    綾部 時芳、中村 公則
  6. 2020年2月
    札幌市
    Society 5.0北海道の地方創生と未来
    母子の健康・腸内の環境
    綾部 時芳
  7. 2020年2月
    旭川市
    第6回旭川IBD研究会
    腸内環境と炎症性腸疾患・非感染性疾患 ―どこまでわかったか
    綾部 時芳
  8. 2020年2月
    札幌市
    第45回札幌市医師会医学会特別講演(市民公開講座)
    腸内細菌はなぜ大切か? 自然免疫と腸内細菌から病気を紐解く
    綾部 時芳
  9. 2020年6月
    札幌市
    第24回腸内細菌学会学術集会 シンポジウムI
    Paneth細胞が担う腸内細菌叢の形成からみた疾患リスク上昇メカニズムの理解
    中村 公則
  10. 2020年7月
    京都市
    第57回日本消化器免疫学会 教育講演
    Paneth細胞が担う腸内細菌との共生と生体恒常性
    綾部 時芳
  11. 2020年9月
    札幌市
    第127回日本消化器病学会北海道支部例会スペシャルシンポジウム 基調講演
    Alpha-defensin異常による腸内細菌叢の破綻とIBD
    綾部時芳、清水由宇、中村公則
  12. 2019年2月
    札幌市
    セルフヘルスケア×ビッグデータで創造する地方創生
    腸からみた人の健康
    綾部 時芳
  13. 2019年3月
    京都市
    第4回京滋腸内細菌研究会
    Alpha-defensinによる腸内細菌叢の制御 ―共生と排除が疾病の鍵を握る
    綾部 時芳
  14. 2019年10月
    岩見沢市
    岩見沢市幌向地域ふれあい健康講座(北大COI拠点健康講座)
    腸から健康になる話-腸内環境を整えて元気でいよう!
    綾部 時芳
  15. 2018年1月
    東京都
    電子情報技術産業協会ヒューマンケア技術分科会 講演会
    腸内環境が拓く健康と疾病のパラダイムシフト
    綾部 時芳
  16. 2018年2月
    東京都
    北大リサーチ&ビジネスパークセミナー 北海道発!「食」から「健康」へ
    エンテロイドを用いた新規・食品機能性成分評価法の構築
    中村 公則
  17. 2018年3月
    名古屋市
    日本農芸化学会年会2018大会 シンポジウム
    Enteroidを用いたPaneth細胞が制御する腸内環境の機能解明
    中村 公則
  18. 2018年7月
    札幌市
    北海道消化管疾患研究会
    Alpha-defensinが担う腸内細菌の制御と疾病
    綾部 時芳
  19. 2018年11月
    札幌市
    川沿消化器病フォーラム
    腸内細菌はなぜ注目されるのか? ―腸における排除と共生が疾患の鍵を握る
    綾部 時芳
  20. 2017年1月
    東京都
    東京農業大学 先端研究プロジェクト最終年度報告会.特別講演
    Enteroidを用いたPaneth細胞の機能解明
    綾部 時芳
  21. 2017年4月
    旭川市
    第35回日本耳鼻咽喉科免疫アレルギー学会 教育講演
    腸内細菌を制御する抗菌ペプチドα-defensinと疾病
    綾部 時芳
  22. 2017年5月
    福岡市
    COIシンポジウムwith九州大学
    腸が創る未来のあなた
    綾部 時芳
  23. 2017年7月
    札幌市
    日本薬局協励会北海道合同支部『学術繋栄講座』
    腸内環境を制御する抗菌ペプチドα-defensinと疾患
    中村 公則
  24. 2017年9月
    札幌市
    第121回日本消化器病学会北海道支部例会 特別講演
    炎症性腸疾患とPaneth細胞:腸内細菌を制御する生体メカニズムの研究から
    綾部 時芳
  25. 2017年9月
    東京都
    第69回日本生物工学会大会 シンポジウム
    αディフェンシン:自然免疫、腸内細菌との共生、疾病への関与
    綾部 時芳
  26. 2017年9月
    札幌市
    HICネットワーク第2回勉強会
    腸の様々なはたらきについて―腸からみた健康と疾病―
    綾部 時芳
  27. 2017年10月
    岩見沢市
    岩見沢市健康と福祉を高めるセミナー
    腸はからだの司令塔:なぜ病気になるのか?
    綾部 時芳
  28. 2017年11月
    東京都
    COI東京シンポジウム
    母子の健康を育む腸内環境
    綾部 時芳
  29. 2016年5月
    岩見沢市
    岩見沢市保健推進会総会研修会
    “うんち”が語るあなたの過去・現在・未来
    綾部 時芳
  30. 2016年9月
    旭川市
    第44回日本潰瘍学会.特別講演
    Paneth細胞が担う腸内細菌との共生と疾患
    綾部 時芳
  31. 2016年9月
    岩見沢市
    第8回 岩見沢ヤクルト健康セミナー
    腸はからだの司令塔! 健康でいるために知っておきたい腸内環境
    綾部 時芳
  32. 2016年9月
    つくば市
    消化系モデル研究の最前線~食による先制医療の効果を探る~.
    COI「食と健康の達人」拠点 筑波大学サテライト講演会
    腸内細菌を制御する自然免疫αディフェンシンからみた健康と疾病
    綾部 時芳
  33. 2016年9月
    岩見沢市
    平成28年度「町連女性の集い」 特別講演
    腸から健康になろう
    綾部 時芳

国際連携ユニット

原著論文
  1. Potent bactericidal activity of reduced cryptdin-4 derived from its hydrophobicity and mediated by bacterial membrane disruption.
    Sato Y., Wang Y., Song Y., Geng W., Yan S., Nakamura K., Kikukawa T., Demura M., Ayabe T., Aizawa T.
    Amino Acids, 54, 289-297 (2022)
    DOI: 10.1007/s00726-021-03115-3
  2. Nakamizo Y., Fujisawa T., Kikukawa T., Okamura A., Baba H., Unno M.
    Low-temperature Raman spectroscopy of sodium-pump rhodopsin from Indibacter alkaliphilus: Insight of Na+ binding for active Na+ transport
    Phys. Chem. Chem. Phys., 23, 2072-2079 (2021)
    DOI: 10.1039/d0cp05652a
  3. Kikuchi C., Kurane H., Watanabe T., Demura M., Kikukawa T., Tsukamoto T.
    Preference of Proteomonas sulcata anion channelrhodopsin for NO3− revealed using a pH electrode method
    Scientific Reports, 11, 7908 (2021)
    DOI: 10.1038/s41598-021-86812-z
  4. Kato T., Tsukamoto T., Demura M., Kikukawa T.
    Real-Time Identification of Two Substrate-Binding Intermediates for the Light-Driven Sodium Pump Rhodopsin
    Journal of Biological Chemistry, 296, 100792 (2021)
    DOI: 10.1016/j.jbc.2021.100792
  5. Omori A., Fujisawa Y., Sasaki S., Shimono K., Kikukawa T., Miyauchi S.
    Protonation State of a Histidine Residue in Human Oligopeptide Transporter 1 (hPEPT1) Regulates hPEPT1-Mediated Efflux Activity
    Biological and Pharmaceutical Bulletin, 44, 678-685 (2021)
    DOI: 10.1248/bpb.b20-01013
  6. Hashimoto M., Murai Y., Morita K., Kikukawa T., Takagi T., Takahashi H., Yokoyama Y., Amii H., Sonoyama M.
    Comparison of functionality and structural stability of bacteriorhodopsin reconstituted in partially fluorinated dimyristoylphosphatidylcholine liposomes with different perfluoroalkyl chain lengths
    Biochimica et Biophysica Acta (BBA) - Biomembranes, 1863, 183686 (2021)
    DOI: 10.1016/j.bbamem.2021.183686
  7. Kikuchi M., Kojima K., Nakao S., Yoshizawa S., Kawanishi S., Shibukawa A., Kikukawa T., Sudo Y.
    Functional expression of the eukaryotic proton pump rhodopsin OmR2 in Escherichia coli and its photochemical characterization
    Scientific Reports, 11, 14765 (2021)
    DOI: 10.1038/s41598-021-94181-w
  8. Sasaki S., Tamogami J., Nishiya K., Demura M., Kikukawa T.
    Replaceability of Schiff base proton donors in light-driven proton pump rhodopsins
    Journal of Biological Chemistry, 297, 101013 (2021)
    DOI: 10.1016/j.jbc.2021.101013
  9. Karasawa M., Yokoyama Y., Takiguchi K., Takahashi H., Kikukawa T., Sonoyama M., Takenaka K.
    Pore Size Distributions Related with Spontaneous Purple Membrane Stacking in Porous Hydrogels
    Journal of the Physical Society of Japan, 90,103801 (2021)
    DOI: 10.7566/JPSJ.90.103801
  10. Fujimoto A., Lyu Y., Kinjo M., Kitamura A.
    Interaction between Spike Protein of SARS-CoV-2 and Human Virus Receptor ACE2 Using Two-Color Fluorescence Cross-Correlation Spectroscopy
    Appl. Sci. 11(22), 10697 (2021)
    DOI: 10.3390/app112210697
  11. Yamamoto A., Tsukamoto T., Suzuki K., Hashimoto E., Kobashigawa Y., Shibasaki K., Uchida T., Inagaki F., Demura M., Ishimori K.
    Spectroscopic Characterization of Halorhodopsin Reconstituted into Nanodisks Using Native Lipids.
    Biophys J., 118, 2853-2865 (2020)
    DOI: 10.1016/j.bpj.2020.04.021
  12. Haque S., Kikukawa T., Tamaoki N.
    Photoisomerization of azobenzene units drives the photochemical reaction cycles of proteorhodopsin and bacteriorhodopsin analogues
    Org Biomol Chem., 18, 6312-6327 (2020)
    DOI: 10.1039/d0ob01486a
  13. Matsuo J., Kikukawa T., Fujisawa T., Hoff D. W., Unno M.
    “Watching” a Molecular Twist in a Protein by Raman Optical Activity
    J. Phys. Chem. Lett., 11, 8579–8584 (2020)
    DOI: 10.1021/acs.jpclett.0c02448
  14. Kojima K., Yoshizawa S., Hasegawa M., Nakama M., Kurihara M., Kikukawa T., Sudo Y.
    Lokiarchaeota archaeon schizorhodopsin-2 (LaSzR2) is an inward proton pump displaying a characteristic feature of acid-induced spectral blue-shift
    Sci Rep., 10, 20857 (2020)
    DOI: 10.1038/s41598-020-77936-9
  15. Murabe K., Tsukamoto T., Aizawa T., Demura M., Kikukawa T.
    Direct Detection of the Substrate Uptake and Release Reactions of the Light-Driven Sodium-Pump Rhodopsin.
    J Am Chem Soc., 142, 16023-16030 (2020)
    DOI: 10.1021/jacs.0c07264
  16. Geng X., Dai G., Chao L., Wen D., Kikukawa T., Iwasa T.
    Two Consecutive Polar Amino Acids at the End of Helix E are Important for Fast Turnover of the Archaerhodopsin Photocycle
    Photochemistry and Photobiology, 95(4), 980-989 (2019)
    DOI: 10.1111/php.13072
  17. Horie Y., Nemoto H., Fujita J., Ikegawa S., Kumaki Y., Ohnishi Y., Kumeta H., Demura M., Aizawa T.
    Studies on the Quality Control of Fermented Brown Rice and Rice Bran with Aspergillus oryzae by Metabolome Analysis Using 1H-NMR1H-NMR
    Nippon Shokuhin Kagaku Kogaku Kaishi, 66(4), 139-146, (2019)
    DOI: 10.3136/nskkk.66.139
  18. Yanagi T., Takagi T., Takahashi H., Kikukawa T., Amii H., Sonoyama M.
    Comparison of two different partially fluorinated phosphatidylcholines with the perfluorobutyl group on thermotropic properties of the bilayer membrane and reconstituted bacteriorhodopsin.
    Biophys. Rev., 11(3), 395-398, (2019)
    DOI: 10.1007/s12551-019-00540-3
  19. Yamanashi T., Maki M., Kojima K., Shibukawa A., Tsukamoto T., Chowdhury S., Yamanaka A., Takagi S., Sudo Y.
    Quantification of the neural silencing activity of anion channelrhodopsin in Caenorhabditis elegansand their applicability for long-term illumination
    Sci. Rep., 9(1), 7863, (2019)
    DOI: 10.1038/s41598-019-44308-x
  20. Geng X., Dai G., Chao L., Wen D., Kikukawa T., Iwasa T.
    Two Consecutive Polar Amino Acids at the End of Helix E are Important for Fast Turnover of the Archaerhodopsin Photocycle
    Photochemistry and Photobiology, 95(4), 980-989, (2019)
    DOI: 10.1111/php.13072
  21. Iizuka A., Kajimoto K., Fujisawa T., Tsukamoto T., Aizawa T., Kamo N., Jung K.H., Unno M., Demura M., Kikukawa T.
    Functional importance of the oligomer formation of the cyanobacterial H+ pump Gloeobacter rhodopsin
    Scientific Reports, 9(1), 10711, (2019)
    DOI: 10.1038/s41598-019-47178-5
  22. Fujisawa T., Kiyota H., Kikukawa T., Unno M.
    Low-Temperature Raman Spectroscopy of Halorhodopsin from Natronomonas pharaonis: Structural Discrimination of Blue-Shifted and Red-Shifted Photoproducts
    Biochemistry, 58(40), 4159-4167, (2019)
    DOI: 10.1021/acs.biochem.9b00643
  23. Sato T., Kikukawa T., Miyoshi R., Kajimoto K., Yonekawa C., Fujisawa T., Unno M., Eki T., Hirose Y.
    Protochromic absorption changes in the two-cysteine photocycle of a blue/orange cyanobacteriochrome
    J. Biol. Chem., 294(49), 18909-18922, (2019)
    DOI: 10.1074/jbc.RA119.010384
  24. Inoue S., Yoshizawa S., Nakajima Y., Kojima K., Tsukamoto T., Kikukawa T. and Sudo Y.
    Spectroscopic characteristics of Rubricoccus marinus xenorhodopsin (RmXeR) and a putative model for its inward H+ transport mechanism
    Phys. Chem. Chem. Phys., 20, 3172-3183 (2018)
    DOI: 10.1039/c7cp05033j
  25. Nakajima Y., Tsukamoto T., Kumagai Y., Ogura Y., Hayashi T., Jaeho S., Kikukawa T., Demura M., Kogure K., Sudo Y. and Yoshizawa S.
    Presence of a Haloarchaeal Halorhodopsin-Like Cl-Pump in Marine Bacteria
    Microbes Environ., 33, 89-97 (2018)
    DOI: 10.1264/jsme2.ME17197
  26. Dai G., Geng X., Chaoluomeng, Tamogami J., Kikukawa T., Demura M., Kamo N., Iwasa T.
    Photocycle of Sensory Rhodopsin II from Halobacterium salinarum (HsSRII): Mutation of D103 Accelerates M Decay and Changes the Decay Pathway of a 13-cis O-like Species.
    Photochem. Photobiol., 94(4), 705-714 (2018)
    DOI: 10.1111/php.12917
  27. Tamogami J., Kikukawa T., Ohkawa K., Ohsawa N., Nara T., Demura M., Miyauchi S., Kimura-Someya T., Shirouzu M., Yokoyama S., Shimono K., Kamo N.
    Interhelical interactions between D92 and C218 in the cytoplasmic domain regulate proton uptake upon N-decay in the proton transport of Acetabularia rhodopsin II
    J Photochem Photobio B, 183, 35-45 (2018)
    DOI: 10.1016/j.jphotobiol.2018.04.012
  28. Takayama R., Kaneko A., Okitsu T., Tsunoda S.P., Shimono K., Mizuno M., Kojima K., Tsukamoto T., Kandori H., Mizutani Y., Wada A., Sudo Y.
    Production of a Light-Gated Proton Channel by Replacing the Retinal Chromophore with Its Synthetic Vinylene Derivative
    J. Phys. Chem. Lett., 9, 2857-2862 (2018)
    DOI: 10.1021/acs.jpclett.8b00879
  29. Shionoya T., Mizuno M., Tsukamoto T., Ikeda K., Seki H., Kojima K., Shibata M., Kawamura I., Sudo Y., Mizutani Y.
    High Thermal Stability of Oligomeric Assemblies of Thermophilic Rhodopsin in a Lipid Environment
    J. Phys. Chem. B, 122, 6945-6953 (2018)
    DOI: 10.1021/acs.jpcb.8b04894
  30. Fujisawa T., Abe M., Tamogami J., Kikukawa T., Kamo N., Unno M.
    Low-temperature Raman spectroscopy reveals small chromophore distortion in primary photointermediate of proteorhodopsin
    FEBS Letters, 592, 3054-3061 (2018)
    DOI: 10.1002/1873-3468.13219
  31. Hasemi T., Kikukawa T., Watanabe Y., Aizawa T., Miyauchi S., Kamo N., Demura M.
    Photochemical study of a cyanobacterial chlorideion pumping rhodopsin
    Biochim Biophys Acta Bioenerg., 1860, 136-146 (2018)
    DOI: 10.1016/j.bbabio.2018.12.001
  32. Takahashi H., Yoshino M., Morita K., Takagi T., Yokoyama Y., Kikukawa T., Amii H., Kanamori T., Sonoyama M.
    Stability of the two-dimensional lattice of bacteriorhodopsin reconstituted in partially fluorinated phosphatidylcholine bilayers
    Biochim Biophys Acta Biomembr., 1861, 631-642 (2018)
    DOI: 10.1016/j.bbamem.2018.12.015
  33. Tamogami J., Kikukawa T., Nara T., Demura M., KimuraT.,Someya, Shirouzu M., Yokoyama S., Miyauchi S., Shimono K., Kamo N.
    Existence of two O-like intermediates in the photocycle of Acetabularia rhodopsin II, a lightdriven proton pump from a marine alga.
    Biophysics and Physicobiology, 14, 49-55 (2017)
    DOI: 10.2142/biophysico.14.0_49
  34. Tsukamoto T., Yoshizawa S., Kikukawa T., Demura M., Sudo Y.
    Implications for the Light-Driven Chloride Ion Transport Mechanism of Nonlabens marinus
    Rhodopsin 3 by Its Photochemical Characteristics.
    Journal of Physical Chemistry B, 121, 2017-2038 (2017)
    DOI: 10.1021/acs.jpcb.6b11101
  35. Md. Ruhul Kuddus., Yamano M., Farhana Rumi., Kikukawa T., Demura M. and Aizawa T.
    Enhanced expression of cysteine-rich antimicrobial peptide snakin-1 in Escherichia coli using an aggregation-prone protein coexpression system
    Biotechnol. Prog., 33(6), 1520-1528 (2017)
    DOI: 10.1002/btpr.2508
  36. Kajimoto K., Kikukawa T., Nakashima H., Yamaryo H., Saito Y., Fujisawa T., Demura M. and Unno M.
    Transient Resonance Raman Spectroscopy of a Light-Driven Sodium-Ion-Pump Rhodopsin from Indibacter alkaliphilus
    J. Phys. Chem. B, 121(17), 4431-4437 (2017)
    DOI: 10.1021/acs.jpcb.7b02421
  37. Tamogami J., Kikukawa T., Nara T., Demura M., Kimura-Someya T., Shirouzu M., Yokoyama S., Miyauchi S., Shimono K. and Kamo N.
    Existence of two O-like intermediates in the photocycle of Acetabularia rhodopsin II, a lightdriven proton pump from a marine alga.
    Biophys. Physicobiol., 14, 49-55 (2017)
    DOI: 10.2142/biophysico.14.0_49
  38. Tsukamoto T., Yoshizawa S., Kikukawa T., Demura M. and Sudo Y.
    Implications for the Light-Driven Chloride Ion Transport Mechanism of Nonlabens marinus
    Rhodopsin 3 by Its Photochemical Characteristics.
    J. Phys. Chem. B, 121(9), 2027-2038 (2017)
    DOI: 10.1021/acs.jpcb.6b11101
  39. Honda N., Tsukamoto T. and Sudo Y.
    Comparative evaluation of the stability of seven-transmembrane microbial rhodopsins to various physicochemical stimuli
    Chem. Phys. Lett., 682, 6-14 (2017)
    DOI: 10.1016/j.cplett.2017.05.055
  40. Yokoyama Y., Tanaka H., Yano S., Takahashi H., Kikukawa T.
    Spontaneous stacking of purple membranes during immobilization with physical cross-linked poly (vinyl alcohol) hydrogel with retaining native-like functionality of bacteriorhodopsin
    J. Appl. Phys., 121, 204701 (2017)
    DOI: 10.1063/1.4984070
  41. Amrutha A.S., Kumar K.R.S., Kikukawa T., Tamaoki N.
    Targeted Activation of Molecular Transportation by Visible Light
    ACS Nano, 11(12), 12292-12301 (2017)
    DOI: 10.1021/acsnano.7b06059
  42. Sato O., Komatsu S., Sakai T., Tsukasaki Y., Tanaka R., Mizutani T., Watanabe T.M., Ikebe R., Ikebe M.
    Human myosin VIIa is a very slow processive motor protein on various cellular actin structures
    The Journal of Biological Chemistry, 292(26), 10950-10960 (2017)
    DOI: 10.1074/jbc.M116.765966
  43. Yahata S., Furusawa K., Nagao K., Nakajima M., Fukuda T.
    Effects of three-dimensional culture of mouse calvaria-derived osteoblastic cells in a collagen gel with a multichannel structure on the morphogenesis behaviors of engineered bone tissues
    ACS Biomaterials Science & Engineering, 3, 3414-3424 (2017)
    DOI: 10.1021/acsbiomaterials.7b00190
  44. Nakamura S., Kikukawa T., Tamogami J., Kamiya M., Aizawa T., Martin W Hahn, Ihara K., Kamo N., Demura M.
    Photochemical characterization of actinorhodopsin and its functional existence in the natural host.
    Biochim. Biophys. Acta - Bioenergetics, 1857, 1900-1908 (2016)
    DOI: 10.1016/j.bbabio.2016.09.006
  45. Baek M., Kamiya M., Kushibiki T., Nakazumi T., Tomisawa S., Abe C., Kumaki Y., Kikukawa T.,
    Demura M., Kawano K., Aizawa T.
    Lipopolysaccharide-bound structure of the antimicrobial peptide cecropin P1 determined by nuclear magnetic resonance spectroscopy.
    Journal of Peptide Science, 22, 214-221 (2016)
    DOI: 10.1002/psc.2865
  46. Md. Ruhul Kuddus, Farhana Rumi, Tsutsumi M., Takahashi R., Yamano M., Kamiya M., Kikukawa T., Demura M., Aizawa T.
    Expression, purification and characterization of the recombinant cysteine-rich antimicrobial peptide snakin-1 in Pichia pastoris.
    Protein Expression and Purification, 122, 15-22 (2016)
    DOI: 10.1016/j.pep.2016.02.002
  47. Tamogami J., Sato K., Kurokawa S., Yamada T., Nara T., Demura M., Miyauchi S., Kikukawa T., Muneyuki E., Kamo N.
    Formation of M-Like Intermediates in Proteorhodopsin in Alkali Solutions (pH > 8.5) Where the Proton Release Occurs First in Contrast to the Sequence at Lower pH.
    Biochemistry, 55, 1036-1048 (2016)
    DOI: 10.1021/acs.biochem.5b01196
  48. Tamaki H., Egawa A., Kido K., Kameda T., Kamiya M., Kikukawa T., Aizawa T., Fujiwara T., Demura M.
    Structure determination of uniformly 13C, 15N labeled protein using qualitative distance restraints from MAS solid-state 13C-NMR observed paramagnetic relaxation enhancement.
    Journal of Biomolecular NMR, 64; 87-101 (2016)
    DOI: 10.1007/s10858-015-0010-0
  49. Tsutsumi M., Muto H., Myoba S., Kimoto M., Kitamura A., Kamiya M., Kikukawa T., Takiya S., Demura M., Kawano K., Kinjo M., Aizawa T.
    In vivo fluorescence-correlation spectroscopy analyses of FMBP-1, a silkworm transcription factor.
    FEBS Open Bio, 6, 106-125 (2016)
    DOI: 10.1002/2211-5463.12026
  50. Hasemi T., Kikukawa T., Kamo N., Demura M.
    Characterization of a Cyanobacterial Chloride-Pumping Rhodopsin and Its Conversion into a Proton Pump.
    J. Biol. Chem., 291, 355-362 (2016)
    DOI: 10.1074/jbc.M115.688614
著書・総説・解説など
  1. Kikukawa M.
    Chapter4 "Functional Mechanism of Cl--Pump Rhodopsin and Its Conversion into H+ pump"
    Optogenetics - Light Sensing Proteins and Their Applications in Neuroscience and Beyond, 55-71 (2021)
  2. 菊川 峰志
    Cl–ポンプロドプシンの分子機構とH+ポンプへの機能変換
    生物物理, 61, 012-015 (2021)
  3. Unno M., Hirose Y., Mishima M., Kikukawa T., Fujisawa T., Iwata T., Tamogami J.
    Spectroscopic approach for exploring structure and function of photoreceptor proteins
    Biophysics and Physicobiology, 18, 127-130 (2021)
    DOI: 10.2142/biophysico.bppb-v18.014
  4. Kikukawa T.
    Unique Cl– pump rhodopsin with close similarity to H+ pump rhodopsin
    Biophysics and Physicobiology, 18, 317-326 (2021)
    DOI: 10.2142/biophysico.bppb-v18.038
  5. 菊川 峰志、尾瀬 農之、金城 政孝、津本 浩平(編集)、前仲 勝実(編集)
    蛍光偏光測定
    創薬研究のための相互作用解析パーフェクト、第1章I-7、74-85 (2021)羊土社
  6. 出村 誠
    タンパク質
    『基礎高分子科学』改訂版, 第9章 生体高分子, 375-388 (2020)
  7. 出村 誠
    シルクと持続可能な開発目標(SDGs)
    繊維機械学会誌『せんい』, Vol.73 (2020)
  8. 出村誠
    カイコ絹糸の模倣からイノベーションへ
    特集 生物機能模倣技術,アグリバイオ,vol.1,
    235-239 (2017)
  9. 出村誠
    カイコ絹糸の模倣からイノベーションへ
    アグリバイオ, 1, 235-239 (2017)
国際学会(招待講演)
  1. July 2018
    Sapporo Convension Center (Sapporo, JAPAN)
    Asia Pasific Society for Biology and Medical Sciences (APSBMS) 2018 Annual Meeting
    Tough physical double network hydrogels based on tri-block copolymers
    Tsukamoto T.
  2. November 2017
    Seoul, South Korea
    8th Asia and Oceania Conferenve on Photobiology
    Cyanobacterial rhodopsin having TSD motif
    Kikukawa T.
  3. October 2016
    Miyagi, Japan
    13th International Conference on Flow Dynamics
    Light-Induced Conformational Change of Inward Cl- Pump Halorhodopsin
    Kikukawa T.
国際学会(口頭発表)
  1. September 2018
    Hockley Vallay Resort (Mono, CANADA)
    18th International Conference on Retinal Proteins Anion Concentration Dependency on the Photocycle of PsuACR1: Implications for the Impairment of its Fast Channel Function.
    Tsukamoto T.
  2. July 2017
    Edinburgh International Conference Center (Edinburgh, Scotland)
    19th International Union of Pure and Applied Biophysics (IUPAB) and 11th European Biophysical
    Societies’ Association (EBSA) Congress
    Photochemistry of cyanobacterial chloride ionpumping rhodopsin
    Kikukawa T., Hasemi T., Aizawa T., Kamo N. and Demura M.
国内招待講演
  1. 2020年9月
    オンライン
    第58回日本生物物理学会年会
    フラッシュフォトリシス法を用いた微生物ロドプシンの光反応解析(Photoreaction analysis of microbial rhodopsin by flash photolysis techniques)
    菊川 峰志
  2. 2019年9月
    柏市
    ISSPワークショップ「レチナールタンパク質の光機能発現の物理と化学」プログラム
    微生物ロドプシンのホモ多量体形成の機能的意義
    菊川 峰志

先端基盤ユニット

原著論文
  1. Kamada T, Otomo K, Murata T, Nakata K, Hiruma S, Uehara R, Hasebe M, Nemoto T.
    Low-invasive 5D visualization of mitotic progression by two-photon excitation spinning-disk confocal microscopy.
    Sci Rep. 17;12(1):809 (2022)
    DOI: 10.1038/s41598-021-04543-7
  2. Yokoyama Y., Yano S., Kurita R., Karasawa M., Tanaka H., Takahashi H., Kikukawa T., Sonoyama M., Takenaka K.
    Effects of salt and gel network structures on purple membrane stacking in hydrogels immobilized with poly(vinyl alcohol)
    J. Appl. Phys., 129, 014701 (2021)
    DOI: 10.1063/5.0032546
  3. Harusawa K., Watanabe C., Kobori Y., Tomita K., Kitamura A., Kinjo M., Yanagisawa M.
    Membrane Surface Modulates Slow Diffusion in Small Crowded Droplets
    Langmuir, 37(1), 437–444 (2021)
    DOI: 10.1021/acs.langmuir.0c03086
  4. Takakura H., Goto Y., Kitamura A., Yoshihara T., Tobita S., Kinjo M.,Ogawa M.
    Analysis of the Triplet-state Kinetics of a Photosensitizer forPhotoimmunotherapy by Fluorescence Correlation Spectroscopy.
    J. Photochem. & Photobiol., A: Chem., 408, 113094 (2021)
    DOI: 10.1016/j.jphotochem.2020.113094
  5. Takakura H., Goto Y., Kitamura A., Yoshihara T., Tobita S., Kinjo M.,Ogawa M.
    Analysis of the Triplet-state Kinetics of a Photosensitizer forPhotoimmunotherapy by Fluorescence Correlation Spectroscopy.
    J. Photochem. & Photobiol., A: Chem., 408, 113094 (2021)
    DOI: 10.1016/j.jphotochem.2020.113094
  6. Yang G., Hiruma S., Kitamura A., Kinjo M., Mishra, M., Uehara R.
    Molecular basis of functional compatibility between ezrin and other actin-membrane associated proteins during cytokinesis.
    Exp. Cell Res., 403, 112600 (2021)
    DOI: 10.1016/j.yexcr.2021.112600
  7. Kitamura A., Numazawa R., Kinjo M.
    Conformational stabilization of Optineurin by the dynamic interaction of linear polyubiquitin.
    Biochem. Biophys. Res. Commun., 559, 203-209 (2021)
    DOI: 10.1016/j.bbrc.2021.04.103
  8. Fukushima R., Yamamoto J., Kinjo M.
    Empirical Bayes method using surrounding pixel information for number and brightness analysis
    Biophysical journal, 120 (11), 2156-2171 (2021)
    DOI: 10.1016/j.bpj.2021.03.033
  9. Fukushima R,, Yamamoto J.,Kinjo M.
    Number and Brightness Analysis: Visualization of Protein Oligomeric State in Living Cells
    Advanced Imaging and Bio Techniques for Convergence Science
    Editors: Kim, Jun Ki, Kim, Jeong Kon, Pack, Chan-Gi (Eds.) 31-58 (2021)
    DOI: 10.1007/978-981-33-6064-8_2
  10. Yamamoto J, Matsui A, Gan F, Oura M, Ando R, Matsuda T, Gong J. P., Kinjo M.
    Quantitative evaluation of macromolecular crowding environment based on translational and rotational diffusion using polarization dependent fluorescence correlation spectroscopy
    Sci Rep.11(1), 10594 (2021)
    DOI: 10.1038/s41598-021-89987-7
  11. Nagata K, Bajo KI, Mitomo H, Fujita R, Uehara R, Ijiro K, Yurimoto H.
    Visualization of DNA Replication in Single Chromosome by Stable Isotope Labeling.
    Cell Struct Funct. 20;46(2):95-101 (2021)
    DOI: 10.1247/csf.21011
  12. Kamasaki T, Miyazaki Y, Ishikawa S, Hoshiba K, Kuromiya K, Tanimura N, Mori Y, Tsutsumi M, Nemoto T, Uehara R, Suetsugu S, Itoh T, Fujita Y.
    FBP17-mediated finger-like membrane protrusions in cell competition between normal and RasV12-transformed cells.
    iScience. 18;24(9):102994 (2021)
    DOI: 10.1016/j.isci.2021.102994
  13. Yang G, Hiruma S, Kitamura A, Kinjo M, Mishra M, Uehara R.
    Molecular basis of functional exchangeability between ezrin and other actin-membrane associated proteins during cytokinesis.
    Exp Cell Res. 15;403(2):112600 (2021)
    DOI: 10.1016/j.yexcr.2021.112600
  14. Mafy N., Matsuo K., Hiiruma S.,Uehara R.,Tamaoki N.,
    Photoswitchable CENP-E Inhibitor Enabling the Dynamic Control of Chromosome Movement and Mitotic Progression.
    J. Am. Chem. Soc., 142, 1763-1767, (2020)
    DOI: 10.1021/jacs.9b12782
  15. Watanabe C., Kobori Y., Yamamoto J., Kinjo M., Yanagisawa M.
    Quantitative Analysis of Membrane Surface and Small Confinement Effectson Molecular Diffusion.
    J. Phys. Chem. B , 124(6), 1090–1098 (2020)
    DOI: 10.1021/acs.jpcb.9b10558
  16. Hanagata N, Takemura T, Kamimura K, Koda T.
    Effect of immunosuppressants on a mouse model of osteogenesis imperfecta type V harboring a heterozygous Ifitm5 c.-14C > T mutation.
    Sci. Rep. 10, 21197 (2020)
    DOI: 10.1038/s41598-020-78403-1
  17. Yoshizawa K., Yaguchi K., Uehara R.,
    Uncoupling of DNA replication and centrosome duplication cycles is a primary cause of haploid instability in mammalian somatic cells
    Frontiers in Cell and Developmental Biology, 8:721 (2020)
    DOI: 10.3389/fcell.2020.00721
  18. Takahashi S., Yamamoto J., Kitamura A., Kinjo M.,Sugimoto N.
    Characterization of Intracellular Crowding Environments with Topology-Based DNA Quadruplex Sensors
    Anal. Chem., 91(4), 2586–2590 (2019)
    DOI: 10.1021/acs.analchem.8b04177
  19. Sugihara M., Morito D., Ainuki S., Hirano Y., Ogino K., Kitamura A., Hirata H., Nagata K.
    The AAA+ ATPase/ubiquitin ligase mysterin stabilizes cytoplasmic lipid droplets
    J Cell Biol. 218(3), 949-960(2019)
    DOI: 10.1083/jcb.201712120
  20. Yamamoto J., Kinjo M.
    Full fiber-optic fluorescence correlation spectroscopy
    Optics Express, 27(10), 14835-14841(2019)
    DOI: 10.1364/OE.27.014835
  21. Aleksandar J. Krmpot., Stanko N., Nikolić, S Oasa., Dimitrios K., Papadopoulos., Marco Vitali., M Oura., S Mikuni., Per Thyberg., S Tisa., M Kinjo.,
    Lennart Nilsson., Lars Terenius., Rudolf Rigler., Vladana Vukojević
    Functional Fluorescence Microscopy Imaging: Quantitative Scanning-Free Confocal Fluorescence Microscopy for the Characterization of Fast Dynamic
    Processes in Live Cells
    Anal. Chem., 91(17), 11129-11137(2019)
    DOI: 10.1021/acs.analchem.9b01813
  22. Kitamura A., Kinjo M.
    Determination of diffusion coefficients in live cells using fluorescence recovery after photobleaching with wide-field fluorescence microscopy.
    Biophysics and Physicobiology, 15, 1-7 (2018)
    DOI: 10.2142/biophysico.15.0_1
  23. Ishida R., Okamoto T., Motojima F., Kubota H., Takahashi H., Tanabe-Ishida M., Oka T., Kitamura A., Kinjo M., Yoshida M., Otaka M., Itoh H.
    Physicochemical properties of mammalian molecular chaperone HSP60.
    International Journal of Molecular Sciences, 19, 489 (2018)
    DOI: 10.3390/ijms19020489
  24. Kitamura A., Ishida Y., Kubota H., Pack C.G., Homma T., Ito S., Araki K., Kinjo M., Nagata K.
    Detection of substrate-binding of a collagen-specific molecular chaperone HSP47 in solution using fluorescence correlation spectroscopy
    Biochem. Biophys. Res. Commun., 497, 279-284 (2018)
    DOI: 10.1016/j.bbrc.2018.02.069
  25. Kijimoto-Ochiai S., Matsumoto-Mizuno T., Kamimura D., Murakami M., Kobayashi M., Matsuoka I., Ochiai H., Ishida H., Kiso M., Kamimura K., Koda T.
    Existence of NEU1 sialidase on mouse thymocytes whose natural substrate is CD5
    Glycobiology, 28, 306-317 (2018)
    DOI: 10.1093/glycob/cwy009
  26. Ishida R., Okamoto T., Motojima F., Kubota H., Takahashi H., Tanabe-Ishida M., Oka T., Kitamura A., Kinjo M., Yoshida M., Otaka M., Itoh H.
    Physicochemical properties of mammalian molecular chaperone HSP60
    International Journal of Molecular Sciences, 19, 489 (2018)
    DOI: 10.3390/ijms19020489
  27. Kitamura A., Ishida Y., Kubota H., Pack C.G., Homma T., Ito S., Araki K., Kinjo M., Nagata K.
    Detection of substrate-binding of a collagenspecific molecular chaperone HSP47 in solution using fluorescence correlation spectroscopy
    Biochem. Biophys. Res. Commun., 497, 279-284 (2018)
    DOI: 10.1016/j.bbrc.2018.02.069
  28. Kitamura A., Kinjo M.
    State-of-the-art Fluorescence Fluctuation-Based Spectroscopic Techniques for the Study of Protein Aggregation
    Int. J. Mol. Sci., 19, 964 (2018)
    DOI: 10.3390/ijms19040964
  29. Fukushima R., Yamamoto J., Ishikawa H., Kinjo M.
    Two-detector number and brightness analysis reveals spatio-temporal oligomerization of proteins in living cells
    Methods, 140-141, 161-171 (2018)
    DOI: 10.1016/j.ymeth.2018.03.007
  30. Oasa S., Mikuni S., Yamamoto J., Kurosaki T., Yamashita D., Kinjo M.
    Relationship Between Homodimeric Glucocorticoid Receptor and Transcriptional Regulation Assessed via an In Vitro Fluorescence Correlation Spectroscopy-Microwell System
    Scientific Reports, 8, 7488 (2018)
    DOI: 10.1038/s41598-018-25393-w
  31. Kitamura A., Shimizu H., Kinjo M.
    Determination of cytoplasmic optineurin foci sizes using image correlation spectroscopy
    The Journal of Biochemistry, 164, 223-229 (2018)
    DOI: 10.1093/jb/mvy044
  32. Kitamura A., Iwasaki N., Kinjo M.
    Molecular chaperone HSP70 prevents formation of inclusion bodies of the 25-kDa C-terminal fragment of TDP-43 by preventing aggregate accumulation
    Cell Stress and Chaperones, 23, 1177-1183 (2018)
    DOI: 10.1007/s12192-018-0930-1
  33. Kitamura A.
    TDP-43 depletion: mechanism of neuronal cell death in ALS
    Future Neurology, 13, 143-149 (2018)
    DOI: 10.2217/fnl-2018-0010
  34. Tsukamoto M., Chiba K., Sobu Y., Shiraki Y., Okumura Y., Hata S., Kitamura A., Nakaya T., Uchida S., Kinjo M., Taru H., Suzuki T.
    The cytoplasmic region of the amyloid betaprotein precursor (APP) is necessary and sufficient for the enhanced fast velocity of APP transport by kinesin-1
    FEBS Letters, 592, 2716-2724 (2018)
    DOI: 10.1002/1873-3468.13204
  35. Sasaki A., Yamamoto J., Kinjo M., Noda N.
    Absolute Quantification of RNA Molecules Using Fluorescence Correlation Spectroscopy with Certified Reference Materials
    Anal. Chem., 90, 10865-10871 (2018)
    DOI: 10.1021/acs.analchem.8b02213
  36. Yamamoto J., Mikuni S., Kinjo M.
    Multipoint fluorescence correlation spectroscopy using spatial light modulator
    Biomedical Optics Express, 9, 5881-5890 (2018)
    DOI: 10.1364/BOE.9.005881
  37. Yaguchi, K., Yamamoto, T., Shimada, M., Sugimoto, R., Nakamura, K., Ayabe, T., Uehara, R.
    Ploidy-dependent change in cyclin D2 expression and sensitization to cdk4/6 inhibition in human somatic haploid cells
    Biochemical and Biophysical Research Communications 504, 231-237 (2018)
    DOI: 10.1016/j.bbrc.2018.08.160
  38. Oura M.,Yamamoto J., Jin T., Kinjo M.
    Investigation of pH-dependent photophysical properties of quantum nanocrystals by fluorescence correlation spectroscopy
    Optics Express, 25(2), 1435-1443 (2017)
    DOI: 10.1364/OE.25.001435
  39. Tanaka H., Oasa S., Kinjo M., Tange K., Nakai Y., Harashima H., Akita H.
    Temperature and pH sensitivity of a stabilized self-nanoemulsion formed using an ionizable lipidlike material via an oil-to-surfactant transition.
    Colloids Surf B Biointerfaces, 151, 95-101 (2017)
    DOI: 10.1016/j.colsurfb.2016.11.020
  40. Kitamura A., Yuno S., Muto H., Kinjo M.
    Different aggregation states of a nuclear localization signal-tagged 25 kDa C-terminal fragment of TAR RNA/DNA-binding protein 43 kDa
    Genes to Cells, 22, 521-534 (2017)
    DOI: 10.1111/gtc.12495
  41. Yamaguchi L., Nishiyama A., Misaki T., Johmura Y., Ueda J., Arita K., Nagao K., Obuse C., Nakanishi M.
    Usp7-dependent histone H3 deubiquitylation regulates maintenance of DNA methylation.
    Sci Rep., 7, 55 (2017)
    DOI: 10.1038/s41598-017-00136-5
  42. Hiraga SI., Ly T., Garzón J., Hořejší Z., Ohkubo YN., Endo A., Obuse C., Boulton SJ., Lamond AI., Donaldson AD.
    Human RIF1 and protein phosphatase 1 stimulate DNA replication origin licensing but suppress origin activation.
    EMBO Rep., 18, 403-419 (2017)
    DOI: 10.15252/embr.201641983
  43. Isono M., Niimi A., Oike T., Hagiwara Y., Sato H., Sekine R., Yoshida Y., Isobe SY., Obuse C., Nishi R., Petricci E., Nakada S., Nakano T., Shibata A.
    BRCA1 Directs the Repair Pathway to Homologous Recombination by Promoting 53BP1
    Dephosphorylation.
    Cell Rep., 18, 520-532 (2017)
    DOI: 10.1016/j.celrep.2016.12.042
  44. Tiwari M., Oasa S., Yamamoto J., Mikuni S., Kinjo M.
    A Quantitative Study of Internal and External Interactions of Homodimeric Glucocorticoid Receptor Using Fluorescence Cross-Correlation Spectroscopy in a Live Cell
    Scientific Reports, 7, 4336 (2017)
    DOI: 10.1038/s41598-017-04499-7
  45. Kitamura A., Yuno S., Muto H., Kinjo M.
    Different aggregation states of a nuclear localization signal-tagged 25-kDa C-terminal fragment of TAR RNA/DNA-binding protein 43kDa
    Genes Cells, 22, 521-534 (2017)
    DOI: 10.1111/gtc.12495
  46. Mikuni S., Yamamoto J., Horio T., Kinjo M.
    Negative Correlation between the Diffusion Coefficient and Transcriptional Activity of the Glucocorticoid Receptor
    Int. J. Mol. Sci., 18, 1855 (2017)
    DOI: 10.3390/ijms18091855
  47. Sobu Y., Furukori K., Chiba K., Nairn A. C., Kinjo M., Hata S., Suzuki T.
    Phosphorylation of multiple sites within an acidic region of Alcadein α is required for kinesin-1 association and Golgi exit of Alcadein α cargo
    Mol. Biol. Cell, 28, 3844-3856 (2017)
    DOI: 10.1091/mbc.E17-05-0301
  48. Sobu Y., Furukori K., Chiba K., Nairn A. C., Kinjo M., Hata S., Suzuki T.
    Phosphorylation of KLC1 modifies interaction with JIP1 and abolishes the enhanced fast velocity of APP transport by kinesin-1
    Mol. Biol. Cell, 28, 3857-3869 (2017)
    DOI: 10.1091/mbc.E17-05-0303
  49. Yahara M., Kitamura A., Kinjo M.
    U6 snRNA expression prevents toxicity in TDP-43-knockdown cells.
    PLOS ONE, 12, e0187813 (2017)
    DOI: 10.1371/journal.pone.0187813
  50. Miyabe Y., Furuta T., Takeda T., Kanno G., Shimizu T., Tanaka Y., Gai Z., Yasui H., Kishimura H.
    Structural properties of phycoerythrin from dulse palmaria palmata
    J. Food Bioch., 41, e12301 (2017)
    DOI: 10.1111/jfbc.12301
  51. Hiruma S., Kamasaki T., Otomo K., Nemoto T., Uehara R.
    Dynamics and function of ERM proteins during cytokinesis in human cells,
    FEBS Letters, 591, 3296-3309 (2017)
    DOI: 10.1002/1873-3468.12844
  52. Oura M., Yamamoto J., Ishikawa H., Mikuni S., Fukushima R., Kinjo M.
    Polarization-dependent fluorescence correlation spectroscopy for studying structural properties of proteins in living cell
    Scientific Reports, 6, 31091 (2016)
    DOI: 10.1038/srep31091
  53. Funami K., Matsumoto M., Oshiumi H., Obuse C., Seya T.
    The dataset of proteins specifically interacted with activated TICAM-1.
    Data Brief., 8, 697-699 (2016)
    DOI: 10.1016/j.dib.2016.06.030
  54. Kaimori J.Y., Maehara K., Hayashi-Takanaka Y., Harada A., Fukuda M., Yamamoto S., Ichimaru N., Umehara T., Yokoyama S., Matsuda R., Ikura T., Nagao K., Obuse C., Nozaki N., Takahara S., Takao T., Ohkawa Y., Kimura H., Isaka Y.
    Histone H4 lysine 20 acetylation is associated with gene repression in human cells.
    Sci Rep., 6, 24318 (2016)
    DOI: 10.1038/srep24318
  55. Funami K., Matsumoto M., Obuse C., Seya T.
    14-3-3-zeta participates in TLR3-mediated TICAM-1 signal-platform formation.
    Mol Immunol., 73, 60-68 (2016)
    DOI: 10.1016/j.molimm.2016.03.010
  56. Suzuki S., Kato H., Suzuki Y., Chikashige Y., Hiraoka Y., Kimura H., Nagao K., Obuse C., Takahata S., Murakami Y.
    Histone H3K36 trimethylation is essential for multiple silencing mechanisms in fission yeast.
    Nucleic Acids Res., 44, 4147-4162 (2016)
    DOI: 10.1093/nar/gkw008
  57. Hamanaka K., Goto K., Arai M., Nagao K., Obuse C., Noguchi S., Hayashi YK., Mitsuhashi S., Nishino I.
    Clinical, muscle pathological, and genetic features of Japanese facioscapulohumeral muscular dystrophy 2 (FSHD2) patients with SMCHD1 mutations.
    Neuromuscul Disord., 26, 300-308 (2016)
    DOI: 10.1016/j.nmd.2016.05.015
著書・総説・解説など
  1. 山本 条太郎、金城 政孝
    回転および並進拡散測定による細胞内混雑状態の解析
    月刊 細胞 The CELL, 53(6) 臨時増刊号, 53-57(2021)
  2. 北村朗、藤本愛
    ALSにおけるTDP-43タンパク質凝集体形成と遺伝子治療
    Bio Clinic, 36 (5), 453-456, (2021)
  3. Kitamura A., Fujimoto A., Kinjo M.
    Detection of Protein Aggregation using Fluorescence Correlation Spectroscopy
    J. Vis. Exp. (170), e62576, (2021)
    DOI: 10.3791/62576
  4. Kitamura A.
    Pinhole Closure Improves Spatial Resolution in Confocal Scanning Microscopy.
    Methods in Molecular Biology, 2274, 385-389 (2021)
    DOI: 10.1007/978-1-0716-1258-3_31.
  5. Kitamura A., Kabayama K.
    Session 2SHP report―decoding intracellular architecture using visualizing device development
    and mathematical modeling
    Biophysical Reviews, (2020)
  6. 北村 朗
    ALSにおけるタンパク質凝集体と遺伝子治療
    メディカル・サイエンス・ダイジェスト (MSD), 46 (12), 763-765 (2020)
  7. Kitamura A., Kinjo M.
    Spatial Image Correlation Spectroscopy(ICS): A Technique for Average Size Determination of SubcellularAccumulated Structures from Fluorescence Microscopic Images.
    Bio-Protocol,  10(10) (2020)
    DOI: 10.21769/BioProtoc.3624
  8. 金城 政孝
    HFSPグラント獲得の方法とコツ
    実験医学, 3(1), 126-129 (2019)
  9. 山本 条太郎、北村 朗、金城 政孝
    蛍光相関分光の発展と応用,その最新動向
    生物物理 59(3) 125-131 (2019)
国際学会(招待講演)
  1. November 2019
    Albanova, KTH Royal Institute of Technology (Stockholm, Sweden)
    QBP/OCS seminar
    Aggregation process of carboxyl terminal fragments of TDP-43
    Kitamura A.
  2. November 2019
    Karolinska Institutet (Stockholm, Sweden)
    Course Functional Fluorescence Microscopy Imaging (fFMI) in Biomedical Research
    FCS and FCCS in live cell
    Kitamura A. & Kinjo M.
  3. Kitamura A., Kinjo M.
    State-of-the-art Fluorescence Fluctuation-Based Spectroscopic Techniques for the Study of Protein Aggregation.
    Int. J. Mol. Sci., 19, 964 (2018)
    DOI: 10.3390/ijms19040964
  4. November 2016
    Stockholm, Sweden
    Course Functional Fluorescence Microscopy Imaging (fFMI) in Biomedical Research
    FCS and FCCS in living cells
    Kitamura A.
  5. November 2016
    Shimane, Japan
    The 10th International 3R Symposium
    BRCA1 directs the repair pathway to homologous recombination by promoting 53BP1 dephosphorylation
    Obuse C.
国際学会(口頭発表)
  1. September 2021
    オンライン開催
    Virtual Workshop on Fluorescence Correlation Spectroscopy (FCS) Dedicated to Prof. Rudolf Rigler on the Occasion of his 85 th Birthday
    Cellular dynamics of biomolecules
    Kinjo M.
  2. 2017年4月
    蘇州、中国
    Cold Spring Harber Asia Meeting “Cilia and Centrosomes”
    Novel link between ploidy level and centrosome homeostasis in mammalian somatic cells
    上原亮太、矢口完、松井崚、塚田祐基、幸田敏明
  3. July 2016
    Prague, Czech Republic
    12th International Congress of Cell Biology (ICCB)
    DNA Double Strand Breaks Repair Pathway is Controlled by Differential Phosphorylation of 53BP1
    Obuse C.
  4. October 2016
    London, England
    X-chromosome inactivation: a tribute to Mary Lyon
    Conserved repressive chromatin properties on inactive X chromosome between human and mouse
    Obuse C.
国内招待講演
  1. 2021年10月
    パシフィコ横浜(オンライン参加)
    第80回 日本癌学会学術総会
    動物非二倍体細胞における細胞分裂障害の発生機序
    上原 亮太
  2. 2021年11月
    オンライン開催
    第94回 日本生化学会大会
    動物生活環を特徴づける”倍数性・中心体リンク”
    上原 亮太
  3. 2021年12月
    山口市
    第17 回バイオオプティクス研究会 
    蛍光相関分光測定の展開とタンパク質相互作用解析
    金城 政孝
  4. 2019年7月
    札幌市
    第3期 第5回レーザー学会「レーザーバイオ医療」技術専門委員会
    偏光蛍光相関分光法を用いた、細胞内微環境の解析
    金城 政孝
  5. 2019年9月
    横浜市
    第92回日本生化学大会
    生細胞内におけるグルココルチコイド受容体2量体形成量と転写活性相関
    金城 政孝
  6. 2019年11月
    札幌市
    定量生物の会 北海道キャラバン2019
    Transient state (TRAST) monitoringを用いた生細胞内RNAフォールドの解析
    北村 朗
  7. 2019年12月
    京都府精華町
    サントリー生命科学財団 生物有機科学研究所 生有研シンポジウム
    蛍光相関分光法とその応用法を用いたALS関連細胞内凝集体形成機構の解析
    北村 朗
  8. 2018年9月
    つくば市
    第27回日本バイオイメージング学会公開講座
    揺らぎ解析の基礎と応用
    金城 政孝
  9. 2017年1月
    吹田市
    ワークショップ「染色体研究の最前線」
    HP1結合因子によるクロマチン制御
    小布施 力史
  10. 2017年3月
    横浜市
    日本化学会第97回春季年会 日本化学会春季年会コラボレーション規格企画 AMED・HFSPシンポジウム
    研究グラント/若手研究グラントの紹介
    金城 政孝
  11. 2017年6月
    仙台市
    第69回日本細胞生物学会大会 シンポジウム
    Molecular mechanism of the contractile ring-the plasma membrane interaction during cytokinesis in human cells.
    上原 亮太、比留間 翔太
  12. 2017年8月
    仙台市
    環境微生物系学会合同大会2017
    HFSPグラントへの招待
    金城 政孝
  13. 2017年9月
    札幌市
    第14回バイオオプティクス研究会
    偏光蛍光相関分光法による高分子混雑の評価
    山本 条太郎
  14. 2017年9月
    熊本市
    第55回日本生物物理学会年会 シンポジウム「高分子混雑が支配する細胞の世界」
    Evaluation of molecular crowding based on the rotational and translational diffusion measurement in living cells
    山本 条太郎
  15. 2017年12月
    神戸市
    2017年度 生命科学系学会合同年次大会 コスモ・バイオ ランチョンセミナー
    エクソソームの新規評価系について
    山本 条太郎
  16. 2016年4月
    京都市
    第1回ATR-X症候群シンポジウム
    HPIの解析から見えてきたヘテロクロマチンの構造と機能
    小布施 力史
  17. 2016年7月
    札幌市
    生化学若手の会・生物物理若手の会合同企画「蛍光イメージングセミナー~基礎から応用まで~」
    蛍光イメージング法による神経変性疾患関連ミスフォールドタンパク質の凝集形成機構解析
    北村 朗
  18. 2016年7月
    東京都
    第7回 ALSフォーラム
    蛍光イメージング手法を用いた ALS関連TDP43凝集形成機構の解析
    北村 朗
  19. 2016年7月
    和光市
    第42回レーザー顕微鏡研究会シンポジウム「レーザー顕微鏡技術の進展開」
    イメージング蛍光相関分光装置開発に向けた新規検出装置
    金城 政孝
  20. 2016年7月
    札幌市
    第53回日本生化学会北海道支部例会 日本生化学会北海道支部・日本生物物理学会北海道支部
    一倍性が動物培養細胞の細胞の細胞複製に及ぼす影響の解析
    上原 亮太
  21. 2016年8月
    豊中市
    大阪大学大学院理学研究科 生物科学セミナー
    ヘテロクロマチンの構造と機能の理解
    小布施 力史
  22. 2016年8月
    ニセコ町
    RNAフロンティアミーティング
    HP1結合タンパク質を通したクロマチン機能の解明
    小布施 力史
  23. 2016年9月
    三島市
    日本遺伝学会 第88回大会【三島大会】
    エピジェネティックコードを基盤としたヘテロクロマチンの形成機構
    小布施 力史
  24. 2016年10月
    三島市
    平成28年度遺伝研研究会
    ヘテロクロマチンとエピジェネティクス
    小布施 力史
  25. 2016年11月
    つくば市
    第54回日本生物物理学会年会シンポジウム「新しい視点が創る光学顕微鏡技術」
    Researches towards bio-molecular dynamics mapping in cell
    山本 条太郎
  26. 2016年11月
    横浜市
    第39回日本分子生物学会
    ヘテロクロマチンの機能構造と疾患との関わり
    小布施 力史
  27. 2016年12月
    前橋市
    第13回バイオオプティクス研究会
    多走査速度ラスター走査画像相関分光法
    山本 条太郎
  28. 2016年12月
    横浜市
    第39回 日本分子生物学会年会 Leicaランチョンセミナー
    FRAP/FCSを用いた分子動態解析を用いた神経変性疾患原因研究の最前線
    北村 朗

附属次世代物質生命科学研究センター

産学連携ユニット

原著論文
  1. Usuki S., Tamura N., Tamura T., Yuyama K., Mikami D., Mukai K., Igarashi Y.
    Konjac Ceramide (kCer)-Mediated Signal Transduction of the Sema3A Pathway Promotes HaCaT Keratinocyte Differentiation.
    Biology 11(1):121 (2022)
    DOI: 10.3390/biology11010121
  2. Murai Y., Yuyama K., Mikami D., Igarashi Y., Monde K.
    Penta-deuterium-labeled 4E, 8Z-sphingadienine for rapid analysis in sphingolipidomics study.
    Chemistry and Physics of Lipids, 245, 105202 (2022)
    DOI: 10.1016/j.chemphyslip.2022.105202
  3. Yaguchi K., Sato K., Yoshizawa K., Mikami D., Yuyama K., Igarashi Y., Banhegy G., Margittai E., Uehara R.
    Mevalonate pathway-mediated ER homeostasis is required for haploid stability in human somatic cells
    Cell Structure and Function, 46(1), 1-9 (2021)
    DOI: 10.1247/csf.20055
  4. Mikami D., Sakai S., Nishimukai M., Yuyama K., Mukai K., Igarashi Y.
    Structure-dependent absorption of atypical sphingoid long-chain bases from digestive tract into lymph
    Lipids in Health and Disease, 20(1), 24 (2021)
    DOI: 10.1186/s12944-021-01448-2
  5. Furukawa J., Hanamatsu H., Yokota I., Hirayama M., Ando T., Kobayashi H., Ohnishi S., Miura N., Okada K., Sakai S., Yuyama K., Igarashi Y., Ito. M., Shinohara Y., Sakamoto N.
    comprehensive glycomic approach reveals novel low-molecular weight blood group-specific glycans in serum and cerebrospinal fluid
    J. Proteome Res., 7;20(5):2812-2822 (2021)
    DOI: 10.1021/acs.jproteome.1c00056
  6. Yaguchi K., Sato K., Yoshizawa K., Mikami D., Yuyama K., Igarashi Y., Banhegy G., Margittai E., Uehara R.
    Mevalonate pathway-mediated ER homeostasis is required for haploid stability in human somatic cells.
    Cell Structure and Function, 46(1):1-9 (2021)
    DOI: 10.1247/csf.20055
  7. Mikami D., Sakai S., Nishimukai M., Yuyama K., Mukai K., Igarashi Y.
    Structure-dependent absorption of atypical sphingoid long-chain bases from digestive tract into lymph.
    Lipids in Health and Disease20(1):24 (2021)
    DOI: 10.1186/s12944-021-01448-2
  8. Furukawa J., Hanamatsu H., Yokota I., Hirayama M., Ando T., Kobayashi H., Ohnishi S., Miura N., Okada K., Sakai S., Yuyama K., Igarashi Y., Ito. M., Shinohara Y., Sakamoto N.
    A comprehensive glycomic approach reveals novel low-molecular weight blood group-specific glycans in serum and cerebrospinal fluid.
    J. Proteome Res. 20(5):2812-2822 (2021)
    DOI: 10.1021/acs.jproteome.1c00056
  9. Mutoh T., Niimi Y., Sakai S., Watanabe H., Ueda A., Shima S., Igarashi Y.
    Species-specific accumulation of ceramides in cerebrospinal fluid from encephalomyeloradiculoneurpathy patients associated with peripheral complement activation: A pilot study.
    BBA molecular and Cell Biology of Lipids. 1867(3):159092 (2021)
    DOI: 10.1016/j.bbalip.2021.159092
  10. Usuki S., Yasutake Y., Tamura N., Tamura T., Tanji K., Saitoh T., MuraiY., Mikami D., Yuyama K., Monde K., Mukai K., Igarashi Y.
    Nrp1 is Activated by Konjac Ceramide Binding-Induced Structural Rigidification of the a1a2 Domain
    Cells, 9(2), 517 (2020)
    DOI: 10.3390/cells9020517
  11. Akiyama H., Ide M., Nagatsuka Y., Sayano T., Nakanishi E., Uemura N., Yuyama K., Yamaguchi Y., Kamiguchi H., Takahashi R., Aerts JMFG., Greimel P., Hirabayashi Y.
    Glucocerebrosidases catalyze a transgalactosylation reaction that yields a newly identified brain sterol metabolite, galactosylated cholesterol
    J. Biol.Chem., 295(16), 5257-5277(2020)
    DOI: 10.1074/jbc.RA119.012502
  12. Usuki S., Yasutake Y., Tamura N., Tamura T., Tanji K., Saitoh T., Murai Y., Mikami D., Yuyama K., Monde K., Mukai K., Igarashi Y.
    Nrp1 is activated by kCer binding-induced structural rigidification of the a1a2 domain
    Cells 9, 517-535 (2020)
    DOI: 10.3390/cells9020517
  13. Sunami H., Shimizu Y., Denda J., Yokota I., Kishimoto H., Igarashi Y.
    A 3D Microfabricated Scaffold System for Unidirectional Cell Migration
    Advanced Biosystems, 4(10), e2000113 (2020)
    DOI: 10.1002/adbi.202000113
  14. Eguchi K., Mikami D., Sun H., Tsumita T., Takahashi K., Mukai K., Yuyama K., Igarashi Y.
    Blood-brain barrier permeability analysis of plant ceramides
    Plos One, 15(11), e0241640 (2020)
    DOI: 10.1371/journal.pone.0241640
  15. Yuyama K., Sun H., MikamiD., Mukai K., Igarashi Y.
    Lysosomal-associated transmembrane protein 4B regulates ceramide-induced exosome release
    FASEB. J., 34(12), 16022-16033 (2020)
    DOI: 10.1096/fj.202001599R
  16. Sugimoto M., Hamada T., Wakabayashi M., Yoshioka T., Kato H., Konishi H., Nagai R., Suzuki M., Numata Y., Igarashi Y., Yukioka H.
    Sphingomyelin synthase 2 loss suppresses steatosis but exacerbates fibrosis in the liver of mice fed with choline-deficient, L-amino acid-defined, high-fat diet
    Biochem Biophys Res Comm., 533(4), 1269-1275 (2020)
    DOI: 10.1016/j.bbrc.2020.09.142
  17. Usuki S., Tamura N., Tamura T., Higashiyama S., Tanji K., Mitsutake S., Inoue A., Aoki J., Mukai K., Igarashi Y.
    Konjac Ceramide (kCer) Regulates Keratinocyte Migration by Sema3A-like Repulsion Mechanism
    Biochemistry and Biophysics Reports, 17, 132-138 (2019)
    DOI: 10.1016/j.bbrep.2018.11.004
  18. Usuki S., Tamura N., Tamura T., Tanji K., Mikami D., Mukai K., Igarashi Y.
    Neurite outgrowth and morphological changes induced by 8-trans unsaturation of sphingadienine in kCer molecular species
    Int. J. Mol. Sci., 20(9), (2019)
    DOI: 10.3390/ijms20092116
  19. Mikami D., Sakai S., Yuyama K., Igarashi Y.
    Isolation of sphingoid bases from starfish Asterias amurensis glucosylceramides and their effects on sphingolipid production in cultured keratinocytes
    J. Oleo Sci., 68(5), 427-441 (2019)
    DOI: 10.5650/jos.ess18256
  20. Yuyama K., Takahashi K., Usuki S., Mikami D., Sun H., Hanamatsu H., Furukawa J., Mukai K., Igarashi Y.
    Plant sphingolipids promote extracellular vesicle release and alleviate amyloid-β pathologies in a mouse model of Alzheimer’s disease
    Sci.Rep., 9(1), 16827 (2019)
    DOI: 10.1038/s41598-019-53394-w
  21. Othman, M. A., Yuyama, K., Murai, Y., Igarashi, Y., Mikami, D., Sivasothy, Y., Awang, K., Monde, K.
    Malabaricone C as Natural Sphingomyelin Synthase Inhibitor against Diet-Induced Obesity and Its Lipid Metabolism in Mice
    ACS Med. Chem. Lett., 10, 1154-1158 (2019)
    DOI: 10.1021/acsmedchemlett.9b00171
  22. Sunami H., Shimizu Y., Denda J., Yokota I., Yoshizawa T., Uechi Y., Nakasone H., Igarashi Y., Kishimoto H., Matsushita M.
    Modulation of surface stiffness and cell patterning on polymer films using micropatterns
    Journal of Biomedical Materials Research: Part B - Applied Biomaterials, 106, 976-985 (2018)
    DOI: 10.1002/jbm.b.33905
  23. Usuki S., Tamura N., Yuyama K., Tamura T., Mukai K., Igarashi Y.
    Konjac Ceramide (kCer) Regulates NGF-Induced Neurite Outgrowth via the Sema3A Signaling Pathway
    J. Oleo Science, 67, 77-86 (2018)
    DOI: 10.5650/jos.ess17141
  24. Usuki S., Tamura N., Tamura T., Mukai K., Igarashi Y.
    Characterization of Konjac Ceramide (kCer) Binding to Sema3A Receptor Nrp1
    J. Oleo Science, 67, 87-94 (2018)
    DOI: 10.5650/jos.ess17142
  25. Nakamichi H., Nagasawa T., Hama Y., Higashiyama S., Igarashi Y., Mitsutake S.
    Phytosphingosine is a novel activator of GPR120
    J. Biochem., 164(1), 27-32 (2018)
    DOI: 10.1093/jb/mvy017
  26. Zama K., Mitsutake S., Okazaki T., Igarashi Y.
    Sphingomyelin in microdomains of the plasma membrane regulates amino acid-stimulated mTOR signal activation
    Cell Biology International, 42(7), 823-831 (2018)
    DOI: 10.1002/cbin.10941
  27. Sunami H., Shimizu Y., Denda J., Yokota I., Yoshizawa T., Uechi Y., Nakasone H., Igarashi Y., Kishimoto H., Matsushita M.
    Modulation of surface stiffness and cell patterning on polymer films using micropatterns Journal of Biomedical Materials Research:
    Part B -Applied Biomaterials, 106, 976-985 (2018)
    DOI: 10.1002/jbm.b.33905
  28. Nakamichi H., Nagasawa T., Hama Y., Higashiyama S., Igarashi Y., Mitsutake S.
    Phytosphingosine is a novel activator of GPR120
    J. Biochem., 164, 27-32 (2018)
    DOI: 10.1093/jb/mvy017
  29. Zama K., Mitsutake S., Okazaki T., Igarashi Y.
    Sphingomyelin in microdomains of the plasma membrane regulates amino acid-stimulated mTOR signal activation
    Cell Biology International, 42, 823-831 (2018)
    DOI: 10.1002/cbin.10941
  30. Esaki S., Nagasawa T., Tanaka H., Tominaga A., Mikami D., Usuki S., Hamajima H., Hanamatsu H., Sakai S., Hama Y., Igarashi Y., Kitagaki H., Mitsutake S.
    The fungal 9-methylsphingadienine is a novel ligand for both PPARg and GPR120
    J. Food Biochem., 42, e12624 (2018)
    DOI: 10.1111/jfbc.12624
  31. Hanamatsu H., Mitsutake S., Sakai S., Okazaki T., Watanabe K., Igarashi Y., Yuyama K.
    Multiple roles of Sms2 in white and brown adipose tissues from diet-induced obese mice
    J. Metabolic Syndrome, 7 (2018)
    DOI: 10.4172/2167-0943.1000241
  32. Ohara M., Ohnishi S., Hosono H., Yamamoto K., Yuyama K., Nakamura H., Qingjie F., Maehara O., Suda G., Sakamoto N.
    Extracellular vesicles from amnion-derived mesenchymal stem cells ameliorate hepatic inflammation and fibrosis in rats
    J Stem Cell International, 3212643 (2018)
    DOI: 10.1155/2018/3212643
  33. Makino A., Abe M., Ishitsuka R., Murate M., Kishimoto T., Sakai S., Hullin-Matsuda F., Shimada Y., Inaba T., Miyatake H., Tanaka H., Kurahashi A., Pack CG., Kasai RS., Kubo S., Schieber NL., Dohmae N., Tochio N., Hagiwara K., Sasaki Y., Aida Y., Fujimori F., Kigawa T., Nishibori K., Parton RG., Kusumi A., Sako Y., Anderluh G., Yamashita M., Kobayashi T., Greimel P., Kobayashi T.
    A novel sphingomyelin/cholesterol domain-specific probe reveals the dynamics of the membrane domains during virus release and in Niemann-Pick type C
    FASEB J., 31, 1301-1322 (2017)
    DOI: 10.1096/fj.201500075R
  34. Saito S., Murai U., Usuki S., Yoshida M., Hammam M.A.S., MItsutake S., Yuyama K., Igarashi Y., Monde K.
    Synthesis of Nontoxic Fluorous Sphingolipids as Molecular Probes of Exogenous Metabolic Studies for Rapid Enrichment by Fluorous Solid Phase Extraction
    Eur. J. Org. Chem., 6, 1045-1051 (2017)
    DOI: 10.1002/ejoc.201601302
  35. Takao Sanaki T., Kasai-Yamamoto E., Yoshioka T., Sakai S., Yuyama K., Fujiwara T., Numata Y., Igarashi Y.
    Direct involvement of arachidonic acid in the development of ear edema via TRPV3
    Journal of Oleo Science, 66, 591-599 (2017)
    DOI: 10.5650/jos.ess16227
  36. Yuyama K., Igarashi Y.
    Exosomes as carriers of Alzheimer’s amyloid-beta
    Frontiers in Neuroscience, 11, 229 (2017)
    DOI: 10.3389/fnins.2017.00229
  37. Sunami H., Shimizu Y., Yokota I., Igarashi Y., Kishimoto H., Matsushita M.
    Live cell migration on a Microfabricated Silicon Wafer
    Hyomen kagaku, 38, 473-478 (2017)
  38. Fukuda N., Noi K., Weng L., Kobashigawa Y., Miyazaki H., Wakeyama Y., Takaki M., Nakahara Y., Tatsuno Y., Uchida-Kamekura M., Suwa Y., Sato T., Ichikawa-Tomikawa N., Nomizu M., Fujiwara Y., Ohsaka F., Saitoh T., Maenaka K., Kumeta H., Shinya S., Kojima C., Ogura T., Morioka H.
    Production of Single-Chain Fv Antibodies Specific for GA-Pyridine, an Advanced Glycation End-Product (AGE), with Reduced Inter-Domain Motion.
    Molecules, 22(10), 1695 (2017)
    DOI: 10.3390/molecules22101695
  39. Kumeta H., Nakayama H., Ogura K.
    Solution structure of the major fish allergen parvalbumin Sco j 1 derived from the Pacific mackerel
    Sci. Rep., 7, 17160 (2017)
    DOI: 10.1038/s41598-017-17281-6
  40. Inaba T., Kishimoto T., Murate M., Tajima T., Sakai S., Abe M., Makino A., Tomishige N., Ishitsuka R., Ikeda Y., Takeoka S., Kobayashi T.
    Phospholipase Cβ1 induces membrane tubulation and is involved in caveolae formation
    Proc. Natl. Acad. Sci. USA., 113, 7834-7839 (2016)
    DOI: 10.1073/pnas.1603513113
  41. Mikami D., Sakai S., Sasaki S., Igarashi Y.
    Effects of Asterias amurensis-derived sphingoid bases on the de novo ceramide synthesis in cultured normal human epidermal keratinocytes
    Journal of Oleo Science, 65, 671-680 (2016)
    DOI: 10.5650/jos.ess16051
  42. Sugimoto M., Shimizu Y., Zhao S., Ukon N., Nishijima K., Wakabayashi M., Yoshioka T., Higashino K., Numata Y., Okuda T., Tamaki N., Hanamatsu H., Igarashi Y., Kuge Y.
    Characterization of the role of sphingomyelin synthase 2 in glucose metabolism in whole-body and peripheral tissues in mice
    BBA - Molecular and Cell Biology of Lipids, 1861, 688-702 (2016)
    DOI: 10.1016/j.bbalip.2016.04.019
  43. Li D., Usuki S., Quarles B., Rivner MH., Ariga T., Yu RK.
    Anti-Sulfoglucuronosyl Paragloboside Antibody: A Potential Serologic Marker of Amyotrophic Lateral Sclerosis.
    ASN Neuro., 8 (2016)
    DOI: 10.1177/1759091416669619
  44. Taniguchi M., Tasaki T., Ninomiya H., Ueda Y., Kuremoto K., Mitsutake S., Igarashi Y., Okazaki T., Takegami T.
    Sphingomyelin generated by sphingomyelin synthase 1 is involved in attachment and infection with Japanese encephalitis virus
    Scientific Reports, 6, 37829 (2016)
    DOI: 10.1038/srep37829
  45. Sekiguchi H., Suzuki T., Sakai S., Takahashi K., Hayashida S., Sutoh K., Usumi K., Katsumata Y., Igarashi Y.
    A Study of Safety and Skin Improvment Effect of Beverage Containing Extracted Glucosylceramide form Tamogitake (Pleurotus cornucopiae var. citrinopileatus)
    Trace Nutrients Research, 33, 21-30 (2016)
著書・総説・解説など
  1. 江口晃一、向井克之、湯山耕平、栗本成敬、田中藍子、勝山(鏡)豊代、西平順、門出健次、五十嵐靖之
    こんにゃく由来グルコシドセラミド摂取による脳内アミロイドβ蓄積に対する抑制効果の探索的試験ープラセボ対照ランダム化二重盲検並行群間比較試験ー
    薬理と治療 8月号 (2021)
  2. 湯山 耕平、五十嵐 靖之
    認知症予防に注目の植物(こんにゃく)セラミド~アルツハイマー病理の軽減効果明らかに(この人に聞く 研究最前線)
    FOODSTYLE21, 2, 8-10 (2020)
  3. 江口 晃一、向井 克之、湯山 耕平、五十嵐 靖之
    こんにゃくセラミドによるエクソソーム産生誘導と認知症予防効
    FOODSTYLE21, 2, 38-41 (2020)
  4. 湯山 耕平、江口 晃一、五十嵐 靖之
    広がりを見せる食餌性植物セラミドの生体調節機能
    バイオサイエンスとインダストリー, 78(4), 302-307 (2020)
  5. 三上 大輔、五十嵐 靖之
    スフィンゴ糖脂質やセラミドの生理機能に基づいた機能性食品の開発
    脂質・脂肪酸関連物質の使いこなし方-素材開発・機能創生・応用技術-, 187-196 (2020)
  6. 湯山 耕平、五十嵐 靖之
    神経変性疾患におけるスフィンゴ脂質の役割
    生化学, 92(5), 640-648 (2020)
  7. 湯山 耕平、五十嵐 靖之
    第6章第5節 認知症病理形成にかかわるエクソソームの働きとその予防・治療標的可能性
    認知症の早期診断技術と進行抑制/予防薬・機能性食品の開発, 221-231 (2019)
  8. 高橋 香織、湯山 耕平、向井 克之、五十嵐 靖之
    第9章第12節 セラミドを利用したアルツハイマー病予防法の研究開発
    認知症の早期診断技術と進行抑制/予防薬・機能性食品の開発, 478-486 (2019)
  9. 五十嵐 靖之
    序説 出版にあたって
    セラミド研究の新展開~基礎から応用へ~(2019)
  10. 湯山 耕平、五十嵐 靖之
    第20章 細胞外小胞の生産・機能に関わるセラミド関連脂質のはたらき
    セラミド研究の新展開~基礎から応用へ~, 173-178 (2019)
  11. 三上 大輔、五十嵐 靖之
    第26章 スフィンゴ脂質の消化吸収機構
    セラミド研究の新展開~基礎から応用へ~, 225-232 (2019)
  12. 臼杵 靖剛
    第31章 EGCaseⅠで調製される植物由来遊離セラミドのSema3A-like活性
    セラミド研究の新展開~基礎から応用へ~, 258-265 (2019)
  13. 湯山 耕平、五十嵐 靖之
    神経変性疾患の病態発現にかかわるエクソソームの働き
    医療を変えるエクソソーム-生体機能から疾患メカニズム、臨床応用まで-, 159-166 (2018)
  14. Sakamoto H., Yoshida T., Sanaki T., Shigaki S., Morita H., Oyama M., Mitsui M., Tanaka Y., Nakano T., Mitsutake S., Igarashi Y., Takemoto H.
    Possible roles of long-chain sphingomyelines and sphingomyelin synthase 2 in mouse macrophage inflammatory response.
    Biochem. Biophys. Res. Commun., 482, 202-207 (2017)
    DOI: 10.1016/j.bbrc.2016.11.041
  15. 湯山耕平、五十嵐靖之
    アルツハイマー病とエクソソーム
    パラダイムシフトをもたらすエクソソーム機能研究 
    最前線~シグナル伝達からがん、免疫、神経疾患との関わり、創薬利用まで~, 175-185 (2017)
  16. 五十嵐靖之
    農林産物由来のセラミド含有有機性素材の開発
    グリーンテクノ情報, 12, 21-24 (2016)
  17. 湯山耕平、五十嵐靖之
    神経細胞由来エクソソームのアミロイドβクリアランス促進機能
    Dementia Japan, 30, 358-366 (2016)
国際学会(招待講演)
  • July 2019
    Tokyo, Japan
    60th ICBL
    Sphingolipid from basic to applied research.
    Igarashi Y.
国内招待講演
  1. 2019年7月
    札幌市
    第61回日本脂質生化学会
    30年の私のスフィンゴ脂質研究をふりかえって
    五十嵐 靖之
  2. 2019年7月
    東京都
    第179回東京脂質談話会
    セラミドによるエクソソーム放出制御とアミロイドAβクリアランス
    五十嵐 靖之
  3. 2019年10月
    札幌市
    第12回セラミド研究会学術集会
    セラミドによるエクソソーム産生誘導とその神経疾患関連機能
    湯山 耕平
  4. 2018年3月
    吹田市
    大阪大学蛋白質研究所セミナー「生体膜上の生物化学2018」
    神経細胞由来細胞外小胞によるアミロイドβタンパク質除去機構
    湯山 耕平
  5. 2017年1月
    東京都
    認知症フォーラム
    アルツハイマー病と細胞外小胞エクソソーム
    湯山 耕平
  6. 2017年3月
    札幌市
    恵庭健康フォーラム
    スフィンゴ脂質、セラミド研究の実用化をめざして:スキンケアとアルツハイマー予防
    五十嵐 靖之
  7. 2016年6月
    東京都
    日経バイオテクプロフェッショナルセミナー
    エクソソーム機能のアルツハイマー病予防・診断・治療への応用可能性
    湯山 耕平
  8. 2016年7月
    札幌市
    北海道バイオ産業振興協会(HOBIA)例会
    セラミドの科学と応用
    五十嵐 靖之
  9. 2016年9月
    仙台市
    東北医科薬科大学生体膜研究所特別講演
    エクソソームによるアルツハイマー病の予防・治療は可能か?
    五十嵐 靖之
  10. 2016年10月
    茨木市
    大阪大学産業科学研究所バイオセミナー
    スフィンゴ脂質の生理機能に基づく創薬、機能性食品創出の試み、その後の展開
    五十嵐 靖之
  11. 2016年10月
    東京都
    エー・イー企画オリジナルセミナー:エクソソーム2016
    神経変性疾患とエクソソーム~アルツハイマー病病理を中心として~
    湯山 耕平
  12. 2016年10月
    東京都
    セラミド研究会第9回学術集会
    アルツハイマー病予防のためのスフィンゴ脂質含有細胞外ベシクル
    湯山 耕平
  13. 2016年11月
    新潟市
    ダイセルコーポレート研究センター講演会
    機能性脂質研究開発-北大産業創出講座で進めている研究とその背景
    五十嵐 靖之

国際連携ユニット

原著論文
  1. Nishimoto T., Enomoto T., Lin C.H., Wu J.G., Gupit C.I., Li X, Luo S.C., Akimoto A.M., Yoshida R.
    Construction of a nano-phase-separated structure on a hydrogel surface
    Soft Matter 18(4) 722-725 (2022)
    DOI: 10.1039/d1sm01659h
  2. Li X.
    Structure and Dynamics of Critical Polymer Clusters Formed with Tetra-Armed Star-Polymers
    Nihon Reoroji Gakkaishi 50(1) 113-117 (2022)
    DOI: 10.1678/rheology.50.113
  3. Ohira M., Katashima T., Naito M., Aoki D., Yoshikawa Y., Iwase H., Takata S., Miyata K., Chung U., Sakai T., Shibayama M., Li X.
    Star‐Polymer–DNA Gels Showing Highly Predictable and Tunable Mechanical Responses
    Advanced Materials 2108818-2108818 (2022)
    DOI: 10.1002/adma.202108818
  4. Kureha T., Ohira M., Takahashi Y., Li X., Gilbert E.P., Shibayama M.
    Nanoscale Structures of Poly(oligo ethylene glycol methyl ether methacrylate) Hydrogels Revealed by Small-Angle Neutron Scattering
    Macromolecules, 55, 1844-1854 (2022)
    DOI: 10.1021/acs.macromol.1c02259
  5. Tsuji Y., Shibayama M., Li X.
    Neutralization and Salt Effect on the Structure and Mechanical Properties of Polyacrylic Acid Gels under Equivolume Conditions
    Gels 7(2) 69-69 (2021)
    DOI: 10.3390/gels7020069
  6. Kozhunova E.Y., Rudyak V.Y., Li X., Shibayama M., Peters G.S., Vyshivannaya O.V., Nasimova I.R., Chertovich A.V.
    Microphase separation of stimuli-responsive interpenetrating network microgels investigated by scattering methods
    Journal of Colloid and Interface Science 597 297-305 (2021)
    DOI: 10.1016/j.jcis.2021.03.178
  7. Yokochi H., Ohira M., Oka M., Honda S., Li X., Aoki D., Otsuka H.
    Topology Transformation toward Cyclic, Figure-Eight-Shaped, and Cross-Linked Polymers Based on the Dynamic Behavior of a Bis(hindered amino)disulfide Linker
    Macromolecules 54(21) 9992-10000 (2021)
    DOI: 10.1021/acs.macromol.1c01437
  8. Kawagoe S., Nakagawa H., Kumeta H., Ishimori K., Saio T.
    Structural insight into proline cis / trans isomerization of unfolded proteins catalyzed by the trigger factor chaperone.
    J Biol Chem., 293, 15095-15106 (2018)
    DOI: 10.1074/jbc.RA118.003579
  9. Stewart N.J., Kumeta H., Tomohiro M., Hashimoto T., Hatae N., Matsumoto S.
    Long-range heteronuclear J-coupling constants in esters: Implications for 13C metabolic MRI by side-arm parahydrogen-induced polarization.
    J Magn Reson., 296, 85-92 (2018)
    DOI: 10.1016/j.jmr.2018.08.009
著書・総説・解説など
  • Li X.,
    A benchmark for gel structures: bond percolation enables the fabrication of extremely homogeneous gels
    Polymer Journal, 53, 765–777 (2021)
    DOI: 10.1038/s41428-021-00479-x

先端基盤ユニット

原著論文
  1. Kijimoto-Ochiai S., Kamimura K., Koda T.
    Neu-medullocytes, sialidase-positive B cells in the thymus, express autoimmune regulator (AIRE)
    Sci. Rep. 9(1): 858 (2019)
    DOI: 10.1038/s41598-018-37225-y
  2. Yaguchi K., Yamamoto T., Matsui R., Shimada M., Shibanuma A., Kamimura K., Koda T., Uehara R.
    Tetraploidy-associated centrosome overduplication in mouse early embryos
    Commun. Integr. Biol. 11(4): e1526605 (2018)
    DOI: 10.1080/19420889.2018.1526605
  3. Yaguchi K., Yamamoto T., Matsui R., Tsukada Y., Shibanuma A., Kamimura K., Koda T., Uehara R.
    Uncoordinated centrosome cycle underlies the instability of non-diploid somatic cells in mammals.
    J. Cell Biol. 217(7): 2463-2483 (2018)
    DOI: 10.1083/jcb.201701151
  4. Kijimoto-Ochiai S., Matsumoto-Mizuno T., Kamimura D., Murakami M., Kobayashi M., Matsuoka I., Ochiai H., Ishida H., Kiso M., Kamimura K., Koda T.
    Existence of NEU1 sialidase on mouse thymocytes whose natural substrate is CD5.
    Glycobiology 28(5): 306-317 (2018)
    DOI: 10.1093/glycob/cwy009