2014年度：基盤支援・産学連携部門

発表論文

  1. Kobayashi M., Nakatani T., Koda T., Matsumoto K., Ozaki R., Mochida N., Takao K., Miyakawa T., Matsuoka I.
    Absence of BRINP1 in mice causes increase of hippocampal neurogenesis and behavioral alterations relevant to human psychiatric disorders.
    Molecular Brain 7, 12 (2014)
  2. Ikeda M., Yamaguchi M., Kato K., Nakamura K., Shiina S., Ichikawa-Ando T., Misaka H., Myojo K., Nakamura K., Sugimoto Y., Hamada H.
    Pr1E11, a novel anti-TROP-2 antibody isolated by adenovirus-based antibody screening, recognizes a unique epitope
    Biochem. Biophys. Res. Commun. 458, 877-882 (2015)
  3. Taira R., Yamaguchi S., Shimizu K., Nakamura K., Ayabe T., Taira T.
    Bacterial cell wall components regulate adipokine secretion from visceral adipocytes
    J. Clin. Biochem. Nutr. 56, 149-154 (2015)
  4. Yamaguchi M., Nishii Y., Nakamura K., Aoki H., Hirai S., Uchida H., Sakuma Y., Hamada H.
    Development of a sensitive screening method for selecting monoclonal antibodies to be internalized by cells
    Biochem. Biophys. Res. Commun. 454, 600-603 (2014)
  5. Nakajima M., Takahashi A., Tsuji T., Karasugi T., Baba H., Uchida K., Kawabata S., Okawa A., Shindo S., Takeuchi K., Taniguchi Y., Maeda S., Kashii M., Seichi A., Nakajima H., Kawaguchi Y., Fujibayashi S., Takahata M., Tanaka T., Watanabe K., Kida K., Kanchiku T., Ito Z., Mori K., Kaito T., Kobayashi S., Yamada K., Takahashi M., Chiba K., Matsumoto M., Furukawa K., Kubo M., Toyama Y.; Genetic Study Group of Investigation Committee on Ossification of the Spinal Ligaments, Ikegawa S.
    A genome-wide association study identifies susceptibility loci for ossification of the posterior longitudinal ligament of the spine.
    Nat Genet. Sep;46(9), 1012-6 (2014)
  6. Kono M., Yasuda S., Stevens RL., Koide H., Kurita T., Shimizu Y., Kanetsuka Y., Oku K., Bohgaki T., Amengual O., Horita T., Shimizu T., Majima T., Koike T., Atsumi T.
    RasGRP4 is Aberrantly Expressed in the Fibroblast-like Synoviocytes of Patients with Rheumatoid Arthritis and Controls their Proliferation
    Arthritis Rheumatol. Feb;67(2):396-407 (2015)
  7. Londono D., Kou I., Johnson TA., Sharma S., Ogura Y., Tsunoda T., Takahashi A., Matsumoto M., Herring JA., Lam TP., Wang X., Tam EM., Song YQ., Fan YH., Chan D., Cheah KS., Qiu X., Jiang H., Huang D., Japanese Scoliosis Clinical Research Group., TSRHC IS Clinical Group., the International Consortium for Scoliosis Genetics., Su P., Sham P., Cheung KM., Luk KD., Gordon D., Qiu Y., Cheng J., Tang N., Ikegawa S., Wise CA.
    A meta-analysis identifies adolescent idiopathic scoliosis association with LBX1 locus in multiple ethnic groups
    J Med Genet. Jun;51(6):401-6 [Epub ahead of print] (2014)
  8. Shimizu T., Takahata M., Kameda Y., Hamano H., Ito T., Kimura-Suda H., Todoh M., Tadano S., Iwasaki N.
    Vitamin K-dependent carboxylation of osteocalcin affects the efficacy of teriparatide (PTH(1-34)) for skeletal repair.
    Bone. Jul;64:95-101 (2014)
  9. Yukata K., Xie C., Li TF., Takahata M., Hoak D., Kondabolu S., Zhang X., Awad HA., Schwarz EM., Beck CA., Jonason JH., O’Keefe RJ.
    Aging periosteal progenitor cells have reduced regenerative responsiveness to bone injury and to the anabolic actions of PTH 1-34 treatment.
    Bone. May;62:79-89 (2014)
  10. Kameda Y., Takahata M., Mikuni S., Shimizu T., Hamano H., Angata T., Hatakeyama S., Kinjo M., Iwasaki N.
    Siglec-15 is a potential therapeutic target for postmenopausal osteoporosis
    Bone. Feb;71:217-26 (2015)
  11. Iwasaki K., Sudo H., Yamada K., Higashi H., Ohnishi K., Tsujimoto T., Iwasaki N.
    Effects of single injection of local anesthetic agents on intervertebral disc degeneration: Ex vivo and long-term in vivo experimental study
    PLOS ONE. Oct 6;9(10), e109851 (2014)
  12. Minami Y., Kohsaka S., Tsuda M., Yachi K., Hatori N., Tanino M., Kimura T., Nishihara H., Minami A., Iwasaki N., Tanaka S.
    SS18-SSX-regulated miR-17 promotes tumor growth of synovial sarcoma by inhibiting p21WAF1/CIP1
    Cancer Science, Sep;105(9):1152-9 (2014)
  13. Salmingo R., Tadano S., AbeY., Ito M.
    Influence of implant rod curvature on sagittal correction of scoliosis deformity
    Spine J, Aug 1;14(8):1432-9 (2014)
  14. Kawamura et al
    Sulfation Patterns of Exogenous Chondroitin Sulfate Affect Chondrogenic Differentiation of ATDC5 Cells
    JOS Nov;19(6):1028-35 (2014)
  15. Iwasaki N.
    Development of cartilage tissue engineering techniques based on biomedical research
    J Orthop Sci. Sep;19(5):699-706 (2014)
  16. Eniwumide JO., Tanaka M., Nagai N., Morita Y., de Bruijn J., Yamamoto S., Onodera S., Kondo E., Yasuda K., Shimomura M.
    The morphology and functions of articular chondrocytes on a honeycomb-patterned surface
    Biomed Res Int, 2014;2014:710354 (2014)
  17. Kawaguchi Y., Kondo E., Takeda R., Akita K., Yasuda K., and Amis AA.
    The role of fibers in the femoral attachment of the ACL in resisting tibial displacements
    Arthroscopy. Mar;31(3):435-44 (2015)
  18. Miyazaki T., Sudo H., Hiratsuka S., Iwasaki N.
    Cervical spondylotic myelopathy with subacute combined degeneration.
    Spine J. Feb 1;14(2):381-382 (2014)
  19. Nagahama K., Sudo H., Abumi K., Ito M., Takahata M., Hiratsuka S., Kuroki K., Iwasaki N.
    Anomalous vertebral and posterior communicating arteries as a risk factor in cervical instrumentation surgery
    Bone Joint J. Apr;96-B(4):535-540 (2014)
  20. Sudo H., Ito M., Abe Y., Abumi K., Takahata M., Nagahama K., Hiratsuka S., Kuroki K., Iwasaki N.
    Surgical treatment of Lenke 1 thoracic adolescent idiopathic scoliosis with maintenance of kyphosis using the simultaneous double-rod rotation technique
    Spine (Phila Pa 1976), Jun 15;39(14):1163-1169 (2014)
  21. Terashima T et al
    External Rotation of the Femoral Component decreases Patellofemoral Contact Stress in Total Knee Arthroplasty
    Knee Surg Sports Traumatol Arthrosc., Jun 11 [Epub ahead of print] (2014)
  22. Onodera J., Kondo E., Omizu N., Ueda D., Yagi T., Yasuda K.
    Beta tricalcium phosphate shows superior absorption rate and osteoconductivity compared to hydroxyapatite in open wedge high tibial osteotomy
    Knee Surg Sports Traumatol Arthrosc., Nov;22(11):2763-70 (2014)
  23. Hojo Y., Ito M., Suda K., Oda I., Yoshimoto H., Abumi K.
    A multicenter study on accuracy and complications of freehand placement of cervical pedicle screws under lateral fluoroscopy in different pathological conditions: CT-based evaluation of more than 1,000 screws.
    Eur Spine J., Oct;23(10):2166-74 (2014)
  24. de Kleuver M., Lewis SJ., Germscheid NM., Kamper SJ., Alanay A., Berven SH., Cheung KM., Ito M., Lenke LG., Polly DW., Qiu Y., van Tulder M., Shaffrey C.
    Optimal surgical care for adolescent idiopathic scoliosis: an international consensus.
    Eur Spine J., Dec;23(12):2603-18 (2014)
  25. Nishio Y., Onodera T., Kasahara Y., Takahashi D., Iwasaki N., Majima T.
    Intraoperative medial pivot affects deep knee flexion angle and patient-reported outcomes after total knee arthroplasty
    J Arthroplasty., Apr;29(4):702-6 (2014)
  26. Matsumoto M., Watanabe K., Kawakami N., Tsuji T., Uno K., Suzuki T., Ito M., Yanagida H., Minami S., Akazawa T.
    Postoperative shoulder imbalance in Lenke Type 1A adolescent idiopathic scoliosis and related factors.
    BMC Musculoskelet Disord., Nov 5;15(1):366 (2014)
  27. Fukui T., Kitamura N., Kurokawa T., Yokota M., Kondo E., Gong JP., Yasuda K.
    Intra-articular administration of hyaluronic acid increases the volume of the hyaline cartilage regenerated in a large osteochondral defect by implantation of a double-network gel
    J Mater Sci Mater Med., Apr;25(4):1173-82 (2014)
  28. Ohara M., Imanishi Y., Nagata Y., Ishii A., Kobayashi I., Mori K., Ito M., Miki T., Nishizawa Y., Inaba M.
    Clinical efficacy of oral risedronate therapy in Japanese patients with Paget’s disease of bone.
    J Bone Miner Metab. Oct 16. [Epub ahead of print] (2014)
  29. Oshima S., Sudo H., Ito M., Abumi K.
    Subaxial sagittal alignment after atlantoaxial fixation techniques
    J Spinal Disord Tech., Feb;28(1):E49-55 (2015)
  30. Watanabe K., Uno K., Suzuki T., Kawakami N., Tsuji T., Yanagida H., Ito M., Hirano T., Yamazaki K., Minami S., Taneichi H., Imagama S., Takeshita K., Yamamoto T., Matsumoto M.
    Risk Factors for Proximal Junctional Kyphosis Associated with Dual-Rod Growing-Rod Surgery for Early-Onset Scoliosis.
    J Spinal Disord Tech. Jul 11. [Epub ahead of print] (2014)
  31. Sekiguchi H., Motomiya M., Sakurai K., Matsumoto D., Funakoshi T., Iwasaki N.
    Brachial artery perforator-based propeller flap coverage for prevention of readhesion after ulnar nerve neurolysis
    Microsurgery., Feb;35(2):158-62 (2015)
  32. Matsui Y., Funakoshi T., Motomiya M., Urita A., Minami M., Iwasaki N.
    Radial shortening osteotomy for kienböck disease: minimum 10-year follow-up.
    J Hand Surg Am., Apr;39(4):679-85 (2014)
  33. Nakahara M., Ito M., Hattori N., Magota K., Takahata M., Nagahama K., Sudo H., Kamishima T., Tamaki N., Iwasaki N.
    18F-FDG-PET/CT better localizes active spinal infection than MRI for successful minimally invasive surgery
    Acta Radiol, Epub ahead of print (2014)
  34. Kinya Ishizaka., Mutsumi Nishida., Makoto Motomiya., Megumi Satoh., Mamiko Inoue., Yusuke Kudoh., Satomi Omotehara., Tatsunori Horie., Tadanao Funakoshi., Norimasa Iwasaki.
    Reliability of peripheral intraneural micro-hemodynamics evaluation by using contrast-enhanced ultrasonography
    Journal of Medical Ultrasonics, 41:481-486 (2014)
  35. Iwata A., Ito M., Abumi K., Sudo H., Kotani Y., Shono Y., Minami A.
    Fungal spinal infection treated with percutaneous posterolateral endoscopic surgery
    J Neurol Surg A Cent Eur Neurosurg., May;75(3):
    170-6 (2014)
  36. Matsuoka M., Inoue M., Shimamoto N., Iwasaki N., Yasuda K.
    Twi-stage arthroscopy-assisted treatment of a large depression fracture in the lateral femoral condyle associated with an acute anterior cruciate ligament tear
    European Orthopaedics and Traumatology
  37. Matsubara S., Motomiya M., Iwasaki N.
    Extensor tendon dislocation caused by improper end-to-side transfer in a rheumatoid patient: a case report.
    Hand Surg

著書・総説・解説等

なし

国際学会

（招待講演）

  1. Sptember 2014
    Oceanside, USA
    Seminar for food and medical innovation in Oceanside
    Paneth cell α-defensins rule intestinal homeostasis and relate to Crohn’s disease and life-style diseases / Intestinal stellate cell as a therapeutic target for intractable fibrosis in Crohn’s disease
    Ayabe T.

（口頭発表）

  1. March 2015
    Las Vegas, United States of America
    Orthopaedic Research Society 2015 Annual Meeting
    Effects of Single Local Injection of local Anesthetic Agents on Intervertebral Disc Degeneration: Ex Vivo and Long-Term In Vivo Experimental Study
    Iwasaki K., Sudo H., Yamada K., Ohnishi T., Tsujimoto T., Iwasaki N.
  2. March 2015
    Las Vegas, United States of America
    Orthopaedic Research Society 2015 Annual Meeting
    Bone Marrow Stimulation Technique Augmented By Ultrapurified Alginate Gel Enhances Osteochondral Repair In A Rabbit Osteochondral Defect Model
    Baba R., Onodera T., Mommma D., Matsuoka M., Hontani K., Iwasaki N.
  3. March 2015
    Las Vegas, United States of America
    American Academy of Orthopaedic Society 2015 Annual Meeting
    Autologous Osteochondral Mosaicplasty For Osteochondritis Dissecans Of The Elbow: Minimum 5 year Follow up
    Urita A., Funakoshi T., Matsui Y., Kawamura D., Tsukuda Y., Iwasaki N.
  4. March 2015
    Las Vegas, United States of America
    American Academy of Orthopaedic Society 2015 Annual Meeting
    Effect Of Teriparatide Versus Bisphosphonate On The Healing Of Osteoporotic Vertebral Fracture
    Iwata A., Kanayama M., Shigenobu K., Oha F., Onda S., Tanaka M., Hashimoto T., Iwasaki N.
  5. March 2015
    Las Vegas, United States of America
    American Academy of Orthopaedic Society 2015 Annual Meeting
    Efficacy Of Linezolid In The Treatment Of Spondylodiscitis Caused By Methicillin-resistant Staphylococcus Aureus
    Takahata M., Ito M., Sudo H., Nagahama K., Iwasaki N.

国内招待

  1. 2014年10月
    札幌市
    北海道大学消化器内科学講演会
    αディフェンシンによる腸内環境の制御と疾病―炎症性腸疾患、肥満、生活習慣病―
    綾部時芳
  2. 2014年10月
    岡崎市
    2014年度生理学研究所研究会「粘膜免疫学と膜輸送生理学の融合」
    Paneth細胞α-defensinによる腸内細菌叢制御と疾患との関連の解明
    中村公則、櫻木直也、綾部時芳
  3. 2014年12月
    東京都
    第20回日本エンドトキシン・自然免疫研究会
    抗菌ペプチドαディフェンシンによる腸内環境の恒常性制御と疾病
    綾部時芳、櫻木直也、中村公則
  4. 2014年12月
    札幌市
    日本顕微鏡学会北海道支部講演会
    小腸陰窩における生命機能と疾病
    綾部時芳
  5. 2015年1月
    札幌市
    第25回札幌IBDミニカンファレンス
    古くて新しい「腸内細菌と疾病」を腸内環境から考える
    綾部時芳
  6. 2015年2月
    福岡市
    第8回これからの健康と栄養を考えるシンポジウム
    免疫力を高める食生活とは？
    綾部時芳
  7. 2015年3月
    札幌市
    第6回安定同位元素イメージング技術による産業イノベーションシンポジウム
    同位体顕微鏡で小腸の吸収機能を視る
    櫻木直也、他

特許

  1. 2014/5/16（出願番号14/359,079）アメリカ、インド、カナダ
    腸管線維症処置剤
    発明者：綾部時芳、中村公則、他
  2. 登録
    国際　21件
    岩崎倫政
    国内　3件
    岩崎倫政
  3. 出願中
    国際　1件
    岩崎倫政
    国内　1件
    須藤英毅