2015年度：基盤支援・産学連携部門

発表論文

  1. Nakamura K., Sakuragi N., Takakuwa A., Ayabe T.
    Paneth cellα-defensins and enteric microbiota in health and disease.
    Biosci Microbiota Food Health (2015) doi: 10.12938/ bmfh. 2015-019
  2. Nukuda A., Sasaki C., Ishihara S., Mizutani T., Nakamura K., Ayabe T., Kawabata K., Haga H.
    Stiff substrates increase YAP-signaling-mediated matrix metalloproteinase-7 expression.
    Oncogenesis 4, e165, (2015) doi: 10.1038/oncsis.2015.24
  3. Eriguchi Y., Nakamura K., Hashimoto D., Shimoda S., Shimono N., Akashi K., Ayabe T., Teshima T.
    Decreased Secretion of Paneth cellα-defensin in Graft-versus-host disease.
    Transpl Infect Dis 17, 702-706 (2015)
  4. Tomisawa S., Sato Y., Kamiya M., Kumaki Y., Kikukawa T., Kawano K., Demura M., Nakamura K., Ayabe T., Aizawa T.
    Efficient production of a correctly folded mouse α-defensin, cryptdin-4, by refolding during inclusion body solubilization.
    Protein Expr Purif 112, 21-28 (2015)
  5. Taira R., Yamaguchi S., Shimizu K., Nakamura K., Ayabe T., Taira T.
    Bacterial cell wall components regulate adipokine secretion from visceral adipocytes.
    J Clin Biochem Nutr 56, 149-154 (2015)
  6. Ikeda M., Yamaguchi M., Kato K., Nakamura K., Shiina S., Ichikawa-Ando T., Misaka H., Myojo K., Nakamura K., Sugimoto Y., Hamada H.
    Pr1E11, a novel anti-TROP-2 antibody isolated by adenovirus-based antibody screening, recognizes a unique epitope.
    Biochem Biophys Res Commun 458, 877-882 (2015)
  7. Gizaw ST., Koda T., Amano M., Kamimura K., Ohashi T., Hinou H., Nishimura S.
    A comprehensive glycome profiling of Huntington’s disease transgenic mice.
    Biochim. Biophys. Acta. 1850(9), 1704-1718 (2015)
  8. Kadoya K., Lu P., Nguyen K., Lee-Kubli C., Kumamaru H., Yao L., Knackert J., Poplawski G., Dulin JN., Strobl H., Takashima Y., Biane J., Conner J., Zhang SC., Tuszynski MH.
    Spinal cord reconstitution with homologous neural grafts enables robust corticospinal regeneration.
    Nat Med. Mar 28. [Epub ahead of print] (5IF=27.14) (2016)
  9. Ogura Y., Kou I., Miura S., Takahashi A., Xu L., Takeda K., Takahashi Y., Kono K., Kawakami N., Uno K., Ito M., Minami S., Yonezawa I., Yanagida H., Taneichi H., Zhu Z., Tsuji T., Suzuki T., Sudo H., Kotani T., Watanabe K., Hosogane N., Okada E., Iida A., Nakajima M., Sudo A., Chiba K., Hiraki Y., Toyama Y., Qiu Y., Shukunami C., Kamatani Y., Kubo M., Matsumoto M., Ikegawa S.
    A functional SNP in BNC2 is associated with adolescent idiopathic scoliosis.
    Am J Hum Genet. Aug 6;97(2):337-42.(5IF=11.17) (2015)
  10. Kondo E., Yasuda K., Kawaguchi Y., Onodera J., Kawaguchi Y., Kitamura N.
    Effects of remnant tissue preservation on clinical and arthroscopic results after anatomic doublebundle anterior cruciate ligament reconstructions.
    Am J Sports Med. Aug;43(8):1882-92.(5IF=5.08) (2015)
  11. Funakoshi T., Furushima K., Momma D., Endo K., Abe Y., Itoh Y., Fujisaki K., Tadanao S., Iwasaki N.
    Alteration of Stress Distribution Patterns in the Symptomatic Valgus Instability of the Elbow in Baseball Players Using Computed Tomography Osteoabsorptiometry.
    Am J Sports Med.(5IF=5.08) In press.
  12. Shimizu T., Takahata M., Kameda Y., Endo T., Hamano H., Hiratsuka S., Ota M., Iwasaki N.
    Sialic acid-binding immunoglobulin-like lectin 15 (Siglec-15) mediates periarticular bone loss., but not joint destruction., in murine antigen-induced arthritis.
    Bone. Oct;79:65-70.(5IF=4.31) (2015)
  13. Sudo H., Mayer M., Kaneda K., Pereira SN., Shono Y., Hitzl W., Iwasaki N., Koller H.
    Maintenance of spontaneous lumbar curve correction following thoracic fusion of main thoracic curves in adolescent idiopathic scoliosis.
    Bone Joint J. (5IF=3.48) In press.
  14. Urita A., Funakoshi T., Suenaga N., Oizumi N., Iwasaki N.
    A combination of subscapularis tendon transfer and small-head hemiarthroplasty for rotator cuff tear arthropathy A PILOT STUDY.
    Bone Joint J. Aug;97(8):1090-95.(5IF=3.48) (2015)
  15. Sudo H., Kaneda K., Shono Y., Iwasaki N.
    Short fusion strategy for thoracolumbar and lumbar adolescent idiopathic scoliosis using anterior dual-rod instrumentation.
    Bone Joint J. Mar;98-b(3):402-9.(5IF=3.48) (2016)
  16. Yunoki S., Hatayama H., Ebisawa M., Kondo E., Yasuda K.
    A novel fabrication method to create a thick collagen bundle composed of uniaxially aligned fibrils: An essential technology for the development of artificial tendon/ligament matrices.
    J Biomed Mater Res A. 103(9). Sep;103(9):3054-65. (5IF=3.45) (2015)
  17. Tsukuda Y., Onodera T., Ito M., Izumisawa Y., Kasahara Y., Igarashi T., Ohzawa N., Todoh M., Tadano S., Iwasaki N.
    Therapeutic effects of intra-articular ultra-purified low endotoxin alginate administration on an experimental canine osteoarthritis model.
    J Biomed Mater Res A. Nov;103(11):3441-8. (5IF=3.45) (2015)
  18. Iwasaki K., Sudo H., Kasahara Y., Yamada K., Ohnishi K., Tsujimoto T., Iwasaki N.
    Effects of multiple intra-articular injections of 0.5% bupivacaine on normal and osteoarthritic joints in rats.
    Arthroscopy. (5IF=3.41) In press.
  19. Hamano H., Takahata M., Ota M., Hiratsuka S., Shimizu T., Kameda Y., Iwasaki N.
    Teriparatide Improves Trabecular Osteoporosis but Simultaneously Promotes Ankylosis of the Spine in the Twy Mouse Model for Diffuse Idiopathic Skeletal Hyperostosis.
    Calcif Tissue Int. Feb;98(2):140-8.(5IF=2.93) (2016)
  20. Kuroki K., Sudo H., Iwasaki N.
    Right thoracic thoracolumbar scoliosis.
    Spine J. May 1;15(5):1154-5.(5IF=2.83) (2015)
  21. Sudo H., Kaneda K., Shono Y., Iwasaki N.
    Selection of the upper vertebra to be instrumented in the treatment of thoracolumbar and lumbar adolescent idiopathic scoliosis by anterior correction and fusion surgery using dual-rod instrumentation: a minimum 12-year follow-up study.
    Spine J. Aug 17. In press.(5IF=2.83) (2015)
  22. Urita A., Funakoshi T., Amano T., Matsui Y., Kawamura D., Kameda Y., Iwasaki N.
    Predictive Factors of long head biceps tendon disorders-the bicipital groove morphology and subscapularis tendon tear.
    J Shoulder Elbow Surg. Mar;25(3):384-9.(5IF=2.74) (2016)
  23. Sudo H., Abe Y., Abumi K., Iwasaki N., Ito M.
    Surgical treatment of double thoracic adolescent idiopathic scoliosis with a rigid proximal thoracic curve.
    Eur Spine J. Feb;25(2);569-77.(5IF=2.50) (2016)
  24. Matsui Y., Funakoshi T., Kobayashi H., Mitsuhashi T., Kamishima T., Iwasaki N.
    Bizarre parosteal osteochondromatous proliferation (Nora’s lesion) affecting the distal end of the ulna: a case report.
    BMC Musculoskelet Disord. Mar 16;17(1):130. (5IF=2.28) (2016)
  25. Kondo E., Kitamura N., Onodera J., Yokota M., Yagi T., Iwasaki N., Yasuda K.
    Effects of initial graft tension on clinical outcome after anatomic double-bundle anterior cruciate ligament reconstruction: Comparison of two graft tension protocols.
    BMC Musculoskelet Disord. Feb 9;17(1):65.(5IF=2.28) (2016)
  26. Mori N., Kimura S., Onodera T., Iwasaki N., Nakagawa I., Masuda T.
    Use of a Pneumatic Tourniquet in Total Knee Arthroplasty Increases the Risk of Distal Deep Vein Thrombosis: A Prospective., Randomized Study.
    The knee.(5IF=2.17) (2016) In press.
  27. Endo K., Yamada S., Todoh M., Takahata M., Iwasaki N., Tadano S.
    Structural strength of cancellous specimens from bovine femur under cyclic compression.
    PeerJ. Jan 25;4:e1562.(5IF=2.11) (2016)
  28. Takahata M., Abumi K., Sudo H., Nagahama K., Iwasaki N.
    Cervical myelopathy due to atraumatic odontoid fracture in patients with rheumatoid arthritis: A case series.
    Mod Rheumatol. Jun 29:1-4.[Epub ahead of pint] (5IF=2.09) (2015)
  29. Matsui Y., Kon S., Funakoshi T., Miyashita T., Matsuda T., Iwasaki N.
    Increased expression ofαv integrin as a regulator of fibrosis in Dupuytren’s nodules.
    J Hand Surg Eur Vol. Mar 11.(5IF=1.90) (2016) In press.
  30. Nakahara M., Ito M., Hattori N., Magota K., Takahata M., Nagahama K., Sudo H., Kamishima T., Tamaki N., Iwasaki N.
    18F-FDG-PET/CT better localizes active spinal infection than MRI for successful minimally invasive surgery.
    Acta Radiol. Jul;56(7):829-36.(5IF=1.65) (2015)
  31. Onodera T., Kasahara Y., Kasemura T., Suzuki Y., Kondo E., Iwasaki N.
    A comparative study with in vitro ultrasonographic and histologic grading of metatarsal head cartilage in rheumatoid arthritis.
    Foot Ankle Int. Jul;36(7):774-779.(5IF=1.54) (2015)
  32. Tsujimoto T., Takahata M., Kokabu T., Matsuhashi M., Iwasaki N.
    Pyogenic spondylodiscitis following anti-interleukin-6 therapy in a patient with rheumatoid arthritis-implication of hematogenous infection risk in degenerative intervertebral discs- : a case report and review of the literature.
    Journal of Orthopedic Science. Jun 30.pii: S0949-
    2658(15)00020-2.doi: 10.1016/j.jos.2015.06.018.
    (5IF=1.18) (2015)
  33. Matsuoka M., Onodera T., Sasazawa F, Momma D., Baba R., Hontani K., Iwasaki N.
    An Articular Cartilage Repair Model in Common C57Bl/6 Mice.
    Tissue Eng Part C Methods. Aug;21(8):767-72. (Current IF=4.64) (2015)
  34. Tsukuda Y., Funakoshi T., Nasuhara Y., Nagano Y., Shimizu C., Iwasaki N.
    Venipuncture nerve injuries in the upper extremity from more than 1 million procedures.
    Journal of Patient Safety.(Current IF=1.49) In press.
  35. Nakamura Y., Kikugawa S., Seki S., Takahata M., Iwasaki N., Terai H., Matsubara M., Fujioka F., Inagaki H., Kobayashi T., Kimura T., Kurahashi H., Kato H.
    PCSK5 mutation in a patient with the VACTERL association.
    BMC Res Notes. Jun 9;8:228. (2015)

著書・総説・解説等

  1. 綾部時芳
    腸上皮のPaneth細胞が担う自然免疫・粘膜免疫
    医学のあゆみ Vol.253, pp349-353 (2015)
  2. 中村公則、綾部時芳
    腸上皮細胞の抗菌ペプチドによる自然免疫
    臨床免疫・アレルギー科 Vol.64, pp20-25 (2015)
  3. 綾部時芳
    腸内環境の新展開と潰瘍性大腸炎－クローン病
    難病と在宅ケア 8月号 Vol.21, pp61-64 (2015)
  4. 櫻木直也、綾部時芳
    自然免疫による腸内細菌叢の制御と共生 疾病との接点
    診断と治療 2月号 Vol.104, pp227-232 (2016)
  5. 綾部時芳、櫻木直也、中村公則
    腸における排除と共生 -抗菌ペプチドと腸内細菌-
    家畜感染症学会学会誌Vol.4, pp133-141 (2015)
  6. Sudo H.
    Neurological and vascular complications after surgery for cervical myelopathy.
    Passias P ed.: Cervical myelopathy, Jaypee Medical
    Publishers, Philadelphia., Chapter 20, in press.

国際学会

（招待講演）

  1. August 2015
    Bangkok, Thailand.
    Current Spine : Cervical Spine.
    Deformity correction and fusion for cervical spine deformity and instability using pedicle screw instrumentation
    Takahata M.
  2. August 2015
    Bangkok, Thailand.
    Current Spine : Cervical Spine.
    Posterior Cervical and Cervico-thoracic Fusion.
    Takahata M.
  3. August 2015
    Bangkok, Thailand.
    Current Spine : Cervical Spine.
    Surgical treatment of myelopathy caused by cervical OPLL.
    Takahata M.
  4. November 2015
    Oceanside, USA
    UTC Seminar on organ fibrosis
    Intestinal stellate cells and novel anti-fibrotic therapy for Crohn’s disease.
    Ayabe T.
  5. January 2016
    Daejeon, Korea
    3rd ACL Symposium
    Biomechanical and clinical evaluations of anatomic double-bundle ACLR.
    Kondo E.
  6. January 2016
    Daejeon, Korea
    3rd ACL Symposium
    Effects of remnat tissue preservation of the clinical outcome after anatomic double-bundle ACLR.
    Kondo E.

（口頭発表）

  1. May 2015
    Jeju island, Korea
    The 23rd annual meeting of the Korean Shoulder and Elbow Society
    Vascularity alterations in different rotator cuff repair technique using contrast-enhanced ultrasound.
    Funakoshi T.
  2. May 2015
    Chicago, Illinois, USA
    12th International Cartliage Repair Society World Congress
    Lack of GalNAc transferase and GD3 synthase enhance cartilage degradation in murine osteoarthritis models.
    Momma D., Onodera T., Sasazawa F., Matsuoka M., Iwasaki N.
  3. May 2015
    Chicago, Illinois, USA
    12th International Cartliage Repair Society World Congress
    Bone marrow stimulation technique augmented by ultrapurified alginate gel enhances osteochondral repair in a rabbit model.
    Baba R., Onodera T., Momma D., Matsuoka M., Hontani K., Elmorsy S., Iwasaki N.
  4. May 2015
    Chicago, Illinois, USA
    12th International Cartliage Repair Society World Congress
    Chondrogenic Differentiation of Mouse Induced Pluripotent Stem Cells (iPSCs) using Ultra-Purified Alginate Gel (UPAL Gel).
    Hontani K., Onodera T., Terashima R., Momma D., Matsuoka M., Baba R., Iwasaki N.
  5. May 2015
    Buenos Aires, Argentina
    Global Spine Congress 2015 – AOSpine Annual Congress
    Effects of Single Local Injection of Local Anesthetic Agents on Intervertebral Disc Degeneration: Ex Vivo and Long-Term In Vivo Experimental Study.
    Iwasaki K., Sudo H., Yamada K., Ohnishi T., Tsujimoto T., Iwasaki N.
  6. June 2015
    Lyon, France
    The 10th Biennial Congress of International Society of Arthroscopy, Knee Surgery and Orthopaedic Sports Medicine
    Clinical outcome and complications after medial open wedge high tibial osteotomy using a locking compression plate.
    Kondo E., Onodera J., Yagi T., Iwasaki N., Yasuda K.
  7. June 2015
    Lyon, France
    The 10th Biennial Congress of International Society of Arthroscopy, Knee Surgery and Orthopaedic Sports Medicine
    Cliniccal outcome after anatomic double-bundle anterior cruciate ligament reconstruction in patients older than forty years : Comparison between different age groups.
    Nishio Y., Kondo E., Onodera J., Kitamura N., Iwasaki N., Yasuda K.
  8. June 2015
    Lyon, France
    The 10th Biennial Congress of International Society of Arthroscopy, Knee Surger and Orthopaedic Sports Medicine
    Is the Load Carried From the ACL Mid-Substance Fibers During Anterior Tibial Translation Transmitted to the Posterior Fan-Like Extension Fibers on the Femoral Attachment?
    Kawaguchi Y., Yasuda K., Kondo E., Takeda R., Halewood C., Akita K., Amis AA.
  9. June 2015
    Lyon, France
    The 10th Biennial Congress of International Society of Arthroscopy, Knee Surgery and Orthopaedic Sports Medicine
    Preservation of Remnant Tissue Improves Knee Stability After Anterior Cruciate Ligament Reconstruction in Sheep.
    Takahashi T., Kondo E., Kawaguchi Y., Onodera J., Iwasaki N., Yasuda K.
  10. September 2015
    Seattle, Washington, USA
    70th Annual Meeting of the American Society for Surgery of the Hand (ASSH)
    av integrin is a crucial regulator in the development of Dupuytren’s contracture.
    Matsui Y., Kon S., Funakoshi T., Miyashita T., Matsuda T., Iwasaki N.
  11. September 2015
    Seattle, Washington, USA
    The 70th Annual Meeting of the American Society for Surgery of the Hand（ ASSH）
    Stress distribution patterns in the elbow ulnar collateral ligament insufficiency.
    Funakoshi T., Furushima K., Oizumi N., Iwasaki N.
  12. September 2015
    Milano, Italy
    The 26th SECEC-ESSSE congress meeting
    Vascularity alterations in different rotator cuff repair technique using contrast-enhanced ultrasound.
    Funakoshi T., Urita A., Iwasaki N.
  13. January 2016
    Busan, Korea
    The 3rd Korea-Japan Osteotomy Symposium
    A new fixation system for opening HTO.
    Kondo E., Onodera J., Yabuuchi K., Kameda T., Onodera T., Kitamura N., Yasuda K., Iwasaki N.
  14. January 2016
    Busan, Korea
    The 3rd Korea-Japan Osteotomy Symposium
    Clinical Outcome after Osteochondral Autologous Transplantation with and without High Tibial Osteotomy for Spontaneous Osteonecrosis of the knee.
    Yabuuchi K., Kondo E., Onodera J., Onodera T., Kameda T., Kitamura N., Yasuda K., Iwasaki N.
  15. January 2016
    Busan, Korea
    The 3rd Korea-Japan Osteotomy Symposium
    OWHTO changes in vivo stress distribution patterns of the PF joint using CT.
    Kameda T., Kondo E., Onodera J., Onodera T., Yabuuchi K., Kitamura N., Yagi T., Yasuda K., Iwasaki N.
  16. March 2016
    Orland, Florida, USA
    The 2016 Annual Meeting of the American Academy of Orthopaedic Surgeons (AAOS)
    Vascular Patterns in the Repaired Rotator Cuff Depending on Suture Methods.
    Urita A., Funakoshi T., Iwasaki N.
  17. March 2016
    Orland, Florida, USA
    The 2016 Annual Meeting of the American Academy of Orthopaedic Surgeons (AAOS)
    Does Spinopelvic Alignment Affect The Union Status in Thoracolumbar Osteoporotic Vertebral Compression Fracture.
    Iwata A., Kanayama M., Oha F., Hashimoto T., Iwasaki N.
  18. March 2016
    Orland, Florida, USA
    Orthopaedic Research Society 2016 Annual Meeting
    Depletion of the gangliosides accelerated the articular cartilage repair through Indian hedgehog pathway.
    Matsuoka M., Onodera T., Sasazawa F., Momma D., Baba R., Hontani K., Joutoku Z., Matsubara S., Homan K., Iwasaki N.
  19. March 2016
    Orland, Florida, USA
    Orthopaedic Research Society 2016 Annual Meeting
    Effects of ligament remnant tissue preservation on the tendon graft after anterior cruciate ligament reconstruction: biomechanical and immunohistological evaluations with a sheep model.
    Takahashi T., Kondo E., Kawaguchi Y., Onodera J., Miyatake S., Iwasaki N., Yasuda K.
  20. March 2016
    Orland, Florida, USA
    Orthopaedic Research Society 2016 Annual Meeting
    Repair of articular cartilage defects by acellular technique with an ultrapurified alginate gel in a canine model.
    Onodera T., Baba R., Matsuoka M., Momma D., Hontani K., Tsuda T., Iwasaki N.
  21. March 2016
    Orland, Florida, USA
    Orthopaedic Research Society 2016 Annual Meeting
    Comprehensive screening of chemokines related to articular cartilage repair.
    Joutoku Z., Onodera T., Momma D., Matsuoka M., Baba R., Hontani K., Matsubara S., Homan K., Hisimura R., Iwasaki N.
  22. March 2016
    Orland, Florida, USA
    Orthopaedic Research Society 2016 Annual Meeting
    A novel bone marrow stimulation techinique augmented by administration of ultrapurified alginate gel enhances osteochondral repair in a rabbit model.
    Baba R., Onodera T., Momma D., Matsuoka M., Hontani K., Elmorsy S., Endo K., Todoh M., Tadano S., Iwasaki N.

国内招待

  1. 2015年6月
    東京都
    第19回腸内細菌学会　シンポジウム特別講演
    Paneth細胞と腸内細菌のクロストークからみた疾病
    綾部　時芳
  2. 2015年8月
    長野県
    第5回オルソオルガノジェネシス検討会　シンポジウム
    αディフェンシンが規定する新しい腸内環境の可能性
    中村　公則
  3. 2015年8月
    小田原市
    第2回県西地域未来産業創造シンポジウム～認知症の予防を目指して
    新しい腸内環境と脳腸相関
    綾部　時芳
  4. 2015年12月
    札幌市
    第5回家畜感染症学会
    腸における排除と共生－抗菌ペプチドと腸内細菌－
    綾部　時芳
  5. 2016年3月
    札幌市
    さっぽろヘルスイノベーション‘Smart-H’平成27年度成果報告会
    腸内環境評価による食の新機能が拓く健康・医療イノベーション
    中村　公則
  6. 2016年3月
    札幌市
    日本農芸化学会2016年度大会　産学官学術交流フォーラム
    腸からみれば！ 食品と免疫と腸内細菌がつくる“腸内環境”の解明と実用化
    綾部　時芳
  7. 2016年3月
    札幌市
    日本農芸化学会2016年度大会　シンポジウム
    Enteroidを用いたPaneth細胞の機能可視化～顆粒分泌・再形成および免疫系クロストーク
    綾部　時芳

特許

なし