Academic Achievements

Academia-Industry Collaboration Unit

Reviewed Paper

  1. Yamamura R, Nakamura K, Kitada N, Aizawa T, Shimizu Y, Nakamura K, Ayabe T, Kimura T, Tamakoshi A.
    Associations of gut microbiota, dietary intake, and serum short-chain fatty acids with fecal short-chain fatty acids
    Biosci Microbiota Food Health 39, 11-17 (2020)
    DOI: 10.12938/bmfh.19-010
  2. Bermejo I. A., Navo C. D., Castro-López J., Guerreiro A., Fernández E. M. S., García-Martín F., Hinou H., Nishimura S.-I., Fernández J. M. G., Mellet C. O., Avenoza A., Busto J. H., Bernardes G. J. L., Hurtado-Guerrero R., Peregrina J. M., Corzana F.
    Synthesis, conformational analysis and in vivo assays of an anti-cancer vaccine that features an unnatural antigen based on an sp2-iminosugar fragment
    Chem. Sci. 11, 3996-4006 (2020)
    DOI: 10.1039/c9sc06334j
  3. Hayakawa A., Matsushita T., Yokoi Y., Wakui H., Fayna Garcia-Martin, Hinou H., Matsuoka K., Nouso H., Kamiyama T., Taketomi A, Nishimura S-I.
    Impaired O-Glycosylation at Consecutive Threonine TTX Motifs in Mucins Generates Conformationally Restricted Cancer Neoepitopes
    Biochemistry 59, 1221-1241 (2020).
    DOI: 10.1021/acs.biochem.0c00007
  4. Soma O., Hatakeyama S., Yoneyama T., Saito M., Sasaki H., Tobisawa Y., Noro D., Suzuki Y., Tanaka M., Nishimura S-I., Harada H., Ishida H., Tanabe K., Satoh S., Ohyama C.
    Serum N-glycan profiling can predict biopsy-proven graft rejection after living kidney transplantation
    Clin. Exp. Nephrol. 24, 174-184 (2020)
    DOI: 10.1007/s10157-019-01820-8
  5. Watanabe T., Kanayama M., Takahata M., Oda I., Suda K., Abe Y., Okumura J., Hojo Y., Iwasaki N.
    Perioperative complications of spine surgery in patients 80 years of age or older: a multicenter prospective cohort study
    J Neurosurg Spine., 32(4)622-630(2020)
    DOI: 10.3171/2019.9.SPINE19754
  6. Miyazaki T., Hanamatsu H., Xu L., Onodera T., Furukawa JI., Homan K., Baba R., Kawasaki T., Iwasaki N.
    Evaluation of Residual Human-Induced Pluripotent Stem Cells in Human Chondrocytes by Cell Type-Specific Glycosphingolipid Glycome Analysis Based on the Aminolysis-SALSA Technique
    Int J Mol Sci., 21(1), pii: E231. (2020)
    DOI: 10.3390/ijms21010231
  7. Kim W., Onodera T., Kondo E., Terkawi MA., Homan K., Hishimura R., Iwasaki N.
    Which contributes to meniscal repair, the synovium or the meniscus? An in vivo rabbit model study with the freeze-thaw method
    Am J Sports Med., 48(6)1406-1415(2020)
    DOI: 10.1177/0363546520906140
  8. Onodera T., Baba R., Kasahara Y., Tsuda T., Iwasaki N.
    Therapeutic effects and adaptive limits of an acellular technique by ultrapurified alginate (UPAL) gel implantation in canine osteochondral defect models
    Regen Ther., 14, 154-159 (2020)
    DOI: 10.1016/j.reth.2020.01.001
  9. Lee WS., Yasuda S., Kono M., Kudo Y., Shimamura S., Kono M., Fujieda Y., Kato M., Oku K., Shimizu T., Onodera T., Iwasaki N., Atsumi T.
    MicroRNA-9 ameliorates destructive arthritis through down-regulation of NF-κB1-RANKL pathway in fibroblast-like synoviocytes
    Clin Immunol., 212, 48-57 (2020)
    DOI: 10.1016/j.clim.2020.108348
  10. Matsui Y., Minami A., Kondo M., Ishikawa J., Motomiya M., Iwasaki N.
    A Minimum 5-Year Longitudinal Study of New Total Wrist Arthroplasty in Patients with Rheumatoid Arthritis
    J Hand Surg Am., 45(3), 255.e1 (2020)
    DOI: 10.1016/j.jhsa.2019.06.011
  11. Ukeba D., Sudo H., Tsujimoto T., Ura K., Yamada K., Iwasaki N.
    Bone marrow mesenchymal stem cells combined with ultra-purified alginate gel as a regenerative therapeutic strategy after discectomy for degenerated intervertebral discs
    EBioMedicine., 53, 102698 (2020)
    DOI: 10.1016/j.ebiom.2020.102698
  12. Usuki S., Yasutake Y., Tamura N., Tamura T., Tanji K., Saitoh T., MuraiY., Mikami D., Yuyama K., Monde K., Mukai K., Igarashi Y.
    Nrp1 is Activated by Konjac Ceramide Binding-Induced Structural Rigidification of the a1a2 Domain
    Cells, 9(2), 517 (2020)
    DOI: 10.3390/cells9020517
  13. Akiyama H., Ide M., Nagatsuka Y., Sayano T., Nakanishi E., Uemura N., Yuyama K., Yamaguchi Y., Kamiguchi H., Takahashi R., Aerts JMFG., Greimel P., Hirabayashi Y.
    Glucocerebrosidases catalyze a transgalactosylation reaction that yields a newly identified brain sterol metabolite, galactosylated cholesterol
    J. Biol.Chem., 295(16), 5257-5277(2020)
    DOI: 10.1074/jbc.RA119.012502
  14. Takakuwa A, Nakamura K, Kikuchi M, Sugimoto R, Ohira S, Yokoi Y, Ayabe T
    Butyric acid and leucine induce a-defensin secretion from small intestinal Paneth cells
    Nutrients 11, 2817 (2019)
    DOI: 10.3390/nu11112817
  15. Shimizu Y, Sakuragi N, Nakamura K, Taira T, Ayabe T, Fukui A
    A simple culture method for liver and intestinal tissue-resident macrophages from neonatal mice
    In Vitro Cell Dev Biol – Animal 55, 436-444 (2019)
    DOI: 10.1007/s11626-019-00359-y
  16. Yokoi Y, Nakamura K, Yoneda T, Kikuchi M, Sugimoto R, Shimizu Y, Ayabe T
    Paneth cell granule dynamics on secretory responses to bacterial stimuli in enteroids
    Sci Rep 9, 2710 (2019)
    DOI: 10.1038/s41598-019-39610-7
  17. Pillai MR, Mihi B, Ishiwata K, Nakamura K, Sakuragi N, Finkelstein DB, McGargill MA, Nakayama T, Ayabe T, Coleman ML, Bix M
    Myc-induced nuclear antigen constrains a latent intestinal epithelial cell-intrinsic anthelmintic pathway
    PLOS ONE 14, e0211244 (2019)
    DOI: 10.1371/journal.pone.0211244
  18. Matsumoto T., Hatakeyama S., Yoneyama T., Tobisawa Y., Ishibashi Y., Yamamoto H., Yoneyama T., Hashimoto Y., Ito H., Nishimura S-I., Ohyama C.
    Serum N-glycan profiling is a potential biomarker for castration-resistant prostate cancer
    Sci. Rep. 9, 168761 (2019)
    DOI: 10.1038/s41598-019-53384-y
  19. Koide R., Nishimura S-I.
    Antiadhesive nanosomes facilitate targeting of lysosomal GlcNAc salvage pathway through derailed cancer endocytosis
    Angew. Chem. Int. Ed. 58, 14513-14518 (2019)
    DOI: 10.1002/anie.201907778
  20. Hideshima S., Hayashi H., Hinou H., Nambuya S., Kuroiwa S., Nakanishi T., Momma T., Nishimura S-I., Sakoda Y., Osaka T.
    Glycan-immobilized dual-channel field effect transistor biosensor for the rapid identification of pandemic influenza viral particles
    Sci. Rep. 9, 11616 (2019)
    DOI: 10.1038/s41598-019-48076-6
  21. Hinou H.
    Aniline Derivative/DHB/Alkali Metal Matrices for Reflectron Mode MALDI-TOF and TOF/TOF MS Analysis of Unmodified Sialylated Oligosaccharides and Glycopeptides
    Int. J. Mass Specytom., 443, 109-115 (2019).
    DOI: 10.1016/j.ijms.2019.06.006
  22. Hinou H., Kikuchi S., Ochi R., Igarashi K., Takada W., Nishimura S-I.
    Synthetic glycopeptides reveal specific binding pattern and conformational change at O-mannosylated position of a-dystroglycan by POMGnT1 catalyzed GlcNAc modification.
    Bioorgan. Med. Chem. 27, 2822-2831 (2019)
    DOI: 10.1016/j.bmc.2019.05.008
  23. Gebrehiwot Abrha G., Seifu Melka D., Mamo Kassaye Y., Gemechu T., Lako W., Hinou H., Nishimura S-I.
    Exploring serum and Immunoglobulin G N-glycome as diagnostic biomarkers for early detection of breast cancer in Ethiopian women
    BMC Cancer 19, 588 (2019)
    DOI: 10.1186/s12885-019-5817-8
  24. Terkawi MA., Kadoya K., Takahashi D., Tian Y., Hamasaki M., Matsumae G., Alhasan H., Elmorsy S., Uetsuki K., Onodera T., Takahata M., Iwasaki N.
    Identification of IL-27 as potent regulator of inflammatory osteolysis associated with vitamin E-blended ultra-high molecular weight polyethylene debris of orthopedic implants
    Acta Biomater., 89, 242-251 (2019)
    DOI: 10.1016/j.actbio.2019.03.028
  25. Otomo N., Takeda K., Kawai S., Kou I., Guo L., Osawa M., Alev C., Kawakami N., Miyake N., Matsumoto N., Yasuhiko Y., Kotani T., Suzuki T., Uno K., Sudo H., Inami S., Taneichi H., Shigematsu H., Watanabe K., Yonezawa I., Sugawara R., Taniguchi Y., Minami S., Kaneko K., Nakamura M., Matsumoto M., Toguchida J., Watanabe K., Ikegawa S.
    Bi-allelic loss of function variants of TBX6 causes a spectrum of malformation of spine and rib including congenital scoliosis and spondylocostal dysostosis
    J Med Genet., 56, 622-628 (2019)
    DOI: 10.1136/jmedgenet-2018-105920
  26. Tsuji O., Suda K., Takahata M., Matsumoto-Harmon S., Komatsu M., Menjo Y., Watanabe K., Ishii K., Nakamura M., Matsumoto M., Minami A., Iwasaki N.
    Early surgical intervention may facilitate recovery of cervical spinal cord injury in DISH
    J Orthop Surg (Hong Kong)., 27(1), 2309499019834783 (2019)
    DOI: 10.1177/2309499019834783
  27. Iwata A., Abumi K., Takahata M., Sudo H., Yamada K., Endo T., Iwasaki N.
    Late Subaxial Lesion after Overcorrected Occipitocervical Reconstruction in Patients with Rheumatoid Arthritis
    Asian Spine J., 13(2), 181-188 (2019)
    DOI: 10.31616/asj.2018.0071
  28. Takeda K., Kou I., Otomo N., Grauers A., Fan YH., Ogura Y., Takahashi Y., Momozawa Y., Einarsdottir E., Kere J., Kawakami N., Tsuji T., Uno K., Suzuki T., Ito M., Minami S., Kotani T., Sakuma T., Yanagida H., Taneichi H., Yonezawa I., Sudo H., Chiba K., Hosogane N., Nishida K., Kakutani K., Akazawa T., Kaito T., Watanabe K., Harimaya K., Taniguchi Y., Shigematsu H., Demura S., Iida T., Kono K., Okada E., Fujita N., Yagi M., Matsumoto M., Qiu Y., Song YQ., Gerdhem P., Watanabe K., Ikegawa S.
    A multi-ethnic meta-analysis defined the association of rs12946942 with severe adolescent idiopathic scoliosis
    J Hum Genet., 64, 493-498 (2019)
  29. Hontani K., Onodera T., Terashima M., Momma D., Matsuoka M., Baba R., Joutoku Z., Matsubara S., Homan K., Hishimura R., Xu L., Iwasaki N.
    Chondrogenic differentiation of mouse induced pluripotent stem cells using the three-dimensional culture with ultra-purified alginate gel
    J Biomed Mater Res A., 107(5), 1086-1093 (2019)
    DOI: 10.1002/jbm.a.36615
  30. Yunoki S., Hatayama H., Ebisawa M., Kondo E., Yasuda K.
    A novel method for continuous formation of cord-like collagen gels to fabricate durable fibers in which collagen fibrils are longitudinally aligned
    J Biomed Mater Res B Appl Biomater., 107(4), 1011-1023 (2019)
    DOI: 10.1002/jbm.b.34194
  31. Aoyagi K., Wang H., Sudo H., Chiba A.
    Simple method to construct process maps for additive manufacturing using support vector machine
    Additive Manufacturing., 27, 353-362 (2019)
    DOI: 10.1016/j.addma.2019.03.013
  32. Endo K., Takahata M., Sugimori H., Yamada S., Tadano S., Wang J., Todoh M., Ito YM., Takahashi D., Kudo K., Iwasaki N.
    Magnetic Resonance Imaging T1 and T2 Mapping Provide Complementary Information on the Bone Mineral Density Regarding Cancellous Bone Strength in the femoral head of post-menopausal women with osteoarthritis
    Clin Biomech., 65, 13-18 (2019)
    DOI: 10.1016/j.clinbiomech.2019.03.010
  33. Yamaji T., Hanamatsu H., Sekizuka T., Kuroda M., Iwasaki N., Ohnishi M., Furukawa JI., Yahiro K., Hanada K.
    A CRISPR Screen Using Subtilase Cytotoxin Identifies SLC39A9 as a Glycan-Regulating Factor
    iScience., 15, 407-420 (2019)
  34. Ishizu H., Shimizu T., Kaibara T., Asano T., Terkawi MA., Takahashi D., Iwasaki N.
    Bilateral subchondral insufficiency fractures of the femoral head in a normally active adolescent patient: A case report
    J Orthop Sci., pii: S0949-2658(19), 30148-4 (2019)
  35. Matsuoka M., Onodera T., Majima T., Iwasaki K., Takahashi D., Kondo E., Iwasaki N.
    Correction osteotomy for bilateral varus knee deformity caused by premature epiphyseal closure induced by hypervitaminosis A: a case report
    BMC Musculoskelet Disord 15., 20(1), 287 (2019)
    DOI: 10.1186/s12891-019-2665-2
  36. Kawaguchi Y., Kondo E., Iwasaki N., Tanaka Y., Yagi T., Yasuda K.
    Autologous living chondrocytes contained in the meniscal matrix play an important role in in vivo meniscus regeneration induced by in situ meniscus fragment implantation
    Orthop Traumatol Surg Res., 105(4), 683-690 (2019)
    DOI: 10.1016/j.otsr.2018.12.017
  37. Yamamoto J., Nakazawa D., Nishio S., Ishikawa Y., Makita M., Kusunoki Y., Nagai S., Fujieda Y., Takahata M., Yamada K., Yamamura T., Yotsukura A., Saito M., Shimazaki M., Atsumi T.
    Impact of Weekly Teriparatide on the Bone and Mineral Metabolism in Hemodialysis Patients With Relatively Low Serum Parathyroid Hormone: A Pilot Study
    Ther Apher Dial., (2019)
    DOI: 10.1111/1744-9987.12867
  38. Endo T., Kadoya K., Suzuki Y., Kawamura D., Iwasaki N.
    A novel experimental model to determine the axon-promoting effects of grafted cells after peripheral nerve injury
    Frontiers in cellular neuroscience., 13, 280 (2019)
    DOI: 10.3389/fncel.2019.00280
  39. Liu J., Wu N; Deciphering Disorders Involving Scoliosis and COmorbidities (DISCO) study, Yang N., Takeda K., Chen W., Li W., Du R., Liu S., Zhou Y., Zhang L., Liu Z., Zuo Y., Zhao S., Blank R., Pehlivan D., Dong S., Zhang J., Shen J., Si N., Wang Y., Liu G., Li S., Zhao Y., Zhao H., Chen Y., Zhao Y., Song X., Hu J., Lin M., Tian Y., Yuan B., Yu K., Niu Y., Yu B., Li X., Chen J., Yan Z., Zhu Q., Meng X., Chen X., Su J., Zhao X., Wang X., Ming Y., Li X., Raggio CL., Zhang B., Weng X., Zhang S., Zhang X., Watanabe K., Matsumoto M., SudoH; Japan Early Onset Scoliosis Research Group, Jin L., Shen Y., Sobreira N., Posey JE., Giampietro PF., Valle D; Baylor-Hopkins Center for Mendelian Genomics, Liu P., Wu Z., Ikegawa S., Lupski JR., Zhang F., Qiu G.
    TBX6-associated congenital scoliosis (TACS) as a clinically distinguishable subtype of congenital scoliosis: further evidence supporting the compound inheritance and TBX6 gene dosage model
    Genet Med., 21, 1548-1558 (2019)
    DOI: 10.1038/s41436-018-0377-x
  40. Kokabu T., Kawakami N., Uno K., Kotani T., Suzuki T., Abe Y., Maeda K., Inage F., Ito YM., Iwasaki N., Sudo H.
    A three-dimensional depth sensor imaging in identifying adolescent idiopathic scoliosis: a prospective multicenter cohort study
    Sci Rep., 9, 9678 (2019)
    DOI: 10.1038/s41598-019-46246-0
  41. Iwasaki K., Inoue M., Kasahara Y., Tsukuda K., Kawahara H., Yokota I., Kondo E., Iwasaki N., Yasuda K.
    Inclination of Blumensaat's line influences on the accuracy of the quadrant method in evaluation for anterior cruciate ligament reconstruction
    Knee Surg Sports Traumatol Arthrosc., (2019)
    DOI: 10.1007/s00167-019-05619-8
  42. Homan K., Hanamatsu H., Furukawa JI., Okada K., Yokota I., Onodera T., Iwasaki N.
    Alteration of the Total Cellular Glycome during Late Differentiation of Chondrocytes
    Int J Mol Sci., 20(14), pii: E3546. (2019)
    DOI: 10.3390/ijms20143546
  43. Irie T., Takahashi D., Asano T., Shimizu T., Arai R., Terkawi AM., Ito YM., Iwasaki N.
    Effects of femoral bone defect morphology on initial polished tapered stem stability in massive defect model: a biomechanical study
    BMC Musculoskelet Disord., 20(1), 355 (2019)
    DOI: 10.1186/s12891-019-2716-8
  44. Kobayashi T., Ogawa K., Furukawa JI., Hanamatsu H., Hato M., Yoshinaga T., Morikawa K., Suda G., Sho T., Nakai M., Higashino K., Numata Y., Shinohara Y., Sakamoto N.
    Quantifying Protein-Specific N-Glycome Profiles by Focused Protein and Immunoprecipitation Glycomics
    J Proteome Res., 18(8), 3133-3141(2019)
    DOI: 10.1021/acs.jproteome.9b00232
  45. Kou I., Otomo N., Takeda K., Momozawa Y., Lu HF., Kubo M., Kamatani Y., Ogura Y., Takahashi Y., Nakajima M., Minami S., Uno K., Kawakami N., Ito M., Yonezawa I., Watanabe K., Kaito T., Yanagida H., Taneichi H., Harimaya K., Taniguchi Y., Shigematsu H., Iida T., Demura S., Sugawara R., Fujita N., Yagi M., Okada E., Hosogane N., Kono K., Nakamura M., Chiba K., Kotani T., Sakuma T., Akazawa T., Suzuki T., Nishida K., Kakutani K., Tsuji T., Sudo H., Iwata A., Sato T., Inami S., Matsumoto M., Terao C., Watanabe K., Ikegawa S.
    Genome-wide association study identifies 14 novel susceptibility loci for adolescent idiopathic scoliosis in Japanese
    Nat Commun., 10, 3685 (2019)
    DOI: 10.1038/s41467-019-11596-w
  46. Sugawara E., Kato M., Kudo Y., Lee W., Hisada R., Fujieda Y., Oku K., Bohgaki T., Amengual O., Yasuda S., Onodera T., Hatakeyama S., Atsumi T.
    Autophagy promotes citrullination of VIM (vimentin) and its interaction with major histocompatibility complex class II in synovial fibroblasts
    Autophagy., 1-10. (2019)
    DOI: 10.1080/15548627.2019.1664144
  47. Yamada K., Sudo H., Iwasaki N., Chiba A.
    Mechanical analysis of notch-free pre-bent rods for spinal deformity surgery
    Spine., 45(6)312-318, (2020)
    DOI: 10.1097/BRS.0000000000003269
  48. Ura K., Sudo H., Iwasaki K., Tsujimoto T., Ohnishi T., Ukeba D., Iwasaki N.
    Effects of intradiscal injection of local anesthetics on intervertebral disc degeneration in rabbit degenerated intervertebral disc
    J Orthop Res., 37, 1963-1971 (2019)
    DOI: 10.1002/jor.24347
  49. Matsubara S, Onodera T, Maeda E, Momma D, Matsuoka M, Homan K, Ohashi T, Iwasaki N.
    Depletion of glycosphingolipids induces excessive response of chondrocytes under mechanical stress
    J Biomech., 94, 22-30 (2019)
    DOI: 10.1016/j.jbiomech.2019.07.006
  50. Nagano Y., Kawamura D., Terkawi A., Urita A., Matsui Y., Iwasaki N.
    Minimum Ten-Year Outcomes of Partial Ulnar Nerve Transfer for Restoration of Elbow Flexion in Patients with Upper Brachial Plexus Injury
    J Hand Surg Asian Pac., 24(3), 283-288 (2019)
    DOI: 10.1142/S2424835519500358
  51. Shimodan S., Sato D., Takahashi K., Nakamura Y., Hyakkan R., Watanabe T., Hishimura R., Ota M., Shimizu H., Hojo Y., Hasegawa Y., Chubachi T., Yasui K., Tsujimoto T., Tsukuda Y., Asano T., Takahashi D., Takahata M., Iwasaki N., Shimizu T.
    Ten years change in post fracture care for hip fracture patients
    J Bone Miner Metab., (2019)
    DOI: 10.1007/s00774-019-01047-3
  52. Endo T., Kadoya K., Suzuki Y., Kawamura D., Iwasaki N.
    Evidence for cell-contact factor involvement in neurite outgrowth of DRG neurons stimulated by Schwann cells
    Experimental Physiology., 104(10), 1447-1454 (2019)
    DOI: 10.1113/EP087634
  53. Sato D., Kondo E., Yabuuchi K., Onodera J., Onodera T., Yagi T., Sakamoto K., Takasawa A., Iwasaki N., Yasuda K.
    Assessment of valgus laxity after release of the medial structure in medial open-wedge high tibial osteotomy: an in vivo biomechanical study using quantitative valgus stress radiography
    BMC Musculoskelet Disord., 20(1), 481 (2019)
    DOI: 10.1186/s12891-019-2859-7
  54. Shimizu H., Endo T., Takahata M., Yasui K., Sodeyama Y., Iwasaki N.
    Occipitoatlantoaxial rotatory fixation caused by minor traumatic occipitoatlantal rotatory fixation with compensatory counter-rotation in atlantoaxial joint: A case report
    J Orthop Sci., 2019 Oct 10
  55. Hanamatsu H., Nishikaze T., Tsumoto H., Ogawa K., Kobayashi T., Yokota I., Morikawa K., Suda G., Sho T., Nakai M., Miura N., Higashino K., Sekiya S., Iwamoto S., Miura Y., Furukawa JI., Tanaka K., Sakamoto N.
    Comparative Glycomic Analysis of Sialyl Linkage Isomers by Sialic Acid Linkage-Specific Alkylamidation in Combination with Stable Isotope Labeling of α2,3-Linked Sialic Acid Residues
    Anal Chem., 91(21), 13343-13348 (2019)
    DOI: 10.1021/acs.analchem.9b0361
  56. Baba R., Kondo E., Iwasaki K., Joutoku Z., Onodera J., Onodera T., Yagi T., Iwasaki N., Yasuda K.
    Impact of Surgical Timing on Clinical Outcomes in Anatomic Double-Bundle Anterior Cruciate Ligament Reconstruction Using Hamstring Tendon Autografts
    Orthop J Sports Med 15., 7(11), 2325967119880553 (2019)
    https://pubmed.ncbi.nlm.nih.gov/31799327/DOI: 10.1177/2325967119880553
  57. El-Sayed S., Rizk MA., Terkawi M., Igarashi I.
    Cocktail Babesia bovis antigens for global detection of Babesia bovis infection in cattle
    Exp Parasitol., 206, 107758 (2019)
    https://pubmed.ncbi.nlm.nih.gov/31521628/DOI: 10.1016/j.exppara.2019.107758
  58. Fujita R., Takahata M., Kokabu T., Oda I., Kajino T., Hisada Y., Takeuchi H., Iwasaki N.
    Retrospective study to evaluate the clinical significance of a second rise in C-reactive protein level following instrumented spinal fusion surgery
    J Orthop Sci., 24(6), 963-968 (2019)
    DOI: 10.1016/j.jos.2019.09.002
  59. Sakai Y., Kaito T., Takenaka S., Yamashita T., Makino T., Hosogane N., Nojiri K., Suzuki S., Okada E., Watanabe K., Funao H., Isogai N., Ueda S., Hikata T., Shiono Y., Watanabe K., Katsumi K., Fujiwara H., Nagamoto Y., Terai H., Tamai K., Matsuoka Y., Suzuki H., Nishimura H., Tagami A., Yamada S., Adachi S., Ohtori S., Orita S., Furuya T., Yoshii T., Ushio S., Inoue G., Miyagi M., Saito W., Imagama S., Ando K., Sakai D., Nukaga T., Kiyasu K., Kimura A., Inoue H., Nakano A., Harimaya K., Doi T., Kawaguchi K., Yokoyama N., Oishi H., Ikegami S., Futatsugi T., Shimizu M., Kakutani K., Yurube T., Oshima M., Uei H., Aoki Y., Takahata M., Iwata A., Seki S., Murakami H., Yoshioka K., Endo H., Hongo M., Nakanishi K., Abe T., Tsukanishi T., Ishii K.
    Complications after spinal fixation surgery for osteoporotic vertebral collapse with neurological deficits: Japan Association of Spine Surgeons with ambition multicenter study
    J Orthop Sci., 24(6), 985-990 (2019)
    DOI: 10.1016/j.jos.2019.08.015
  60. Watanabe K., Katsumi K., Ohashi M., Shibuya Y., Hirano T., Endo N., Kaito T., Yamashita T., Fujiwara H., Nagamoto Y., Matsuoka Y., Suzuki H., Nishimura H., Terai H., Tamai K., Tagami A., Yamada S., Adachi S., Yoshii T., Ushio S., Harimaya K., Kawaguchi K., Yokoyama N., Oishi H., Doi T., Kimura A., Inoue H., Inoue G., Miyagi M., Saito W., Nakano A., Sakai D., Nukaga T., Ikegami S., Shimizu M., Futatsugi T., Ohtori S., Furuya T., Orita S., Imagama S., Ando K., Kobayashi K., Kiyasu K., Murakami H., Yoshioka K., Seki S., Hongo M., Kakutani K., Yurube T., Aoki Y., Oshima M., Takahata M., Iwata A., Endo H., Abe T., Tsukanishi T., Nakanishi K., Watanabe K., Hikata T., Suzuki S., Isogai N., Okada E., Funao H., Ueda S., Shiono Y., Nojiri K., Hosogane N., Ishii K.
    Surgical outcomes of spinal fusion for osteoporotic vertebral fracture in the thoracolumbar spine: Comprehensive evaluations of 5 typical surgical fusion techniques
    J Orthop Sci., 24(6), 1020-1026 (2019)
    DOI: 10.1016/j.jos.2019.07.018
  61. Ota M., Tanaka Y., Nakagawa I., Jiang JJ., Arima Y., Kamimura D., Onodera T., Iwasaki N., Murakami M.
    Chondrocytes play a role in the development of rheumatoid arthritis via TMEM147-mediated NF-κB activation
    Arthritis Rheumatol., (2019)
    DOI: 10.1002/art.41182
  62. Ohnishi T., Yamada K., Iwasaki K., Tsujimoto T., Higashi H., Kimura T., Iwasaki N., Sudo H.
    Caspase-3 knockout inhibits intervertebral disc degeneration related to injury but accelerates degeneration related to aging
    Sci Rep., 9, 19324 (2019)
    DOI: 10.1038/s41598-019-55709-3
  63. Fujita R., Hamano H., Kameda Y., Arai R., Shimizu T., Ota M., Sato D., Kobayashi H., Iwasaki N., Takahata M.
    Breast cancer cells expressing cancer-associated sialyl-Tn antigen have less capacity to develop osteolytic lesions in a mouse model of skeletal colonization
    Clin Exp Metastasis., 36(6), 539-549 (2019)
    DOI: 10.1007/s10585-019-09999-6
  64. Momma D., Iwamoto W., Iwasaki N.
    Long-term stress distribution patterns across the wrist joint in gymnasts assessed by computed tomography osteoabsorptiometry
    J Hand Surg Eur., 44(10), 1098-1100 (2019)
    DOI: 10.1177/1753193419870037
  65. Kawamura D., Funakoshi T., Iwasaki N.
    Trapeziectomy with Ligament Reconstruction and Interposition Arthroplasty using the Palmaris Longus Tendon: An Average 5-Year Follow-Up
    Clin Orthop Surg., 11(4), 453-458 (2019)
    DOI: 10.4055/cios.2019.11.4.453
  66. Ogawa K., Kobayashi T., Furukawa JI., Hanamatsu H., Nakamura A., Suzuki K., Kawagishi N., Ohara M., Umemura M., Nakai M., Sho T., Suda G., Morikawa K., Baba M., Furuya K., Terashita K., Kobayashi T., Onodera M., Horimoto T., Shinada K., Tsunematsu S., Tsunematsu I., Meguro T., Mitsuhashi T., Hato M., Higashino K., Shinohara Y., Sakamoto N.
    Tri-antennary tri-sialylated mono-fucosylated glycan of alpha-1 antitrypsin as a non-invasive biomarker for non-alcoholic steatohepatitis: a novel glycobiomarker for non-alcoholic steatohepatitis
    Sci Rep., 10(1), 321 (2020)
    DOI: 10.1038/s41598-019-56947-1
  67. Endo T., Takahata M., Koike Y., Iwasaki N.
    Clinical characteristics of patients with thoracic myelopathy caused by ossification of the posterior longitudinal ligament
    J Bone Miner Metab., 38(1), 63-69 (2020)
    DOI: 10.1007/s00774-019-01026-8
  68. Yamaguchi T., Urita A., Endo T., Ota M., Iwasaki N.
    Charcot arthropathy of the shoulder joint in a patient with Guillain-Barre syndrome: A case report
    JBJS Cases Connector., 10(1), e0530 (2019)
  69. Usuki S., Tamura N., Tamura T., Tanji K., Mikami D., Mukai K., Igarashi Y.
    Neurite outgrowth and morphological changes induced by 8-trans unsaturation of sphingadienine in kCer molecular species
    Int. J. Mol. Sci., 20(9), (2019)
    DOI: 10.3390/ijms20092116
  70. Mikami D., Sakai S., Yuyama K., Igarashi Y.
    Isolation of sphingoid bases from starfish Asterias amurensis glucosylceramides and their effects on sphingolipid production in cultured keratinocytes
    J. Oleo Sci., 68(5), 427-441 (2019)
    DOI: 10.5650/jos.ess18256
  71. Othman MA., Yuyama K., Murai Y., Igarashi Y., Mikami D., Sivasothy Y., Awang K., Monde K.
    Malabaricone C as natural sphingomyelin synthase inhibitor against diet-induced obesity and its lipid metabolism in mice
    ACS Medicinal Chemistry Letters, 10(8), 1154-1158 (2019)
    DOI: 10.1021/acsmedchemlett.9b00171
  72. Yuyama K., Takahashi K., Usuki S., Mikami D., Sun H., Hanamatsu H., Furukawa J., Mukai K., Igarashi Y.
    Plant sphingolipids promote extracellular vesicle release and alleviate amyloid-β pathologies in a mouse model of Alzheimer’s disease
    Sci.Rep., 9(1), 16827 (2019)
    DOI: 10.1038/s41598-019-53394-w

Article

  1. Iwasaki N.
    Arthritis. Chapter 13 Glycans in Osseous Tissue and Articulation
    Glycoscience: Basic Science to Applications. (Ed. Naoyuki Taniguchi, Tamao Endo, Jun Hirabayashi, Shoko Nishimara, Kenji Kadomatsu, Kazunari Akiyoshi, Kiyoko F. Aoki-Kinoshita) (Springer Nature Singapore Pte Ltd.), 224-226 (2019)
  2. Sudo H., Abumi K.
    UPPER CERVICAL - C2 pedicle screw fixation technique (Heiko Koller / Yohan Robinson: Cervical Spine Surgery: Standard and Advanced Techniques, Springer)
    Chapter 37 - SURGICAL TECHNIQUES - , 259-264 (2019)

Int. Invited Lecture

  1. January 2020
    Bagalore, INDIA
    107th Indian Science Congress
    Chemical Glycobiology (Starting from Glycoconjugate Syntheses)
    Hinou H.
  2. May 2019
    Los Angeles, USA
    Hokudai-USC Research Workshop “Gut-Organ Crosstalk”
    Paneth cell in health and disease – an overview from intestinal homeostasis and inter organ network
    Ayabe T
  3. May 2019
    Los Angeles, USA
    Hokudai-USC Research Workshop “Gut-Organ Crosstalk”
    Dynamics and mechanisms of Paneth cell granule secretory responses in enteroids
    Yokoi Y, Nakamura K, Sugimoto R, Ohira S, Kikuchi M, Ayabe T
  4. May 2019
    Los Angeles, USA
    Hokudai-USC Research Workshop “Gut-Organ Crosstalk”
    Paneth cell α-defensin misfolding leads to dysbiosis and subsequent ileitis in a murine model of Crohn's disease
    Shimizu Y, Nakamura K, Kikuchi M, Shinozaki R, Ayabe T
  5. July 2019
    Sapporo, JAPAN
    APSBMS 2019 Annual Meeting
    Mid-sized drugs based on peptides & glycopeptides: from the chemical synthesis to the biological evaluation
    Garcia Martin Fayna Maria
  6. July 2019
    Tokyo, Japan
    60th ICBL
    Sphingolipid from basic to applied research.
    Igarashi Y.
  7. August 2019
    San Diego, USA
    Japanese-American Symposium on Applied & Translational Glycosciences, ACS Fall 2019 National Meeting
    Novel matrix system for reflectron mode MALDI-TOF and TOF/TOF MS analysis of unmodified sialylated oligosaccharides and glycopeptides
    Hinou H.
  8. October 2019
    Seoul, Korea
    The 63rd Annual Congress of the Korean Orthopaedic Associaton
    Inverted V-shaped high tibial osteotomy for medial osteoarthritis of the knee with severe varus deformity.
    Kondo E.

Int. Oral Presentation

  1. American Society for Cell Biology Annual Meeting 2019
    Acetylcholine-induced Paneth cell granule secretion via muscarinic M3 receptor in mouse small intestine
    Yokoi Y, Nakamura K, Sugimoto R, Ohira S, Kikuchi M, Ayabe T
  2. American Society for Cell Biology Annual Meeting 2019
    Paneth cell dysfunction in pathophysiology of nonalcoholic steatohepatitis
    Nakamura S, Nakamura K, Kikuchi M, Yokoi Y, Ohira S, Shimizu Y, Nishida T, Ayabe T
  3. April 2019
    Chengdu, China
    2019 Asia-Pacific knee, arthroscopy and sports medicine society and the 16th International forum on orthopedics sports medicine and arthroscopy
    Inverted V-shaped high tibial osteotomy for osteoarthritic knees with severe varus deformity.
    Kondo E.
  4. May 2019
    San Sebastian, Spain
    XXVIII Biennial Meeting of the Spanish Royal Association of Chemistry
    Probing the Effect of Iminosugars on Mucin 1 Glycopeptide–Antibody Recognition
    Garcia Martin Fayna Maria
  5. May 2019
    Cancun, Mexico
    The 12th biennial Congress of International Society of Arhroscopy, Knee Surgery and Orthopaedic Sports Medicine
    ACLR with remnant preservation: So what?
    Kondo E.
  6. May 2019
    Cancun, Mexico
    The 12th biennial Congress of International Society of Arthroscopy, Knee Surgery and Orthopaedic Sports Medicine
    Inverted V-shaped high tibial osteotomy for medial osteoarthritic knees with severe varus deformity.
    Kondo E.
  7. July 2019
    Sapporo, Japan
    Asia Pacific Society for Biology and Medical Sciences (APSBMS)
    A double-edged sword in aseptic loosening of total joint arthroplasty.
    Terkawi MA.
  8. October 2019
    Vancouver, Canada
    The 19th Annual meeting of International Cartilage Regeneration and Joint Preservation Society (ICRS 2019)
    Inflamed macrophages by articular cartilage fragments elicits typical gene expression signature of endochondral ossification in co-cultured chondrocytes.
    Onodera T.
  9. October 2019
    Seoul, Korea
    The 63rd Annual Congress of the Korea Orthopaedic Association
    The Effect of the First Metatarsal Shortening in the Modified Lapidus procedure.
    Onodera T.
  10. November 2019
    Nice, France
    The 59th International Spinal Cord Society Annual Scientific Meeting
    Age is a critical factor for segmental motor recovery after severe cervical spinal cord injury: Analysis of complete paralysis cases at 72 hours after injury.
    Kadoya K.

Global Collaboration Unit

Reviewed Paper

  1. Hirabayashi Y., Nakamura K., Sonehara T., Suzuki D., Hanzawa S., Shimizu Y., Aizawa T., Nakamura K., Tamakoshi A., Ayabe T.
    Analysis of Serotonin in Human Feces Using Solid Phase Extraction and Column-switching LC-MS/MS
    Mass Spectrometry, 8, A0081, (2020)
  2. Response surface method for polyhydroxybutyrate (PHB) bioplastic accumulation in Bacillus drentensis BP17 using pineapple peel.
    Penkhrue W., Jendrossek D., Khanongnuch C., Pathom-Aree W., Aizawa T., Behrens R.L., Lumyong S.
    PLoS One., 15(3), e0230443, (2020)
    DOI: 10.1371/journal.pone.0230443
  3. Nonoyama T., Lee Y.W., Ota K., Fujioka K., Hong W., Gong J.P.
    Instant Thermal Switching from Soft Hydrogel to Rigid Plastics Inspired by Thermophile Proteins
    Advanced Materials, 32(4), 1905878 (7 pages) (2020)
    https://onlinelibrary.wiley.com/doi/full/10.1002/adma.201905878DOI: 10.1002/adma.201905878
  4. Guo H., Uehara Y., Matsuda T., Kiyama R., Li L., Ahmed J., Katsuyama Y., Nonoyama T., Kurokawa T.
    Surface charges dominated protein adsorption on hydrogels
    Soft Matter, 16(7), 1897-1907 (2020)
    DOI: 10.1039/c9sm01999e
  5. Fukao K., Nakajima T., Nonoyama T., Kurokawa T., Kawai T., Gong J.P.
    Effect of Relative Strength of Two Networks on Internal Fracture Process of Double Network Hydrogels as Revealed by in situ Small-Angle X-ray Scattering
    Macromolecules, 53(4), 1154-1163 (2020)
    DOI: 10.1021/acs.macromol.9b02562
  6. Hui C.Y., Liu Z., Phoenix S.L., King D.R., Cui W., Huang Y., Gong J.P.
    Mechanical Behavior of Unidirectional Fiber Reinforced Soft Composites
    Extreme Mechanics Letters, 35, 100642 (13 pages) (2020)
    DOI: 10.1016/j.eml.2020.100642
  7. Hirayama S., Kurokawa T., Gong J.P.
    Non-Linear Rheological Study of Hydrogel Sliding Friction in Water and Concentrated Hyaluronan Solution
    Tribology International, 147, 106270 (7 pages) (2020)
    DOI: 10.1016/j.triboint.2020.106270
  8. Horie Y., Nemoto H., Fujita J., Ikegawa S., Kumaki Y., Ohnishi Y., Kumeta H., Demura M., Aizawa T.
    Studies on the Quality Control of Fermented Brown Rice and Rice Bran with Aspergillus oryzae by Metabolome Analysis Using 1H-NMR1H-NMR
    Nippon Shokuhin Kagaku Kogaku Kaishi, 66(4), 139-146, (2019)
    DOI: 10.3136/nskkk.66.139
  9. Yanagi T., Takagi T., Takahashi H., Kikukawa T., Amii H., Sonoyama M.
    Comparison of two different partially fluorinated phosphatidylcholines with the perfluorobutyl group on thermotropic properties of the bilayer membrane and reconstituted bacteriorhodopsin.
    Biophys. Rev., 11(3), 395-398, (2019)
  10. Yamanashi T., Maki M., Kojima K., Shibukawa A., Tsukamoto T., Chowdhury S., Yamanaka A., Takagi S., Sudo Y.
    Quantification of the neural silencing activity of anion channelrhodopsin in Caenorhabditis elegansand their applicability for long-term illumination
    Sci. Rep., 9(1), 7863, (2019)
    DOI: 10.1038/s41598-019-44308-x
  11. Geng X., Dai G., Chao L., Wen D., Kikukawa T., Iwasa T.
    Two Consecutive Polar Amino Acids at the End of Helix E are Important for Fast Turnover of the Archaerhodopsin Photocycle
    Photochemistry and Photobiology, 95(4), 980-989, (2019)
    DOI: 10.1111/php.13072
  12. Iizuka A., Kajimoto K., Fujisawa T., Tsukamoto T., Aizawa T., Kamo N., Jung K.H., Unno M., Demura M., Kikukawa T.
    Functional importance of the oligomer formation of the cyanobacterial H+ pump Gloeobacter rhodopsin
    Scientific Reports, 9(1), 10711, (2019)
    DOI: 10.1038/s41598-019-47178-5
  13. Fujisawa T., Kiyota H., Kikukawa T., Unno M.
    Low-Temperature Raman Spectroscopy of Halorhodopsin from Natronomonas pharaonis: Structural Discrimination of Blue-Shifted and Red-Shifted Photoproducts
    Biochemistry, 58(40), 4159-4167, (2019)
    DOI: 10.1021/acs.biochem.9b00643
  14. Sato T., Kikukawa T., Miyoshi R., Kajimoto K., Yonekawa C., Fujisawa T., Unno M., Eki T., Hirose Y.
    Protochromic absorption changes in the two-cysteine photocycle of a blue/orange cyanobacteriochrome
    J. Biol. Chem., 294(49), 18909-18922, (2019)
    DOI: 10.1074/jbc.RA119.010384
  15. Yasuda S., Akiyama T., Nemoto S., Hayashi T., Ueta T., Kojima K., Tsukamoto T., Nagatoishi S., Tsumoto K., Sudo Y., Kinoshita M., Murata T.
    Methodology for Further Thermostabilization of an Intrinsically Thermostable Membrane Protein Using Amino Acid Mutations with Its Original Function Being Retained
    J. Chem. Inf. and Model., 60(3), 1709-1716, (2020)
    DOI: 10.1021/acs.jcim.0c00063
  16. Poncet P., Aizawa T., Sénéchal H.
    The subtype of Cupressaceae pollinosis associated with Pru p 7 sensitization is characterized by a sensitization to a cross-reactive gibberellin-regulated protein in cypress pollen: BP14.
    Clin Exp Allergy, 49(8), 1163-1166, (2019)
    DOI: 10.1111/cea.13418
  17. Yamamura R., Nakamura K., Kitada N., Aizawa T., Shimizu Y., Nakamura K., Ayabe T., Kimura T., Tamakoshi A.
    Associations of gut microbiota, dietary intake, and serum short-chain fatty acids with fecal short-chain fatty acids.
    Biosci Microbiota Food Health., 39(1), 11-17, (2020)
    DOI: 10.12938/bmfh.19-010
  18. Mai T.T., Matsuda T., Nakajima T., Gong J.P., Urayama K.
    Damage Cross-effect and Anisotropy in Tough Double Network Hydrogels Revealed by Biaxial Stretching
    Soft Matter, 15(18), 3719-3732 (2019)
    DOI: 10.1039/c9sm00409b
  19. Huang Y., King D.R., Cui W., Sun T.L., Guo H., Kurokawa T., Brown H.R., Hui C.Y., Gong J.P.
    Superior Fracture Resistance of Fiber Reinforced Polyampholyte Hydrogels Achieved by Extraordinarily Large Energy-dissipative Process Zones
    Journal of Materials Chemistry A, 7(22), 13431-13440 (2019)
    DOI: 10.1039/c9ta02326g
  20. Guo H., Nakajima T., Hourdet D., Marcellan A., Creton C., Hong W., Kurokawa T., Gong J.P.
    Hydrophobic Hydrogels with Fruit-like Structure and Functions
    Advanced Materials, 31(25), 1900702 (2019)
    DOI: 10.1002/adma.201900702
  21. Hubbard A.M., Cui W., Huang Y., Takahashi R., Dickey M.D., Genzer J., King D.R., Gong J.P.
    Hydrogel/Elastomer Laminates Bonded via Fabric Interphases for Stimuli-Responsive Actuators
    Matter, 1(3), 674-689 (2019)
    DOI: 10.1016/j.matt.2019.04.008
  22. Matsuda T., Nakajima T., Gong J.P.
    Fabrication of Tough and Stretchable Hybrid Double-Network Elastomers Using Ionic Dissociation of Polyelectrolyte in Nonaqueous Media
    Chemistry of Materials, 31(10), 3766-3776 (2019)
    DOI: 10.1021/acs.chemmater.9b00871
  23. Chen L., Sun T.L., Cui K., King D.R., Kurokawa T., Saruwatari Y., Gong J.P.
    Facile Synthesis of Novel Elastomers with Tunable Dynamics for Toughness, Self-healing and Adhesion
    Journal of Materials Chemistry A, 7(29), 17334-17344 (2019)
    DOI: 10.1039/c9ta04840e
  24. Takahashi R., Ikai T., Kurokawa T., King D.R., Gong J.P.
    Double Network Hydrogels Based on Semi-rigid Polyelectrolyte Physical Networks
    Journal of Materials Chemistry B Emerging Investigators, 7(41), 6347-6354 (2019)
    DOI: 10.1039/c9tb01217f
  25. Zhang H.J., Luo F., Ye Y., Sun T.L., Nonoyama T., Kurokawa T., Nakajima T.
    Tough Triblock Copolymer Hydrogels with Different Micromorphologies for Medical and Sensory Materials
    ACS Applied Polymer Materials, 1(8), 1948-1953 (2019)
    DOI: 10.1021/acsapm.9b00395
  26. Khiêm V.N., Mai T.T., Urayama K., Gong J.P.,Itskov M.
    A Multi-axial Theory of Double Network Hydrogels
    Macromolecules, 52(15), 5937-5947 (2019).
    DOI: 10.1021/acs.macromol.9b01044
  27. Murai J., Nakajima T., Matsuda T., Tsunoda K., Nonoyama T., Kurokawa T., Gong J.P.
    Tough Double Network Elastomers Reinforced by the Amorphous Cellulose Network
    Polymer, 178, 121686 (7pages) (2019)
    DOI: 10.1016/j.polymer.2019.121686
  28. Murakawa K., King D.R., Sun T.L., Guo H., Kurokawa T., Gong J.P.
    Polyelectrolyte Complexation via Viscoelastic Phase Separation Results in Tough and Self-Recovering Porous Hydrogel
    Journal of Materials Chemistry B, 7(35), 5296-5305 (2019)
    DOI: 10.1039/c9tb01376h
  29. Frauenlob M., King D.R., Guo H., Ishihara S., Tsuda M., Kurokawa T., Haga H., Tanaka S., Gong J.P.
    Modulation and Characterization of the Double Network Hydrogel Surface-bulk Transition
    Macromolecules, 52(17), 6704-6713 (2019)
    DOI: 10.1021/acs.macromol.9b01399
  30. Qiao L., Du C., Gong J.P., Wu Z.L., Zheng Q.
    Programmed Diffusion Induces Anisotropic Superstructure in Hydrogel with High Mechano-Optical Sensitivity
    Advanced Materials Technologies, 4(11), 1900665 (2019)
    https://onlinelibrary.wiley.com/doi/abs/10.1002/admt.201900665DOI: 10.1002/admt.201900665
  31. King D.R., Okumura T., Takahashi R., Kurokawa T., Gong J.P.
    Macroscale Double Networks: Design Criteria for Optimizing Strength and Toughness
    ACS Applied Materials & Interfaces, 11(38), 35343-35353 (2019)
    DOI: 10.1021/acsami.9b12935
  32. Guo H., Hong W., Kurokawa T., Matsuda T., Wu Z.L., Nakajima T., Takahata M., Sun T.L., Rao P., Gong J.P.
    Internal Damage Evolution in Double-Network Hydrogels Studied by Microelectrode Technique
    Macromolecules, 52(18), 7114-7122 (2019)
    DOI: 10.1021/acs.macromol.9b01308
  33. Tao Z., Fan H., Huang J., Sun T.L., Kurokawa T., Gong J.P.
    Fabrication of Tough Hydrogels Composites from Photo-responsive Polymers to Show Double Network Effect
    ACS Applied Materials & Interfaces, 11(40), 37139-37146 (2019)
    DOI: 10.1021/acsami.9b13746
  34. Cui K., Ye Y.N., Sun T.L., Chen L., Li X., Kurokawa T., Nakajima T., Nonoyama T., Gong J.P.
    Effect of Structure Heterogeneity on Mechanical Performance of Physical Polyampholytes Hydrogels
    Macromolecules, 52(19), 7369-7378 (2019)
    DOI: 10.1021/acs.macromol.9b01676
  35. Nakajima T., Ozaki Y., Namba R., Ota K., Maida Y., Matsuda T., Kurokawa T., Gong J.P.
    Tough Double-Network Gels and Elastomers from the Non-Prestretched First Network
    ACS Macro Letters, 8(11), 1407-1412 (2019)
    DOI: 10.1021/acsmacrolett.9b00679
  36. Ye.Y.N., Cui K., Indei T., Nakajima T., Hourdet D., Kurokawa T, Gong J.P.
    Relaxation Dynamics and Underlying Mechanism of a Thermally Reversible Gel from Symmetric Triblock Copolymer
    Macromolecules, 52(22), 8651-8661 (2019)
    DOI: 10.1021/acs.macromol.9b01856
  37. Fan H., Wang J., Tao Z., Huang J., Rao P., Kurokawa K., Gong J.P.
    Adjacent Cationic-Aromatic Sequences Yield Strong Electrostatic Adhesion of Hydrogels in Seawater
    Nature Communications, 10, 5127 (2019)
    DOI: 10.1038/s41467-019-13171-9
  38. Kumagai Y,. Nio-Kobayashi J,. Ishida-Ishihara S,. Tachibana H,. Omori R,. Enomoto A,. Ishihara S,. Haga H.
    The intercellular expression of type-XVII collagen, laminin-332, and integrin-β1 promote contact following during the collective invasion of a cancer cell population.
    Biochemical and biophysical research communications, 514(4), 1115-1121 (2019)
    DOI: 10.1016/j.bbrc.2019.05.058
  39. Mizutani Y,. Kobayashi H,. Iida T,. Asai N,. Masamune A,. Hara A,. Esaki N,. Ushida K,. Mii S,. Shiraki Y,. Ando K,. Weng L,. Ishihara S,. Ponik SM,. Conklin MW,. Haga H,. Nagasaka A,. Miyata T,. Matsuyama M,. Kobayashi T,. Fujii T,. Yamada S,. Yamaguchi J,. Wang T,. Woods SL,. Worthley D,. Shimamura T,. Fujishiro M,. Hirooka Y,. Enomoto A,. Takahashi M.
    Meflin-Positive Cancer-Associated Fibroblasts Inhibit Pancreatic Carcinogenesis.
    Cancer research. 79, 5367-5381 (2019)
    https://cancerres.aacrjournals.org/content/79/20/5367DOI: 10.1158/0008-5472.CAN-19-0454

Article

  • Nonoyama T., Gong J.P.
    Meet the phase-separation polymeric gel
    The Innovation Platform, Issue 1, 73-74 (2020)

Int. Invited Lecture

  1. January 2020
    Ventura, USA
    2020 Gordon Research Conference on Multifunctional Materials and Structures
    Self-Growing Hydrogels Inspired by Biological Metabolism
    Nakajima T.
  2. May 2019
    Budapest, Hungary
    Frontiers in Polymer Science 2019
    Self-growing double network hydrogels by repetitive mechanical training
    Gong J.P.
  3. June 2019
    Xi'an, China
    The 3nd International Symposium for Advanced Gel Materials & Soft Matters
    Self-growing hydrogels by repetitive mechanical training
    Gong J.P.
  4. June 2019
    Shenzhen, China
    Joint Meeting of the 5th International Symposium of Flexible and Stretchable Electronics 2019 (ISFSE 2019) and the 5th International Workshop on Soft Machines and Mechanics 2019 (IWSMM 2019)
    Macroscale Double Networks: Design Criteria for Optimizing Strength and Toughness
    King D.R.
  5. June 2019
    Shenzhen, China
    Joint Meeting of the 5th International Symposium of Flexible and Stretchable Electronics 2019 (ISFSE 2019) and the 5th International Workshop on Soft Machines and Mechanics 2019 (IWSMM 2019)
    Bone-Inspired Soft Composite Possessing Osteo-Activity
    Nonoyama T.
  6. July 2019
    Guangzhou, China
    Seminar at South China University of Technology
    Macroscale Double Networks: A Universal Method for Improving the Strength and Toughness of Soft Materials
    King D.R.
  7. July 2019
    Guangzhou, China
    Seminar at South China University of Technology
    Bone-Inspired Soft Ceramics Possessing Osteo-Activity
    Nonoyama T.
  8. July 2019
    Kashiwa, Japan
    Seminar at the University of Tokyo
    Macroscale Double Networks: Extending the “Double Network Concept” to Large Length-Scales
    King D.R.
  9. July 2019
    Cork, Ireland
    ECI Colloidal, Macromolecular and Biological Gels II
    Macroscale Double Networks: Expanding the “Sacrificial Bond Concept” to Large Length-Scales
    King D.R.
  10. July 2019
    Capri, Italy
    DoDyNet Summer School
    Molecular design of self-growing hydrogels in response to mechanical training
    Gong J.P.
  11. July 2019
    Sapporo, Japan
    International Symposium on Biopolymer Synthesis and Degradation
    Quick & Reversible Thermo-Robustizing Hydrogels Exhibiting 1000 Times Modulus Jump
    Nonoyama T.
  12. August 2019
    Yangon, Myanmar
    International Congress on Pure & Applied Chemistry (ICPAC Yangon 2019)
    Activity Measurement of Polyelectrolyte in Hydrogels by Microelectrode Technique
    Kurokawa T.
  13. September 2019
    Beijing, China
    7th Asian Symposium on Advanced Materials (ASAM-7)
    Self-Growing Hydrogels by Mechanical Training
    Gong J.P.
  14. September 2019
    Fukui, Japan
    第68回高分子討論会(日韓ジョイントセッション)
    Self-growong gels inspired by metabolism
    Nakajima T.
  15. October 2019
    Tokyo, Japan
    JST CREST International Workshop : New Developments toward Wearable Photonics: From Materials to Devices CREST (「次世代フォトニクス」国際シンポジウム~ウェアラブルフォトニクスに向けた新しい展開:マテリアルからデバイスへ~)
    Self-growing materials under mechanical training
    Gong J.P.
  16. October 2019
    Xi’an, China
    2019 National Polymer Congress of CHINA / 2019年全国高分子学術論文報告会China-Japan Joint Symposium for Young Polymer Scientists
    Hydrogel Possessing Rubbery-to-Glassy Transition at Elevated Temperature
    Nonoyama T.
  17. October 2019
    Xi’an, China
    Seminar at Shaanxi University of Science & Technology, Shaanxi University of Science & Technology
    Robust Phase-Separation Induced Rubbery-to-Glassy Transition at Elevated Temperature
    Nonoyama T.
  18. November 2019
    Tokyo, Japan
    Millennium Science Forum (MSF)
    Strengthening materials using weak bonds-A novel strategy
    Gong J.P.
  19. November 2019
    Paris, France
    Seminar at ESPCI
    Self-Growing Hydrogels by Mechanical Training
    Gong J.P.
  20. December 2019
    Hyderabad, India
    2nd India-Japan Workshop on Magnetic Resonance
    Development and application of novel overexpression systems for NMR analysis of antimicrobial peptides
    Aizawa T.
  21. December 2019
    Tokyo, Japan
    CEMS International Symposium on Supramolecular Chemistry and Functional Materials 2019 (CEMSupra2019) (理化学研究所 創発物性科学研究センター 国際会議)
    Self-growing hydrogels by repetitive mechanical training
    Gong J.P.
  22. December 2019
    Yokohama, Japan
    Materials Research Meeting 2019 (MRM2019)
    Fiber Reinforced Hydrogels With Extra-Ordinarily High Toughness
    Gong J.P.
  23. December 2019
    Philadelphia, USA
    Seminar at University of Pennsylvania, University of Pennsylvania
    Macroscale Double Networks: Extending the “Double Network Concept” to Large Length-Scales
    King D.R.

Int. Oral Presentation

  1. February 2020
    Charleston, USA
    The Adhesion Society 43rd Annual Meeting
    Double network gels from semi-rigid polyelectrolyte physical networks with controlled anisotropy
    King D.R.
  2. July 2019
    Montreal, Canada
    The 2nd Conference on Multiscale Mechanochemistry and Mechanobiology
    Self-growing hydrogels through a metabolic-like mechanochemical process
    Nakajima T.
  3. October 2019
    Okinawa, Japan
    The 13th Pacific Rim Conference of Ceramic Societies (PACRIM13)
    Bioceramics Toughening Soft & Wet Materials
    Nonoyama T.
  4. November 2019
    Sapporo, Japan
    2nd ICReDD International Symposium
    Stress Responsive Disulfide Bond Reduction in Tough Double Network Hydrogels
    Nakajima T.
  5. December 2019
    Boston, USA
    2019 MRS Fall Meetings & Exhibits
    Macroscale Double Networks: A Universal Method for Improving the Strength and Toughness of Soft Materials
    King D.R.

Advanced Facility Unit

Reviewed Paper

  1. Koolath S., Murai, Y., Suga, Y., Monde, K.
    Chiral Combinatorial Preparation and Biological Evaluation of Unique Ceramides for Inhibition of Sphingomyelin Synthase
    Chirality, 32, 308-313 (2020)
    DOI: 10.1002/chir.23179
  2. Lkhamkhuu E., Zikihara K., Katsura H., Tokutomi S., Hosokawa T., Usami Y., Ichihashi M., Yamaguchi J., Monde K.
    Effect of Circularly Polarized Light on Germination, Hypocotyl Elongation and Biomass Production of Arabidopsis and Lettuce
    Involvement of Phytochrome B
    Plant Biotechnology, 37, 57-67 (2020)
    DOI: 10.5511/plantbiotechnology.19.1219a
  3. Koshino S., Takikawa A., Ishida K., Taniguchi T., Monde K., Kwon E., Umemiya S., Hayashi Y.
    Inversion of the axial information during oxidative aromatization in the synthesis of axially chiral biaryls using organocatalyst as a key step
    Chem. Eur. J., 26, 4524-4530 (2020)
    DOI: 10.1002/chem.201905814
  4. Usuki S., Yasutake Y., Tamura N., Tamura T., Tanji K., Saitoh T., Murai Y., Mikami D., Yuyama K., Monde K., Mukai K., Igarashi Y.
    Nrp1 is activated by kCer binding-induced structural rigidification of the a1a2 domain
    Cells 9, 517-535 (2020)
    DOI: 10.3390/cells9020517
  5. Sun X., Ye Y., Sakurai N., Kato K., Yuasa K., Tsuji A., Yao M.
    Crystallographic analysis of Eisenia hydrolysis-enhancing protein using a long wavelength for native-SAD phasing.
    Acta Crystallographica Section F Structural Biology Communications, 76, 20-24, (2020)
    DOI: 10.1107/S2053230X19016716
  6. Wang H., Yu J., Satoh Y., Nakagawa Y., Tanaka R., Kato K., Yao M.
    Crystal structures clarify cofactor binding of plant tyrosine decarboxylase
    Biochemical and Biophysical Research Communications, 523(2)500-505, (2020)
    DOI: 10.1016/j.bbrc.2019.12.077
  7. Mafy N., Matsuo K., Hiiruma S.,Uehara R.,Tamaoki N.,
    Photoswitchable CENP-E Inhibitor Enabling the Dynamic Control of Chromosome Movement and Mitotic Progression.
    J. Am. Chem. Soc., 142, 1763-1767, (2020)
    DOI: 10.1021/jacs.9b12782
  8. Goshima Y., Nakaoka S., Ohashi K., Sakamaki H., Shibuya K., Shibuya A.
    A mathematical model for dynamics of soluble form of DNAM-1 as a biomarker for graft-versus-host disease
    PLoS ONE, 15, e0228508 (2020)
    https://pubmed.ncbi.nlm.nih.gov/32040515/DOI: 10.1371/journal.pone.0228508
  9. Othman, M. A., Yuyama, K., Murai, Y., Igarashi, Y., Mikami, D., Sivasothy, Y., Awang, K., Monde, K.
    Malabaricone C as Natural Sphingomyelin Synthase Inhibitor against Diet-Induced Obesity and Its Lipid Metabolism in Mice
    ACS Med. Chem. Lett., 10, 1154-1158 (2019)
    DOI: 10.1021/acsmedchemlett.9b00171
  10. Okamura, H., Fujioka, T., Mori, N., Taniguchi, T., Monde, K., Watanabe, H., Takikawa, H.
    First enantioselective synthesis of salinipostin A, a marine cyclic enol-phosphotriester isolated from Salinispora sp
    Tetrahedron Lett., 60, 150917-150919 (2019)
    DOI: 10.1016/j.tetlet.2019.07.008
  11. Saaidin S. A., Murai, Y., Ishikawa, T., Monde, K.
    Design and Synthesis of Ligand‐Tag Exchangeable Photoaffinity Probe Utilizing Nosyl Chemistry.
    Eur. J. Org. Chem., 46, 7563-7567 (2019)
    DOI: 10.1002/ejoc.201901348
  12. Morishita Y., Okazaki Y., Yi Yi Luo, Nunoki J., Taniguchi T., Oshima Y., Asai T.
    Use of plant hormones to activate silent polyketide biosynthetic pathways in Arthrinium sacchari, a fungus isolated from a spider.
    Org. Biomol. Chem. 2019, 17, 780-784 (2019)
    DOI: 10.1039/c8ob02837k
  13. Christiane Kiske, Anja Devenie Riegel, Ronja Hopf, Anna Kvindt, Iulia Poplacean, Tohru Taniguchi, Mahadeva M. M. Swamy, Kenji Monde, Wolfgang Eisenreich, Karl-Heinz Engel;
    Determination of the Absolute Configurations and Sensory Properties of the Enantiomers of a Homologous Series (C6-C10) of 2-Mercapto-4-alkanones.
    J. Agric. Food Chem. 2019, 67, 1187-1196 (2019)
    DOI: 10.1021/acs.jafc.8b06599
  14. Takahashi S., Yamamoto J., Kitamura A., Kinjo M.,Sugimoto N.
    Characterization of Intracellular Crowding Environments with Topology-Based DNA Quadruplex Sensors
    Anal. Chem., 91(4), 2586–2590 (2019)
    DOI: 10.1021/acs.analchem.8b04177
  15. Sugihara M., Morito D., Ainuki S., Hirano Y., Ogino K., Kitamura A., Hirata H., Nagata K.
    The AAA+ ATPase/ubiquitin ligase mysterin stabilizes cytoplasmic lipid droplets
    J Cell Biol. 218(3), 949-960(2019)
    DOI: 10.1083/jcb.201712120
  16. Yamamoto J., Kinjo M.
    Full fiber-optic fluorescence correlation spectroscopy
    Optics Express, 27(10), 14835-14841(2019)
    DOI: 10.1364/OE.27.014835
  17. Aleksandar J. Krmpot., Stanko N., Nikolić, S Oasa., Dimitrios K., Papadopoulos., Marco Vitali., M Oura., S Mikuni., Per Thyberg., S Tisa., M Kinjo.,
    Lennart Nilsson., Lars Terenius., Rudolf Rigler., Vladana Vukojević
    Functional Fluorescence Microscopy Imaging: Quantitative Scanning-Free Confocal Fluorescence Microscopy for the Characterization of Fast Dynamic
    Processes in Live Cells
    Anal. Chem., 91(17), 11129-11137(2019)
    DOI: 10.1021/acs.analchem.9b01813
  18. Ye Y., Meirong C., Kato K., Yao M.
    The pH-dependent conformational change of eukaryotic translation initiation factor 5: Insights into partner-binding manner.
    Biochemical and Biophysical Research Communications, 519, 186-191, (2019)
    DOI: 10.1016/j.bbrc.2019.08.128
  19. Li L., Adachi M., Yu J., Kato K., Shinoda A., Ostermann A., E.Schrader T., Ose T., and Yao M.
    Neutron crystallographic study of heterotrimeric glutamine amidotransferase CAB
    Acta Crystallogr F Struct Biol Commun., 75, 193-196, (2019)
    DOI: 10.1107/S2053230X19000220
  20. Hashimoto T., Ye Y., Matsuno A.,Ohnishi Y., Kitamura A., Kinjo M., Abe S., Ueno T., Yao M., Ogawa T., Matsui T., and Tanaka, Y.
    Encapsulation of biomacromolecules by soaking and co-crystallization into porous protein crystals of hemocyanin
    Biochem. Biophys. Res. Commun., 509, 577-584, (2019)
    DOI: 10.1016/j.bbrc.2018.12.096
  21. Kumar Sasmal S., Takeuchi Y., Nakaoka S.
    T-cell mediated adaptive immunity and antibody-dependent enhancement in secondary dengue infection
    Journal of Theoretical Biology, 470, 50-63 (2019)
    DOI: 10.1016/j.jtbi.2019.03.010

Article

  1. Kitamura A., Kabayama K.
    Session 2SHP report―decoding intracellular architecture using visualizing device development
    and mathematical modeling
    Biophysical Reviews, (2020)
  2. Taniguchi T.
    The World of Solution-State Molecules Seen with Using Vibrational Circular Dichroism Spectroscopy.
    Chemistry and Education 2019, 66, 825-826. (written in Japanese)
  3. Nakaoka S., Matsuyama K.
    Information and statistical analysis pipeline for high-throughput RNA sequencing data
    Springer protocol Epidermis, 1-10 (2019)

Int. Invited Lecture

  1. July 2019
    A3 symposium (Sendai, Japan)
    Application of energy landscape analysis for cellular differentiation process
    Nakaoka S.
  2. October 2019
    Hunter Collage Seminor
    New York, NY
    Sphingosine Chemical Biology
    Monde K.
  3. November 2019
    The Fourth A3 Roundtable Meeting
    on Asia Chemical Probe Research Hub
    Sendai, Japan,
    Naturally Occurring Sphingomyelin Synthase Inhibitors against
    Diet-Induced Obesity and their Action Mechanism
    Monde K.
  4. November 2019
    Albanova, KTH Royal Institute of Technology (Stockholm, Sweden)
    QBP/OCS seminar
    Aggregation process of carboxyl terminal fragments of TDP-43
    Kitamura A.
  5. November 2019
    Karolinska Institutet (Stockholm, Sweden)
    Course Functional Fluorescence Microscopy Imaging (fFMI) in Biomedical Research
    FCS and FCCS in live cell
    Kitamura A. & Kinjo M.
  6. December 2019
    Adichunchanagiri Univerisy, Nagara, India
    Symposium “Recent Trends in Medicinal Chemistry”
    Sphingolipid Chemical Biology toward Drug Discovery from Nature
    Monde K.
  7. December 2019
    2nd Chemical Biology Workshop (ChemBiol Workshop)
    Nampo Hound Premier Hotel, Busan, Korea
    Naturally Occurring Sphingomyelin Synthase Inhibitors against
    Diet-Induced Obesity and their Action Mechanism
    Monde K.

Int. Oral Presentation

  1. July 2019
    The International Congress on Industrial and Applied Mathematics 2019 (Balencia, Spain)
    Derivation of potential energy function from quantitative cell survival data.
  2. October 2019
    4th Workshop on Virus Dynamics (Paris, France)
    A computational method to detect key factors associated with critical transition of gene expression profile in viral infection
    Nakaoka S.
  3. December 2019
    National Univ. of Singapore (シンガポール)
    アジア結晶学会
    Dynamic structure is requited for transslufursome on the Cys-tRNA(Cys) synthesis in indirect pathway
    Yao M.
  4. December 2019
    The 2019 International Symposium on Nonlinear Theory and Its Applications (Kuala Lumpur, Malaysia)
    Investigation of possible coherent metabolic modes in auxotrophic bacterial community
    Nakaoka S.