2011 : Division for Supporting Basic Science & Industrial Cooperation


  1. Nakamura K., Ayabe T.
    Paneth cells and stem cells in the intestinal stem cell niche and their association with inflammatory bowel disease.
    Inflammation Regeneration., 32, 53-60 (2012)
  2. Sato Y., Tomisawa S., Aizawa T., Sakai N., Kamiya M.,
    Kikukawa T., Kumaki Y., Demura M., Ayabe T., Kawano K.
    Conststruction of a novel expression system for cryptdin-4 by using inclusion body formation.
    Peptide Science 2011.,393-394 (2012)
  3. Son SH., Abe Y., Yuasa M., Yamagishi Y., Sakai N., Ayabe T., Yamada K.
    A systematic analysis of aromatic heterocyclic rings in solvatochromic fluorophores.
    Chem Lett., 40, 378-380 (2011)
  4. Masuda K., Sakai N., Nakamura K., Yoshioka S., Ayabe T.
    Bactericidal activity of mouse α-defensin, cryptdin-4 predominantly affects non-commensal bacteria.
    J Innate Immun., 3, 315-326 (2011)
  5. Masuda K., Nakamura K., Yoshioka S., Fukaya R., Sakai N., Ayabe T.
    Regulation of microbiota by antimicrobial peptides in the gut.
    Adv Otorhinolaryngol., 72, 97-99 (2011)
  6. Kurotaki D, Kon S, Bae K, Ito K, Matsui Y, Nakayama Y, Kanayama M, Kimura C, Narita Y, Nishimura T, Iwabuchi K, Mack M, van Rooijen N, Sakaguchi S, Uede T, Morimoto J.
    CSF-1-dependent red pulp macrophages regulate CD4 T cell responses.
    Journal Immunology.,186, 2229-2237 (2011)
  7. Kitajima M, Ito T, Tumes DJ, Endo Y, Onodera A, Hashimoto K, Motohashi S, Yamashita M, Nishimura T, Ziegler S, Nakayama T.
    Memory type 2 helper T cells induce long-lasting anti-tumor immunity by activating natural killer cells.
    Cancer Research., 71, 4790-4798 (2011)
  8. Tajima M, Wakita D, Satoh T, Kitamura H, Nishimura T.
    IL-17/IFN-γ double producing CD8+ T (Tc17/IFN-γ) cells: A novel cytotoxic T-cell subset converted from Tc17 cells by IL-12.
    International Immunology., 23, 71-79 (2011)
  9. Takahashi N, Ohkuri T, Homma S, Ohtake J, Wakita D, Togashi Y, Kitamura H, Todo S, Nishimura T.
    First clinical trial of cancer vaccine therapy with artificially synthesized helper/killer-hybrid epitope long peptide of MAGE-A4 cancer antigen.
    Cancer Science., 130, 150-153 (2012)
  10. Kobayashi M, Ashino S, Shiohama Y, Wakita D, Kitamura H, Nishimura T.
    IFN-γ elevates airway hyperresponsiveness via upregulation of neurokinin A/neurokinin-2 receptor signaling in a severe asthma model.
    European Journal Immunology., 42, 393-402 (2011)
  11. Majima T., Nishiike O., Sawaguchi N., Susuda K., Minami A.
    Patella Eversion Reduces Early Knee Range of Motion and Muscle Torque Recovery after Total Knee Arthroplasty: Comparison between Minimally Invasive Total Knee Arthroplasty and Conventional Total Knee Arthroplasty.
    Arthritis. 2011, 854651 (2011)
  12. Ding X., Takahata M., Akazawa T., Iwasaki N., Abe Y., Komatsu M., Murata M., Ito M., Abumi K., Minami A.
    Improved bioabsorbability of synthetic hydroxyapatite through partial dissolution-precipitation of its surface.
    J Mater Sci Mater Med.22(5), 1247-55 (2011)
  13. Onodera T., Majima T., Sawaguchi N., Kasahara Y., Ishigaki T., Minami A.
    Risk of deep venous thrombosis in drain clamping with tranexamic acid and carbazochrome sodium sulfonate hydrate in total knee arthroplasty.
    J Arthroplasty. 27(1), 105-8 (2012)
  14. Irie T., Majima T., Sawaguchi N., Funakoshi T., Nishimura S., Minami A.
    Biomechanical and histologic evaluation of tissue engineered ligaments using chitosan and hyaluronan hybrid polymer fibers: a rabbit medial collateral ligament reconstruction model.
    J Biomed Mater Res A. 97(2), 111-7. (2011)
  15. Nagahama K., Kanayama M., Togawa D., Hashimoto T., Minami A.
    Does alendronate disturb the healing process of posterior lumbar interbody fusion? A prospective randomized trial.
    J Neurosurg Spine. 14(4), (2011)
  16. Momma D., Iwasaki N., Oizumi N., Nakatsuchi H., Funakoshi T., Kamishima T., Tadano S., Minami A.
    Long-term stress distribution patterns across the elbow joint in baseball players assessed by computed tomography osteoabsorptiometry.
    Am J Sports Med. 39(2), 336-41 (2011)
  17. Hojo Y., Ito M., Abumi K., Kotani Y., Sudo H., Takahata M., Minami A.
    A late neurological complication following posterior correction surgery of severe cervical kyphosis.
    Eur Spine J. 20(6), 890-8 (2011)
  18. Kotani Y., Abumi K., Ito M, Sudo H., Abe Y., Minami A.
    Mid-term clinical results of minimally invasive decompression and posterolateral fusion with percutaneous pedicle screws versus conventional approach for degenerative spondylolisthesis with spinal stenosis.
    Eur Spine J. (2011) in press
  19. Oizumi N., Suenaga N., Funakoshi T., Yamaguchi H., Minami A.
    Recovery of sensory disturbance after arthroscopic decompression of the suprascapular nerve.
    J Shoulder Elbow Surg. (2011) in press
  20. Matsuhashi T., Iwasaki N., Kato H., Minami M., Minami A.
    Clinical outcomes of excision arthroplasty for Kienbock’s disease.
    Hand Surg. 16(3), 277-82 (2011)
  21. Matsuki H., Ishikawa J., Iwasaki N., Uchiyama S., Minami A., Kato H.
    Non-vascularized bone graft with Herbert-type screw fixation for proximal pole scaphoid nonunion.
    J Orthop Sci. 16(6), 749-55 (2011)
  22. Funakoshi T., Iwasaki N., Kamishima T., Nishida M., Ito Y., Nishida K., Motomiya M., Suenaga N., Minami A.
    In vivo vascularity alterations in repaired rotator cuffs determined by contrast-enhanced ultrasound.
    Am J Sports Med. 39(12), 2640-6 (2011)
  23. Iwasaki N., Nishida K., Motomiya M., Funakoshi T., Minami A.
    Arthroscopic-assisted repair of avulsed triangular fibrocartilage complex to the fovea of the ulnar head: a 2- to 4-year follow-up study.
    Arthroscopy. 27(10), 1371-8 (2011)
  24. Urita A., Matsuhashi T., Onodera T., Nakagawa H., Hato M., Amano M., Seito N., Minami A., Nishimura S., Iwasaki N.
    Alterations of high-mannose type N-glycosylation in human and mouse osteoarthritis cartilage.
    Arthritis Rheum. 63(11), 3428-38 (2011)
  25. Matsuhashi T., Nagahama K., Suenaga N., Oizumi N., Minami A.
    Midterm outcomes after humeral head replacement with rotator cuff repair in patients with syringomyelia shoulder neuroarthropathy: a report on three cases.
    J Shoulder Elbow Surg. 20(8), e8-15 (2011)
  26. Ito H., Tanino H., Yamanaka Y., Minami A., Matsuno T.
    Intermediate to long-term results of periacetabular osteotomy in patients younger and older than forty years of age.
    J Bone Joint Surg Am. 93(14), 1347-54 (2011)
  27. Abe Y., Ito M., Abumi K., Kotani Y., Sudo H., Minami A.
    A novel cost-effective computer-assisted imaging technology for accurate placement of thoracic pedicle screws.
    J Neurosurg Spine. 15(5), 479-85 (2011)
  28. Makabe H., Iwasaki N., Kamishima T., Oizumi N., Tadano S., Minami A.
    Computed tomography osteoabsorptiometry alterations in stress distribution patterns through the wrist after radial shortening osteotomy for Kienböck disease.
    J Hand Surg Am. 36(7), 1158-64 (2011)
  29. Sudo H., Minami A.
    Caspase 3 as a therapeutic target for regulation of intervertebral disc degeneration in rabbits.
    Arthritis Rheum. 63(6), 1648-57 (2011)
  30. Yamazaki H., Kato H., Uchiyama S., Iwasaki N., Ishikura H., Minami A.
    Long term results of early active extension and passive flexion mobilization following one-stage tendon grafting for neglected injuries of the flexor digitorum profundus in children.
    J Hand Surg Eur 36(4), 303-7 (2011)
  31. Iwasaki N., Kamishima T., Kato H., Funakoshi T., Minami A.
    A retrospective evaluation of magnetic resonance imaging effectiveness on capitellar osteochondritis dissecans among overhead athletes.
    Am J Sports Med. 40(3), 624-30 (2012)
  32. Inoue K., Suenaga N., Oizumi N., Tanaka Y., Minami A.
    A vascularized scapular graft for juvenile osteonecrosis of the humeral head.
    J Shoulder Elbow Surg. 21(4), e9-e13 (2012)
  33. Sukegawa A., Iwasaki N., Kasahara Y., Onodera T., Igarashi T., Minami A.
    Repair of Rabbit Osteochondral Defects by an Acellular Technique with an Ultrapurified Alginate Gel Containing Stromal Cell-Derived Factor-1.
    Tissue Eng Part A. (2012) in press
  34. Igarashi T., Iwasaki N., Kawamura D., Kasahara Y., Tsukuda Y., Ohzawa N., Ito M., Izumisawa Y., Minami A.
    Repair of articular cartilage defects with a novel injectable in situ forming material in a canine model.
    J Biomed Mater Res A. 100(1), 180-7 (2012)
  35. Motomiya M., Iwasaki N., Minami A.
    Index finger clawing associated with fracture of the distal radius.
    J Hand Surg Eur Vol. (2012) in press
  36. Kotani Y., Abumi K., Ito M., Sudo H., Takahata M., Nagahama K., Iwata A., Minami A.
    Impact of deep extensor muscle-preserving approach on clinical outcome of laminoplasty for cervical spondylotic myelopathy: comparative cohort study.
    Eur Spine J. (2012) in press
  37. Seito N., Yamashita T., Tsukuda Y., Matsui Y., Urita A., Onodera T., Mizutani T., Haga H., Fujitani N., Shinohara Y., Minami A., Iwasaki N.
    Interruption of glycosphingolipid synthesis enhances osteoarthritis development in mice.
    Arthritis Rheum. doi: 10.1002/art.34463 (2012) in press
  38. Motomiya M., Iwasaki N., Minami A.
    Cubital tunnel syndrome associated with arthrogryposis: a case report.
    Hand Surg. 17(1), 85-7 (2012)
  39. Nishida K., Iwasaki N., Funakoshi T., Motomiya M., Minami A.
    Prevention of instability of the proximal end of the radius after radial head resection using an anconeus muscle flap.
    Hand Surg. 17(1), 25-31 (2012)
  40. Momma D., Iwasaki N., Oizumi N., Fujisaki K., Funakoshi T., Abe Y., Kamishima T., Tadano S., Minami A.
    Alterations in stress distribution patterns through the forearm joint surface of the elbow in baseball players assessed using computed tomography osteoabsorptiometry.
    J Orthop Sci. (2012) in press
  41. Nishida K., Iwasaki N., Fujisaki K., Funakoshi T., Kamishima T., Tadano S., Minami A.
    Distribution of bone mineral density at osteochondral donor sites in the patellofemoral joint among baseball players and controls.
    Am J Sports Med. 40(4), 909-14 (2012)
  42. Shimizu T., Iwasaki N., Nishida K., Minami A., Funakoshi T.
    Glenoid Stress Distribution in Baseball Players Using Computed Tomography Osteoabsorptiometry: A Pilot Study.
    Clin Orthop Relat Res. (2012) in press
  43. Arai R., Tsuda M., Watanabe T., Ose T., Obuse C., Maenaka K., Minami A., Ohba Y.
    Simultaneous inhibition of Src and Aurora kinases by SU6656 induces therapeutic synergy in human synovial sarcoma growth, invasion and angiogenesis in vivo.
    Eur J Cancer. (2012) in press
  44. Majima T., Inoue M., Kasahara Y., Onodera T., Takahashi D., Minami A.
    Effect of the Japanese herbal medicine, Boiogito, on the osteoarthritis of the knee with joint effusion.
    Sports Med Arthrosc Rehabil Ther Technol. 4:3 (2012)
  45. Niimi, K., Nishioka, C., Miyamoto, T., Takahashi, E., Miyoshi, I., Itakura, C. Yamashita T.
    Impairment of neuropsychological behaviors in ganglioside GM3-knockout mice.
    Biochem Biophys Res Commun. 406 : 524-528. (2011)
  46. Mitsutake, S., Zama, K., Yokota, H., Yoshida, T., Tanaka, M., Mitsui, M., Ikawa, M., Okabe, M., Tanaka, Y., Yamashita, T., Takemoto, H., Okazaki, T., Watanabe, K.
    and Igarashi, Y.
    Dynamic modification of sphingmyelin in lipid microdomains controls development of obesity, fatty liver, and type 2 diabetes.
    J Biol Chem. 286 : 28544-28555. (2011)
  47. Ohyanagi, T., Nagahori, N., Shimawaki, K., Hinou, H., Yamashita, T., Sasaki,  A., Jin, T., Iwanaga, T., Kinjyo, M. and Nishimura, S.
    Importance of sialic acid residues illuminated by live animal imaging using phosphorylcholine self-assembled monolayers-coated quantum dots.
    J. Am. Chem. Soc. 133 : 12507-12517. (2011)
  48. Shinohara, Y., Takimori, S., Shimaoka, H., Furukawa, J., Yamashita, T., Amano, M,. Fujitani, N., Takegawa, Y., Hammarström, L., Kacskovics, I. and Nishimura S.
    Alteration of the N-glycome of bovine milk glycoproteins during early lactation.
    FEBS J. 278 : 3769-3781. (2011)
  49. Nagahori, N., Uchida, M., Kinjo, M. and Yamashita T.
    Use of carbohydrate-conjugated nanoparticles for an integrated approach to functional imaging of glycans and understanding of their molecular mechanisms.
    Curr. Pharmaceutical Biotech. in press.
  50. Nagafuku M, Okuyama K, Onimaru Y, Suzuki A, Odagiri Y, Yamashita T, Iwasaki K, Fujiwara M, Takayanagi M, Ohno I, Inokuchi J.
    CD4 and CD8 T cells require different membrane gangliosides for activation.
    Proc.Natl, Acad. Sci. In press
  51. Yokoyama M, Takegawa Y, Yamashita T.
    Establishment of an analytical method for sialyl glycoprotein extraction from the experimental hormone-induced estrous cycle of the mouse ovary.
    J. Glycomics & Lipidomics In press
  52. Nguyen S.V., Icatlo F.C. Jr., Nakano T., Isogai E., Hirose K., Mizugai H., Kobayashi-Sakamoto M., Isogai H., Chiba I.
    Anti-cell-associated glucosyltransferase immunoglobulin Y suppression of salivary mutans streptococci in healthy young adults.
    J Am Dent Assoc.,142(8), 943-749(2011)

Books etc

  1. 中村公則、綾部時芳
    実験医学、羊土社, 29 (18), 2955-2961 (2011)
  2. 綾部時芳,、中村公則
    臨床免疫・アレルギー科、科学評論社, 57 (1), 25-31 (2021)
  3. 綾部時芳
    FOOD STYLE21, 食品化学新聞社, 16 (3), 210-22 (2012)
  4. 西村孝司、脇田大功
    科学評論社 臨床免疫・アレルギー科 56(1),7-17 (2011)
  5. 西村孝司
    実地医療と臨床研究 1 がん特異的免疫治療の進歩と細胞治療の問題点
    科学評論社 腫瘍内科 8(5),470-477 (2011)
  6. 西村孝司、脇田大功、富樫裕二、北村秀光
    カレントテラピー 29(12), 61-66 (2011)
  7. 松井雄一郎、岩崎倫政、今重之、高橋大介、三浪明男、上出利光
    整形災害外科 54, 772-773 (2011)
  8. 岩崎倫政、本宮真、三浪明男
    手指のリウマチに対する手術治療の現況 関節リウマチ手関節に対する手術療法
    整形・災害外科 55, 157-153 (2012)
  9. 岩崎倫政
    臨床スポーツ医学 28, 493-495 (2011)
  10. 西田欽也、岩崎倫政 整形
    整形・災害外科 54, 1068-1069 (2011)
  11. 本宮真、岩崎倫政
    MB Orthopaedics 24, 25-32 (2011)
  12. 船越忠直、岩崎倫政、神島保、西田陸
    新しい医療技術 造影超音波による組織血流測定
    整形・災害外科 54, 963-968 (2011)
  13. 岩崎倫政
    MB Orthopaedics 25, 25-29 (2012)
  14. 松井雄一郎、岩崎倫政
    整形外科看護 17, 52-55 (2012)
  15. 本宮真、岩崎倫政
    変形性関節症まるごとガイド 手―手指のOA
    整形外科看護 17, 46-51 (2012)
  16. 岩崎倫政
    スキル関節鏡下手術アトラス、越智光夫、別府諸兄 文光堂、 東京, 40-46頁 (2011)
  17. 岩崎倫政
    三角線維軟骨複合体損傷 鏡視下縫合術
    整形外科手術イラストレイテッド7巻「手関節・手指の手術」. 戸山芳昭、三浪明男 中山書店、東京, 118-122 820129

Conference Activities & Talks

(Invited talk)

  1. September, 2011
    Sapporo, JAPAN
    XIII International Union of Microbiological Societies 2011 Congress (IUMS2011)
    Selection and regulation of intestinal microbiota by Paneth cell α-defensins
    Ayabe T, Nakamura K
  2. November, 2011
    Sapporo, JAPAN
    International Society for Nutraceuticals and Functional Foods Annual Conference (ISNFF2011)
    Foods-induced innate immune responses of Paneth cell α-defensin uncover novel functions of foods
    Ayabe T, Kuroishi A, Kobayashi M, Nakamura K

(Oral presentation)

  1. February, 2012
    San Francisco, CA
    Annual Meeting of Orthopaedic Research Society
    Ganglioside GM3 plays a critical role in pathogenesis of mice collagen-induced arthritis.
    Tsukuda Y, Yamashita T, Kanayama M, Seito N, Asano T, Minami A, Iwasaki N.
  2. July, 2011
    Okinawa, Japan
    7th Academic Congress of the Asian shoulder assocication (ACASA)
    A novel rotator cuff repair fixation technique -in vitro analyses and surgical outcomes-
    Funakoshi T, Sunega N, Oizumi N, Urita A.
  3. July, 2011
    Okinawa, Japan
    7th Academic Congress of the Asian shoulder assocication (ACASA)
    In vivo vascularity alterations in rotator cuff repair using contrast-enhanced ultrasound
    Fuankoshi T, Iwasaki N, Suenga N, Minami A.
  4. July, 2011
    Okinawa, Japan
    7th Academic Congress of the Asian shoulder assocication (ACASA)
    Predicting factors of humeral head replacement with rotator cuff repair or tendon transfer for cuff tear arthropathy
    Inoue K, Iwasaki N, Minami A.
  5. February, 2012
    San Fransisco, United States
    American Academy of Orthopaedic Surgeons (AAOS)
    Stress distribution of the glenoid in asymptomatic baseball players by computed-tomography osteoabsorptiometry
    Funakoshi T, Shimizu T, Iwasaki N, Nishida K, Motomiya M, Urita A, Matsui Y, Minami A, Suenaga N, Oizumi N.

Invited talk (in Japan)

  1. 2011年9月
  2. 2011年11月
  3. 2012年1月
    第27回IBD club in Hamamatsu
  4. 2012年3月
    αディフェンシンが解き明かす腸内環境と病気 ―自然免疫のパラダイムシフト―
  5. 2011年4月
  6. 2011年5月
  7. 2011年6月
  8. 2011年6月
  9. 2011年9月
    小野学園女子高等学校修学旅行 食育プログラム
  10. 2011年10月
  11. 2011年10月1日
  12. 2011年10月
  13. 2011年11月
    免疫バランスと健康 —子どもの未来と地域創造における重要性 —
  14. 2011年11月
  15. 2011年12月
  16. 2011年12月
    Helper/killer hybrid epitope long peptide (H/K-HELP)を用いた次世代がんワクチン細胞治療
  17. 2012年1月
  18. 2012年1月
  19. 2012年2月
  20. 2012年2月
    Helper/killer hybrid epitope long peptide (H/K-HELP)を用いた次世代癌ワクチン治療の開発
  21. 2011年6月
  22. 2011年9月
    第17回日本手外科学会 秋季教育研修会
  23. 2011年11月
  24. 2011年11月
  25. 2011年10月
    第23回 日本整形外科基礎学術集会 シンポジウム
  26. 2011年6月


  1. 2011/5/27(国際出願:PCT/JP2011/062209、優先権基礎出願:特願2010-122951)
  2. 2012/01/20(特願2012-009759)
  3. 2011/5/13(特許第4740369号)
  4. 2011/9/28(特許番号2010/03665)
  5. 2011/11/7(特許番号584869号)