HINOU HiroshiProfessor
- Laboratory
- Laboratory of Advanced Chemical Biology
- Research Theme
- Matrix life-chemistry research based on glycotyping technology and rapid synthesis of carbohydrates
- Research Keywords
organic chemistry, glycotechnology, glycomedicine, chemical biology, inhibitor, synthetic probe, mass spectrometry, microarray, infection, immunity, cancer, lectin, glycotyping
Overview of Research
Carbohydrates (glycans) are indispensable to living matter not only as essential energy sources but also as signal molecules of intra- and intercellular systems. Our interests are focused on glycotechnology to elucidate and utilize the function of carbohydrates as signal molecules, and on chemical biology towards a new age of medicinal science.
To achieve these targets, we are developing innovative synthetic methods and structural&functional analytical methods for glycoconjugates such as glycopeptides, glycolipids, and oligosaccharides. Development of probing systems using these glycoconjugates is also in progress to elucidate and apply the functions of glycans in living matter.
Inhibitors of glycosidases and glycosyltransferases are also an exciting research area. Development of ultra-rapid glycotyping technologies “Glycotyping” is in progress.
Charge
- School of Science:
Biological Science course (Macromolecular Functions), Core Laboratories - Graduate School of Life Science:
Division of Life Science, Transdisciplinary Life Science Course, Biosystem and Biomolecule Control Science
Message
I’m focusing on the study of chemistry and biological function of glycoconjugates as a key probe to next-generation life sciences.
Representative Publications
Bryan M. Montalban, Hiroshi Hinou* “Glycoblotting-Based Ovo-Sulphoglycomics Reveals Phosphorylated N-Glycans as a Possible Host Factor of AIV Prevalence in Waterfowls” ACS Infectious Diseases, 10, 650-661, 2024. https://doi.org/10.1021/acsinfecdis.3c00520
Bryan M. Montalban, Hiroshi Hinou* “Glycoblotting Enables Seamless and Straightforward Workflow for MALDI-TOF/MS-based Sulphoglycomics of N- and O-glycans” Proteomics, 23, 2300012, 2023. https://doi.org/10.1002/pmic.202300012
Shogo Urakami, Hiroshi Hinou* “Sodium-Doped 3-Amino-4-Hydroxybenzoic Acid: Rediscovered Matrix for Direct MALDI Glycotyping of O-linked Glycopeptides and Intact Mucins” Int. J. Mol. Sci. 24, 16836, 2023. https://doi.org/10.3390/ijms242316836
Lareno L. Villones Jr., Anna-Kristin Ludwig, Hiroyuki Kumeta, Seiya Kikuchi, Rika Ochi, Tomoyasu Aizawa, Shin-Ichiro Nishimura, Hans-Joachim Gabius, Herbert Kaltner,* Hiroshi Hinou* “Altering the Modular Architecture of Galectins Affects its Binding with Synthetic α-Dystroglycan O-Mannosylated Core M1 Glycoconjugates In situ” ChemBioChem, e202200783, 2023. https://doi.org/10.1002/cbic.202200783
Refer to HOKKAIDO UNIVERSITY RESEARCHERS DIRECTORY
Note
<Office Hour>
– Time: Anytime during the lecture period
– Place: Frontier-AMLS, 6F
Please contact in advance by E-mail.
E-mail: hinou[at]sci.hokudai.ac.jp
<Research seeds>
https://seeds.mcip.hokudai.ac.jp/en/view/396/
https://seeds.mcip.hokudai.ac.jp/en/view/395/
https://seeds.mcip.hokudai.ac.jp/en/view/381/
https://seeds.mcip.hokudai.ac.jp/en/view/119/
<Research Group Homepage>
https://sites.google.com/eis.hokudai.ac.jp/hinou
Affiliation
- Faculty of Advanced Life Science, Department of Advanced Transdisciplinary Sciences, Drug Discovery Research
- Frontier Research Center for Advanced Material and Life Science, Academia-Industry Collaboration Unit