Staff

HINOU HiroshiProfessor

Laboratory
Laboratory of Advanced Chemical Biology
Research Theme
Matrix life-chemistry research based on glycotyping technology and rapid synthesis of carbohydrates
Research Keywords

organic chemistry, glycotechnology, glycomedicine, chemical biology, inhibitor, synthetic probe, mass spectrometry, microarray, infection, immunity, cancer, lectin, glycotyping

Overview of Research

Carbohydrates (sugar chains) are indispensable to living matter not only as essential energy sources but also as signal molecules of intra- and intercellular systems. Our interests are focused on glycotechnology to elucidate and utilize the function of carbohydrates as signal molecules, and on chemical biology towards a new age of medicinal science.
To achieve these targets, we are developing innovative synthetic methods and structural&functional analytical methods for glycoconjugates such as glycopeptides, glycolipids, and oligosaccharides. Development of probing systems using these glycoconjugates is also in progress to elucidate and apply the functions of glycans in living matter.
Inhibitors of glycosidases and glycosyltransferases are also an exciting research area. Development of ultra-rapid glycotyping technologies “Glycotyping” is in progress.

Charge

Message

I’m focusing on the study of chemistry and biological function of glycoconjugates as a key probe to next-generation life sciences.

Representative Publications

Lareno L. Villones Jr., Anna-Kristin Ludwig, Hiroyuki Kumeta, Seiya Kikuchi, Rika Ochi, Tomoyasu Aizawa, Shin-Ichiro Nishimura, Hans-Joachim Gabius*, Hiroshi Hinou* “Exploring the In situ Pairing of Human Galectins toward Synthetic O-Mannosylated Core M1 Glycopeptides of α-Dystroglycan” Scientific Reports, 12, 17800, 2022. https://doi.org/10.1038/s41598-022-22758-0

Lareno L. Villones Jr., Anna-Kristin Ludwig, Hiroyuki Kumeta, Seiya Kikuchi, Rika Ochi, Tomoyasu Aizawa, Shin-Ichiro Nishimura, Hans-Joachim Gabius, Herbert Kaltner,* Hiroshi Hinou* “Altering the Modular Architecture of Galectins Affects its Binding with Synthetic α-Dystroglycan O-Mannosylated Core M1 Glycoconjugates In situ” ChemBioChem in press.

Shogo Urakami, Hiroshi Hinou* “Direct MALDI Glycotyping of Glycoproteins Toward Practical Subtyping of Biological Samples” ACS Omega, 7, 39280-39286, 2022. http://doi.org/10.1021/acsomega.2c05429

Erina Barada, Hiroshi Hinou* “BOA/DHB/Na: an Efficient UV-MALDI Matrix for High-Sensitivity and Auto-Tagging Glycomics” Int. J. Mol. Sci, 23, 12510, 2022. https://doi.org/10.3390/ijms232012510

Shogo Urakami, Hiroshi Hinou* “Glycan Selective MALDI In-source Decay Analysis of Intact Glycoprotein” Analysis & Sensing 2, e20210004, 2022. https://doi.org/10.1002/anse.202100040

Refer to HOKKAIDO UNIVERSITY RESEARCHERS DIRECTORY
(https://researchers.general.hokudai.ac.jp/profile/en.BoN81hZ5xVfjVZ08Md3jlg==.html)

Note

<Office Hour>
– Time: Anytime during the lecture period
– Place: Frontier-AMLS, 6F
Please contact in advance by E-mail.
E-mail: hinou[at]sci.hokudai.ac.jp

<Research seeds>
https://seeds.mcip.hokudai.ac.jp/en/view/396/
https://seeds.mcip.hokudai.ac.jp/en/view/395/
https://seeds.mcip.hokudai.ac.jp/en/view/381/
https://seeds.mcip.hokudai.ac.jp/en/view/119/

<Research Group Homepage>
https://sites.google.com/eis.hokudai.ac.jp/hinou

Affiliation