OSE ToyoyukiProfessor
- Laboratory
- Laboratory of Structural & Biological Chemistry
- Research Theme
- Protein science of signal trunsduction and natural product biosynthesis
- Research Keywords
protein chemistry, structure biology, virology, signal transduction, quantum biology
Overview of Research
We focus on machinery structure, molecular-molecular interaction, and chemical reaction mechanism of signal transduction pathways related to infectious disease. In addition to normal structural biology methodology, we would like to introduce neutron diffraction to understand quantum properties of biomolecules which govern the biology world.
Charge
- School of Science:
Biological Science course (Macromolecular Functions), Core Laboratories - Graduate School of Life Science:
Division of Life Science, Transdisciplinary Life Science Course, Bioinformation and Molecular Sciences
Message
Our goal is interlink of quantum-organic chemistry, hydrogen atom included protein structure, and cellular biology.
Representative Publications
The measles virus V protein binding site to STAT2 overlaps that of IRF9, Yuma Nagano, Aoi Sugiyama, Madoka Kimoto, Takuya Wakahara, Yasuyo Noguchi, Xinxin Jiang, Shinya Saijo, Nobutaka Shimizu, Nana Yabuno, Min Yao, Paul Gooley, Gregory Moseley, Takashi Tadokoro, Katsumi Maenaka, Toyoyuki Ose, Virol. 94, e01169-20 (2020)
Structural comparison of the C-terminal domain of functionally divergent lyssavirus P proteins, Aoi Sugiyama, Tomo Nomai, Xinxin Jiang, Miku Minami, Min Yao, Katsumi Maenaka, Naoto Ito, Paul R Gooley, Gregory W Moseley, Toyoyuki Ose, Biochem. Biophys. Res. Commun., 529 507 – 512 (2020)
Structural Elucidation of Viral Antagonism of Innate Immunity at the STAT1 Interface, Hossain MA, Larrous F, Rawlinson SM, Zhan J, Sethi A, Ibrahim Y, Aloi M, Lieu KG, Mok YF, Griffin MDW, Ito N, Ose T, Bourhy H, Moseley GW, Gooley PR., Cell Rep. 29, 1934-1945(2019)
Structure of MHC class I-like MILL2 reveals heparan-sulfate binding and interdomain flexibility, Mizuho Kajikawa, Toyoyuki Ose, Yuko Fukunaga, Yuki Okabe, Naoki Matsumoto, Kento Yonezawa, Nobutaka Shimizu, Simon Kollnberger, Masanori Kasahara & Katsumi Maenaka, Nature Commun. 9 4330 (2018)
Solution structure of an avirulence protein, AVR-Pia, from Magnaporthe oryzae, Toyoyuki Ose, Azusa Oikawa, Yukiko Nakamura, Katsumi Maenaka, Yuya Higuchi, Yuki Satoh, Shiho Fujiwara, Makoto Demura, Teruo Sone and Masakatsu Kamiya, Biomol. NMR 63, 229-35 (2015)
Refer to HOKKAIDO UNIVERSITY RESEARCHERS DIRECTORY
Note
<Office Hour>
– Time: Anytime during the lecture period
– Place: Science Bldg. No.5, 3F, #5-312
Please contact in advance by E-mail.
E-mail: structbio_ose[at]sci.hokudai.ac.jp
Affiliation
- Faculty of Advanced Life Science, Department of Advanced Transdisciplinary Sciences, X-Ray Structural Biology
- Frontier Research Center for Advanced Material and Life Science, Advanced Facility Unit