Excessive ER stress in Paneth cells causes dysbiosis and subsequent enteritis via production of reduced-formα-defensins. – Expected to develop novel therapeutics for many diseases associated with dysbiosis such as Crohn’s disease.
This research topic is related to the sustainable development goals (SDGs);
- GOOD HEALTH AND WELL-BEING
- INDUSTRY, INNOVATION AND INFRASTRUCTURE
Paneth cell α-defensin misfolding correlates with dysbiosis and ileitis in Crohn’s disease model mice
Yu Shimizu, Kiminori Nakamura, Aki Yoshii, Yuki Yokoi, Mani Kikuchi, Ryuga Shinozaki, Shunta Nakamura, Shuya Ohira, Rina Sugimoto, Tokiyoshi Ayabe, Life Science Alliance, DOI 10.26508/lsa.201900592
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