Study elucidated that secreted α-defensin from Paneth cells in the small intestine is lower in the elderly people than the middle-aged and involved in changes of the intestinal microbiota with aging. Further it showed previously unknown immunosenescence, which may contribute to maintaining health.
This research topic is related to the sustainable development goals (SDGs);
- GOOD HEALTH AND WELL-BEING
- DECENT WORK AND ECONOMIC GROWTH
- INDUSTRIAL INNOVATION AND INFRASTRUCTURE
Yu Shimizu, Kiminori Nakamura, Mani Kikuchi, Shigekazu Ukawa, Koshi Nakamura, Emiko Okada, Akihiro Imae, Takafumi Nakagawa, Ryodai Yamamura, Akiko Tamakoshi, Tokiyoshi Ayabe. Lower human defensin 5 in elderly people compared to middle-aged is associated with differences in the intestinal microbiota composition: the DOSANCO Health Study. GeroScience 2021. doi: 10.1007/s11357-021-00398-y