Laboratory of Molecular Cell Dynamics

Research Theme
Elucidation of cell / life systems based on molecule interaction analysis
Research Keywords

Fluorescence Correlation Spectroscopy, Fluorescence Cross Correlation Spectroscopy, single molecule detection, neurodegenerative disease, ALS, glaucoma, molecular interaction, Live cell imaging, proteostasis, protein aggregation, C. elegans


Overview of Research and Education

Research Contents: Biological system is the typical example of the general concept of supramolecule, where the numerous functions are originated from the complex interactions among the biologically active molecules, cells, tissues and organs. Using non-invasive techniques, such as optical method, our research is targeting the functions and structures of the system from the single molecule to cell and cells such as brain, for understanding supramolecular system. Furthermore, various new optical techniques are developing to analyze these systems and to establish the new methodology in biomedical field.

  1. Study of the higher cell function by optical imaging technique.
  2. Investigation of tissue spectroscopy using time-resolved technique and fluctuation spectroscopic techniques such as lifetime measurement, fluorescence correlation spectroscopy and single molecule detection.
  3. Spectroscopic analysis of formation and toxicity in neurodegenerative disorder-linked protein aggregation in the cell.

Laboratory of Molecular Cell Dynamics (pdf)



Kita-21 Nishi-11 Kita-ku, Sapporo, Hokkaido
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Representative Publications

Aleksandar J. Krmpot, Stanko N. Nikolić, Sho Oasa, Dimitrios K. Papadopoulos, Marco Vitali, Makoto Oura, Shintaro Mikuni, Per Thyberg, Simone Tisa, Masataka Kinjo, Lennart Nilsson, Lars Terenius, Rudolf Rigler, and Vladana Vukojević., Functional Fluorescence Microscopy Imaging: Quantitative Scanning-Free Confocal Fluorescence Microscopy for the Characterization of Fast Dynamic Processes in Live Cells, Anal. Chem 91(17), 11129-11137(2019)

Yamamoto J. and Kinjo M., Full fiber-optic fluorescence correlation spectroscopy, Optics Express, 27(10), 14835-14841 (2019)

Sugihara M, Morito D, Ainuki S, Hirano Y, Ogino K, Kitamura A, Hirata H, Nagata K, The AAA+ ATPase/ubiquitin ligase mysterin stabilizes cytoplasmic lipid droplets, J Cell Biol. 218(3), 949-960(2019)

Takahashi S., Yamamoto J., Kitamura A., Kinjo M.,Sugimoto N., Characterization of Intracellular Crowding Environments with Topology-Based DNA Quadruplex Sensors, Anal. Chem., 91(4), pp 2586–2590 (2019)

Kitamura A., Kinjo M., State-of-the-art Fluorescence Fluctuation-Based Spectroscopic Techniques for the Study of Protein Aggregation., Int. J. Mol. Sci., 19, 964, (2018)