Staff

ADACHI HiroakiAssociate Professor

Laboratory
Laboratory of Plant Immunity
Research Theme
Molecular mechanisms of pathogen recognition by plant immune receptors / Mechanisms of immune signal activation and regulation in plants
Research Keywords

Plant-microbe interaction, Plant immunity, Immune receptor, Effector, Signaling, Genome, Genetics, Biochemistry, Molecular biology, Plant physiology, Structural biology, Structure modeling, Gene editing

Overview of Research

In the field of plant pathology, I am particularly interested in plant immunity research. In our lab, we focus on plant NLR (nucleotide-binding leucine-rich repeat) immune receptors to understand the basic mechanisms underlying the diversity of pathogen recognition and the commonalities of immune induction. By integrating genome analysis, AI and protein structure analysis, we will predict the molecular functions of plant NLRs from genome sequence information and assess their molecular functions to comprehensively elucidate the plant NLR immune system.

Charge

Message

Driven by a passion to protect plants from disease, we conduct research on plant immunity. Pathogenic microorganisms are constantly evolving, and in some cases, host jump of pathogens can cause pandemics in agricultural fields. I hope you are interested in studying plant immunity to combat these pathogens.

Representative Publications

T. Sakai, A. Toghani, and H. Adachi: Phylogenomics of Plant NLR Immune Receptors to Identify Functionally Conserved Sequence Motifs, BIO-PROTOCOL, 14, (2024).

T. Sakai, M. P. Contreras, C. Martinez-Anaya, D. Lüdke, S. Kamoun, C.-H. Wu, and H. Adachi: The NRC0 gene cluster of sensor and helper NLR immune receptors is functionally conserved across asterid plants, The Plant Cell, 36, 3344-3361, (2024).

H. Adachi, T. Sakai, J. Kourelis, H. Pai, J. L. Gonzalez Hernandez, Y. Utsumi, M. Seki, A. Maqbool, and S. Kamoun: Jurassic NLR: Conserved and dynamic evolutionary features of the atypically ancient immune receptor ZAR1, The Plant Cell, 35, 3662-3685, (2023).

H. Adachi, T. Sakai, A. Harant, H. Pai, K. Honda, A. Toghani, J. Claeys, C. Duggan, T. O. Bozkurt, C.-H. Wu, and S. Kamoun: An atypical NLR protein modulates the NRC immune receptor network in Nicotiana benthamiana, PLoS Genetics, 19, e1010500, (2023).

Harant, H. Pai, T. Sakai, S. Kamoun, and H. Adachi: A vector system for fast-forward studies of the HOPZ-ACTIVATED RESISTANCE1 (ZAR1) resistosome in the model plant Nicotiana benthamiana, Plant Physiology, 188, 70-80, (2022).

H. Adachi, M. P. Contreras, A. Harant, C.-H. Wu, L. Derevnina, T. Sakai, C. Duggan, E. Moratto, T. O. Bozkurt, A. Maqbool, J. Win, and S. Kamoun: An N-terminal motif in NLR immune receptors is functionally conserved across distantly related plant species, eLife, 8, e49956, (2019).

Note

<Office Hour>
– Time: Anytime during the lecture period
– Place: Science Bldg. No.2, 3F, #2-318
Please contact in advance by E-mail.
E-mail: hadachi[at]sci.hokudai.ac.jp

Affiliation