2008年度：バイオミクスイノベーションハブ

発表論文

  1. Kimata Y., Matsuyama A., Nagao K., Furuya K., Obuse C., Yoshida M., Yanagida M.
    Diminishing HDACs by drugs or mutations promotes normal or abnormal sister chromatid separation by affecting APC/C and adherin.
    J Cell Sci., 121, 1107-18(2008).
  2. Tatsumi Y., Ezura K., Yoshida K., Yugawa T., Narisawa-Saito M., Kiyono T., Ohta S., Obuse C., Fujita M.
    Involvement of Human ORC and TRF2 in Pre-Replication Complex Assembly at Telomeres.
    Gene Cells., 13,1045-59(2008).
  3. Uehara R., Nozawa R., Tomioka A., Petry S., Vale R.D., Obuse C., Goshima G.
    The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells.
    Proc.Natl.Acad.Sci. USA., 106, 6998-7003(2009).
  4. Hanyu Y., Imai K K., Kawasaki Y., Nakamura T., Nakaseko Y., Nagao K., Kokubu A., Ebe M., Fujisawa A., Hayashi T., Obuse C., Yanagida M.
    S. pombe cell division cycle under limited glucose requires Ssp1 kinase, the putative CaMKK, and Sds23, a PP2A-related phosphatase inhibitor
    Genes to Cells., in press(2009).
  5. Perpelescu M., Nozaki N., Obuse C., Yang H., Yoda Y.
    Active establishment of centromeric CENP-A chromatin by RSF complex
    J.Cell Biol., 185, 397-407(2009).
  6. Baudino L., Nimmerjahn F., Shinohara Y., Furukawa J.-I., Petry F., Verbeek S., Nishimura S.-I., Ravetch V. J., and Izui S.,
    Impact of a Three Amino-Acid Deletion in the CH2 Domain of Murine IgG1 on Fc-associated Effector Functions
    J. Immunol., 181, 4107-12 (2008)
  7. Su F., Xu C., Taya M., Murayama K., Shinohara Y. and Nishimura S.-I.,
    Detection of Carcinoembryonic Antigens Using a Surface Plasmon Resonance Biosensor
    Sensors., 8, 4282-95 (2008)
  8. Nakagawa H., Ohira M., Hayashi S., Abe S., Saito S., Nagahori N., Monde K., Shinohara Y., Fujitani N., Kondo H., Akiyama S.-I., Nakagawara A., Nishimura S.-I.,
    Alterations in the glycoform of cisplatin-resistant human carcinoma cells are caused by defects in the endoplasmic reticulum-associated degradation system
    Cancer Lett., 270, 295–301 (2008)
  9. Baudino L., Shinohara Y., Nimmerjahn F., Furukawa J.-I., Nakata M., Martínez-Soria E., Petry F., Ravetch V. J., Nishimura S.-I., and Izui S.
    Crucial Role of Aspartic Acid at Position 265 in the CH2 Domain for Murine IgG2a and IgG2b Fc-associated Effector Functions
    J. Immunol., 181, 6664-9 (2008)
  10. Uematsu R., Shinohara Y., Nakagawa H., Kurogochi M., Furukawa J.-i, Miura Y., Akiyama M., Shimizu H., Nishimura S.-I.
    Glycosylation specific for adhesion molecules in epidermis and its receptor revealed by glycoform-focused reverse genomics
    Mol. Cell. Proteomics., 8, 232-44 (2009)
  11. Yamada M., Fujii K., Koyama K., Hirohashi S., Kondo T.
    The proteomic profile of pancreatic cancer cell lines corresponding to carcinogenesis and metastasis
    J. Proteomics Bioinform., 2, 1-18 (2009).
  12. Suehara Y., Kondo T., Seki K., Shibata T., Fujii K., Gotoh M., Hasegawa T., Shimada Y., Sasako M., Shimoda T., Kurosawa H., Beppu Y., Kawai A., Hirohashi S.
    Pfetin as a prognostic biomarker of gastrointestinal stromal tumors revealed by proteomics
    Clin. Cancer Res.,14, 1707-17 (2008).
  13. Matsuhashi T, Iwasaki N, Nakagawa H, Hato M, Kurogochi M, Majima T, Minami A, Nishimura SI.
    Alteration of N-glycans related to articular cartilage deterioration after anterior cruciate ligament transection in rabbits.
    Osteoarthritis Cartilage., 16, 772-8, (2008)
  14. Takegawa, Y., Ito, H., Keira, T., Deguchi, K., Nakagawa, H., Nishimura, S.-I.
    Profiling of N- and O-glycopeptides of　erythropoietin by capillary zwitterionic-type of hydrophilic interaction chromatography/electrospray ionization mass spectrometry
    J. Sep. Sci., 31, 1585-93 (2008)
  15. Takegawa, Y., Hato, M., Deguchi, K., Nakagawa, H., Nishimura, S.-I.
    Chromatographic deuterium isotope effects of derivatized N-glycans and N-glycopeptides in a zwitterionic type of hydrophilic interaction chromatography
    J. Sep. Sci., 31, 1594-7 (2008)
  16. Deguchi, K., Keira, T., Yamada, K., Ito, H., Takegawa, Y., Nakagawa, H., Nishimura, S.-I.
    Two-dimensional hydrophilic interaction chromatography coupling anion-exchange and hydrophilic interaction columns for separation of 2-pyridylamino derivatives of neutral and sialylated N-glycans
    J. Chromatogr. A., 1189, 169-74 (2008)

国際学会・口頭発表

  1. September 2008
    New York, U.S.A
    CSHL meeting on Dynamic organization of nuclear function
    A HP1-Interacting zinc-finger protein POGOZ/ZNF280E is involved in mitotic chromosome
    Nozawa R., Nagao K., Masuda H., Obuse C.

国内招待

  1. 2008年5月
    東京都
    平成20年度日本環境変異原学会公開シンポジウム
    「プロテオミクス技術を用いたヒト染色体の維持・伝達機構の解明」
    小布施力史
  2. 2008年8月
    札幌市
    17th Meeting of Methods in Protein Structure Analysis (MPSA2008)
    「タンパク質複合体解析のための新技術」
    小布施力史
  3. 2008年5月
    つくば市
    第56回質量分析総合討論会
    「Matrix-Dependent Selective Fragmentation (MDSF)法による糖鎖・糖ペプチドのMALDI-TOF/TOF解析」
    黒河内政樹
  4. 2008年12月
    札幌市
    バイオ知財セミナー
    「生体内の微量糖鎖分析による病理診断技術」
    古川潤一

特許

  1. 特許出願　3件
  2. 2009/3/6 （特願2009-53700）
    被検物質回収装置及び被検物質回収方法
    発明者：藤井清永、入江　勉、関口修司、久保田英博
  3. 2008/11/21 （特願2008-298819）
    細胞の状態を評価する方法
    発明者：西村紳一郎、天野麻穂、武川泰啓