1. Tsuji K., Satoh S., Mitsutake S,, Murakami I., Jeong-Ju Park; Qian Li; Young-Tae Chang; Sung-Kee Chung., Igarashi Y.
    Evaluation of synthetic sphingolipid analogs as ligands for peroxisome proliferator-activated receptors
    Bioorganic & Medicinal Chemistry Letters., 19, 1643-6 (2009).
  2. Akiyama T., Hamazaki S., Monobe Y., Nishimura H., Irei I., Igarashi Y., Sadahira Y.
    Sphingosine-1-phosphate receptor 1 is a useful adjunct for distinguishing vascular neoplasms from morphological mimics
    Virchows Archiv., 454, 217-22 (2008).
  3. Hara-Yokoyama M., Terasawa K., Kihara A., Kim J-W., Park S-j., Hirabayashi Y., Igarashi Y., Yanagishita M.
    Sphingosine kinase 2 inhibitor accelerates Fas-mediated cell death progression in A20/2J cells.
    The Open Bioactive Com. J., 1, 22-7 (2008).
  4. Sato T., Nagafuku M., Shimizu K., Taira T., Igarashi Y., Inokuchi J-I.
    Physiological levels of insulin and IGF-1 synergistically enhance the differentiation of mesenteric adipocytes.
    Cell Biol Int., 32, 1397-404 (2008).
  5. Sato T., Nihei Y., Nagafuku M., Tagami S., Chin R., Kawamura M., Miyazaki S., Suzuki M., Sugahara S-i., Takahashi Y., Saito A., Igarashi Y., Inokuchi J-I.
    Circulating levels of ganglioside GM3 in metabolic syndrome: Apilotstudy.
    Obesity Research & Clinical Practice., 2, :231-8 (2008).
  6. Yamanaka M., Anada Y., Igarashi Y.
    A splicing isoform of LPP1, LPP1a, exhibits high phosphatase activity toward FTY720 phosphate.
    BBRC., 375, 675-9 (2008).
  7. Akiyama T., Sadahira Y., Matsubara K., Mori M., Igarashi Y.
    Immunohistochemical detection of sphingosine-1-phosphate receptor 1 in vascular andlymphatic endothelial cells.
    Journal of Molecular Histology., 39, 527-33 (2008).
  8. Mizutani Y., Kihara A., Chiba H., Tojo H., and Igarashi Y.
    Synthesis of 2-hydroxy-ceramide by ceramide synthase family members: enzymatic basis for the preference of fatty acid chain length in cultured cell models
    J. Lipid Res., June 9 (2008).
  9. Ikeda M., Kanao Y., Yamanaka M., Sakuraba H., Mizutani., Igarashi Y., Kihara A.
    Characterization of four mammalian 3-hydroxyacyl-CoA dehydratases involved in very long-chain fatty acid synthesis.
    FEBS Lett., 582, 2435-40 (2008).
  10. Shi YX., Yoo HS., Lee YM., Kihara A., Igarashi Y., So HY., Yim YH.
    A sphingosine kinase activity assay using direct infusion electrospray ionization tandem mass spectrometry.
    Anal. Biochem., 380, 35-40 (2008).
  11. Tsuji K., Mitsutake S., Yokose U., Sugiura, M., Kohama T. & Igarashi Y.
    Role of ceramide kinase in peroxisome proliferator-activated receptor beta-induced cell survival of mouse keratinocytes.
    FEBS J., 275, 3815-26 (2008).
  12. Kihara A. & Igarashi Y.
    Production and release of sphingosine 1-phosphate and the phosphorylated form of the immunomodulator FTY720.
    Biochim Biophys Acta., 1781, 496-502 Review
  13. Tomiyama T., kaihou S., Ishida M., Nishikawa H., Yamazaki N., Tsuji K., Mitsutake S.,& Igarashi Y.
    The water retention effects and action for atopic dermatitis-like symptoms of ethyl alcohol extracts ( from Tamogi-take mushroom) on animal model of atopic dermatitis.
    J. Jpn. Soc. Nutr. Food Sci., 61, 21-6 (2008).
  14. Kohno T., Igarashi Y.
    Attenuation of cell motility observed with high doses of sphingosine 1-phosphate or phosphorylated FTY720 involves RGS2 through its interactions with the receptor S1P1.
    Gene Cell., 13, 747-57 (2008).
  15. Kihara A., Sakuraba H., Ikeda M., Denpoh A., Igarashi Y.
    Membrane topology and essential amino acid residues of PHS1, a 3-hydoroxyacyl-CoA Dehydratase involved in very long-chain fatty acid elongation.
    J. Biol. Chem., 11199-209 (2008).
  16. Ikeda M., Kihara A., Denpoh A., Igarashi Y.
    The Rim101 pathway is involved in Rsb1 expression induced by altered lipid asymmetry.
    Mol. Biol. Cell., 19, 1922-31 (2008).
  17. Hinou H., and Nishimura S.-I.
    Mechanism-Based Probing, Characterization, and Inhibitor Design of Glycosidases and Glycosyltransferases.
    Curr. Top. Med. Chem., 9, 106-116 (2009)
  18. Hachisu M., Hinou H., Takamichi M., Tsuda S., Koshida S., and Nishimura S.-I.
    One-pot synthesis of cyclic antifreeze glycopeptides .
    Chem. Commun., 1641-3 (2009)
  19. Kondo N., Nishimura S.-I.
    MALDI-TOF mass spectrometry-based versatile method for the characterization of protein kinases.
    Chem. Eur. J., 15, 1413-21 (2009)
  20. Uematsu R., Shinohara Y., Nakagawa H., Kurogochi M., Furukawa J.-i, Miura Y., Akiyama M., Shimizu H., Nishimura S.-I.
    Glycosylation specific for adhesion molecules in epidermis and its receptor revealed by glycoform-focused reverse genomics.
    Mol. Cell. Proteom., 8, 232-44 (2009)
  21. Nagahori N., Abe M., Nishimura S.-I.
    Structural and functional glycosphingolipidomics by glycoblotting with aminooxy-functionalized gold nanoparticle.
    Biochemistry., 48, 583-94 (2009)
  22. Gao X-D, Moriyama S, Miura N, Dean N and Nishimura S-I.
    Interaction between the C-termini of Alg13 and Alg14 mediate formation of the active UDP-N-acetylglucosamine transferase complex.
    J. Biol. Chem., 283, 32534-41 (2008)
  23. Kouno T., Fujitani N., Mizuguchi M., Osaki T., Nishimura S.-I., Kawabata S-i, Aizawa T., Demura M., Nitta K., Kawano K.
    A Novel β-defensin Structure: a Strategy of Big Defesin for a Resistance by Gram-positive Bacteria.
    Biochemistry., 47, 10611-9 (2008)
  24. Sadamoto R., Matsubayashi T., Shimizu M., Ueda T., Koshida S., Koda T., and Nishimura S.-I.
    Bacterial surface engineering utilizing glucosamine phosphate derivatives as cell wall precursor surrogates.
    Chem. Eur. J., 14,10192-5 (2008)
  25. Shimizu H., Yoshimura Y., Hinou H., Nishimura S.-I.
    A New Glycosylation Method Part III: Study of Microwave Effects at Low Temperatures to Control Reaction Pathways and Reduce.
    Tetrahedron., 64,10091-6(2008)
  26. Baudino L., Shinohara Y., Nimmerjahn F., Furukawa J.-I., Nakata M., Martínez-Soria E., Petry F., Ravetch V. J., Nishimura S.-I., and Izui S.
    Crucial Role of Aspartic Acid at Position 265 in the CH2 Domain for Murine IgG2a and IgG2b Fc-associated Effector Functions.
    J. Immunol., 181, 6664-9 (2008)
  27. Nakagawa H., Ohira M., Hayashi S., Abe S., Saito S., Nagahori N., Monde K., Shinohara Y., Fujitani N., Kondo H., Akiyama S.-I., Nakagawara A., Nishimura S.-I.
    Alterations in the glycoform of cisplatin-resistant human carcinoma cells are caused by defects in the endoplasmic reticulum-associated degradation system.
    Cancer Lett., 270, 295–301 (2008)
  28. Averbeck N., Gao X-D., Nishimura S.-I., and Dean N.
    Alg13, the catalytic subunit of the ER UDP-GlcNAc glycosyltransferase, is a target for proteasomal degradation.
    Mol. Biol. Cell., 19, 2169-78 (2008)
  29. Su F., Xu C., Taya M., Murayama K., Shinohara Y. and Nishimura S.-I.
    Detection of Carcinoembryonic Antigens Using a Surface Plasmon Resonance Biosensor.
    Sensors., 8, 4282-95 (2008)
  30. Baudino L., Nimmerjahn F., Shinohara Y., Furukawa J.-I., Petry F., Verbeek S., Nishimura S.-I., Ravetch V. J., and Izui S.
    Impact of a Three Amino-Acid Deletion in the CH2 Domain of Murine IgG1 on Fc-associated Effector Functions.
    J. Immunol., 181, 4107-12 (2008)
  31. Sasaki T., Iwasaki N., Kohno K., Kishimoto M., Majima T., Nishimura S.-I., and Minami A.
    Magnetic nanoprticles for improving cell invasion in tissue engineering.
    J. Biomed. Mater. Res. A., 86, 969-78 (2008)
  32. Takegawa Y., Hato M., Deguchi K., Nakagawa H., Nishimura S.-I.
    Chromatographic deuterium isotope effects of derivatized N-glycans and N-glycopeptides in a zwitterionic type of hydrophilic interaction chromatography.
    J. Sep. Sci., 31, 1594-7 (2008)
  33. Takegawa Y., Ito H., Keira T., Deguchi K., Nakagawa H., Nishimura S.-I.
    Profiling of N- and O-glycopeptides of erythropoietin by capillary zwitterionic-type of hydrophilic interaction chromatography/electrospray ionization mass spectrometry.
    J. Sep. Sci., 31, 1585-93 (2008)
  34. Kasahara Y., Iwasaki N., Yamane S., Igarashi T., Majima T., Nonaka S., Harada K., Nishimura S.-I., and Minami A.
    Development of mature cartilage constructs using novel three-dimensional porous scaffolds for enhanced repair of osteochondral defects.
    J. Biomed. Mater. Res. Part A., 86A, 127-36 (2008)
  35. *Li, F., *ten Dam, G. B., Murugan, S., Yamada, S., Hashiguchi, T., Mizumoto, S., Oguri, K., Okayama, M., van Kuppevelt, T. H., Sugahara, K. (*Equal contribution)
    Involvement of highly sulfated chondroitin sulfate in the metastasis of the Lewis lung carcinoma cells.
    J. Biol. Chem., 283, 34294-304 (2008).
  36. Kitagawa, H., Tsutsumi, K., Ikegami-Kuzuhara, Nadanaka, S., A., Goto, F., Ogawa, T., Sugahara, K.
    Sulfation of the galactose residues in the glycosaminoglycan-protein linkage region by recombinant human chondroitin 6-O-Sulfotransferase-1.
    J. Biol. Chem., 283, 27438-43 (2008).
  37. *van Roij, M.H.H., *Mizumoto,S., Yamada, S., Morgan, Tim., Tan-Sindhunata, M.B., Meijers-Heijboer, H., Verbeke, J.I.L.M., Markie, D., Sugahara, K., Robertson, S. P. (*Equal contribution)
    Spondyloepiphyseal dysplasia, Omani type: further definition of the phenotype.
    Am. J. Med. Genet., 146A, 2376-84 (2008).
  38. Tone, Y., Pedersen, L. C., Yamamoto, T., Izumikawa, T., Kitagawa, H., Nishihara, J., Tamura, J., Negishi, M., Sugahara, K.
    2-O-Phosphorylation of xylose and 6-O-sulfation of galactose in the protein linkage region of glycosaminoglycans influence the glucuronyltransferase-I activity involved in the linkage region’s synthesis.
J. Biol. Chem., 283, 16801-7 (2008).
  39. *Kaneiwa, T., *Yamada, S., Mizumoto, S., Montano, A. M., Mitani, S., Sugahara, K. (*Equal contribution)
Identification of a novel chondroitin hydrolase in Caenorhabditis elegans.
    J. Biol. Chem., 283, 14971-9 (2008).
  40. Izumikawa, T., Koike, T., Shiozawa, S., Sugahara, K., Tamura, J., Kitagawa, H.
Identification of chondroitin sulfate glucuronyltransferase as chondroitin synthase-3 involved in chondroitin polymerization: Chondroitin polymerization is achieved by multiple enzyme complexes consisting of chondroitin synthase family members.
    J. Biol. Chem., 283, 11396-406 (2008).
  41. *Li, F., *Yamada, S., Basappa, Shetty, A. K., Sugiura, M., Sugahara, K. (*Equal contribution)
    Determination of iduronic acid and glucuronic acid in sulfated chondroitin/dermatan hybrid chains by 1H-nuclear magnetic resonance spectroscopy.
    Glycoconjugate J., 25, 603-10 (2008).
  42. Nakahashi, A., Miura, N., Monde, K., Tsukamoto, S.
    Stereochemical studies of hexylitaconic acid, an inhibitor of p53-HDM2 interaction.
    Bioorg. Med. Chem. Lett., 19, 3027-30 (2009).
  43. Taniguchi, T., Martin, C., Monde, K., Nakanishi, K., Berova, N., Overman, L.
    Absolute Configuration of Actinophyllic Acid as Determined through Chiroptical Data.
    J. Nat. Prod., 72, 430-2 (2009).
  44. An, D. L., Chen, Q., Fang, J., Yan, H., Orita, A., Miura, N., Nakahashi, A., Monde, K., Otera, J.
    Vibrational CD Spectroscopy as a Powerful Tool for Stereochemical Study of Cyclophynes in Solution.
    Tetrahedron Lett., 50, 1689-92 (2009).
  45. Yaguchi, Y., Nakahashi, A., Miura, N., Sugimoto, D., Monde, K., Emura, M.
    Stereochemical Study of Chiral Tautomeric Flavorous Furanones by Vibrational Circular Dichroism.
    Org. Lett., 10, 4883-5 (2008).
  46. Taniguchi, T., Monde, K., Nakanishi, K., Berova, N.
    Chiral Sulfinates Studied by Optical Rotation, ECD and VCD: the Absolute Configuration of a Cruciferous Phytoalexin Brassicanal C
    Org. Biomol. Chem., 6, 4399-4405 (2008).
  47. Ishihara M, Suda Y, Inoue I, Tanaka T, Takahashi T, Gao X-D, Fukui Y, Ihara S, Neiman AM, Tachikawa H.
    A protein phosphatase type 1-interacting protein Ysw1 is involved in proper septin organization and prospore membrane formation during sporulation.
    Eukaryot Cell. in press (2009).
  48. Nakajima K, Nakamura M, Gao X-D, Kozakai T.
    Possible Involvement of Prolactin in Synthesis of Lactoferrin in Bovine Mammary Epithelial Cells.
    Bioscience, Biotechnology, and Biochemistry., 72 (4), p1103-06 (2008)
  49. Tsuji K., Satoh S., Mitsutake S,, Murakami I., Jeong-Ju Park; Qian Li; Young-Tae Chang; Sung-Kee Chung., Igarashi Y.
    Evaluation of synthetic sphingolipid analogs as ligands for peroxisome proliferator-activated receptors.
    Bioorganic & Medicinal Chemistry Letters., 19, 1643-6 (2009).
  50. Nagashima I., Shimizu H., Matsushita T., Nishimura, S.-I.
    Chemical and enzymatic synthesis of neoglycolipids in the presence of cyclodextrins.
    Tetrahedron Lett., 49, 3413-18 (2008)


  1. 五十嵐靖之
    予防医学に貢献する機能性食品の創出へ セラミドの基礎研究から応用、そして産業へと橋をかける
    FOODSTYLE21 この人に聞く 研究最前線, 1, 12-15(2008).
  2. Nagahori N., and Nishimura S.-I.
    13 Direct Monitoring of Enzymatic Reaction by Using Glyco-Nanoassembly.
    Bottom-Up Nanofablication, Ariga K., and Nalwa S., American Scientific Publishers., 4, 283-99 (2009)
  3. 中原拓、 西村紳一郎
    VIII. バイオインフォマティクス、メタボローム:大規模高速グライコミクスが明らかにするプロテオームのダイナミクス
    蛋白質 核酸 酵素, 共立出版, 53, 1708-15 (2008)
  4. Yamada, S., Sugahara, K.
    Potential therapeutic application of chondroitin sulfate/dermatan sulfate.
    Curr. Drug Discov. Technol., 5, 289-301 (2008)
  5. Sugahara, K., Yamada, S.
Microsequencing of functional chondroitin sulfate oligosaccharides
    Experimental Glycoscience ”Glycochemistry” (Taniguchi N., Suzuki A., Ito Y., Narimatsu H., Kawasaki T., Hase S., eds), pp. 64-9, Springer, Tokyo (2008).
  6. Mizumoto, S., Kitagawa, H.
    Heparan sulfate synthases and related genes
    Experimental Glycoscience ”Glycobiology” (Taniguchi N., Suzuki A., Ito Y., Narimatsu H., Kawasaki T., Hase S., eds), pp. 59-63, Springer, Tokyo (2008).
  7. *Malavaki, C., *Mizumoto, S., Karamanos, N., Sugahara, K. (*Equal contribution)
    Recent advances in the structural study of functional chondroitin sulfate and dermatan sulfate in health and disease
    Connect. Tissue Res., 49, 133-9 (2008).
  8. 赤津ちづる、山田修平、菅原一幸

    遺伝子医学MOOK11号『臨床糖鎖バイオマーカーの開発–糖鎖機能の解明とその応用』 メディカルドゥ, pp. 172-9 (2008).
  9. 水本秀二、菅原一幸

    蛋白質核酸酵素 増刊号『糖鎖情報の独自性と普遍性』 共立出版社,Vol.53 No.12, pp. 1448-55 (2008).
  10. 菅原一幸
    『第3の生命鎖:糖鎖の謎が今、解る』 (文部科学省特定領域研究 糖鎖によるタンパク質と分子複合体の機能調節 Functional Glycomics研究成果公開発表シンポジウム)技報堂, pp. 205-10, (2009).
  11. Miura N. and Nishimura S.-I.
    Glycoconjugate Data Bank.
    N. Taniguchi A. Suzuki, Y. Ito, H. Narimatsu, T. Kawasaki, and S. Hase (ed.)
    Experimental Glycoscience Glycobiology.
    Springer Japan., 435-440 (2008)
  12. Hinou H. and Nishimura S.-I.
    Mechanism-Based Probing, Characterization, and Inhibitor Design of Glycosidases and Glycosyltransferases
    Current Topics in Medicinal Chemistry., 9, 106-116 (2009).


  1. October 2008
    Compiegne, France
    5th Lipidomics Meeting- Lipids for the Future: From Agroresources to Human Health 
    Dietary Glucosylceramide Improves Skin Barrier Function in Hairless Mice
    Igarashi Y.
  2. October 2008
    Compiegne, France
    5th Lipidomics Meeting- Lipids for the Future: From Agroresources to Human Health 
    Ceramide Synthesis in Keratinocyte by Ceramide Synthase Family: Enzymatic Basis for the Preference of Fatty Acid Chain Length and Hydroxylation
    Igarashi Y.
  3. March 2008
    Charleston, USA
    5th International Charleston Ceramide Conference
    Ceramide Biosynthesis in keratinocyte and its role in Skin Function
    Igarashi Y.
  4. July 2008
    Institute for Research in Biomedicine, Barcelona, Spain
    BCN Biomed Seminar IRB
    Toward carbohydrate-based drug discovery
    Nishimura S-I
  5. August 2008
    ICS2008(International Carbohydrate Symposium)
    Glycoblotting allows large-scale functional glycomics
    Nishimura S-I
  6. March 2009
    Department of Biology, Johns Hopkins University, USA
    Johns Hopkins Univ. Special Lecture
    Glycoblotting: Potential “PCR” for Glycobiology?
    Nishimura S-I
  7. March 2009
    NCI-Frederick Special Seminar
    New Trends in discovery research for cancer markers and glycosyltransferases inhibitors
    Nishimura S-I
  8. October 2008
    Sapporo, JAPAN
    CRC International Symposium on Bio-interface and Conversion
    What can we do for Biomolecules using Vibrational Circular Dichroism (VCD) ? -Chiroptical Analysis of Glycoconjugates and Related Materials-
    Monde K.
  9. July 2008
    Geneva Switzerland
    20th International Symposium on Chirality, Chirality 2008
    A DFT study on helical perfluoroalkyl chains
    Miura N., Hashimoto M., Nakahashi A., Yoshida M., and Monde K.
  10. March 2009
    The 6th SYMPOSIUM FOR FUTURE DRUG DISCOVERY AND MEDICAL CARE (“Molecular Imaging for Integrated Medical Therapy”)
    Functional and structural Analysis reveals dual function on C-terminal a helix of Alg13 protein
    Xiao-Dong GAO


  1. 2008年4月
  2. 2008年7月
    「セラミド合成酵素 LASS 3(CerS 3) の基質特異性とその皮膚に置ける役割」
    水谷有紀子、 木原章雄、 五十嵐靖之、 東城博雅(阪大)
  3. 2008年8月
    「Regulation of ligand/agonist -stimulated sphingosine 1-photosphate receptor」
  4. 2008年9月
    「Rim101 経路は脂質非対称シグナルに関与する」
    木原章雄、 池田未佳、 五十嵐靖之
  5. 2008年11月
    Imaging-Luminescent and Fluorescent Probing Technology II
    「Ceramide metabolism and functions in the skin-an expectation to photo-imaging studies-」
  6. 2008年12月
    「脂質非対称変化によるスフィンゴイド塩基トランスロカーゼ Rsb1発現誘導へのRim101経路の関与
    The Rim101 pathway is involved in expression of the sphingoid base translocase Rsb1 induced by altered lipid asymmetry」
    木原章雄、 池田未佳、 小原圭介、 五十嵐靖之
  7. 2008年12月
    セラミド研究会 第1回学術集会
  8. 2008年5月
  9. 2008年6月
  10. 2008年6月
  11. 2008年8月
    平成20年度 日本学術会議第三部夏季部会 市民公開講演会
  12. 2008年8月
  13. 2008年10月
    BioJapan2008 World Business Forum
    「Large-scale quantitative glycomics by glycoblotting method」
  14. 2008年10月
  15. 2008年11月
    Tateshina Conference on Organic Chemistry (蓼科有機化学会議)
    「Chemistry and biological impact of comlpex carbohydrates」
  16. 2009年1月
  17. 2009年1月
    「Chemistry and Biological Impact of Complex Carbohydrates」
  18. 2009年2月
    OKINAWAライフサイエンスシンポジウム 生命科学の最前線と沖縄の可能性
  19. 2008年5月
  20. 2008年10月
  21. 2008年12月
  22. 2009年1月
  23. 2008年6月
    「赤外円二色性スペクトル Vibrational Circular Dichroism ―絶対配置決定と複合糖質への応用―」
  24. 2008年9月
  25. 2008年12月
    時空間階層生命科学 公開シンポジウム
    光武 進


  1. 2008/12/5ファイトスフィンゴシン骨格を有するセラミド化合物を有効成分とする、ペルオキシゾーム増殖剤応答性受容体活性化剤発明者:光武 進、田村潔美、村上逸雄、五十嵐靖之
  2. 特許出願 9件、PCT出願 5件発明者:西村紳一郎 他
  3. 2008/4/30(特願2008-118237)モノクロナール抗体、ハイブリドーマ、免疫原の製造方法発明者:菅原一幸、山田修平
  4. 2008/3/10 (特願2008-59657)O-マンノース型糖鎖結合アミノ酸及びそれを用いた糖ペプチドの製造方法発明者:西村紳一郎、比能 洋