2011年度：創薬科学基盤イノベーションハブ

発表論文

  1. Yuyama K., Sun H., Mitsutake S., Igarashi Y.
    Sphingolipid-modulated exosome secretion promotes theclearance of amyloid-beta by microglia.
    J. Biol. Chem. 287(14):10977-10986 (2012)
  2. Fujii Y., Ohtake H., Ono N., Hara T., Sakurai T.,Takahashi S., Takayama T., Fukasawa Y., Shiozawa F.,Tsukahara N., Hirayama T., Igarashi Y., Goitsuka R.
    Lymphopenia induced by a novel selective S1P1antagonist structurally unrelated to S1P.
    BBA, molecular and cell biology of lipid,. Volume 1821 Issue 4:600-6006.(2012)
  3. Fujii Y., Ueda Y., Ohtake H., Ono N, Takayama T., Nakazawa K., Igarashi Y., Goitsuka R.
    Blocking S1P interaction with S1P1 receptor by a novel competitive S1P1-selective antagonist inhibits angiogenesis.
    Biochem Biophys Res Commun., 419(4):754-760. (2012)
  4. Fujii Y., Hirayama T., Ohtake H., Ono N., Inoue T., Sakurai T., Takayama T., Matsumoto K., Tsukahara N., Hidano S., Harima N., Nakazawa K., Igarashi Y., Goitsuka R.
    Amelioration of Collagen-Induced Arthritis by a Novel S1P1 Antagonist with Immunomodulatory Activities.
    J Immunol., 188(1):206-215. (2012)
  5. Fujitani N., Takegawa Y., Ishibashi Y., Araki K., Furukawa JI., Mitsutake S., Igarashi Y., Ito M., Shinohara Y.
    Qualitative and Quantitative Cellular Glycomics of Glycosphingolipids Based on Rhodococcal EGCase -Assisted Glycan Cleavage, Glycoblotting-Assisted Sample Preparation and MALDI-TOF/TOF MS Analysis.
    J Biol Chem., 286(48):41669-41679. (2011)
  6. Shakor AB., Taniguchi M., Kitatani K., Hashimoto M., Asano S., Hayashi A., Nomura K., Bielawski J., Bielawska A., Watanabe K., Kobayashi T., Igarashi Y., Umehara H., Takeya H., Okazaki T.
    SMS1-generatedsphingomyelin plays an important role in transferrin trafficking and cell proliferation
    J. Biol. Chem., 286(41):36053-36062. (2011)
  7. Murakami I., Wakasa Y., Yamashita S., Kurihara T., Zama K., Kobayashi N., Mizutani Y., Mitsutake S., Shigyo T., Igarashi Y.
    Phytoceramide and sphingoid bases derived from brewer’s yeast Saccharomyces pastorianus activate peroxisome proliferator-activated receptors
    Lipids in Health and Disease., 10:150.(2011)
  8. Mitsutake S., Zama K., Yokota H., Yoshida T., Tanaka M., Mitsui M., Ikawa M., Okabe M., Tanaka Y., Yamashita T., Takemoto H., Okazaki T., Watanabe K., Igarashi Y.
    Dynamics modification of sphingomyelin in lipid microdomains control development of obesity, fatty liver, and type 2 diabetes
    J. Biol. Chem., 286(32):28544-28555.(2011)
  9. Furukawa T., Hinou H, Nishimura S-I.
    Strict Stereocontrol by 2,4-O-Di-tert-butylsilylene Group on β-Glucuronylations.
    Org. Lett., 14, 2102-2105 (2012)
  10. Kai H, Hinou H, Nishimura S-I.
    Aglycone-focused randomization of 2-difluoromethylphenylsialoside-type suicide substrates for neuraminidases.
    Bioorgan. Med. Chem., 20, 2739-2746 (2012)
  11. Hoshi H., Shimawaki K., Takegawa Y., Ohyanagi T., Amano M., Hinou H., and Nishimura S-I.
    Molecular shuttle between extracellular and cytoplasmic space allows for monitoring of GAG biosynthesis in human articular chondrocytes.
    Biochim. Biophys. Acta, in press (2012)
  12. Nishimura S-I., Hato M., Hyugaji S., Feng F., and Amano M.
    Glycomics for drug discovery: Metabolic perturbation in androgen-independent prostate cancer cells induced by unnatural hexosamine mimics.
    Angew. Chem. Int. Ed., 51, 3386-3390 (2012)
  13. Garcia-Martin F., Hinou H., Matsushita T., Hayakawa S., and Nishimura S-I.
    An efficient protocol for the solid-phase synthesis of glycopeptides under microwave irradiation.
    Org. Biomol. Chem., 10, 1612-1617 (2012)
  14. Yoshimura Y., Aaron S. Nudelman, Steven B. Levery, Hans H. Wandall, Eric P. Bennett, Ole Hindsgaul, Henrik Clausen, and Nishimura S-I.
    Elucidation of the sugar recognition ability of the lectin domain of UDP-GalNAc:polypeptide
    N-acetylgalactosaminyltransferase 3 by using unnatural glycopeptide substrates.
    Glycobiology, 22, 429-438 (2012)
  15. Abe M., Shimaoka H., Fukushima M., and Nishimura S-I.
    A cross-linked polymer possessing a high density of hydrazide groups: High-throughput glycan purification and labeling for high-performance liquid chromatography analysis.
    Polym. J.,44, 269-277 (2012)
  16. Amano M., Hashimoto R., and Nishimura S-I.
    Effects of single genetic damage in carbohydrate recognizing proteins on mouse serum N-glycan profile revealed by a simple glycotyping analysis.
    ChemBioChem., 13, 451-464 (2012)
  17. Takimori S., Shimaoka H., Furukawa J-i., Yamashita T., Amano M., Fujitani N., Takegawa Y., Hammarstrom L., Kacskovics I., Shinohara Y., and Nishimura S-I.
    Alteration of the N-glycome of bovine milk glycoproteins during early lactation.
    FEBS J., 278, 3769-3781 (2011)
  18. Furukawa T, Hinou H, Shimawaki K, Nishimura S-I.
    A potential glucuronate glycosyl donor with 2-O-acyl-6,3-lactone structure: efficient synthesis of glycosaminoglycan disaccharides.
    Tetrahedoron Lett., 52, 5567-5570 (2011)
  19. Hinou H., Saito N., Maeda T., Matsuda M., Kamiya Y., and Nishimura S-I.
    Toward Green and Sustainable Chemical Glycosylation: Enhanced Lewis Acidity of Recyclable Solid Super Acid Catalyst, SO4/ZrO2 by CaC12 Dpoing.
    J. Carbohyd. Chem, 30, 575-586 (2011)
  20. Ohyanagi T., Nagahori N., Shimawaki K., Hinou H., Yamashita T., Sasaki A., Jin T., Iwanaga T., Kinjo M., and Nishimura S-I.
    Importance of sialic acid residues illuminaterd by live animal imaging using phosphorylcholine self-assembled monolayers-coated quantum dots.
    J. Am. Chem. Soc., 133, 12507-12517(2011)
  21. Ishihara T., Fukuda I., Morita A., Takinami Y., Okamoto H., Nishimura S-I., and Numata Y.
    Development of quantitative plasma N-glycoproteomics using label-free 2-D LC-MALDI MS and its applicability for biomarker discovery in hepatocellular carcinoma.
    J. Proteomics,74, 2159-2168 (2011)
  22. Urita A., Matsuhashi T., Onodera T., Nakagawa H., Hato M., Amano M., Seito N., Minami A., and Nishimura S-I.
    Alterations of High-mannose Type N-Glycosylation in Human and Mouse Ostesarthritis Cartilage.
    Arthritis & Rheumatism, 50, 3428-3438 (2011)
  23. Hirose K., Amano M., Hashimoto R., Yuan L and Nishimura S-I.
    Insight into glycan diversity and evolutionary lineage based on comparative avio-N-glycomics and sialic acids analysis of 88 egg whites of Galloanserae.
    Biochemistry, 50, 4757-4774 (2011)
  24. Hinou H., Miyoshi R., Takasu Y., Kai H., Kurogochi M., Arioka S., Gao X-D., Miura N., Fujitani N., Otomo S., Yoshinaga T., Fujiwara T., Noshi T., Togame H., Takemoto H., and Nishimura S-I.
    A Strategy for Neuraminidase Inhibitors Using Mechanism-Based Labeling Information.
    Chem. Asian J., 6, 1048-1056 (2011)
  25. Naruchi K., and Nishimura S-I.
    Membrane-Bound Stable Glycosyltransferases: Highly Oriented Protein Immobilization by a C-Terminal Cationic Amphipathic Peptide.
    Angew. Chem. Int. Ed., 50, 1328-1331 (2011)
  26. Hashimoto R., Fujitani N., Takegawa Y., Kurogochi M., Matsushita T., Naruchi K., Ohyabu N., Hinou H., Gao X-D., Manri N., Satake H., Kaneko A., Sakamoto T., and Nishimura S-I.
    An efficient approach for the characterization of mucin type glycopeptides: The effect of O-glycosylation on the conformation of synthetic mucin peptides.
    Chem. Eur. J., 17, 2393-2404 (2011)
  27. Irie T, Majima T, Sawaguchi N, Funakoshi T, Nishimura S-I, Minami A
    Biomechanical and histologic evaluation of tissue engineered ligaments using chitosan and hyaluronan hybrid polymer fibers: A rabbit medial collateral ligament reconstruction model.
    J. Biomed. Mater. Res. Part A., 97A, 111-117 (2011)
  28. Hinou H., Hyugaji K., Garcia-Martin F., Nishimura S.-I., Albericio F.
    H-Bonding Promotion of Peptide Solubility and Cyclization by Fluorinated Alcohol
    RSC Advances, 2, 2729-2731 (2012)
  29. Purushothaman A., Hurst D. R., Pisano C., Mizumoto S., Sugahara K., Sanderson R. D.
    Heparanase-mediated loss of nuclear syndecan-1 enhances histone acetyltransferase (HAT) activity to promote expression of genes that drive an aggressive tumor phenotype.
    J. Biol. Chem., 286, 30377-30383 (2011)
  30. Chen J., Yamada S., Hama Y., Shetty A. K., Kobayashi T., Oda H., Seiki K., Kim E., Kimura T., Takahashi N., Hidari K. I. P. J., Suzuki T., Suzuki Y., Sugahara K.
    Unique heparan sulfate from shrimp heads exhibits a strong inhibitory effect on infections by dengue virus and Japanese encephalitis virus.
    Biochem. Biophys. Res. Commun., 412, 136-142 (2011)
  31. Kozlowski E. O., Lima P. C., Vicente C. P., Lotufo T., Bao X., Sugahara K., Pavao M. S. G.
    Dermatan sulfate in tunicate phylogeny: Order-specific sulfation pattern and the effect of [->4IdoA(2-Sulfate)beta-1->3GalNAc(4-Sulfate)beta-1->] motifs in dermatan sulfate on heparin cofactor II
    activity.
    BMC Biochem., 12, 29 (doi:10.1186/1471-2091-12-29)(2011)
  32. *Baasanjav S., *Al-Gazali L., *Hashiguchi T., Mizumoto S., Fischer B., Horn D., Seelow D., Ali B. R., Aziz S. A. A., Langer R., Saleh A. A. H., Becker C., Nunberg G., Cantagrel V., Gleeson J. G., Gomez D., Michel J-. B., Stricker S., Lindner T. H., Nunberg P., Sugahara K., Mundlos S., Hoffmann K. (*Equal contribution).
    Faulty initiation of proteoglycan synthesis causes cardiac and joint defects.
    Am. J. Hum. Genet., 89, 15-27 (2011)
  33. Kim E., Okumura M., Sawa H., Miyazaki T., Fujikura D., Yamada S., Sugahara K., Sasaki M., Kimura T.
    Paradoxical effects of chondroitin sulfate-E on Japanese encephalitis viral infection.
    Biochem. Biophys. Res. Commun., 409, 717-722 (2011)
  34. Akatsu C., Mizumoto S., Kaneiwa T., Maccarana M., Malmström A., Yamada S., Sugahara K.
    Dermatan sulfate epimerase 2 is the predominant isozyme in the formation of the chondroitin
    sulfate/dermatan sulfate hybrid structure in postnatal developing mouse brain.
    Glycobiology, 21, 565-574 (2011)
  35. Hashiguchi T., Kobayashi T., Fongmoon D., Shetty A. K., Mizumoto S., Miyamoto N., Nakamura T., Yamada
    S., Sugahara S.
    Demonstration of the hepatocytegrowth factor signaling pathway in the in vitro neuritogenic activity of chondroitin sulfate from ray fish cartilage.
    Biochim. Biophys. Acta, 1810, 406-413 (2011)
  36. Taniguchi T., Monde K.
    The Exciton Chirality Method in Vibrational Circular Dichroism
    J. Am. Chem. Soc., 134(2012)
  37. Asai T., Luo D., Obara Y., Taniguchi T., Monde K., Yamashita K., Oshima Y.
    Dihydrobenzofurans as cannabinoid receptor ligands from Cordyceps annullata, an entomopathogenic fungus
    cultivated
    in the presence of an HDAC inhibitor.
    Tetrahedron Lett., 53, 2239-2243(2012)
  38. Shibata T., Miyoshi M., Uchiyama T., Endo K., Miura N., Monde K.
    Enantioselective synthesis of tripodal cyclophanes and pyridinophanes by intramolecular [2+2+2] cycloaddition
    Tetrahedron, 68, 2679–2686(2012)
  39. Nakahashi A., Yaguchi Y., Miura N., Emura M., Monde K.
    A Vibrational Circular Dichroism Approach to the Determination of the Absolute Configurations of Flavorous 5-
    Substituted-2(5H)-furanones
    J. Nat. Prod., 74, 707-711(2011)
  40. Aoyagi Y., Yamazaki A., Kato R., Tobe F., Fukaya H., Nishikawa T., Nakahashi A., Miura N., Monde K., Takeya K
    Salvileucalin C, a novel rearranged neoclerodane diterpene from Salvia leucantha
    Tetrahedron Lett., 52, 1851-1853(2011)
  41. Lu J., Takahashi T., Ohoka A., Nakajima K.-I., Hashimoto R., Miura N., Tachikawa H. and Gao X.-D.
    Alg14 organizes the formation of a multi-glycosyltransferase complex involved in initiation of lipid-linked oligosaccharide biosynthesis
    Glycobiology, 22, 504-16 (2011)
  42. Li Y., Mitsuhashia S., Ikejo M., Miura N., Kawamura T., Hamakubo T., and Ubukata M.
    Relationship between ATM and Ribosomal Protein S6 Revealed by the Chemical Inhibition of Ser/Thr Protein Phosphatase Type 1
    Bioscience, Biotechnology, and Biochemistry, in press(2011)
  43. Yuyama K., Sekino-Suzuki N., Yamamoto N., Kasahara K.
    Ganglioside GD3 monoclonal antibody-induced paxillin tyrosine phosphorylation and filamentous actin assembly in cerebellar growth cones.
    J. Neurochem., 116(5): 845-50(2011)

著書・総説・解説等

  1. 光武進、五十嵐靖之
    スフィンゴ脂質研究の医薬品開発への応用展開
    バイオサイエンスとインダストリー2月号　（70 pp 102-107.）（2012）
  2. 木原章雄、五十嵐靖之
    総論：生理活性脂質とは
    臨床検査 2月号 56巻2 pp 107-116.（2012）
  3. 光武進、五十嵐靖之
    第24章　セラミド関連脂質とメタボリックシンドローム
    セラミド-基礎と応用-　ここまできたセラミド研究最前線（食品化学新聞社）pp 2.（2011）
  4. 水谷有紀子、五十嵐靖之
    第5章　セラミド生成酵素概論
    セラミド-基礎と応用-　ここまできたセラミド研究最前線（食品化学新聞社）pp 36-42.（2011）
  5. 五十嵐靖之
    序説　セラミド研究序論
    セラミド-基礎と応用-　ここまできたセラミド研究最前線（食品化学新聞社）pp 2.（2011）
  6. 西村紳一郎
    （特集 日本の化学：その元気度は？） それぞれの大志を抱け！－留学先での新渡戸稲造博士との出会い－
    化学, 化学同人, Vol.67, 25-27 (2012)
  7. Shin-Ichiro Nishimura
    Phosphorylcholine self-assembled monolayers-coated quantum dots: Real-time imaging of live animals by cell surface mimetic glyco-nanoparticles.
    Clinics in Laboratory Medicine, Vol.32, 73-87(2012)
  8. Shin-Ichiro Nishimura
    Phosphorylcholine self-assembled monolayers-coated quantum dots: Real-time imaging of live animals by cell surface mimetic glyco-nanoparticles.
    Clinics in Laboratory Medicine, Vol.32, 73-87(2012)
  9. Shin-Ichiro Nishimura
    TOWARD AUTOMATED GLYCAN ANALYSIS
    Advances in Carbohydrate Chemistry and Biochemistry, ELSEVIER, Vol.65, Chapter5, 219-271 (2011)
  10. Purushothaman A., Sugahara K., Faissner A.
    Chondroitin sulfate “wobble motifs” modulate the maintenance and differentiation of neural stem cells and their progeny.
    J. Biol. Chem., 287, 2935-2942 (2012)
  11. Kosho T., Miyake N., Mizumoto S., Hatamochi A., Fukushima Y., Yamada S., Sugahara K., Matsumoto N.
    A response to: Loss of dermatan-4-sulfotransferase 1 (D4ST1/CHST14) function represents the first dermatan sulfate biosynthesis defect, “Dermatan sulfate-deficient adducted thumb-clubfoot syndrome”. Which name is appropriate, “Adducted thumb-clubfoot syndrome” or “Ehlers-Danlos syndrome”?
    Human Mutation, 32, 1507-1509 (2011)
  12. Mizumoto S., Sugahara K.
    Bone and skin disorders caused by a disturbance in the bioynthesis of chondroitin sulfate and dermatan sulfate.
    Extracellular matrix: Pathobiology and signaling (N. Karamanos ed.) De Gruyter, Berlin, Germany, in press.
  13. Sugahara K., Mizumoto S.
    Chondroitin sulfate E-type structure at tumor cell surface is involved in experimental metastasis.
    Advances in Experimental Medicine and Biology “Biochemical Roles of Eukaryotic Cell Surface Macromolecules”, (P. R. Sudhakaran and A. Surolia, eds), Springer, New York, in press
  14. Mizumoto S., Sugahara K.
    Glycosaminoglycan chain analysis and characterization (Glycosylation/Epimerization).
    Methods in Molecular Biology, “Proteoglycans: Methods and Protocols” Humana Press, Springer, vol. 836, pp. 99-115 (2012)
  15. T. Taniguchi, K. Monde
    Electronic Circular Dichroism and Vibrational Circular Dichroism of Glycoconjugates,
    Ed. Nina Berova, Prasad Polavarapu, Koji Nakanishi,
    Robert Woody, Comprehensive Chiroptical Spectroscopy,
    John Wiley & Sons, 795-818 (2011)
  16. Yamada, S.
    Chondroitin sulfate-specific novel hydrolase in human.
    Advances in Experimental Medicine and Biology “Biochemical Roles of Eukaryotic Cell Surface Macromolecules”, (P. R. Sudhakaran and A. Surolia, eds), Springer, New York, in press
  17. 山田修平
    新規のコンドロイチン硫酸に特異的な加水分解酵素
    応用糖質科学, 印刷中,(2012)
  18. Mizumoto S.
    Disorder of biosynthesis of dermatan sulfate causes a new type of Ehlers-Danlos syndrome.
    Trends in Glycoscience and Glycotechnology, 23, 197-199 (2011)

国際学会

（招待講演）

  1. August 2011
    Beijing, China
    BIT 1st Annual World Congress of Molecular & Cell Biology Regulation of Sphingolipid Metabolism in Human Health.
    Igarashi Y.
  2. August 30~September 3 2011
    Warsow, Poland
    52th International Conference on the Bioscience of Lipids
    Sphingomyelin synthase 2 is responsible for obesity and lipid droplet formation in liver and is a novel regulator of membrane microdomain.
    Mitsutake S & Igarashi Y
  3. October 31~November 1 2011
    Beijing, China
    The 2nd Chinese Lopid Biochemistry
    Role sphingomyelin in lipid droplet formation in liver and obesity.
    Igarashi Y
  4. April 2011
    Lyon, France
    European Young Investigators Workshop
    Identification of Disease Specific Glycopeptide Epitopes
    Nishimura S-I.
  5. April, 2011
    Montreal, Canada
    National Research Council (Canada)
    Roles of Proteoglycans in Health and Diseases.
    Sugahara K.
  6. September, 2011
    Spetses, Greece
    The 3rd FEBS-MPST Advanced Lecture Course on Matrix Pathobiology, Signaling and Molecular Targets (FEBS-MPST2011)
    Involvement of chondroitin sulphate E–type structure in the experimental metastasis of the Lewis lung carcinoma cell line.
    Sugahara K.
  7. July, 2011
    Oxford, United Kingdom
    Said Business School
    13th International Conference on Chiroptical Spectroscopy (CD2011)
    Structural Analysis of Sphingolipids by Vibrational Circular Dichroism
    Monde K.

（口頭発表）

  1. Sptember 2011
    Warsaw, Poland
    52nd ICBL Conference
    Sphingomyelin synthase 2 is responsible for obesity and lipid droplet formation in liver and is a novel regulator of membrane microdomain
    S. Mitsutake, H. Yokota, K. Zama, T. Yoshida, T. Yamashita, T. Okazaki, K. Watanabe, Y. Igarashi
  2. December, 2011
    Hong Kong
    City University of Hong Kong
    International Symposium on Fluorous Technologies 2011 (ISoFT’11)
    SYNTHESIS AND METABOLIC ANALYSIS OF FLUOROUS SPHINGOLIPIDS
    Saito S., Yoshida M., Nakahashi A., M. A. S. Hammam, Taniguchi T., Mitsutake S., Igarashi Y., Monde K.
  3. October, 2011
    Sydney, Australia
    7th International Conference on Proteoglycans
    Characterization of a receptor for glycosaminoglycans that mediate experimental lung metastasis.
    Sugahara K., Mizumoto S., Takahashi J.
  4. October, 2011
    Sydney, Australia
    7th International Conference on Proteoglycans
    Involvement of HNK-1 sulfotransferase in the biosynthesis of chondroitin sulfate and the GlcUA(3-O-sulfate)-Gal-Gal-Xyl tetrasaccharide found in -thrombomodulin from human urine.
    Hashiguchi T., Mizumoto S., Nishimura Y., Tamura J., Yamada S., Sugahara K.
  5. July, 2011
    Brisbane, Australia
    Brisbane Convention Centre
    27th International Symposium on the Chemistry of Natural Products (ISCNP27)
    7th International Conference on Biodiversity (ICOB7)
    VIBRATIONAL CIRCULR DICHROSIM
    a powerful tool for the determination of the structure and absolute configuration of chiral natural products in solution state.
    Monde K.

国内招待

  1. 2012年3月
    東京都
    新化学技術推進協会（JACI）ライフサイエンス技術部会
    スフィンゴ脂質研究とその応用展開
    五十嵐　靖之
  2. 2012年1月
    熊本県
    熊本大学発生医学研究所ゴローバルCOEリエゾンラボ研究会
    Recent development of sphingolipid biology
    五十嵐　靖之
  3. 2011年4月
    富山市
    第25回日本臨床検査自動化学会
    高速糖鎖解析技術による疾患検査マーカーの探索
    西村紳一郎
  4. 2011年8月
    札幌市
    第51回日本臨床化学会年次学術集会
    全自動糖鎖解析システムの開発と臨床応用
    西村紳一郎
  5. 2011年10月
    弘前市
    第5回ＧＦＲG研究会シンポジウム
    糖鎖医薬品の研究開発を支援する新技術・デバイス
    西村紳一郎
  6. 2011年10月
    大阪市
    第6回メタボロームシンポジウム
    メタボロミクスターゲットとしての糖鎖修飾
    西村紳一郎
  7. 2011年12月
    岡山市
    日本肝臓学会西部会
    疾患グライコミクス
    西村紳一郎
  8. 2012年3月
    弘前市
    第7回臨床糖鎖研究会
    医薬品開発のためのグライコミクス －高分枝型糖鎖マーカーを活用する前立腺癌治療薬の探索－
    西村紳一郎
  9. 2012年3月
    東京、大阪
    AB SCIEX LC/MS ユーザーズミーティング2012
    各種質量分析システムを用いた糖タンパク質の特性解析　～バイオ医薬品の開発における合理的アプローチ～
    西村紳一郎
  10. 2011年12月
    東京
    第５回お茶の水女子大学糖鎖科学教育研究センター公開シンポジウム
    コンドロイチン硫酸などの多糖類と健康と疾病
    菅原一幸
  11. 2011年9月
    札幌市
    第48回ペプチド討論会
    糖ペプチドコンビナトリアルケミストリーによるMUC1エピトープの迅速探索
    ガルシア　マルティンファイナ

特許

  1. 2012/2/21（特願2012-035546）
    コンドロイチン硫酸オリゴ糖の製造方法
    発明者：松嶋景一郎、浦晴雄、鎌田樹志、宮本宜之、菅原一幸、山田修平
  2. 2011/10/14（特願2011-226786）
    アミロイドß関連疾患用の医薬とそのスクリーニング技術
    発明者: 湯山耕平、 五十嵐靖之、光武進、吉田哲也