2013年度：創薬科学基盤イノベーションハブ

発表論文

  1. Asai T., Otsuki S., Taniguchi T., Monde K., Yamashita K., Sakurai H., Ozeki T., Oshima Y.
    Structures and absolute configurations of short-branched fatty acid dimers from an endophytic fungus of Aloe arborescens
    Tetrahedron Lett. 54, 3402-3405 (2013)
  2. Asai, T., Yamamoto T., Shirata N., Taniguchi T., Monde K., Fujii I., Gomi K., Oshima Y.
    Structurally diverse chaetophenol productions induced by chemically mediated epigenetic manipulation of fungal gene expression
    Org. Lett. 15, 3346-3349 (2013)
  3. Asai T., Taniguchi T., Yamamoto T., Monde K., Oshima Y.
    Structures of Spiroindicumides A and B, Unprecedented Carbon Skeletal Spirolactones, and Determination of the Absolute Configuration by Vibrational Circular Dichroism Exciton Approach
    Org. Lett. 15, 4320–4323 (2013)
  4. Komori K., Taniguchi T., Mizutani S., Monde K., Kuramochi K., Tsubaki K.i.
    Short Synthesis of Berkeleyamide D and Determination of the Absolute Configuration by the Vibrational Circular Dichroism Exciton Chirality Method
    Org. Lett. 16, 1386-1389 (2014)
  5. Shibuta, T., Sato, S., Shibuya, M., Kanoh, N., Taniguchi, T., Monde, K., Iwabuchi, Y.
    Enantioselective intramolecular aza-spiroannulation onto benzofurans using chiral rhodium catalysis
    Heterocycles, 89, 631-639(2014)
  6. Matsushita T, Handa S, Naruchi K, Garcia-Martin F., Hinou H, Nishimura S-I.
    A novel approach for the parallel synthesis of glycopeptides by combining solid-phase peptide synthesis and dendrimer-supported enzymatic modifications
    Polym. J. 45, 854-862 (2013)
  7. Kamiyama T., Yokoo H., Furukawa J., Kurogochi M., Togashi T., Miura N., Nakanishi K., Kamachi H., Kakisaka T., Tsuruga Y., Taketomi A., Nishimura S-I., Todo S.
    Identification of novel serum biomarkers of hepatocellular carcinoma using glycomic analysis
    Hepatology 57, 2314-2325 (2013)
  8. Matsushita T., Ohyabu N., Fujitani N., Naruchi K., Shimizu H., Hinou H., Nishimura S-I.
    Site-specific conformational alteration induced by sialylation of MUC1 tandem repeating glycopeptides at an epitope region for anti-KL-6 monoclonal antibody
    Biochemistry , 52, 402-414 (2013)
  9. Nouso K., Amano M., Miyahara K., Ito M. Y., Miyahara K., Morimoto Y., Kato H., Tsutsumi K., Tomoda T., Yamamoto N., Nakamura S., Kobayashi S., Kuwaki K., Hagihara H., Onishi H., Miyake Y., Ikeda F., Shiraha H., Takaki A., Nakahara T., Nishimura S-I., Yamamoto K.
    Clinical utility of high-throughput glycome analysis in patients with pancreatic cancer
    J. Gastroenterology 48, 1171-1179 (2013)
  10. Feng F., Sakoda Y., Ohyanagi T., Nagahori N., Shibuya H., Okamastu M., Miura N., Kida H., Nishimura S-I.
    Novel thiosialosides tethered to metal nanoparticles as potent influenza A virus hemagglutinin blockers
    Antivir. Chem. Chemoth. 23, 59-65 (2013)
  11. Hideshima S., Hinou H., Ebihara D., Sato R., Kuroiwa S., Nakanishi T., Nishimura S-I., Osaka T.
    Attomolar Detection of Influenza A Virus Hemagglutinin Human H1 and Avian H5 Using Glycan-blotted Field Effect Transistor Biosensor
    Anal. Chem. 85, 5641-5644 (2013)
  12. Miyahara K., Nouso K., Saito S., Hiraoka S., Harada K., Takahashi S., Morimoto Y., Kobayashi S., Ikeda F., Miyake Y., Shiraha H., Takaki A., Amano, M. Nishimura S.-I, Yamamoto K.
    Serum glycan markers for evaluation of disease activity and prediction of clinical course in patients with ulcerative colitis.
    PLOS ONE 8, e74861 (2013)
  13. Kumar R., Naruchi K., Miyoshi R., Hinou H., Nishimura S-I.
    A New Approach for the Synthesis of Hyper-Branched N-Glycan Core Structures from Locust Bean Gum
    Org. Lett. 15, 6278-6281 (2013)
  14. Takeuchi M., Amano M., Kitamura H., Tsukamoto T., Masumori N., Hirose K., Ohashi T and Nishimura S-I.
    N- and O-glycome analysis of serum and urine from bladder cancer patients using a high-throughput glycoblotting method
    Journal of Glycomics & Lipidomics 3, 108 (2013)
  15. Hatakeyama S., Amano M., Tobisawa Y., Yoneyama T., Tsushima M., Hirose K., Yoneyama T., Hashimoto Y., Koie T., Saitoh H., Yamaya K., Funyu T., Nisimura S-I., and Ohyama C.
    Serum N-glycan profiling predicts prognosis in patients undergoing hemodialysis
    Sci. World J. 2013, ID268407 (2013)
  16. Nakagawa S., Shimamura S., Takaki Y., Suzuki Y., Murakami S., Watanabe T., Fujiyoshi S., Mino S., Sawabe T., Maeda T., Makita H., Nemoto S., Nishimura S-I., Watanabe H., Watsuji T., Takai K.
    Allying with armored snails: the complete genome of gammaproteobacterial endosymbiont
    ISME J. 8, 40-51 (2014)
  17. Miyahara K., Nouso K., Miyake Y., Nakamura S., Obi S., Amano M., Hirose K., Nishimura S-I., Yamamoto K.
    Serum glycan as a prognostic marker in patients with advanced hepatocellular carcinoma treated with sorafenib
    Hepatology 59, 355-356 (2014)
  18. Ishihara T., Kakiya K., Takahashi K., Miwa H., Rokushima M., Yoshinaga T., Tanaka T., Togame T., Takemoto H., Amano M., Iwasaki N.,Minami A., Nishimura S-I.
    Discovery of novel differentiation markers in the early stage of chondrogenesis by glycoform-focused reverse proteomics and genomics
    BBA-GenSubjects 1840, 645-655 (2014)
  19. Matsushita T., Takada W., Igarashi K., Naruchi K., Miyoshi R., Garcia-Martin F., Amano M., Hinou H., Nishimura S-I.
    A straightforward protocol for the preparation of high performance microarray displaying synthetic MUC1 glycopeptides
    BBA-GenSubjects 1840, 1105-1116 (2014)
  20. Hatakeyama S., Amano M., Tobisawa Y., Yoneyama T., Tsuchiya N., Habuchi T., Nishimura S-I., Ohyama C.
    Serum N-glycan alteration associated with renal cell carcinoma detected by high-throughput glycan analysis
    J. Urol. 191, 805-813 (2014)
  21. Ishida J., Hinou H., Naruchi K., Nishimura S-I.
    Synthesis of neoglycosphingolipid from nethoxyamino-functionalized ceramide
    Bioorg. Med. Chem. Lett. 24, 1197-1200 (2014)
  22. Mizutani Y., Sun H., Ohno Y., Sassa T., Wakashima T., Obara M., Yuyama K., Kihara A., Igarashi Y.
    Cooperative Synthesis of Ultra Long-chain Fatty Acid and Ceramide during Keratinocyte Differentiation.
    Plos one, 8(6), e67317 (2013)
  23. Sunami H., Yokota I., Igarashi Y.
    Influence of the pattern size of micropatterned scaffolds on cell morphology, proliferation, migration and F-actin expression.
    Biomater. Sci., 2, 399-409 (2014)
  24. Sunami H., Yokota I., Igarashi Y.
    Estimation of the angles migrating cells turn on three-dimensional micro-patterned scaffolds by live cell imaging with an inverted microscope.
    e-Journal of Surface Science and Nanotechnology, 12, 289-298 (2014)
  25. Furukawa T., Arai M., Garcia-Martin F., Amano M., Hinou H., Nishimura S.-I.
    Glycoblotting-based high throughput protocol for the structural characterization of hyaluronan degradation products during enzymatic fragmentation
    Glycoconjugate J., 30, 171-182 (2013)
  26. Kai H., Hinou H., Naruchi K., Matsushita T., Nishimura S.-I.
    Macrocyclic Mechanism-based Inhibitor for Neuraminidases
    Chem. Euro. J., 19, 1364-1372 (2013)
  27. Nishimura S.-I., Matsushita T., Handa S., Naruchi K., Garcia-Martin F., Hinou H.
    A novel approach for the parallel synthesis of glycopeptides by combining solid-phase peptide synthesis and dendrimer-supported enzymatic modifications
    Polymer Journal, 45, 854-862 (2013)
  28. Izumi R., Matsushita T., Fujitani N., Naruchi K., Shimizu H., Tsuda S., Hinou H., Nishimura S.-I.
    Microwave-assisted solid-phase synthesis of antifreeze glycopeptides
    Chem. Euro. J., 19, 3913-3920 (2013)
  29. Matsushita T., Takada W., Igarashi K., Naruchi K., Garcia-Martin F., Amano M., Hinou H., Nishimura S.-I.
    A straightforward protocol for the preparation of high performance microarray displaying synthetic MUC1 glycopeptides
    BBA-General Subject, 59, 355-356 (2014)
  30. Shibuta T., Sato S., Shibuya M., Kanoh N., Taniguchi T., Monde K., Iwabuchi Y.
    Enantioselective Intramolecular Aza-spiroannulation onto Benzofurans Using Chiral Rhodium Catalysis.
    Heterocycles, 89, 631-639 (2014)
  31. Sakurai M., Masuda K., Wang L., Murai Y., Sakihama Y., Hashidoko Y., Hatanaka Y., Hashimoto M.
    Synthesis of methoxy-substituted diazirinyl phenylalanine –a novel photoreactive aspartame derivative for functional analysis of sweet receptors.
    Heterocycles, 88(1), 629-637 (2014)
  32. Murai Y., Wang L., Muto Y., Sakihama Y., Hashidoko Y., Hatanaka Y., Hashimoto M.
    Simple and stereocontrolled preparation of benzoylated phenylalanine using Friedel – Crafts reaction in trifluoromethanesulfonic acid for photoaffinity labeling.
    Heterocycles, 87(10), 2119-2126 (2013)
  33. Wang L., Hisano W., Murai Y., Sakurai M., Muto Y., Ikemoto H., Okamoto M., Murotani T., Isoda R., Kim D., Sakihama Y., Sitepu I. R., Hashidoko Y., Hatanaka Y., Hashimoto M.
    Distinct metabolites for photoreactive L-phenylalanine derivatives in Klebsiella sp. CK6 isolated from rhizosphere of a wild dipterocarp sapling.
    Molecules, 18, 8393-8401 (2013)
  34. Murai Y., Wang L., Masuda K., Sakihama Y., Hashidoko Y., Hatanaka Y., Hashimoto M.
    Rapid and controllable hydrogen/deuterium exchange on aromatic rings of α-amino acids and peptides.
    Eur. J. Org. Chem., (23), 5111-5116 (2013)
  35. Ueda Y., Makino A., Murase-Tamada K., Sakai S., Inaba T., Hullin-Matsuda F., Kobayashi T.
    Sphingomyelin regulates the transbilayer movement of diacylglycerol in the plasma membrane of Madin-Darby canine kidney cells.
    FASEB Journal, 27(8), 3284-3297 (2013)
  36. Luquain-costaz C., Lefai E., Arnal M., Markina D., Sakai S., Euthine V., Makino A., Guichardant M., Yamashita S., Kobayashi T., Lagarde M., Moulin P., Vandenbroucke I.
    Bis(monoacylglycero)phosphate accumulation in macrophages attenuates LXR/ABCA1/G1 pathway and impairs cholesterol efflux.
    Arterioscler, Thromb,Vasc Biol, 33(8), 1803-11 (2013)

著書・総説・解説等

  1. 門出健次
    赤外円二色性スペクトルによる絶対配置の決定
    日本化学会　編　CSJ　カレントレビュー 「キラル化学」13
    高田十志和、門出健次、八島栄次　編集WG
    化学同人43-49　（2013）
  2. 比能　洋、西村紳一郎
    糖タンパク質の糖鎖を付け替える―均一な糖鎖構造をもつ糖タンパク質の効率的合成
    化学―最新のトピックス、化学同人、Vol.69、68-69（2014）
  3. 酒井祥太、光武進、五十嵐靖之
    食品成分としてのスフィンゴ脂質の生理機能
    ビタミン誌11月号87，605-609(2013)
  4. Maho Amano, Hiroshi Hinou, Risho Miyoshi, Shin-Ichiro Nishimura
    Potential usage for in vivo lectin screening in live animals utilized by cell surface mimetic glyco-nanoparticles, phosphorylcholine-coated quantum dots (PC-QDs)
    Methods in Molecular Biology, in press
  5. Yu RK, Usuki S.
    Human antiglycosphingolipids antibodies in Guillain-Barre syndrome.
    Autoantibodies 3rd edition, 581-692(2014)
  6. 谷口透
    赤外円二色性によるキラル分子の構造解析
    化学と工業　66 (10), 825-826.
  7. Yuyama K., Mitsutake S., Igarashi Y.
    Pathological roles of ceramide and its metabolites in metabolic syndrome and Alzheimer’s disease.
    BBA – Molecular and Cell Biology of Lipids, 1841(5), 793-798 (2014)

国際学会

（招待講演）

  1. June 2013
    Split, Croatia
    ISABS Conference
    Toward personalized medicine from glycan biomarkers discovered by glycoblotting-assisted high throughput serum glycomics
    Nishimura S-I.
  2. August 2013
    Taipei, Taiwan
    Seminar on Institute of Biomedical Sciences (IBMS)
    Toward personalized medicine from chemical glycobiology
    Nishimura S-I.
  3. September 2013
    Indianapolis, USA
    246th ACS National Meeting & Expositions
    Autoantibodies to cancer-associated MUC1 fragments in healthy human sera discovered by high performance glycopeptide microarray platform
    Nishimura S-I.
  4. January 2014
    Mysore, India
    International Symposium on Chemical Biology – Drug Discovery
    Toward personalized medicine from glycan biomarkers discovered by glycoblotting-assisted high throughput serum glycomics
    Nishimura S-I.
  5. January 2014
    Bangalore, India
    27th International Carbohydrate Symposium (ICS2014)
    High Performance Glycopeptide Microarray: Rapid Epitope Profiling of Monoclonal Antibodies and Serum AutoantibodiSpes
    Nishimura S-I.
  6. March 2014
    Baltimore, USA
    Special Lecture at Johns Hopkins School of Medicine
    Antigenic glycopeptides: Conformational impact of protein glycosylation and disease-relevant antigenic structure
    Nishimura S-I.
  7. April 2013
    Cancun, Mexico
    ISN-ASN SATELLITE SYMPOSIUM
    Exosomal sphingolipids responsible for the clearance of Alzheimer’s amyloid
    Igarashi Y.
  8. November 2013
    Haikou, china
    BIT’s 11th Annual Congress of Internatinal Drug Discovery Science&Technology
    Neuronal exosomes can eliminate Alzheimer’s amyloid protein in vitro and in vivo model mouse.
    Igarashi Y.
  9. March 2014
    Singapore, Singapore
    5th International Singapore Lipid Symposium 2014
    Neuronal exosomes in clearance of Alzheimer amyloid proteins and regulatory roles of sphingo (glyco) lipids.
    Igarashi Y.
  10. September . 6th, 2013
    Detroit, USA
    Special Seminar at Chemistry Department of Wane State University
    New Strategy for Peptide Cyclization H-bonding effect of fluorinated alcohol
    Hinou H,
  11. January. 10th, 2014
    Mysore, India
    International Symposium on Chemical Biology-Drug Discovery, Mysore University
    Synthesis and Application of Bicyclic Carbohydrates
    Hinou H,

（口頭発表）

  1. September. 8th, 2013
    Indianapolis (IN), USA
    246th American Chemical Society Meeting & Exposition
    Highly Efficient Synthesis of Hyperbranched N-glycans from Locust Bean Gum
    H. V. Ravi Kumar, Naruchi K, Hinou H, Miyoshi R, Nishimura S-I.

国内招待

  1. 2013年7月
    石和市
    Conference for BioSignal and Medicine2013（CBSM2013）
    糖鎖研究からの創薬－新しい抗体医薬品の開発を目指して
    西村　紳一郎
  2. 2014年3月
    和光市
    RIKEN Wise UP
    Peptides and Carbohydrates, attractive biomolecules with high potential inside
    Fayna Garcia Martin
  3. 2013年5月
    大阪市
    塩野義医薬研究センター
    スフィンゴ脂質の生理機能と創薬への展開
    五十嵐　靖之
  4. 2013年5月
    赤穂市
    アース製薬研究所
    アルツハイマー病と細胞外顆粒エキソソーム：新しい治療法の構築にむけて
    五十嵐　靖之
  5. 2014年2月
    宇治市
    ユニチカ中央研究所
    スフィンゴ脂質研究とその応用展開 −創薬と機能性食品の開発に向けて−
    五十嵐　靖之

特許

  1. 2013/05/09（特許公開日）（US20130115170A1 ）
    GM1-like peptides and uses thereof.
    発明者：Yu RK, Wu Han-Chung, Usuki S.
  2. 2013/05/20 （特許公開日）（US8513197B2 ）
    Ganglioside epitopes for treating Guillain-Barre syndromeGM1-like peptides and uses thereof.
    発明者：Yu RK, Usuki S.