2015年度：創薬科学基盤イノベーションハブ

発表論文

  1. Mamatha Bhanu L.S., Nishimura S-I., Aparna H.S.
    Inhibitory potential of Buffalo (Bubalus bubalis) colostrum immunoglobulin G on Klebsiella pneumoniae
    Int. J. Boil. Macromol. 88, 138-145 (2016)
  2. Rangappa S., Gerard Artigas, Miyoshi M., Yokoi Y., Hayakawa S., Fayna Garcia-Martin, Hinou H., and Nishimura S-I.
    Effects of the multiple O-glycosylation states on antibody recognition of the immunodominant motif in MUC1 extracellular tandem repeats
    MedChemComm in press
  3. Sato R., Tsuchiya K., Matsuzaki H., Takei N., Itoh H., Kanayama N., Suda T., Watanabe H., Ohashi T., Tanaka M., Nishimura S-I., Maekawa M.
    Fetal environment and glycosylation status in neonatal cord blood: a comprehensive mass
    spectrometry-based glycosylation analysis
    Medicine 94, e3219 (2016)
  4. Gizaw S., Ohashi T., Tanaka M., Hinou H., Nishimura S-I.
    Glycoblotting method allows for rapid and efficient glycome profiling of human Alzheimer’s disease brain, serum and cerebrospinal fluid towards potential biomarker discovery
    BBA-GenSubjects in press
  5. Hayakawa S., Koide R., Hinou H., Nishimura S-I.
    Synthetic Human NOTCH1 EGF Modules Unraveled Molecular Mechanisms for the Structural and Functional Roles of Calcium Ions and O-glycans in the Ligand-binding Region
    Biochemistry 55, 776-787 (2016)
  6. Hinou H., Abe Y., Hayakawa H., Naruchi K., Fujitani N., Nishimura S-I.
    Solid-phase Synthesis of C-mannosylated Glycopeptide on WSXWS Motif of Human Erythropoietin Receptor
    Tetrahedron let. 57, 791-795 (2016)
  7. Inafuku S., Noda K., Amano M., Nishimura S-I., Ishida S.
    Increase of Sialylated N-glycans in Eyes with Neovascular Glaucoma Secondary to Proliferative Diabetic Retinopathy
    Curr. Eye Res. 41, 721-724 (2016)
  8. Tomoda T., Nouso K., Kato H., Miyahara K., Dohi C., Morimoto Y., Kinugasa H., Akimoto Y., Matsumoto K., Yamamoto N., Noma Y., Horiguchi S., Tsutsumi K., Amano M., Nishimura S-I.,
    Yamamoto K.
    Alteration of serum N-glycan profile in patients with autoimmune pancreatitis
    Pancreatology 16, 44-51 (2015)
  9. Kitatsuji C., Izumi K., Nambu S., Kurogochi M., Uchida T., Nishimura S-I., Iwai K., Mark R. O’ Brian, Ikeda-Saito M., and Ishimori K.
    Protein oxidation mediated by heme-induced active site conversion specific for heme-regulated transcription factor, iron response regulator
    Sci. Rep. 6, 18703 (2016)
  10. Udono M., Fujii K., Harada G., Tsuzuki Y., Kadooka K., Zhang P., Fujii H., Amano M., Nishimura S-I., Tashiro K., Kuhara S., and Katakura Y.
    Impaired ATP6V0A2 expression contributes to Golgi dispersion and glycosylation changes in senescent cells
    Sci. Rep. 5, 17342 (2015)
  11. Akimoto Y., Nouso K., Kato H., Miyahara K., Dohi C., Morimoto Y., Kinugasa H., Tomoda T., Yamamoto N., Tsutsumi K., Kuwaki K., Onishi H., Ikeda F., Nakamura S., Shiraha H., Takaki A., Okada H., Amano M., Nishimura S-I., Yamamoto K.
    Serum N-glycan profiles in patients with intraductal papillary mucinous neoplasms of the pancreas
    Pancreatology 15, 432-438 (2015)
  12. Rehan I., Ueda K., Mitani T., Amano M., Hinou H, Ohashi T., Kondo S., and Nishimura S-I.
    Large-scale Glycomics of Livestock: Discovery of Highly Sensitive Serum Biomarkers Indicating an Environmental Stress Affecting I mmune Responses and Productivity of Holstein Dairy Cows
    J. Agric. Food. Chem. 63, 10578-10590 (2015)
  13. Coelho H., Matsushita T., Artigas G., Hinou H., Cañada FJ., Lo-Man R., Leclerc C., Cabrita EJ., Barbero JJ., Nishimura S-I., Garcia-Martin F., and Marcelo F.
    The Quest for Anticancer Vaccines: Deciphering the Fine-Epitope Specificity of Cancer-Related Monoclonal Antibodies by Combining Microarray Screening and Saturation Transfer Difference NMR
    J. Am. Chem. Soc. 137, 12438-12441 (2015)
  14. Mamatha Bhanu L.S., Amano M., Nishimura S-I., Aparna H. S.
    Glycome characterization of immunoglobulin G from buffalo (Bubalus bubalis) colostrum
    Glycoconj. J. 32, 625-634 (2015)
  15. Roger S. Tan, Naruchi K., Amano M., Hinou H., Nishimura S-I.
    Rapid Endolysosomal Escape and Controlled Intracellular Trafficking of Cell Surface Mimetic Quantum – Dots – Anchored Peptides and Glycopeptides
    ACS Chem. Biol. 10, 2073-2086 (2015)
  16. Inafuku S., Noda K., Amano M., Murata M., Saito W., Ohashi T., Kanda A., Nishimura S-I., Ishida S.
    Alteration of N-glycan profiles in Diabetic Retinopathy
    Invest. Ophthalmol. Vis. Sci. 56, 5316-5322 (2015)
  17. Gizaw S., Koda T., Amano M., Kamimura K., Ohashi T., Hinou H., Nishimura S-I.
    A comprehensive glycome profiling of Huntington’s disease transgenic mice
    BBA-GenSubjects 1850, 1704-1718 (2015)
  18. Miyahara K., Nouso K., Morimoto Y., Kinugasa H., Kato H., Yamamoto N., Tsutsumi K., Kuwaki K., Onishi H., Ikeda F., Nakamura S., Shiraha H., Takaki A., Nakahara T., Miura Y., Asada H., Amano M., Nishimura S-I., Yamamoto K.
    Prognostic Value of Altered N-Glycosylation of Circulating Glycoproteins in Patients With Unresectable Pancreatic Cancer Treated With Gemcitabine
    Pancreas 44, 551-556 (2015)
  19. Miyahara K., Nouso K., Dohi C., Morimoto Y., Kinugasa H., Wada N., Takeuchi Y., Kuwaki K., Onishi H., Ikeda F., Miyake Y., Nakamura S., Shiraha H., Takaki A., Amano M., Nishimura S-I., and Yamamoto K.
    Alteration of N-glycan profiles in patients with chronic hepatitis and hepatocellular carcinoma
    Hepatol. Res. 45, 986-993 (2015)
  20. Yamasaki Y., Nouso K., Miyahara K., Wada N., Dohi C., Morimoto Y., Takeuchi Y., Yasunaka T., Kuwaki K., Onishi H., Ikeda F., Miyake Y., Nakamura S., Shiraha H., Takaki A., Amano M., Nishimura S-I., and Yamamoto K.
    Use of noninvasive serum glycan markers to distinguish nonalcoholic steatohepatitis from simple steatosis
    J. Gastroen. Hepatol. 30, 528-534 (2015)
  21. Kimura K., Nishimura S-I., Miyoshi R., Hoque A., Miyoshi T., Watanabe Y.
    Application of glyco-blotting for identification of structures of polysaccharides causing membrane fouling in a pilot-scale membrane bioreactor treating municipal wastewater
    Bioresource Technol. 179, 180-186 (2015)
  22. Sugimoto M., Shimizu Y., Yoshioka T., Wakabayashi M., Tanaka Y., Higashino K., Numata Y., Sakai S., Kihara A., Igarashi Y., Kuge Y.
    Histological analyses by matrix-assisted laser desorption/ionization-imaging mass spectrometry reveal differential localization of sphingomyelin molecular species regulated by particular ceramide synthase in mouse brains
    BBA-Molecular and Cell Biology of Lipids. 1851(12), 1554-1565 (2015)
  23. Furukawa J., Sakai S., Yokota I., Okada K., Hanamatsu H., Kobayashi T., Yoshida Y., Higashino K., Tamura T., Igarashi Y., Shinohara Y.
    Quantitative glycosphingolipid-glycome analysis of human whole serum based on an endoglycoceramidase digestion and glycoblotting method
    J. Lipid Res. 56(12), 2399-2407 (2015)
  24. Suzuki M., Cao K., Kato S., Komizu Y., Mizutani N., Tanaka K., Arima C., Tai MC., Yanagisawa K., Togawa N., Shiraishi T., Usami N., Taniguchi T., Fukui T., Yokoi K., Wakahara K., Hasegawa Y., Mizutani Y., Igarashi Y., Inokuchi J., Iwaki S., Fujii S., Satou A., Matsumoto Y., Ueoka R., Tamiya- Koizumi K., Murate T., Nakamura M., Kyogashima M., Takahashi T.
    Targeting CERS6-dependent Metastasis-prone Phenotype in Lung Cancer Cells
    J. Clin. Invest. 126(1), 254-265 (2016)
  25. Yu RK., Usuki S., Itokazu Y., Wu HC.
    Novel GM1 ganglioside-like peptide mimics prevent the association of cholera toxin to human intestinal epithelial cells in vitro.
    Glycobiology 26(1):63-73 (2016)
  26. Usuki S., Tamura N., Sakai S., Tamura T., Mukai K., Igarashi Y.
    Chemoenzymatically prepared konjac ceramide inhibits NGF-induced neurite outgrowth by a semaphorin 3A-like action
    Biochemistry and Biophysics Reports 5, 160-167 (2016)
  27. Gowda BS., Usuki S., Mostafa H., Murai Y., Igarashi Y., Monde K.
    Highly efficient preparation of sphingoid bases from glucosylceramides by Cchemoenzymatic method
    J. LIpid Res. 57(2), 325-331 (2016)
  28. Yuyama K., Igarashi Y.
    Physiological and pathological roles of exosomes in the nervous system
    Biomolecular Concepts 7(1), 53-68 (2016)
  29. Sugimoto M., Wakabayashi M., Shimizu Y., Yoshioka T., Higashino K., Numata Y., Okuda T., Zhao S., Sakai S., Igarashi Y., Kuge Y.
    Imaging mass spectrometry reveals acyl-chain–and region-specific sphingolipid metabolism in the kidneys of sphingomyelin synthase 2-deficient mice
    PLoS One 11(3), e015219111 (2016)
  30. Hayashi Y., Yamazaki T., Nakanishi Y., Ono T., Taniguchi T., Monde K., Uchimaru T.
    Asymmetric Nitrocyclopropanation ofα-Substituted α,β-Enals Catalyzed by Diphenylprolinol Silyl Ether for the Construction of All-Carbon Quaternary Stereogenic Centers
    Eur.J. Org. Chem., 2015, 5747-5754 (2015)
  31. Ye Y., Minami A., Mandi A., Liu C., Taniguchi T., Kuzuyama T., Monde K., Gomi K., Oikawa H.
    Genome Mining for Sesterterpenes Using Bifunctional Terpene Synthases Reveals a Unified Intermediate of Di/Sesterterpenes
    J. Am. Chem. Soc., 137, 11846-11853 (2015)
  32. Taniguchi T., Manai D., Shibata M., Itabashi Y., Monde K.
    Stereochemical Analysis of Glycerophospholipids by Vibrational Circular Dichroism
    J. Am. Chem. Soc., 137, 12191-12194 (2015)
  33. Asai T., Morita S., Taniguchi T., Monde K., Oshima Y.
    Epigenetic stimulation of polyketide production in Chaetomium cancroideum by an NAD+- dependent HDAC inhibitor.
    Org. Biomol. Chem., 14, 646-651 (2016)
  34. Swamy M. M. M., Mándi A., Anetai M., Monde K.
    Stereochemistry of a Rhododaurichromanic Acid Derivative
    Nat. Prod. Commun., 11, 193-195 (2016)
  35. Kato M., Hammam M. A. S., Taniguchi T., Suga Y., Monde K.
    What Is the True Structure of D609, a Widely Used Lipid Related Enzyme Inhibitor?
    Org. Lett., 18, 768-771 (2016)
  36. Wang S., Taniguchi T., Monde K., Kawahata M., Yamaguchi K., Otani Y., Ohwada T.
    Hydrogen Bonding to Carbonyl Oxygen of Nitrogen-Pyramidalized Amide – Detection of Pyramidalization Direction Preference by Vibrational Circular Dichroism Spectroscopy
    Chem. Commun., 52, 4018-4021 (2016)
  37. Murai Y., Yoshida T., Wang L., Masuda K., Hashidoko Y., Monde K., Hatanaka Y., Hashimoto M.
    Efficient Synthesis of Photoreactive 2- Propoxyaniline Derivatives as Artificial Sweeteners
    Synlett, 27, 946-950 (2016)
  38. Wang M., Tachibana S., Murai Y., Li L., Lau Sharon Y. L., Cao M., Zhu G., Hashimoto M., Hashidoko Y.
    Indole-3-Acetic Acid Produced by Burkholderia heleia acts as a Phenylacetic Acid antagonist to disrupt tropolone biosynthesis in Burkholderia plantarii
    Scientific Reports, 6, 22596 (2016)
  39. Tahara Y., Obinata S., Kanyiva K. S., Shibata T., Mándi A., Taniguchi T., Monde K.
    Enantioselective Synthesis of Aminoindan Carboxylic Acid Derivatives by the Catalytic Intramolecular [2+2+2] Cycloaddition of Amino Acid-Tethered Triynes
    Eur. J. Org. Chem., 2016, 1405-1413 (2016)
  40. Wang S., Taniguchi T., Monde K., Kawahata M., Yamaguchi K., Otani Y., Ohwada T.
    Hydrogen Bonding to Carbonyl Oxygen of Nitrogen-Pyramidalized Amide – Detection of Pyramidalization Direction Preference by Vibrational Circular Dichroism Spectroscopy
    Chem. Commun., 52, 4018-4021 (2016)
  41. Mandi A., Swamy M. M. M., Taniguchi T., Anetai M., Monde K.
    Reducing Molecular Flexibility by Cyclization for Elucidation of Absolute Configuration by CD Calculations: Daurichromenic Acid
    Chirality, 28, 453-459 (2016)

著書・総説・解説等

  1. 比能洋、西村紳一郎
    酵素合成Ⅱ；糖転移酵素を利用した糖鎖合成
    糖鎖の新機能開発応用ハンドブック, 394-396 (2015)
  2. 比能洋
    糖鎖修飾の多様性に着目した糖ペプチドライブラリ構築技術の開発と機能解析・利用
    PEPTIDE NEWSLETTER JAPAN, 98, 2-5 (2015)
  3. 比能洋
    「ペプチド・糖ペプチド環化技術－水素結合制御により環化効率を飛躍的に向上－」
    北海道大学研究シーズ集, 2, 34 (2015)
  4. 湯山耕平、五十嵐靖之
    エクソソームによるアミロイドβ蛋白質除去作用
    細胞2016年1月号（Vol.48 No.1）
  5. Taniguchi T.
    3D-Structural Analysis of Polymers in Solution by Vibrational Circular Dichroism
    Polymers, 65, in press (2016)
  6. 谷口透
    赤外円二色性による天然物の三次元構造解明
    現代化学, 531, 34-35 (2015)
  7. Yaguchi Y., Nakahashi A., Miura N., Taniguchi T., Sugimoto D., Emura M., Zaizen K., Kusano Y., Monde K.
    Vibrational CD (VCD) Spectroscopy as a Powerful Tool for Chiral Analysis of Flavor Compounds
    ACS Symp. Ser., 1212, 35-56 (2015)

国際学会

（招待講演）

  1. May 2015
    Izmir, Turkey
    International Ceramide Conference
    Function of ganglioside and sphingolipid-linked exosome secretion in sequestering Alzheimer amyloid-β.
    Igarashi Y.
  2. June 2015
    Rehovot, Israel
    EMBO Workshop
    Epitope-defined antibody developed by new class glycotechnology platform
    Nishimura S-I.
  3. June 2015
    Kanazawa, Japan
    10th Sphingo Therapy Conference
    Sphingolipid biology and sphingolipid -related drug and functional food development: 30 years study in USA and in Japan.
    Igarashi Y.
  4. June 2015
    East Lansing, MI, USA
    Organic Seminar, Department of Chemistry, Michigan State University
    Vibrational Circular Dichroism (VCD) exciton chirality method: Powerful tool for stereochemical determination of small- medium- and large sized molecules
    Monde K.
  5. July 2015
    San Francisco, USA
    Nuerological Diseases Summit
    A potential function of secreted exosomes in sequestering Alzheimer’s amyloid-b peptide.
    Igarashi Y.
  6. September 2015
    Split, Croatia
    Glyco23
    EPITOPE-DEFINED ANTIBODIES AS NEW CLASS THERAPEUTIC AND DIAGNOSTIC REAGENTS : TOWARD PERSONALIZED MEDICINE FROM CHEMICAL GLYCOBIOLOGY
    Nishimura S-I.
  7. September 2015
    Iguazu, Argentina
    56th ICBL
    Function of ganglioside and sphingolipid-linked exosome secretion in sequestering Alzheimer’s amyloid-β.
    Yuyama K., Igarashi Y.
  8. December 2015
    Honoluru, Hawaii, USA
    Stereochemical determination of small – medium – and large sized molecules without theoretical calculation
    Monde K.
  9. January 2016
    Bangalore, INDIA
    103rd Indian Science Congress 2016
    Toward personalized medicine: Chemical and enzymatic synthesis of disease-relevant glycoproteins
    Nishimura S-I.

（口頭発表）

  1. June 2015
    Boston, USA
    Chirality 2015 (27th International Symposium on Chiral Discrimination, ISCD-27)
    Vibrational Circular Dichroism (VCD) exciton chirality method: Powerful tool for stereochemical determination of small- medium- and large sized molecules
    Monde K.
  2. July 2015
    Budapest, Hungary
    14th International conference on Bioactive Lipids in Cancer, Inflammation and Related Disease
    Highly efficient extraction of natural sphingoids by novel chemoselective resin-towards construction of their chemical library
    Monde K.
  3. December 2015
    Honolulu, Hawaii, USA
    Pacifichem 2015
    Highly efficient preparation of sphingoid bases from glucocerebrosides toward construction of lipids and glyco-lipids chemical library
    Monde K.
  4. January 2016
    Jakarta, Indonesia
    Asian Chemical Biology Initiative (ACBI) 2016
    Sphingosine Chemical Biology Constriction of Hybrid Type Sphigoshine Library and their Applications
    Monde K.

国内招待

  1. 2015年4月
    名古屋市
    基礎血液談話会
    Epitope-defined antibody drugs discovered by novel glycotechnology
    西村　紳一郎
  2. 2015年5月
    札幌市
    第64回高分子学会年次大会
    赤外円二色性によるキラル構造解析から拓く生体高分子化学
    谷口　透
  3. 2015年6月
    赤穂市
    アース製薬研究所
    最近のスフィンゴ脂質研究のトピック
    五十嵐　靖之
  4. 2015年7月
    宝塚市
    住友化学株式会社　健康・農業関連事業研究所
    ライフサイエンス分野におけるVCDキラル分析法の活用法
    門出　健次
  5. 2015年7月
    東京都
    お茶の水女子大学理学部　化学科講演会
    キラル分光法で生理活性物質・糖・ペプチドの立体構造を視る
    谷口　透
  6. 2015年7月
    東京都
    上智大学理工学部　2015年度 物質生命理工学科コロキウム
    キラル分光法による低分子・高分子の立体構造解明
    谷口　透
  7. 2015年8月
    函館市
    2015年度北海道高分子若手研究会
    赤外円二色性で見るキラル高分子の立体構造
    谷口　透
  8. 2015年8月
    塩尻市
    第47回若手ペプチド夏の勉強会
    糖ペプチド迅速合成法の開発と展開
    比能　洋
  9. 2015年9月
    秋田市
    秋田県立大学　博士課程後期課程セミナー
    振動円二色性（VCD: Vibrational circular dichroism）スペクトルによる構造解析
    門出　健次
  10. 2015年10月
    東京都
    第２回公開シンポジウム：難治性“かゆみ”の発症
    機構と予防・治療法開発の研究基盤構築
    スフィンゴ脂質の生理機能に基づく創薬と機能性食品創成の試み
    五十嵐　靖之
  11. 2015年11月
    札幌市
    第12回消化器外科Ⅰモーニングセミナー
    Posttranslational glycosylation and cancer cell’s life cycle: From discovery of disease-relevant epitope to development of new class anti-cancer drugs
    西村　紳一郎
  12. 2015年11月
    仙台市
    東北薬科大学
    脂質研究の新時代：スフィンゴ脂質の生理機能と創薬を中心として
    五十嵐　靖之
  13. 2016年1月
    岡山市
    第1回国際的キャリア展望に向けた生命科学研究者による講演会
    糖質の化学生物学
    比能　洋
  14. 2016年1月
    札幌市
    日本分光学会北海道支部シンポジウム
    ライフサイエンス分野のキラルツールとして貢献する赤外円二色性分光
    門出　健次
  15. 2016年2月
    福岡市
    九州大学
    スフィンゴ脂質研究と創薬、機能性素材の開発
    五十嵐　靖之
  16. 2016年3月
    札幌市
    第23回農芸化学Frontiersシンポジウム
    ナニガナンダカワケノワカラナイモノとの格闘
    谷口　透

特許

  1. 2016/1/19（特願）2016-007702 発明者：門出健次、ハンマン　モスタファ　アハメド　サベット　アハメド、須賀好子、吉田裕、松村謙一