1. Koda T., Kijimoto-Ochiai S., Uemura S., Inokuchi J.
    Specific expression of Neu2 type B in mouse thymus and the existence of a membrane-bound form in COS cells.
    Biochem. Biophys. Res. Commun., 387, 729-735 (2009).
  2. Ishikawa C, Tanabe H, Maemoto A, Ito T, Watari J, Kono T, Fujiya M, Ashida T, Ayabe T, Kohgo Y.
    Precursor processing of human defensin-5 is essential to the multiple functions in vitro and in vivo.
    J Innate Immun., 2, 66-76 (2010).
  3. Inaba Y, Ashida T, Ito T, Ishikawa C, Tanabe H, Maemoto A, Watari J, Ayabe T, Mizukami Y, Fujiya M, Kohgo Y.
    Expression of the antimicrobial peptide alpha-defensin/cryptdins in intestinal crypts decreases at the initial phase of intestinal inflammation in a model of inflammatory bowel disease, IL-10-deficient mice.
    Inflamm Bowel Dis. doi: 10.1002/ibd.21253, (2010) .
  4. Tamura S, Amano S, Kono T, Kondoh J, Yamaguchi K, Kobayashi S, Ayabe T, Moriyama T.
    Molecular characteristics and physiological functions of major royal jelly protein 1 oligomer.
    Proteomics., 9, 5534-43 (2009).
  5. Ashino S., Wakita D., Shiohama Y., Iwakura Y., Chamoto K., Ohkuri T., Kitamura H., Nishimura T.
    Tumor–polarized cell population that has infiltrated the lung requires cells that convert to IFN-g production in order to induce airway hyper-responsiveness.
    Int Immunol., in press(2010).
  6. Chamoto K., Wakita D., Ohkuri T., Uchinami Y., Matsushima K., Kitamura H., Nishimura T.
    3-Methylcholanthrene-induced transforming growth factor-beta-producing carcinomas, but not sarcomas, are refractory to regulatory T cell-depletion therapy.
    Cancer Sci., 101, 855-61 (2010).
  7. Takeshima T., Chamoto K., Wakita D., Ohkuri T., Togashi Y., Shirato H., Kitamura H., Nishimura T.
    Local radiation therapy inhibits tumor growth through the generation of tumor-specific CTL: Its potentiation by combination with Th1 cell therapy.
    Cancer Res., 70, 2697-706 (2010) .
  8. Wakita D., Chamoto K., Ohkuri T., Narita Y., Ashino S., Sumida K., Nishikawa H., Shiku H., Togashi Y., Kitamura H., Nishimura T.
    IFN-γ-dependent type 1 immunity is crucial for immunosurveillance against squamous cell carcinoma in a novel mouse carcinogenesis model.
    Carcinogenesis., 30, 1408-15 (2009).
  9. Ohkuri T., Wakita D., Chamoto K., Togashi Y. Kitamura H., Nishimura T.
    Identification of novel helper epitops of MAGE-A4 tumor antigen: Useful tool for the propagation of Th1 cells.
    Br J Cancer., 100, 1135-43 (2009).
  10. Chamoto K., Takeshima T., Wakita D., Ohkuri T., Ashino S., Omatsu T., Shirato H., Kitamura H., Nishimura T.
    Combination immunotherapy with radiation and CpG-based tumor vaccination for the eradication of radio- and immuno-resistant lung carcinoma cells.
    Cancer Sci., 100, 934-9 (2009).
  11. Goto M., Tanaka Y., Murakawa M., Kadoshima-Yamaoka K., Inoue H., Murafuji H., Nagahira A., Kanki S., Hayashi Y., Nagahira K., Ogata A., Miura K., Nakatsuka T., Chamoto K., Fukuda Y., Nishimura T.
    Inhibition of phosphodiesterase 7A ameliorates Concanavalin A-induced hepatitis in mice.
    Int Immunopharmacol., 9, 1347-51 (2009).
  12. Goto M., Murakawa M., Kadoshima-Yamaoka K., Tanaka Y., Inoue H., Murafuji H., Hayashi Y., Miura K., Nakatsuka T., Nagahira K., Chamoto K., Fukuda Y., Nishimura T.
    Phosphodiesterase 7A inhibitor ASB16165 suppresses proliferation and cytokine production of NKT cells.
    Cell Immunol., 258, 147-51 (2009).
  13. Takahashi A., Kurokawa M., Konno S., Ito K., Kon S., Ashino S., Nishimura T., Uede T., Hizawa N., Huang SK., Nishimura M.
    Osteopontin is involved in migration of eosinophils in asthma.
    Clin Exp Allergy., 39, 1152-9 (2009).
  14. Shimode K, Iwasaki N, Majima T, Funakoshi T, Sawaguchi N, Onodera T, Minami A.
    Local up-regulation of stromal cell-derived factor-1 after ligament injuries enhances homing rate of bone marrow stromal cells in rats.
    Tissue Eng Part A., 15, 2277-84( 2009).
  15. Iwasaki N, Minami A.
    Arthroscopically assisted reattachment of avulsed triangular fibrocartilage complex to the fovea of the ulnar head.
    J Hand Surg Am., 34, 1323-6( 2009).
  16. Matsui Y, Iwasaki N, Kon S, Takahashi D, Morimoto J, Matsui Y, Denhardt DT, Rittling S, Minami A, Uede T.
    Accelerated Development of Aging-Associated and Instability- Induced Osteoarthritis in Osteopontin-Deficient Mice.
    Arthritis Rheum., 60, 2362-71( 2009).
  17. Matsuhashi T, Iwasaki N, Oizumi N, Kato H, Minami M, Minami A.
    Radial Overgrowth after Radial Shortening Osteotomies for Teenage Patients with Kienböck’s Disease
    J Hand Surg Am., 34, 1242-7( 2009).
  18. Takahashi D, Iwasaki N, Kon S, Matsui Y, Majima T, Minami A, Uede T.
    Down-regulation of cathepsin K in synovium leads to progression of osteoarthritis in rabbits.
    Arthritis Rheum., 60, 2371-80( 2009).
  19. Iwasaki N, Kato H, Ishikawa J, Masuko T, Funakoshi T, Minami A.
    Autologous osteochondral mosaicplasty for osteochondritis dissecans of the elbow in teenage athletes.
    J Bone Joint Surg Am., 91, 2359-66( 2009).
  20. Kanayama M, Kurotaki D, Morimoto J, Asano T, Matsui Y, Nakayama Y, Saito Y, Ito K, Kimura C, Iwasaki N, Suzuki K, Harada T, Li HM, Uehara J, Miyazaki T, Minami A, Kon S, Uede T.
    alpha-9 integrin and its ligands constitute critical joint microenvironments for development of autoimmune arthritis.
    J Immunol., 182, 8015-25( 2009).
  21. Iwasaki N, Kato H, Kamishima T, Minami A.
    Sequential alterations in magnetic resonance imaging findings after osteochondral mosaicplasty for young athletes with osteochondritis dissecans of the humeral capitellum.
    Am J Sports Med., 37, 2349-54( 2009).
  22. Masuko T, Iwasaki N, Ishikawa J, Kato H, Minami A.
    Radiolunate fusion with distraction using corticocancellous bone.
    Hand Surg., 14, 15-21( 2009).
  23. Tohyama H, Yasuda K, Minami A, Majima T, Iwasaki N, Muneta T, Sekiya I, Yaghishita K, Takahashi S, Kurokouchi K, Uchio Y, Iwasa J, Deie M, Adachi N, Sugawara K, Ocho M.
    Atelocollagen-Associated Autologous Chondrocyte Implantation for the Repair of Chondral Defects of the Knee. A Prospective Multicenter Clinical Trial in Japan
    J Orthop Sci., 14( 5)., 579-88( 2009).
  24. Iwasaki N, Kato H, Ishikawa J, Masuko T, Funakoshi T, Minami A.
    Autologous osteochondral mosaicplasty for osteochondritis dissecans of the elbow in teenage athletes.
    J Bone Joint Surg Am., 91( 10), 2359-66( 2009).
  25. Amano M, Yamaguchi M, Takegawa Y, Yamashita T, Terashima M, Furukawa J, Miura Y, Shinohara Y, Iwasaki N, Minami A, Nishimura S.
    Threshold in stage specific embryonic glycotype uncovered by a full portrait of dynamic N-glycan expression during cell differentiation.
    Mol Cell Proteomics., 9( 3), 523-37( 2010).
  26. Igarashi T, Iwasaki N, Kasahara Y, Minami A.
    A Cellular Implantation System Using an Injectable Ultrapurified Alginate Gel for Repair of Osteochondral Defects in a Rabbit Model.
    J Biomed. Mater. Res. 2010 Mar 24.( Epub ahead of print).
  27. Iwasaki N, Masuko T, Minami A.
    Forearm fascial hernia by harvesting the Palmaris longus tendon.
    J Hand Surg Eur., 34, 408-9( 2009).
  28. Nishida K, Iwasaki N, Minami A.
    Anconeus Muscle Flap for the Treatment of Soft Tissue Defects over the Olecranon after Total Elbow Arthroplasty.
    J Hand Surg Eur., 34, 538-9( 2009).
  29. Kamishima T, Hasegawa A, Kubota KC, Oizumi N, Iwasaki N, Minami A, Sasaki S, Yamamoto Y, Omatsu T, Onodera Y, Terae S, Shirato H.
    Intravenous Pyogenic Granuloma of the finger; Report on two case
    Jpn J Radiol., 27, 328-32( 2009).
  30. Iwasaki N, Minami A.
    Brown tumor of the wrist with primary hyperparathyroidism.
    J Hand Surg Eur., 35, 71-2( 2010).
  31. Kotani, Y., Abumi, K., Ito, M., Sudo, H., Takahata, M., Ohshima, S., Hojo, T, and Minami, A.
    Minimum 2-year outcome of cervical laminoplasty with deep extensor muscle-preserving approach: impact on cervical spine function and quality of life.
    Eur Spine J., 18( 5), 663-71( 2009).
  32. Matsumoto, D., Suenaga, N., Oizumi, N., Hisada, Y., and Minami, A.
    A new nerve block procedure for the suprascapular nerve based on a cadaveric study.
    J Shoulder Elbow Surg., 18( 4), 607-11( 2009).
  33. Takeda, N., Kobayashi, T., Tandai, S., Matasuno, T., Shirado, O., Watanabe, T., and Minami, A.
    Treatment of giant cell tumors in the sacrum and spine with curettage and argon beam coagulator.
    J Orthop Sci., 14, 210-4( 2009).
  34. Watanabe, T., Tsuda, M., Makino, Y., Konstantinou, T., Nishihara, H., Majima, T., Minami, A., Feller, SM, and Tanaka, S.
    Crk adaptor protein-induced phosphorylation of Gab1 on tyrosine 307 via Src is important for organization of focal adhesions and enhanced cell migration.
    Cell Res., 19, 638-50( 2009).
  35. Kotani, Y., ito, M., Abumi, K., Ito, M., Yasui, K., and Minami, A.
    Neurological recovery from pentaplegia after resection for sacral plasmacytoma presenting with POEMS syndrome.
    J Neurosurg Spine., 10, 324-428( 2009).
  36. Nakamura, K., Hirachi, K., Uchiyama, S., Takahara, M., Minami, A., Imaeda, T., and Kato, H.
    Long-term clinical and radiographic outcomes after open reduction for missed Monteggia fracture-dislocations in children.
    J Bone Joint Surg Am., 91, 1394-404( 2009).
  37. Watanabe, T., Tsuda, M., Tanaka, S., Ohba, Y., Kawaguchi, H., Majima, T., Sawa, H., and Minami, A.Adaptor protein Crk induces Src-dependent activation of p38 MAPK in regulation of synovial sarcoma cell proliferation.
    Mol Cancer Res., 7( 9), 1582-92( 2009).
  38. Sawaguchi, N., Majima, T., Ishigaki, T., Mori, N., Terashima, T., and Minami, A.
    Mobile-Bearing Total Knee Arthroplasty Improves Patellar Tracking and Patellofemoral Contact Stress In Vivo
    Measurements in the Same Patients.
    Arthroplasty., in press( 2009).
  39. Ito, M., Sudo, H., Abumi, K., Kotani, Y., Takahata, M., Fujita, M., and Minami, A.
    Minimally invasive surgical treatment for tuberculous spondylodiscitis.
    Minim Invas Neurosurg., 52, 1-4( 2009)
  40. Takeda, N., Kobayashi, T., Atsuta, Y., Matasuno, T., Shirado, O., and Minami, A.
    Changes in the sagittal spinal alignment of the elderely without vertebral fractures: a minimum 10-year longitudinal study.
    J Orthop Sci., 14, 748-53( 2009).
  41. Ito, H., Tanino, H., Yamanaka, Y., Sato, T., Minami, A., and Matsuno, T.
    Porous-coated cementless acetabular components without bulk bone graft in revision surgery.
    J Arthroplasty., in press( 2009).
  42. Ito, M., Sudo, H., Abumi, K., Kotani, Y., Takahata, M., Fujita, M., and Minami, A.
    Minimally invasive surgical treatment for tuberculous spondylodiscitis.
    Invasive Neurosurg., 52, 250-3( 2009)


  1. 綾部時芳
    消化管症候群(第2版)下巻 新領域別症候群シリーズNo.12 日本臨床社 東京 pp 312-4 (2009)
  2. 綾部時芳
    消化管 (腸管)
    炎症・再生医学事典、松島綱治、西脇 徹編、朝倉書店 東京 pp467-9 (2009)
  3. 田邊裕貴、前本篤男、綾部時芳、伊藤貴博、河野 透、蘆田知史、高後 裕.
    先端医学社 分子消化器病.6 (No.2), 133-9 (2009)
  4. 綾部時芳
    先端医学社 IBD Research.3 (No. 3), 188-92 (2009)
  5. 但馬正樹、西村孝司
    ニューサイエンス社 Medical Science Digest vol.36 No.2, 15-17 (2010)
  6. 脇田大功、西村孝司
    「癌の発生、増殖におけるprotumor cellとしてのIL-17産生γδT細胞の意義」
    ニューサイエンス社 Medical Science Digest vol.36 No.2, 18-20 (2010)
  7. 西村孝司、脇田大功、茶本健司、大栗敬幸 
    最新医学社 最新医学 第64巻/第11号 2408-2419
  8. 大栗敬幸、脇田大功、茶本健司、西村孝司
    ISIM国際総合医学会誌 Vol.1. No1 June 2009
  9. 脇田大功、茶本健司、大栗敬幸、西村孝司
    癌と化学療法社 Biotherapy 5月号, 23 (3), 231-240 (2009)
  10. 茶本健司、西村孝司 
    先端医学社 炎症と免疫 5月号, 17(3), 20-28 (2009)
  11. Chamoto K., Wakita D., Koizumi S., Masuko K., Ikeda T., Mitamura R., Nishimura T.
    「Interaction of NK cells with bacteria」
    (Elsevier) Natural killer cell; chapter 39, Interaction of NK Cells with Bacteria, Edited by Michael T. Lotze and Angus W.
    Thomson (2009)
  12. 岩崎倫政
    札医通信 No.498 14-16, 2010
  13. 岩崎倫政、松橋智弥、瓜田 淳、高畑雅彦、三浪明男、西村紳一郎
    遺伝子医学MOOK 別冊“ますます重要になる細胞周辺環境の最新科学技術”55-59, 2009



  1. July 2009
    Tokyo, JAPAN
    The 9th World Congress on Inflammation
    Preferential production of IL-17 by tumor-infiltrating gd T cells enhances angiogenesis and tumor growth
    Daiko Wakita, Takashi Nishimura
  2. July 2009
    Tokyo, JAPAN
    The 9th World Congress on Inflammation
    Indispensable role of IFN-g in Th17 cell-dependent airway hyperresponsiveness
    Shigeru Ashino, Takashi Nishimura
  3. November 2009
    Seoul, Republic of Korea
    2009 Current Progress of Cancer Immunotherapy Workshop
    A novel immunosuppressive tumor escape mechanisis and its overcoming by Th1 therapy
    Takashi Nishimura
  4. November 2009
    Seoul, Republic of Korea
    The Third International Conference on Cell Therapy
    Th1 cell Therapy to overcome Immunosuppressive Tumor-Escape Mechanisms
    Takashi Nishimura
  5. March 2009
    Sapporo, JAPAN
    Sapporo Bio Cluster Internatinal Symposium 2010
    Research of immune balance control and development of functional foods
    Takashi Nishimura
  6. March 2010
    New Orleans
    56th Annual Meeting of Orthopaedic Research Society
    Therapeutic Effects of the Intraarticular Administration of Ultra-purified Low Endotoxin Alginate on Experimental Osteoarthritis in Rabbits
    Iwasaki N, Igarashi T, Kawamura D, Abe R, Izumisa Y, Minami A.


  1. 2009年4月
    第9回鎌倉カンファレンス 特別講演
  2. 2009年12月
    第13回バイオ治療法研究会 特別講演
  3. 2010年4月
    第83回日本細菌学会 International Symposium 1 招待講演
    Regulation of intestinal microbiota by Paneth cell alphadefensins
    Ayabe T, Masuda K, Nakamura K, Sakai N.
  4. 2009年4月
    IL-2-induced killer細胞の発見から始まったTh1細胞治療の開発:基礎研究から臨床応用への橋渡し
  5. 2009年5月
  6. 2009年5月
  7. 2009年5月
  8. 2009年6月
  9. 2009年7月
    健康づくり大学 洞爺湖キャンパス事業 親子三代で楽しむ「スポーツゲームス in 洞爺湖」
  10. 2009年8月
  11. 2009年9月
    修学旅行食育プログラム 東京都小野学園女子高等学校キャンパスツアー
  12. 2009年10月
    留萌の魅力再発見 モニターツアー
  13. 2009年10月
  14. 2009年10月
  15. 2009年11月
    北海道観光振興機構 地域観光商品開発促進事業
  16. 2009年11月
  17. 2009年11月
  18. 2009年11月
    第22回日本バイオセラピィ学会学術総会 市民公開講座 
  19. 2009年12月
  20. 2009年12月
  21. 2010年1月
  22. 2010年1月
    健康を考える観光 (ヘルスツーリズム)の推進による新北海道開拓-「食、健康、環境、医療」を結びつけた社会基盤構築の重要性-
  23. 2010年3月
  24. 2010年3月
    OKINAWA型産業振興プロジェクト推進ネットワーク 沖縄ウエルネスシンポジウム
  25. 2009年11月
    第22回 日本バイオセラピィ学会学術総会
  26. 2009年8月


  1. 2009/10/2(特願2009-230904)
  2. 2009/8/6(特願2009-183696)
  3. 2009/5/16(PCT/JP2009/59097)
  4. 2010/3/18(PCT/JP2010/054663)