Faculty of Advanced Life Science

Hokkaido University

Department of Advanced Transdisciplinary Sciences

Reviewed Paper

1. Yamamura R, Nakamura K, Kitada N, Aizawa T, Shimizu Y, Nakamura K, Ayabe T, Kimura T, Tamakoshi A.
   Associations of gut microbiota, dietary intake, and serum short-chain fatty acids with fecal short-chain fatty acids
   Biosci Microbiota Food Health 39, 11-17 (2020) DOI: 10.12938/bmfh.19-010
2. Bermejo I. A., Navo C. D., Castro-López J., Guerreiro A., Fernández E. M. S., García-Martín F., Hinou H., Nishimura S.-I., Fernández J. M. G., Mellet C. O., Avenoza A., Busto J. H., Bernardes G. J. L., Hurtado-Guerrero R., Peregrina J. M., Corzana F.
   Synthesis, conformational analysis and in vivo assays of an anti-cancer vaccine that features an unnatural antigen based on an sp2-iminosugar fragment
   Chem. Sci. 11, 3996-4006 (2020)DOI: 10.1039/c9sc06334j
3. Hayakawa A., Matsushita T., Yokoi Y., Wakui H., Fayna Garcia-Martin, Hinou H., Matsuoka K., Nouso H., Kamiyama T., Taketomi A, Nishimura S-I.
   Impaired O-Glycosylation at Consecutive Threonine TTX Motifs in Mucins Generates Conformationally Restricted Cancer Neoepitopes
   Biochemistry 59, 1221-1241 (2020).DOI: 10.1021/acs.biochem.0c00007
4. Soma O., Hatakeyama S., Yoneyama T., Saito M., Sasaki H., Tobisawa Y., Noro D., Suzuki Y., Tanaka M., Nishimura S-I., Harada H., Ishida H., Tanabe K., Satoh S., Ohyama C.
   Serum N-glycan profiling can predict biopsy-proven graft rejection after living kidney transplantation
   Clin. Exp. Nephrol. 24, 174-184 (2020)DOI: 10.1007/s10157-019-01820-8
5. Nonoyama T., Lee Y.W., Ota K., Fujioka K., Hong W., Gong J.P.
   Instant Thermal Switching from Soft Hydrogel to Rigid Plastics Inspired by Thermophile Proteins
   Advanced Materials, 32(4), 1905878 (7 pages) (2020)https://onlinelibrary.wiley.com/doi/full/10.1002/adma.201905878DOI: 10.1002/adma.201905878
6. Guo H., Uehara Y., Matsuda T., Kiyama R., Li L., Ahmed J., Katsuyama Y., Nonoyama T., Kurokawa T.
   Surface charges dominated protein adsorption on hydrogels
   Soft Matter, 16(7), 1897-1907 (2020) DOI: 10.1039/c9sm01999e
7. Fukao K., Nakajima T., Nonoyama T., Kurokawa T., Kawai T., Gong J.P.
   Effect of Relative Strength of Two Networks on Internal Fracture Process of Double Network Hydrogels as Revealed by in situ Small-Angle X-ray Scattering
   Macromolecules, 53(4), 1154-1163 (2020)DOI: 10.1021/acs.macromol.9b02562
8. Hui C.Y., Liu Z., Phoenix S.L., King D.R., Cui W., Huang Y., Gong J.P.
   Mechanical Behavior of Unidirectional Fiber Reinforced Soft Composites
   Extreme Mechanics Letters, 35, 100642 (13 pages) (2020)DOI: 10.1016/j.eml.2020.100642
9. Hirayama S., Kurokawa T., Gong J.P.
   Non-Linear Rheological Study of Hydrogel Sliding Friction in Water and Concentrated Hyaluronan Solution
   Tribology International, 147, 106270 (7 pages) (2020)DOI: 10.1016/j.triboint.2020.106270
10. Koolath S., Murai, Y., Suga, Y., Monde, K.
    Chiral Combinatorial Preparation and Biological Evaluation of Unique Ceramides for Inhibition of Sphingomyelin Synthase
    Chirality, 32, 308-313 (2020)DOI: 10.1002/chir.23179
11. Lkhamkhuu E., Zikihara K., Katsura H., Tokutomi S., Hosokawa T., Usami Y., Ichihashi M., Yamaguchi J., Monde K.
    Effect of Circularly Polarized Light on Germination, Hypocotyl Elongation and Biomass Production of Arabidopsis and Lettuce
    Involvement of Phytochrome B
    Plant Biotechnology, 37, 57-67 (2020)DOI: 10.5511/plantbiotechnology.19.1219a
12. Koshino S., Takikawa A., Ishida K., Taniguchi T., Monde K., Kwon E., Umemiya S., Hayashi Y.
    Inversion of the axial information during oxidative aromatization in the synthesis of axially chiral biaryls using organocatalyst as a key step
    Chem. Eur. J., 26, 4524-4530 (2020)DOI: 10.1002/chem.201905814
13. Sun X., Ye Y., Sakurai N., Kato K., Yuasa K., Tsuji A., Yao M.
    Crystallographic analysis of Eisenia hydrolysis-enhancing protein using a long wavelength for native-SAD phasing.
    Acta Crystallographica Section F Structural Biology Communications, 76, 20-24, (2020)DOI: 10.1107/S2053230X19016716
14. Wang H., Yu J., Satoh Y., Nakagawa Y., Tanaka R., Kato K., Yao M.
    Crystal structures clarify cofactor binding of plant tyrosine decarboxylase
    Biochemical and Biophysical Research Communications, 523(2)500-505, (2020) DOI: 10.1016/j.bbrc.2019.12.077
15. Goshima Y., Nakaoka S., Ohashi K., Sakamaki H., Shibuya K., Shibuya A.
    A mathematical model for dynamics of soluble form of DNAM-1 as a biomarker for graft-versus-host disease
    PLoS ONE, 15, e0228508 (2020)https://pubmed.ncbi.nlm.nih.gov/32040515/DOI: 10.1371/journal.pone.0228508
16. Matsumoto T., Hatakeyama S., Yoneyama T., Tobisawa Y., Ishibashi Y., Yamamoto H., Yoneyama T., Hashimoto Y., Ito H., Nishimura S-I., Ohyama C.
    Serum N-glycan profiling is a potential biomarker for castration-resistant prostate cancer
    Sci. Rep. 9, 168761 (2019)DOI: 10.1038/s41598-019-53384-y
17. Koide R., Nishimura S-I.
    Antiadhesive nanosomes facilitate targeting of lysosomal GlcNAc salvage pathway through derailed cancer endocytosis
    Angew. Chem. Int. Ed. 58, 14513-14518 (2019)DOI: 10.1002/anie.201907778
18. Hideshima S., Hayashi H., Hinou H., Nambuya S., Kuroiwa S., Nakanishi T., Momma T., Nishimura S-I., Sakoda Y., Osaka T.
    Glycan-immobilized dual-channel field effect transistor biosensor for the rapid identification of pandemic influenza viral particles
    Sci. Rep. 9, 11616 (2019)DOI: 10.1038/s41598-019-48076-6
19. Hinou H.
    Aniline Derivative/DHB/Alkali Metal Matrices for Reflectron Mode MALDI-TOF and TOF/TOF MS Analysis of Unmodified Sialylated Oligosaccharides and Glycopeptides
    Int. J. Mass Specytom., 443, 109-115 (2019).DOI: 10.1016/j.ijms.2019.06.006
20. Hinou H., Kikuchi S., Ochi R., Igarashi K., Takada W., Nishimura S-I.
    Synthetic glycopeptides reveal specific binding pattern and conformational change at O-mannosylated position of a-dystroglycan by POMGnT1 catalyzed GlcNAc modification.
    Bioorgan. Med. Chem. 27, 2822-2831 (2019)DOI: 10.1016/j.bmc.2019.05.008
21. Gebrehiwot Abrha G., Seifu Melka D., Mamo Kassaye Y., Gemechu T., Lako W., Hinou H., Nishimura S-I.
    Exploring serum and Immunoglobulin G N-glycome as diagnostic biomarkers for early detection of breast cancer in Ethiopian women
    BMC Cancer 19, 588 (2019)DOI: 10.1186/s12885-019-5817-8
22. Yasuda S., Akiyama T., Nemoto S., Hayashi T., Ueta T., Kojima K., Tsukamoto T., Nagatoishi S., Tsumoto K., Sudo Y., Kinoshita M., Murata T.
    Methodology for Further Thermostabilization of an Intrinsically Thermostable Membrane Protein Using Amino Acid Mutations with Its Original Function Being Retained
    J. Chem. Inf. and Model., 60(3), 1709-1716, (2020)DOI: 10.1021/acs.jcim.0c00063
23. Poncet P., Aizawa T., Sénéchal H.
    The subtype of Cupressaceae pollinosis associated with Pru p 7 sensitization is characterized by a sensitization to a cross-reactive gibberellin-regulated protein in cypress pollen: BP14.
    Clin Exp Allergy, 49(8), 1163-1166, (2019)DOI: 10.1111/cea.13418
24. Mai T.T., Matsuda T., Nakajima T., Gong J.P., Urayama K.
    Damage Cross-effect and Anisotropy in Tough Double Network Hydrogels Revealed by Biaxial Stretching
    Soft Matter, 15(18), 3719-3732 (2019)DOI: 10.1039/c9sm00409b
25. Huang Y., King D.R., Cui W., Sun T.L., Guo H., Kurokawa T., Brown H.R., Hui C.Y., Gong J.P.
    Superior Fracture Resistance of Fiber Reinforced Polyampholyte Hydrogels Achieved by Extraordinarily Large Energy-dissipative Process Zones
    Journal of Materials Chemistry A, 7(22), 13431-13440 (2019)DOI: 10.1039/c9ta02326g
26. Guo H., Nakajima T., Hourdet D., Marcellan A., Creton C., Hong W., Kurokawa T., Gong J.P.
    Hydrophobic Hydrogels with Fruit-like Structure and Functions
    Advanced Materials, 31(25), 1900702 (2019)DOI: 10.1002/adma.201900702
27. Hubbard A.M., Cui W., Huang Y., Takahashi R., Dickey M.D., Genzer J., King D.R., Gong J.P.
    Hydrogel/Elastomer Laminates Bonded via Fabric Interphases for Stimuli-Responsive Actuators
    Matter, 1(3), 674-689 (2019)DOI: 10.1016/j.matt.2019.04.008
28. Matsuda T., Nakajima T., Gong J.P.
    Fabrication of Tough and Stretchable Hybrid Double-Network Elastomers Using Ionic Dissociation of Polyelectrolyte in Nonaqueous Media
    Chemistry of Materials, 31(10), 3766-3776 (2019)DOI: 10.1021/acs.chemmater.9b00871
29. Chen L., Sun T.L., Cui K., King D.R., Kurokawa T., Saruwatari Y., Gong J.P.
    Facile Synthesis of Novel Elastomers with Tunable Dynamics for Toughness, Self-healing and Adhesion
    Journal of Materials Chemistry A, 7(29), 17334-17344 (2019)DOI: 10.1039/c9ta04840e
30. Takahashi R., Ikai T., Kurokawa T., King D.R., Gong J.P.
    Double Network Hydrogels Based on Semi-rigid Polyelectrolyte Physical Networks
    Journal of Materials Chemistry B Emerging Investigators, 7(41), 6347-6354 (2019)DOI: 10.1039/c9tb01217f
31. Zhang H.J., Luo F., Ye Y., Sun T.L., Nonoyama T., Kurokawa T., Nakajima T.
    Tough Triblock Copolymer Hydrogels with Different Micromorphologies for Medical and Sensory Materials
    ACS Applied Polymer Materials, 1(8), 1948-1953 (2019)DOI: 10.1021/acsapm.9b00395
32. Khiêm V.N., Mai T.T., Urayama K., Gong J.P.,Itskov M.
    A Multi-axial Theory of Double Network Hydrogels
    Macromolecules, 52(15), 5937-5947 (2019).DOI: 10.1021/acs.macromol.9b01044
33. Murai J., Nakajima T., Matsuda T., Tsunoda K., Nonoyama T., Kurokawa T., Gong J.P.
    Tough Double Network Elastomers Reinforced by the Amorphous Cellulose Network
    Polymer, 178, 121686 (7pages) (2019)DOI: 10.1016/j.polymer.2019.121686
34. Murakawa K., King D.R., Sun T.L., Guo H., Kurokawa T., Gong J.P.
    Polyelectrolyte Complexation via Viscoelastic Phase Separation Results in Tough and Self-Recovering Porous Hydrogel
    Journal of Materials Chemistry B, 7(35), 5296-5305 (2019)DOI: 10.1039/c9tb01376h
35. Frauenlob M., King D.R., Guo H., Ishihara S., Tsuda M., Kurokawa T., Haga H., Tanaka S., Gong J.P.
    Modulation and Characterization of the Double Network Hydrogel Surface-bulk Transition
    Macromolecules, 52(17), 6704-6713 (2019)DOI: 10.1021/acs.macromol.9b01399
36. Qiao L., Du C., Gong J.P., Wu Z.L., Zheng Q.
    Programmed Diffusion Induces Anisotropic Superstructure in Hydrogel with High Mechano-Optical Sensitivity
    Advanced Materials Technologies, 4(11), 1900665 (2019)https://onlinelibrary.wiley.com/doi/abs/10.1002/admt.201900665DOI: 10.1002/admt.201900665
37. King D.R., Okumura T., Takahashi R., Kurokawa T., Gong J.P.
    Macroscale Double Networks: Design Criteria for Optimizing Strength and Toughness
    ACS Applied Materials & Interfaces, 11(38), 35343-35353 (2019)DOI: 10.1021/acsami.9b12935
38. Guo H., Hong W., Kurokawa T., Matsuda T., Wu Z.L., Nakajima T., Takahata M., Sun T.L., Rao P., Gong J.P.
    Internal Damage Evolution in Double-Network Hydrogels Studied by Microelectrode Technique
    Macromolecules, 52(18), 7114-7122 (2019)DOI: 10.1021/acs.macromol.9b01308
39. Tao Z., Fan H., Huang J., Sun T.L., Kurokawa T., Gong J.P.
    Fabrication of Tough Hydrogels Composites from Photo-responsive Polymers to Show Double Network Effect
    ACS Applied Materials & Interfaces, 11(40), 37139-37146 (2019)DOI: 10.1021/acsami.9b13746
40. Cui K., Ye Y.N., Sun T.L., Chen L., Li X., Kurokawa T., Nakajima T., Nonoyama T., Gong J.P.
    Effect of Structure Heterogeneity on Mechanical Performance of Physical Polyampholytes Hydrogels
    Macromolecules, 52(19), 7369-7378 (2019)DOI: 10.1021/acs.macromol.9b01676
41. Nakajima T., Ozaki Y., Namba R., Ota K., Maida Y., Matsuda T., Kurokawa T., Gong J.P.
    Tough Double-Network Gels and Elastomers from the Non-Prestretched First Network
    ACS Macro Letters, 8(11), 1407-1412 (2019)DOI: 10.1021/acsmacrolett.9b00679
42. Ye.Y.N., Cui K., Indei T., Nakajima T., Hourdet D., Kurokawa T, Gong J.P.
    Relaxation Dynamics and Underlying Mechanism of a Thermally Reversible Gel from Symmetric Triblock Copolymer
    Macromolecules, 52(22), 8651-8661 (2019)DOI: 10.1021/acs.macromol.9b01856
43. Fan H., Wang J., Tao Z., Huang J., Rao P., Kurokawa K., Gong J.P.
    Adjacent Cationic-Aromatic Sequences Yield Strong Electrostatic Adhesion of Hydrogels in Seawater
    Nature Communications, 10, 5127 (2019) DOI: 10.1038/s41467-019-13171-9
44. Kumagai Y,. Nio-Kobayashi J,. Ishida-Ishihara S,. Tachibana H,. Omori R,. Enomoto A,. Ishihara S,. Haga H.
    The intercellular expression of type-XVII collagen, laminin-332, and integrin-β1 promote contact following during the collective invasion of a cancer cell population.
    Biochemical and biophysical research communications, 514(4), 1115-1121 (2019)DOI: 10.1016/j.bbrc.2019.05.058
45. Mizutani Y,. Kobayashi H,. Iida T,. Asai N,. Masamune A,. Hara A,. Esaki N,. Ushida K,. Mii S,. Shiraki Y,. Ando K,. Weng L,. Ishihara S,. Ponik SM,. Conklin MW,. Haga H,. Nagasaka A,. Miyata T,. Matsuyama M,. Kobayashi T,. Fujii T,. Yamada S,. Yamaguchi J,. Wang T,. Woods SL,. Worthley D,. Shimamura T,. Fujishiro M,. Hirooka Y,. Enomoto A,. Takahashi M.
    Meflin-Positive Cancer-Associated Fibroblasts Inhibit Pancreatic Carcinogenesis.
    Cancer research. 79, 5367-5381 (2019)https://cancerres.aacrjournals.org/content/79/20/5367DOI: 10.1158/0008-5472.CAN-19-0454
46. Othman, M. A., Yuyama, K., Murai, Y., Igarashi, Y., Mikami, D., Sivasothy, Y., Awang, K., Monde, K.
    Malabaricone C as Natural Sphingomyelin Synthase Inhibitor against Diet-Induced Obesity and Its Lipid Metabolism in Mice
    ACS Med. Chem. Lett., 10, 1154-1158 (2019)DOI: 10.1021/acsmedchemlett.9b00171
47. Okamura, H., Fujioka, T., Mori, N., Taniguchi, T., Monde, K., Watanabe, H., Takikawa, H.
    First enantioselective synthesis of salinipostin A, a marine cyclic enol-phosphotriester isolated from Salinispora sp
    Tetrahedron Lett., 60, 150917-150919 (2019)DOI: 10.1016/j.tetlet.2019.07.008
48. Saaidin S. A., Murai, Y., Ishikawa, T., Monde, K.
    Design and Synthesis of Ligand‐Tag Exchangeable Photoaffinity Probe Utilizing Nosyl Chemistry.
    Eur. J. Org. Chem., 46, 7563-7567 (2019)DOI: 10.1002/ejoc.201901348
49. Morishita Y., Okazaki Y., Yi Yi Luo, Nunoki J., Taniguchi T., Oshima Y., Asai T.
    Use of plant hormones to activate silent polyketide biosynthetic pathways in Arthrinium sacchari, a fungus isolated from a spider.
    Org. Biomol. Chem. 2019, 17, 780-784 (2019)DOI: 10.1039/c8ob02837k
50. Christiane Kiske, Anja Devenie Riegel, Ronja Hopf, Anna Kvindt, Iulia Poplacean, Tohru Taniguchi, Mahadeva M. M. Swamy, Kenji Monde, Wolfgang Eisenreich, Karl-Heinz Engel;
    Determination of the Absolute Configurations and Sensory Properties of the Enantiomers of a Homologous Series (C6-C10) of 2-Mercapto-4-alkanones.
    J. Agric. Food Chem. 2019, 67, 1187-1196 (2019)DOI: 10.1021/acs.jafc.8b06599
51. Ye Y., Meirong C., Kato K., Yao M.
    The pH-dependent conformational change of eukaryotic translation initiation factor 5: Insights into partner-binding manner.
    Biochemical and Biophysical Research Communications, 519, 186-191, (2019)DOI: 10.1016/j.bbrc.2019.08.128
52. Li L., Adachi M., Yu J., Kato K., Shinoda A., Ostermann A., E.Schrader T., Ose T., and Yao M.
    Neutron crystallographic study of heterotrimeric glutamine amidotransferase CAB
    Acta Crystallogr F Struct Biol Commun., 75, 193-196, (2019)DOI: 10.1107/S2053230X19000220
53. Hashimoto T., Ye Y., Matsuno A.,Ohnishi Y., Kitamura A., Kinjo M., Abe S., Ueno T., Yao M., Ogawa T., Matsui T., and Tanaka, Y.
    Encapsulation of biomacromolecules by soaking and co-crystallization into porous protein crystals of hemocyanin
    Biochem. Biophys. Res. Commun., 509, 577-584, (2019)DOI: 10.1016/j.bbrc.2018.12.096
54. Kumar Sasmal S., Takeuchi Y., Nakaoka S.
    T-cell mediated adaptive immunity and antibody-dependent enhancement in secondary dengue infection
    Journal of Theoretical Biology, 470, 50-63 (2019)DOI: 10.1016/j.jtbi.2019.03.010

Article

1. Nonoyama T., Gong J.P.
   Meet the phase-separation polymeric gel
   The Innovation Platform, Issue 1, 73-74 (2020)
2. Taniguchi T.
   The World of Solution-State Molecules Seen with Using Vibrational Circular Dichroism Spectroscopy.
   Chemistry and Education 2019, 66, 825-826. (written in Japanese)
3. Nakaoka S., Matsuyama K.
   Information and statistical analysis pipeline for high-throughput RNA sequencing data
   Springer protocol Epidermis, 1-10 (2019)

Int. Invited Lecture

1. January 2020
   Bagalore, INDIA
   107th Indian Science Congress
   Chemical Glycobiology (Starting from Glycoconjugate Syntheses)
   Hinou H.
2. January 2020
   Ventura, USA
   2020 Gordon Research Conference on Multifunctional Materials and Structures
   Self-Growing Hydrogels Inspired by Biological Metabolism
   Nakajima T.
3. August 2019
   San Diego, USA
   Japanese-American Symposium on Applied & Translational Glycosciences, ACS Fall 2019 National Meeting
   Novel matrix system for reflectron mode MALDI-TOF and TOF/TOF MS analysis of unmodified sialylated oligosaccharides and glycopeptides
   Hinou H.
4. May 2019
   Budapest, Hungary
   Frontiers in Polymer Science 2019
   Self-growing double network hydrogels by repetitive mechanical training
   Gong J.P.
5. June 2019
   Xi'an, China
   The 3nd International Symposium for Advanced Gel Materials & Soft Matters
   Self-growing hydrogels by repetitive mechanical training
   Gong J.P.
6. June 2019
   Shenzhen, China
   Joint Meeting of the 5th International Symposium of Flexible and Stretchable Electronics 2019 (ISFSE 2019) and the 5th International Workshop on Soft Machines and Mechanics 2019 (IWSMM 2019)
   Macroscale Double Networks: Design Criteria for Optimizing Strength and Toughness
   King D.R.
7. June 2019
   Shenzhen, China
   Joint Meeting of the 5th International Symposium of Flexible and Stretchable Electronics 2019 (ISFSE 2019) and the 5th International Workshop on Soft Machines and Mechanics 2019 (IWSMM 2019)
   Bone-Inspired Soft Composite Possessing Osteo-Activity
   Nonoyama T.
8. July 2019
   Guangzhou, China
   Seminar at South China University of Technology
   Macroscale Double Networks: A Universal Method for Improving the Strength and Toughness of Soft Materials
   King D.R.
9. July 2019
   Guangzhou, China
   Seminar at South China University of Technology
   Bone-Inspired Soft Ceramics Possessing Osteo-Activity
   Nonoyama T.
10. July 2019
    Kashiwa, Japan
    Seminar at the University of Tokyo
    Macroscale Double Networks: Extending the “Double Network Concept” to Large Length-Scales
    King D.R.
11. July 2019
    Cork, Ireland
    ECI Colloidal, Macromolecular and Biological Gels II
    Macroscale Double Networks: Expanding the “Sacrificial Bond Concept” to Large Length-Scales
    King D.R.
12. July 2019
    Capri, Italy
    DoDyNet Summer School
    Molecular design of self-growing hydrogels in response to mechanical training
    Gong J.P.
13. July 2019
    Sapporo, Japan
    International Symposium on Biopolymer Synthesis and Degradation
    Quick & Reversible Thermo-Robustizing Hydrogels Exhibiting 1000 Times Modulus Jump
    Nonoyama T.
14. August 2019
    Yangon, Myanmar
    International Congress on Pure & Applied Chemistry (ICPAC Yangon 2019)
    Activity Measurement of Polyelectrolyte in Hydrogels by Microelectrode Technique
    Kurokawa T.
15. September 2019
    Beijing, China
    7th Asian Symposium on Advanced Materials (ASAM-7)
    Self-Growing Hydrogels by Mechanical Training
    Gong J.P.
16. September 2019
    Fukui, Japan
    第68回高分子討論会（日韓ジョイントセッション）
    Self-growong gels inspired by metabolism
    Nakajima T.
17. October 2019
    Tokyo, Japan
    JST CREST International Workshop : New Developments toward Wearable Photonics: From Materials to Devices CREST （「次世代フォトニクス」国際シンポジウム～ウェアラブルフォトニクスに向けた新しい展開：マテリアルからデバイスへ～）
    Self-growing materials under mechanical training
    Gong J.P.
18. October 2019
    Xi’an, China
    2019 National Polymer Congress of CHINA / 2019年全国高分子学術論文報告会China-Japan Joint Symposium for Young Polymer Scientists
    Hydrogel Possessing Rubbery-to-Glassy Transition at Elevated Temperature
    Nonoyama T.
19. October 2019
    Xi’an, China
    Seminar at Shaanxi University of Science & Technology, Shaanxi University of Science & Technology
    Robust Phase-Separation Induced Rubbery-to-Glassy Transition at Elevated Temperature
    Nonoyama T.
20. November 2019
    Tokyo, Japan
    Millennium Science Forum (MSF)
    Strengthening materials using weak bonds-A novel strategy
    Gong J.P.
21. November 2019
    Paris, France
    Seminar at ESPCI
    Self-Growing Hydrogels by Mechanical Training
    Gong J.P.
22. December 2019
    Hyderabad, India
    2nd India-Japan Workshop on Magnetic Resonance
    Development and application of novel overexpression systems for NMR analysis of antimicrobial peptides
    Aizawa T.
23. December 2019
    Tokyo, Japan
    CEMS International Symposium on Supramolecular Chemistry and Functional Materials 2019 (CEMSupra2019) （理化学研究所 創発物性科学研究センター 国際会議）
    Self-growing hydrogels by repetitive mechanical training
    Gong J.P.
24. December 2019
    Yokohama, Japan
    Materials Research Meeting 2019 (MRM2019)
    Fiber Reinforced Hydrogels With Extra-Ordinarily High Toughness
    Gong J.P.
25. December 2019
    Philadelphia, USA
    Seminar at University of Pennsylvania, University of Pennsylvania
    Macroscale Double Networks: Extending the “Double Network Concept” to Large Length-Scales
    King D.R.
26. July 2019
    A3 symposium (Sendai, Japan)
    Application of energy landscape analysis for cellular differentiation process
    Nakaoka S.
27. October 2019
    Hunter Collage Seminor
    New York, NY
    Sphingosine Chemical Biology
    Monde K.
28. November 2019
    The Fourth A3 Roundtable Meeting
    on Asia Chemical Probe Research Hub
    Sendai, Japan,
    Naturally Occurring Sphingomyelin Synthase Inhibitors against
    Diet-Induced Obesity and their Action Mechanism
    Monde K.
29. December 2019
    Adichunchanagiri Univerisy, Nagara, India
    Symposium “Recent Trends in Medicinal Chemistry”
    Sphingolipid Chemical Biology toward Drug Discovery from Nature
    Monde K.

Int. Oral Presentation

1. February 2020
   Charleston, USA
   The Adhesion Society 43rd Annual Meeting
   Double network gels from semi-rigid polyelectrolyte physical networks with controlled anisotropy
   King D.R.
2. July 2019
   Montreal, Canada
   The 2nd Conference on Multiscale Mechanochemistry and Mechanobiology
   Self-growing hydrogels through a metabolic-like mechanochemical process
   Nakajima T.
3. October 2019
   Okinawa, Japan
   The 13th Pacific Rim Conference of Ceramic Societies (PACRIM13)
   Bioceramics Toughening Soft & Wet Materials
   Nonoyama T.
4. November 2019
   Sapporo, Japan
   2nd ICReDD International Symposium
   Stress Responsive Disulfide Bond Reduction in Tough Double Network Hydrogels
   Nakajima T.
5. December 2019
   Boston, USA
   2019 MRS Fall Meetings & Exhibits
   Macroscale Double Networks: A Universal Method for Improving the Strength and Toughness of Soft Materials
   King D.R.
6. October 2019
   4th Workshop on Virus Dynamics (Paris, France)
   A computational method to detect key factors associated with critical transition of gene expression profile in viral infection
   Nakaoka S.
7. December 2019
   National Univ. of Singapore　(シンガポール）
   アジア結晶学会
   Dynamic structure is requited for transslufursome on the Cys-tRNA(Cys) synthesis in indirect pathway
   Yao M.
8. December 2019
   The 2019 International Symposium on Nonlinear Theory and Its Applications (Kuala Lumpur, Malaysia)
   Investigation of possible coherent metabolic modes in auxotrophic bacterial community
   Nakaoka S.

Department of Functional Life Sciences

Reviewed Paper

1. Hirabayashi Y., Nakamura K., Sonehara T., Suzuki D., Hanzawa S., Shimizu Y., Aizawa T., Nakamura K., Tamakoshi A., Ayabe T.
   Analysis of Serotonin in Human Feces Using Solid Phase Extraction and Column-switching LC-MS/MS
   Mass Spectrometry, 8, A0081, (2020)
2. Response surface method for polyhydroxybutyrate (PHB) bioplastic accumulation in Bacillus drentensis BP17 using pineapple peel.
   Penkhrue W., Jendrossek D., Khanongnuch C., Pathom-Aree W., Aizawa T., Behrens R.L., Lumyong S.
   PLoS One., 15(3), e0230443, (2020)DOI: 10.1371/journal.pone.0230443
3. Mafy N., Matsuo K., Hiiruma S.,Uehara R.,Tamaoki N.,
   Photoswitchable CENP-E Inhibitor Enabling the Dynamic Control of Chromosome Movement and Mitotic Progression.
   J. Am. Chem. Soc., 142, 1763-1767, (2020)DOI: 10.1021/jacs.9b12782
4. Takakuwa A, Nakamura K, Kikuchi M, Sugimoto R, Ohira S, Yokoi Y, Ayabe T
   Butyric acid and leucine induce a-defensin secretion from small intestinal Paneth cells
   Nutrients 11, 2817 (2019) DOI: 10.3390/nu11112817
5. Shimizu Y, Sakuragi N, Nakamura K, Taira T, Ayabe T, Fukui A
   A simple culture method for liver and intestinal tissue-resident macrophages from neonatal mice
   In Vitro Cell Dev Biol – Animal 55, 436-444 (2019) DOI: 10.1007/s11626-019-00359-y
6. Yokoi Y, Nakamura K, Yoneda T, Kikuchi M, Sugimoto R, Shimizu Y, Ayabe T
   Paneth cell granule dynamics on secretory responses to bacterial stimuli in enteroids
   Sci Rep 9, 2710 (2019) DOI: 10.1038/s41598-019-39610-7
7. Pillai MR, Mihi B, Ishiwata K, Nakamura K, Sakuragi N, Finkelstein DB, McGargill MA, Nakayama T, Ayabe T, Coleman ML, Bix M
   Myc-induced nuclear antigen constrains a latent intestinal epithelial cell-intrinsic anthelmintic pathway
   PLOS ONE 14, e0211244 (2019)DOI: 10.1371/journal.pone.0211244
8. Horie Y., Nemoto H., Fujita J., Ikegawa S., Kumaki Y., Ohnishi Y., Kumeta H., Demura M., Aizawa T.
   Studies on the Quality Control of Fermented Brown Rice and Rice Bran with Aspergillus oryzae by Metabolome Analysis Using 1H-NMR1H-NMR
   Nippon Shokuhin Kagaku Kogaku Kaishi, 66(4), 139-146, (2019)DOI: 10.3136/nskkk.66.139
9. Yanagi T., Takagi T., Takahashi H., Kikukawa T., Amii H., Sonoyama M.
   Comparison of two different partially fluorinated phosphatidylcholines with the perfluorobutyl group on thermotropic properties of the bilayer membrane and reconstituted bacteriorhodopsin.
   Biophys. Rev., 11(3), 395-398, (2019)
10. Yamanashi T., Maki M., Kojima K., Shibukawa A., Tsukamoto T., Chowdhury S., Yamanaka A., Takagi S., Sudo Y.
    Quantification of the neural silencing activity of anion channelrhodopsin in Caenorhabditis elegansand their applicability for long-term illumination
    Sci. Rep., 9(1), 7863, (2019)DOI: 10.1038/s41598-019-44308-x
11. Geng X., Dai G., Chao L., Wen D., Kikukawa T., Iwasa T.
    Two Consecutive Polar Amino Acids at the End of Helix E are Important for Fast Turnover of the Archaerhodopsin Photocycle
    Photochemistry and Photobiology, 95(4), 980-989, (2019)DOI: 10.1111/php.13072
12. Iizuka A., Kajimoto K., Fujisawa T., Tsukamoto T., Aizawa T., Kamo N., Jung K.H., Unno M., Demura M., Kikukawa T.
    Functional importance of the oligomer formation of the cyanobacterial H+ pump Gloeobacter rhodopsin
    Scientific Reports, 9(1), 10711, (2019)DOI: 10.1038/s41598-019-47178-5
13. Fujisawa T., Kiyota H., Kikukawa T., Unno M.
    Low-Temperature Raman Spectroscopy of Halorhodopsin from Natronomonas pharaonis: Structural Discrimination of Blue-Shifted and Red-Shifted Photoproducts
    Biochemistry, 58(40), 4159-4167, (2019)DOI: 10.1021/acs.biochem.9b00643
14. Sato T., Kikukawa T., Miyoshi R., Kajimoto K., Yonekawa C., Fujisawa T., Unno M., Eki T., Hirose Y.
    Protochromic absorption changes in the two-cysteine photocycle of a blue/orange cyanobacteriochrome
    J. Biol. Chem., 294(49), 18909-18922, (2019) DOI: 10.1074/jbc.RA119.010384
15. Yamamura R., Nakamura K., Kitada N., Aizawa T., Shimizu Y., Nakamura K., Ayabe T., Kimura T., Tamakoshi A.
    Associations of gut microbiota, dietary intake, and serum short-chain fatty acids with fecal short-chain fatty acids.
    Biosci Microbiota Food Health., 39(1), 11-17, (2020) DOI: 10.12938/bmfh.19-010
16. Takahashi S., Yamamoto J., Kitamura A., Kinjo M.,Sugimoto N.
    Characterization of Intracellular Crowding Environments with Topology-Based DNA Quadruplex Sensors
    Anal. Chem., 91(4), 2586–2590 (2019)DOI: 10.1021/acs.analchem.8b04177
17. Sugihara M., Morito D., Ainuki S., Hirano Y., Ogino K., Kitamura A., Hirata H., Nagata K.
    The AAA+ ATPase/ubiquitin ligase mysterin stabilizes cytoplasmic lipid droplets
    J Cell Biol. 218(3), 949-960(2019)DOI: 10.1083/jcb.201712120
18. Yamamoto J., Kinjo M.
    Full fiber-optic fluorescence correlation spectroscopy
    Optics Express, 27(10), 14835-14841(2019)DOI: 10.1364/OE.27.014835
19. Aleksandar J. Krmpot., Stanko N., Nikolić, S Oasa., Dimitrios K., Papadopoulos., Marco Vitali., M Oura., S Mikuni., Per Thyberg., S Tisa., M Kinjo.,
    Lennart Nilsson., Lars Terenius., Rudolf Rigler., Vladana Vukojević
    Functional Fluorescence Microscopy Imaging: Quantitative Scanning-Free Confocal Fluorescence Microscopy for the Characterization of Fast Dynamic
    Processes in Live Cells
    Anal. Chem., 91(17), 11129-11137(2019)DOI: 10.1021/acs.analchem.9b01813

Article

• Kitamura A., Kabayama K.
  Session 2SHP report―decoding intracellular architecture using visualizing device development
  and mathematical modeling
  Biophysical Reviews, (2020)

Int. Invited Lecture

1. May 2019
   Los Angeles, USA
   Hokudai-USC Research Workshop “Gut-Organ Crosstalk”
   Paneth cell in health and disease – an overview from intestinal homeostasis and inter organ network
   Ayabe T
2. May 2019
   Los Angeles, USA
   Hokudai-USC Research Workshop “Gut-Organ Crosstalk”
   Dynamics and mechanisms of Paneth cell granule secretory responses in enteroids
   Yokoi Y, Nakamura K, Sugimoto R, Ohira S, Kikuchi M, Ayabe T
3. May 2019
   Los Angeles, USA
   Hokudai-USC Research Workshop “Gut-Organ Crosstalk”
   Paneth cell α-defensin misfolding leads to dysbiosis and subsequent ileitis in a murine model of Crohn's disease
   Shimizu Y, Nakamura K, Kikuchi M, Shinozaki R, Ayabe T
4. November 2019
   Albanova, KTH Royal Institute of Technology (Stockholm, Sweden)
   QBP/OCS seminar
   Aggregation process of carboxyl terminal fragments of TDP-43
   Kitamura A.
5. November 2019
   Karolinska Institutet (Stockholm, Sweden)
   Course Functional Fluorescence Microscopy Imaging (fFMI) in Biomedical Research
   FCS and FCCS in live cell
   Kitamura A. & Kinjo M.
6. December 2019
   2nd Chemical Biology Workshop (ChemBiol Workshop)
   Nampo Hound Premier Hotel, Busan, Korea
   Naturally Occurring Sphingomyelin Synthase Inhibitors against
   Diet-Induced Obesity and their Action Mechanism
   Monde K.

Int. Oral Presentation

1. American Society for Cell Biology Annual Meeting 2019
   Acetylcholine-induced Paneth cell granule secretion via muscarinic M3 receptor in mouse small intestine
   Yokoi Y, Nakamura K, Sugimoto R, Ohira S, Kikuchi M, Ayabe T
2. American Society for Cell Biology Annual Meeting 2019
   Paneth cell dysfunction in pathophysiology of nonalcoholic steatohepatitis
   Nakamura S, Nakamura K, Kikuchi M, Yokoi Y, Ohira S, Shimizu Y, Nishida T, Ayabe T

Frontier Research Center for Advanced Material and Life Science

Reviewed Paper

1. Usuki S., Yasutake Y., Tamura N., Tamura T., Tanji K., Saitoh T., MuraiY., Mikami D., Yuyama K., Monde K., Mukai K., Igarashi Y.
   Nrp1 is Activated by Konjac Ceramide Binding-Induced Structural Rigidification of the a1a2 Domain
   Cells, 9(2), 517 (2020)DOI: 10.3390/cells9020517
2. Akiyama H., Ide M., Nagatsuka Y., Sayano T., Nakanishi E., Uemura N., Yuyama K., Yamaguchi Y., Kamiguchi H., Takahashi R., Aerts JMFG., Greimel P., Hirabayashi Y.
   Glucocerebrosidases catalyze a transgalactosylation reaction that yields a newly identified brain sterol metabolite, galactosylated cholesterol
   J. Biol.Chem., 295(16), 5257-5277(2020)DOI: 10.1074/jbc.RA119.012502
3. Usuki S., Yasutake Y., Tamura N., Tamura T., Tanji K., Saitoh T., Murai Y., Mikami D., Yuyama K., Monde K., Mukai K., Igarashi Y.
   Nrp1 is activated by kCer binding-induced structural rigidification of the a1a2 domain
   Cells 9, 517-535 (2020)DOI: 10.3390/cells9020517
4. Usuki S., Tamura N., Tamura T., Tanji K., Mikami D., Mukai K., Igarashi Y.
   Neurite outgrowth and morphological changes induced by 8-trans unsaturation of sphingadienine in kCer molecular species
   Int. J. Mol. Sci., 20(9), (2019)DOI: 10.3390/ijms20092116
5. Mikami D., Sakai S., Yuyama K., Igarashi Y.
   Isolation of sphingoid bases from starfish Asterias amurensis glucosylceramides and their effects on sphingolipid production in cultured keratinocytes
   J. Oleo Sci., 68(5), 427-441 (2019)DOI: 10.5650/jos.ess18256
6. Othman MA., Yuyama K., Murai Y., Igarashi Y., Mikami D., Sivasothy Y., Awang K., Monde K.
   Malabaricone C as natural sphingomyelin synthase inhibitor against diet-induced obesity and its lipid metabolism in mice
   ACS Medicinal Chemistry Letters, 10(8), 1154-1158 (2019)DOI: 10.1021/acsmedchemlett.9b00171
7. Yuyama K., Takahashi K., Usuki S., Mikami D., Sun H., Hanamatsu H., Furukawa J., Mukai K., Igarashi Y.
   Plant sphingolipids promote extracellular vesicle release and alleviate amyloid-β pathologies in a mouse model of Alzheimer’s disease
   Sci.Rep., 9(1), 16827 (2019)DOI: 10.1038/s41598-019-53394-w

Int. Invited Lecture

• July 2019
  Tokyo, Japan
  60th ICBL
  Sphingolipid from basic to applied research.
  Igarashi Y.