Laboratory of Cellular Machinery Science

Research Theme
Cell biology
Research Keywords

Cell division, ploidy, cytoskeleton, motor protein, self organization, cancer, aging, liver disease, microscopic analysis, biochemistry, molecular biology, cell culture, mouse model, transcriptome, mathematical modeling, compound screen


Overview of Research and Education

Research Contents: Precisely controlled cell division is an essential process of heredity, development and homeostasis. However, it is not known how a cell equally distributes its contents, or generates force to divide itself. Using cutting-edge microscopes and cellular biological techniques, we are trying to elucidate structure and function of cellular machineries that govern elaborate regulation of cell division.

Laboratory of Cellular Machinery Science (pdf)



〒001-0021 Frontier Research Center for Advanced Material and Life Science 5F, Kita 21 Nishi 11, Sapporo
ruehara* (Please replace * with @ when sending e-mail.)

Representative Publications

Kan Yaguchi, Kimino Sato, Koya Yoshizawa, Daisuke Mikami, Kohei Yuyama, Yasuyuki Igarashi, Gabor Banhegyi, Eva Margittai, and Ryota Uehara*
Mevalonate pathway-mediated ER homeostasis is required for haploid stability in human somatic cells
Cell Structure and Function (2021) 46:1-9

Koya Yoshizawa, Kan Yaguchi, and Ryota Uehara* (*corresponding author)
Uncoupling of DNA replication and centrosome duplication cycles is a primary cause of haploid instability in mammalian somatic cells
Frontiers in Cell and Developmental Biology (2020) 8:721

Mafy, N., Matsuo, K., Hiruma, S., Uehara, R. *, and Tamaoki, N. *, Photoswitchable CENP-E Inhibitor Enabling the Dynamic Control of Chromosome Movement and Mitotic Progression, Journal of American Chemical Society. (2020) 142:1763-1767

Yaguchi, K.#, Yamamoto, T.#, Shimada, M.#, Sugimoto, R.#, Nakamura, K., Ayabe, T., and Uehara, R.*, Ploidy-dependent change in cyclin D2 expression and sensitization to cdk4/6 inhibition in human somatic haploid cells, Biochemical and Biophysical Research Communications (2018)

Yaguchi, K., Yamamoto, T.#, Matsui, R.#, Tsukada, Y., Shibanuma, A., Kamimura, K., Koda, T., and Uehara, R.*, Uncoordinated centrosome cycle underlies the instability of non-diploid somatic cells in mammals, Journal of Cell Biology (2018) 217: 2463-2483

(*corresponding author; #equally contributed)