Antiadhesive nanosome elicits role of glycocalyx of tumor cell-derived exosomes in the organotropic cancer metastasis (Prof. Shin-Ichiro Nishimura’s group)

Point of this article

  • Developed a method to copy the entire glycocalyx (sugar chain pattern) of cancer cells and present it on nanoparticles.
  • The organ-directedness of nanoparticles administered into mice differs depending on the glycocalyx.
  • We aim to develop a new therapeutic method to inhibit the formation of pre-metastatic niches prior to cancer metastasis.