Study revealed by functional classification of Paneth cells using sugar chains that intestinal microbiota and immune cell-derived cytokines control Paneth cell subsets, expecting development of new preventive approach and therapeutics for various diseases.
This research topic is related to the sustainable development goals (SDGs);
3. GOOD HEALTH AND WELL-BEING
9. INDUSTRIAL INNOVATION AND INFRASTRUCTURE
Mariko Kamioka, Yoshiyuki Goto, Kiminori Nakamura, Yuki Yokoi, Rina Sugimoto, Shuya Ohira, Yosuke Kurashima, Shingo Umemoto, Shintaro Sato, Jun Kunisawa, Yu Takahashi, Steven E. Domino, Jean-Christophe Renauld, Susumu Nakae, Yoichiro Iwakura, Peter B. Ernst, Tokiyoshi Ayabe, Hiroshi Kiyono. Intestinal commensal microbiota and cytokines regulate Fut2+ Paneth cells for gut defense.
Proc. Natl. Acad. Sci. U.S.A. 2022. doi: 10.1073/pnas.2115230119