A research group led by Dr. Yuyama (from the Faculty of Advanced Life Science, Hokkaido University/the Institute for the Promotion of Business-Regional Collaboration), in collaboration with Toranomon Hospital and the Japanese Foundation for Cancer Research has discovered exosomal proteins that are altered in the pathogenesis of Alzheimer’s disease. This research result has been published in the journal Brain.
Points in the report
- The study collected cerebrospinal fluid of the participants in the Alzheimer’s disease continuum, and comprehensively analyzed proteins in extracellular vesicles (exosomes).
- Several proteins, including cathepsin B, either increased or decreased with the progression of Alzheimer’s disease pathology.
- These exosomal proteins are expected to be utilized as new diagnostic biomarkers and therapeutic targets for Alzheimer’s disease.
Please see the following press releasefor the detail (in Japanese) .