AIZAWA TomoyasuProfessor

Laboratory of Protein Science
Research Theme
Studies on proteins and peptides by using NMR method and protein engineering, NMR metabolomics
Research Keywords

protein science, structural biology, protein engineering, NMR, metabolome, biomarker research, biological defense, innate immunity, antimicrobial peptides, allergen, cytokines, microbiological control

Overview of Research

Protein folding: Proteins are biological “machines.” Proteins must “fold” in order to carry out these functions as machines. However, the process of protein folding remains unclear in many ways. We study the mechanisms of protein folding and the structures of proteins. Our ultimate goal is to be able to design the three-dimensional structure of protein.



Let’s try to solve the mystery of proteins!

Representative Publications

Song Y, Wang Y, Yan S, Nakamura K, Kikukawa T, Ayabe T, Aizawa T., Efficient recombinant production of mouse-derived cryptdin family peptides by a novel facilitation strategy for inclusion body formation. Microb Cell Fact., 22, 9 (2023)

Gu H, Kato T, Kumeta H, Kumaki Y, Tsukamoto T, Kikukawa T, Demura M, Ishida H, Vogel HJ, Aizawa T.,  Three-Dimensional Structure of the Antimicrobial Peptide Cecropin P1 in Dodecylphosphocholine Micelles and the Role of the C-Terminal Residues., ACS Omega., 7, 31924-31934 (2022)

Iizuka T, Takei M, Saito Y, Rumi F, Zheng J, Lu X, Chafey P, Broussard C, Guilloux-Assalet L, Charpin D, Ebisawa M, Sénéchal H, Aizawa T, Poncet P., Gibberellin-regulated protein sensitization in Japanese cedar (Cryptomeria japonica) pollen allergic Japanese cohorts., Allergy., 76, 2297-2302 (2021)

Komatsu Y, Shimizu Y, Yamano M, Kikuchi M, Nakamura K, Ayabe T, Aizawa T., Disease Progression-Associated Alterations in Fecal Metabolites in SAMP1/YitFc Mice, a Crohn’s Disease Model., Metabolomics, 16, 48 (2020)

Sénéchal H, Šantrůček J, Melčová M, Svoboda P, Zídková J, Charpin D, Guilloux L, Shahali Y, Selva MA, Couderc R, Aizawa T, Poncet P., A new allergen family involved in pollen food-associated syndrome: Snakin/gibberellin-regulated proteins., J Allergy Clin Immunol, 141, 411-414 (2018)

Penkhrue W, Sujarit K, Kudo T, Ohkuma M, Masaki K, Aizawa T, Pathom-Aree W, Khanongnuch C, Lumyong S., Amycolatopsis oliviviridis sp. nov., a novel polylactic acid-bioplastic-degrading actinomycete isolated from paddy soil., Int J Syst Evol Microbiol, 68, 1448-1454 (2018)

Hayase E, Hashimoto D, Nakamura K, Noizat C, Ogasawara R, Takahashi S, Ohigashi H, Yokoi Y, Sugimoto R, Matsuoka S, Ara T, Yokoyama E, Yamakawa T, Ebata K, Kondo T, Hiramine R, Aizawa T, Ogura Y, Hayashi T, Mori H, Kurokawa K, Tomizuka K, Ayabe T, Teshima T., R-Spondin1 expands Paneth cells and prevents dysbiosis induced by graft-versus-host disease., J Exp Med, 214, 3507-3518 (2017)

Baek M, Kamiya M, Kushibiki T, Nakazumi T, Tomisawa S,, Abe C, Kumaki Y, Kikukawa T, Demura M, Kawano K, Aizawa T, Lipopolysaccharide-bound structure of the antimicrobial peptide cecropin P1 determined by nuclear magnetic resonance spectroscopy., J. Peptide Sci, 22, 214-21 (2016)

Ishida H, Nguyen LT, Gopal R, Aizawa T, Vogel HJ, Overexpression of Antimicrobial, Anticancer, Transmembrane Peptides in Escherichia coli through a Calmodulin-Peptide Fusion System., J Am Chem Soc, 138, 11318-26 (2016)



<Office Hour>
– Time: Anytime during the lecture period
– Place: Science Bldg. No.2, 7F, #2-713
Please contact in advance by E-mail.
E-mail: aizawa[at]