Staff

IGARASHI YasuyukiVisiting Professor

Laboratory
Lipid Biofunction Section
Research Theme
Elucidation of physiological functions of sphingolipids and application development based on them
Research Keywords

Sphingolipids, ceramides, sphingomyelin, sphingosine1-phosphate, glycolipids, sphingolipids and metabolic syndrome pathology, sphingolipids and exosomes, Alzheimer’s disease, sphingolipid drug development, sphingo functional foods, cosmetics development

Overview of Research

1. Signal transduction via sphingosine 1-phosphate (S1P) receptor
2. Sphingolipid dynamics and cell membrane function
3. Ceramide / sphingomyelin metabolism and metabolic syndrome, Atsuheimer’s pathology, drug development research to improve it
4. Analysis of ceramide skin function and basic development research of ceramide-containing functional foods

Sphingolipids are one of the major lipids that make up cell membranes.
The cell membrane is not uniform, and there are microdomains in which sphingolipids, cholesterol, etc. are accumulated, and it is thought that they play an important role as a place for signal transduction pathways.

In our laboratory, we are mainly conducting research on the following two issues.
1) Basic research and applied development research on the function of metabolic enzymes of sphingosine-1 phosphate (S1P), sphingomyelin and ceramide, which are important lipid mediators, and fatty liver and obesity, as well as his relationship with Alzheimer’s disease.
2) Create an “industry creation department” with companies such as basic research on the molecular mechanism of the barrier function of ceramide in the skin and the development of functional materials and foods that are useful for skin water retention, improvement of atopic disease and prevention of Alzheimer’s disease. We are working together.

Charge

  • School of Science:
    No
  • Graduate School of Life Science:
    No

Affiliation

  • Frontier Research Center for Advanced Material and Life Science, Lipid Biofunction Section, Academia-Industry Collaboration Unit, Frontier Research Center for Advanced Material and Life Science
  • Frontier Research Center for Advanced Material and Life Science, Academia-Industry Collaboration Unit, Lipid Biofunction Section