Laboratory of Molecular Device

Learn from nature
Research Theme
Development of self-assembled nanoparticles for bioengineering applications
Research Keywords

Self-organization, self-assembly, biomimetics, functional device, biosensor, DNA, protein, biomolecule, cell, molecular recognition, drug delivery system, vaccine, gold nanoparticle, surface plasmon, stimulus-response, nanocapsule


Overview of Research and Education

Bio organisms are capable of efficient energy transformation, selective synthesis of biomolecules and interactive information processing. All these processes are based on effective molecular recognition at highly organized supramolecular assemblies. This research group is concerned with the construction of hierarchical molecular devices by the combination of nanosize molecular assemblies with micro size structures derived from dissipative processes. The following themes are in progress.
1) Development of novel drug delivery system using nanostructures, 2) Control of self-assembly of nanoparticles and creation of functions, 3) Development of supersensitive gel based plasmonic biosensors, 4) Development of high efficient nanoparticle vaccine

Laboratory of Molecular Device (pdf)



North 21 West 10, Kita-ku, Sapporo, Japan
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Representative Publications

Yu Sekizawa, Hideyuki Mitomo, Mizuki Nihei, Satoshi Nakamura, Yusuke Yonamine, Akinori Kuzuya, Takehiko Wada, Kuniharu Ijiro “Reversible Changes in the Orientation of Gold Nanorod Arrays on Polymer Brushes”, Nanoscale Advances, 2, 3798-3803 (2020). (Front Cover)

Satoshi Nakamura, Hideyuki Mitomo, Yu Sekizawa, Takeshi Higuchi, Yasutaka Matsuo, Hiroshi Jinnai, Kuniharu Ijiro, “Strategy for Finely Aligned Gold Nanorod Arrays using Polymer Brushes as a Template”, Langmuir, 36, 3590-3599 (2020). (Front Cover)

Satoru Hamajima, Hideyuki Mitomo, Takeharu Tani, Yasutaka Matsuo, Kenichi Niikura, Masayuki Naya, Kuniharu Ijiro, “Nanoscale uniformity in the active tuning of a plasmonic array using polymer gel volume change”, Nanoscale Advances, 1, 1731-1739 (2019). (Inside Front Cover)

Ryo Iida, Hideyuki Mitomo, Kenichi Niikura, Yasutaka Matsuo, and Kuniharu Ijiro, “Two-step assembly of thermoresponsive gold nanorods coated with a single kind of ligand”, Small, 14, 1704230 (2018). (Inside Front Cover)
Satoshi Nakamura, Hideyuki Mitomo, Miho Aizawa, Takeharu Tani, Yasutaka Mastuo, Kenichi Niikura, Andrew Pike, Masayuki Naya, Atsushi Shishido, Kuniharu Ijiro, “DNA brush-directed vertical alignment of extensive gold nanorod arrays with controlled density”, ACS Omega, 2, 2208-2213 (2017).

Jinjian Wei, Kenichi Niikura, Takeshi Higuchi, Takashi Kimura, Hideyuki Mitomo, Hiroshi Jinnai, Yasumasa Joti, Yoshitaka Bessho, Yoshinori Nishino, Yasutaka Matsuo, and Kuniharu Ijiro, “Yolk/shell assembly of gold nanoparticles by size segregation in solution”, J. Am. Chem. Soc., 138, 3274-3277 (2016).