Staff

TSUDA MasumiAssociate Professor

Laboratory
Laboratory of Pathology
Research Theme
Elucidation of human disorders using hydrogel and the medical application
Research Keywords

biomaterial, cancer stem cell, molecular targeted therapy, regenerative medicine, cartilage regeneration, neuroregeneration

Overview of Research

Students acquire basic knowledge of basic medicine, clinical medicine, and regenarative medicine necessary for medical application of soft matter (synthetic polymer hydrogel). Particularly, by analyzing cell phenomena and in vivo reactivity on soft matter that mimics in vivo environment, students deepen their understanding of diseases in the field of cancer treatment, articular cartilage, and regenerative medicine. Ultimately, we aim to contribute to medical development toward an advanced precision medicine and aging society, by fusing medicine and soft matter.

Charge

Message

Soft matter (polymer synthetic hydrogel) has the unknown power to change the fate of cells. We aim to develop innovative medical treatment by elucidating the causes and conditions of various diseases using soft matter.

Representative Publications

Suzuka J, Tsuda M, Wang L, Kohsaka S, Kishida K, Semba S, Sugino H, Aburatani S, Frauenlob M, Kurokawa T, Kojima S, Ueno T, Ohmiya Y, Mano H, Yasuda K, Gong JP, Tanaka S. Rapid reprogramming of tumour cells into cancer stem cells on double-network hydrogels. Nat Biomed Eng. 2021, in press.

Yachi K, Tsuda M, Kohsaka S, Wang L, Oda Y, Tanikawa S, Ohba Y, Tanaka S. miR-23a promotes invasion of glioblastoma via HOXD10-regulated glial-mesenchymal transition. Signal Transduct Target Ther. 3: 33, 2018.

Fujioka Y, Tsuda M, Nanbo A, Hattori T, Sasaki J, Sasaki T, Miyazaki T, Ohba Y. A Ca(2+)-dependent signaling circuit regulates influenza A virus internalization and infection. Nat Commun, 4, 2763, 2013

Watanabe T, Tsuda M, Makino Y, Konstantinou T, Nishihara H, Majima T, Minami A, Feller SM, Tanaka S. Crk adaptor protein induced-phosphorylation of Gab1 on tyrosine 307 via Src is important for organization of focal adhesions and enhanced cell migration. Cell Res, 19, 638-650, 2009

Tsuda M, Davis IJ, Argani P, Shukla N, McGill GG, Nagai M, Saito T, Laé M, Fisher DE, Ladanyi M. TFE3 fusions activate MET signaling by transcriptional up-regulation, defining another class of tumors as candidates for therapeutic MET inhibition. Cancer Res, 67, 919-929, 2007

Ye YN, Frauenlob M, Wang L, Tsuda M, Sun TL, Cui K, Takahashi R, Zhang HJ, Nakajima T, Nonoyama T, Kurokawa T, Tanaka S, Gong JP. Tough and self-recoverable thin hydrogel membranes for biological applications. Adv Funct Mater, 28, 1801489, 2018

Refer to HOKKAIDO UNIVERSITY RESEARCHERS DIRECTORY
(https://researchers.general.hokudai.ac.jp/profile/en.kzHw9KIOBcsqR-g1pQ3MdA==.html)

Note

<Office Hour>
– Time: Anytime during the lecture period
– Place: Faculty of Medicine, Central Research Bldg. 4F, C4・104-2
Please contact in advance by E-mail.
E-mail: tsudam[at]med.hokudai.ac.jp

Affiliation

  • Faculty of Medicine