Laboratory of Frontier Biomaterials Science

Creating nanomedicine by fusion of life sciences and nanotechnology.
Research Theme
Development of nucleic acid nanomedicines for immunomodulation / Control of cellular function on material surface
Research Keywords

Nanomedicine, nanobiotechnology, protein engineering, nucleic acid-based drug, adjuvant, DNA aptamer, biosensor, immune system, nanoparticle, DNA delivery, Living radical polymerzation, polymer brush, nanofiber, biointerface, biomaterials


Overview of Research and Education

The National Institute for Materials Science (NIMS) and the Graduate School of Life Science of the Hokkaido University have established a joint Doctoral Program in the Field of Frontier Biomaterials Science. The laboratory is located in NIMS in Tsukuba city, Ibaraki.
When pathogens infect us, our cells recognize DNA or RNA molecules of bacteria and viruses and the immune system is activated. With attention to this biological immune system, we are developing nucleic acid-based nanomedical molecules, and also nanoparticle-conjugated nanomedicines, and applying these to the treatment of infectious diseases and allergies.

Laboratory of Frontier Biomaterials Science (pdf)



1-2-1 Sengen, Tsukuba, Ibaraki 305-0047, Japan
Research Center for Macromolecules and Biomaterials, National Institute for Materials Science
029-859-2345, 029-860-4717
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Representative Publications

N.B.T. Le, A.T.T. Tu, D. Zhao, C. Yoshikawa, K. Kawakami, Y. Kaizuka, T. Yamazaki* Influence of the Charge Ratio of Guanine-Quadruplex Structure-Based CpG Oligodeoxynucleotides and Cationic DOTAP Liposomes on Cytokine Induction Profiles. Biomolecules, 13, 1639 (2023).

R.A. Fenati, Z. Chen, Y. Yamagishi, K. Tsukakoshi, K. Ikebukuor, A. Manian, S.P. Russo, T. Yamazaki*, A.V. Ellis* Enhancement of DNAzymatic activity using iterative in silico maturation. J Mater Chem B, 10, 8960-8969 (2022).

A.T.T. Tu, K. Hoshi, Y. Ma, T. Oyama, S. Suzuki, K. Tsukakoshi, K. Nagasawa, K. Ikebukuro, T. Yamazaki* Effects of G-Quadruplex Ligands on the Topology, Stability, and Immunostimulatory Properties of G-Quadruplex-Based CpG Oligodeoxynucleotides. ACS Chem Biol, 17, 1703-1713 (2022).

C. Yoshikawa*, R. Takagi, T. Nakaji-Hirabayashi, T. Ochi, Y. Kawamura, H. Thissen. Marine antifouling coatings based on durable bottlebrush polymers. ACS Applied Mate. Inter. 2022, 14, 32497-32509.

C. Yoshikawa*, K. Sakakibara, P. Nonsuwan, M. Shobo, Y. Xisa, K. Matsumura. Cellular Flocculation Driven by Concentrated Polymer Brush-Modified Cellulose Nanofibers with Different Surface Charges. Biomacromolecules 2022, 23, 3186-3197. Selected as supplementary cover.

P. Nonsuwan, N. Nishijima, K. Sakakibara, T. Nakaj-Hirabayashi, C. Yoshikawa*. Concentrated Polymer Brush-Modified Cellulose Nanofibers Promote Chondrogenic Differentiation of Human Mesenchymal Stem Cells by Controlling Self-Assembly J. Mater. Chem. B 2022, 10(14), 2444-2453. Selected as back cover.


NIMS-University of Hokkaido Joint Graduate School

NIMS Graduate Research Assistantship
NIMS offers the NIMS Graduate Research Assistantship to doctoral students who aspire to a career as researchers in materials science. The assistantship carries a monthly stipend to assist academically deserving students in fulfilling their academic goals.