YAMAZAKI TomohikoVisiting Associate Professor

Laboratory of Frontier Biomaterials Science
Research Theme
Bio-nanomolecules for Diagnostic and Therapy Applications
Research Keywords

Protein, Peptide, Oligodeoxynucleotide, Artificial recognition element, Toll like receptor, Adjuvant, G-quadruplex, Hemozoin

Overview of Research

We are developing novel bio-nanomolecules such as oligonucleotide-, peptide-, and protein-based materials, with knowledge gained from the life sciences. We seek to utilize the novel bio-nanomolecules to diagnostic and therapy of cancer, infection and immunological disease.
Toll-like receptor 9 (TLR9) is one of innate immunity receptors recognizing single-stranded DNA derived from viruses and microorganisms, and hemozoin which is malaria-derived heme crystals. The ligands of TLR9 act as a molecule that immuno-activator or suppressor. We elucidated the interaction between TLR 9 and the natural ligand molecule, then developed novel ligand with superior function to natural ligand molecules.


  • School of Science:
  • Graduate School of Life Science:
    Division of Life Science, Transdisciplinary Life Science Course, Frontier Biomaterials Science (Inter-field Cooperation with NIMS)


In our research, integration of scientific knowledge and technique of various fields, such as molecular biology, cell biology, protein engineering, protein function analysis, and also a biomaterial, is indispensable. We offer a supportive environment for promoting your research. Anyone who is interested in our project, please contact us.

Representative Publications

Anh Thi Tram Tu, Kazuaki Hoshi, Kazunori Ikebukuro, Nobutaka Hanagata, Tomohiko Yamazaki. Monomeric G-Quadruplex-Based CpG Oligodeoxynucleotides as Potent Toll-Like Receptor 9 Agonists. Biomacromolecules. 21 [9] (2020) 3644-3657

Akane Sakaguchi-Mikami, Kazuhiro Fujimoto, Tetsushi Taguchi, Karube Isao, Tomohiko Yamazaki. A novel biofunctionalizing peptide for metallic alloy. Biotechnology Letters. 42 [5] (2020) 747-756

Satoshi Migita, Kosuke Sakashita, Yuta Saito, Suyalatu, Tomohiko Yamazaki. Co–Cr–Mo alloy binding peptide as molecular glue for constructing biomedical surfaces. Journal of Applied Biomaterials & Functional Materials. 18 (2020) 228080002092473

Kazuaki Hoshi, Tomohiko Yamazaki, Yuuki Sugiyama, Kaori Tsukakoshi, Wakako Tsugawa, Koji Sode, Kazunori Ikebukuro. G-Quadruplex Structure Improves the Immunostimulatory Effects of CpG Oligonucleotides. Nucleic Acid Therapeutics. 29 [4] (2019) 224-229

Kazuaki Hoshi, Tomohiko Yamazaki, Chiaki Yoshikawa, Wakako Tsugawa, Kazunori Ikebukuro, Koji Sode. Synthesis of a hemin-containing copolymer as a novel immunostimulator that induces IFN-gamma production. International Journal of Nanomedicine. 13 (2018) 4461-4472


Profile on NIMS SAMURAI database


  • National Institute for Materials Science, Research Center for Functional Materials, Nanomedicine Group