- Laboratory of Advanced Chemical Biology
- Research Theme
- Fine syntheses of glycoconjugate probes, and their medicinal application
- Research Keywords
organic chemistry, glycotechnology, glycomedicine, chemical biology, inhibitor, synthetic probe, mass spectrometry, microarray, infection, immunity, cancer, lectin
Overview of Research
Carbohydrates (sugar chains) are indispensable to living matter as a not only essential energy source but also signal molecules of intra- and intercellular systems. Our interests are focused on glycotechnology to elucidate and utilize the function of carbohydrates as signal molecules, and on chemical biology towards a new age of medicinal science.
To achieve these targets, we are developing innovative synthetic methods for glycoconjugates such as glycopeptides, glycolipids, and oligosaccharides. Development of probing systems using these glycoconjugates is also in progress to elucidate and apply the functions of glycans in living matter.
Inhibitors of glycosidases and glycosyltransferases are also exciting research area. Development of a new type of mechanism-based inhibitors based on protein dynamics is in progress.
- School of Science:
Biological Science course (Macromolecular Functions), Core Laboratories
- Graduate School of Life Science:
Division of Life Science, Transdisciplinary Life Science Course, Biosystem and Biomolecule Control Science
Hiroshi Hinou “Aniline Derivative/DHB/Alkali Metal Matrices for Reflectron Mode MALDI-TOF and TOF/TOF MS Analysis of Unmodified Sialylated Oligosaccharides and Glycopeptides” International Journal of Mass Spectrometry 443, 109-115, 2019. DOI: org/10.1016/j.ijms.2019.06.006.
Hiroshi Hinou, Seiya Kikuchi, Rika Ochi, Kota Igarashi, Wataru Takada, Shin-Ichiro Nishimura “Synthetic glycopeptides reveal specific binding pattern and conformational change at O-mannosylated position of α-dystroglycan by POMGnT1 catalyzed GlcNAc modification” Bioorganic&Medicinal Chemistry, 27, 2822-2831, 2019. DOI: org/10.1016/j.bmc.2019.05.008
Gerard Artigas, Hiroshi Hinou, Fayna Garcia-Martin, Hans-Joachim Gabius, Shin-Ichiro Nishimura “Synthetic Mucin-like Glycopeptides as Versatile Tools to Measure Effects of Glycan Structure/Density/Position on the Interaction with Adhesion/Growth-regulatory Galectins in Arrays” Chemistry An Asian Journal, 12, 159-167, 2017. DOI: 10.1002/asia.201601420
Refer to HOKKAIDO UNIVERSITY RESEARCHERS DIRECTORY
– Time: Anytime during the lecture period
– Place: Frontier-AMLS, 6F
Please contact in advance by E-mail.
- Faculty of Advanced Life Science, Department of Advanced Transdisciplinary Sciences, Drug Discovery Research
- Frontier Research Center for Advanced Material and Life Science, Academia-Industry Collaboration Unit