Staff

HINOU HiroshiProfessor

Laboratory
Laboratory of Advanced Chemical Biology
Research Theme
Matrix life-chemistry research based on glycotyping technology and rapid synthesis of carbohydrates
Research Keywords

organic chemistry, glycotechnology, glycomedicine, chemical biology, inhibitor, synthetic probe, mass spectrometry, microarray, infection, immunity, cancer, lectin, glycotyping

Overview of Research

Carbohydrates (sugar chains) are indispensable to living matter not only as essential energy sources but also as signal molecules of intra- and intercellular systems. Our interests are focused on glycotechnology to elucidate and utilize the function of carbohydrates as signal molecules, and on chemical biology towards a new age of medicinal science.
To achieve these targets, we are developing innovative synthetic methods and structural&functional analytical methods for glycoconjugates such as glycopeptides, glycolipids, and oligosaccharides. Development of probing systems using these glycoconjugates is also in progress to elucidate and apply the functions of glycans in living matter.
Inhibitors of glycosidases and glycosyltransferases are also an exciting research area. Development of ultra-rapid glycotyping technologies is in progress.

Charge

Message

I’m focusing on the study of chemistry and biological function of glycoconjugates as a key probe to next-generation life sciences.

Representative Publications

Shogo Urakami, Hiroshi Hinou “Glycan Selective MALDI In-source Decay Analysis of Intact Glycoprotein” Analysis & Sensing in press. https://doi.org/10.1002/anse.202100040

Hiroshi Hinou “Aniline Derivative/DHB/Alkali Metal Matrices for Reflectron Mode MALDI-TOF and TOF/TOF MS Analysis of Unmodified Sialylated Oligosaccharides and Glycopeptides” International Journal of Mass Spectrometry 443, 109-115, 2019. DOI: org/10.1016/j.ijms.2019.06.006.

Hiroshi Hinou, Seiya Kikuchi, Rika Ochi, Kota Igarashi, Wataru Takada, Shin-Ichiro Nishimura “Synthetic glycopeptides reveal specific binding pattern and conformational change at O-mannosylated position of α-dystroglycan by POMGnT1 catalyzed GlcNAc modification” Bioorganic&Medicinal Chemistry, 27, 2822-2831, 2019. DOI: org/10.1016/j.bmc.2019.05.008

Refer to HOKKAIDO UNIVERSITY RESEARCHERS DIRECTORY
(https://researchers.general.hokudai.ac.jp/profile/en.BoN81hZ5xVfjVZ08Md3jlg==.html)

Note

<Office Hour>
– Time: Anytime during the lecture period
– Place: Frontier-AMLS, 6F
Please contact in advance by E-mail.
E-mail: hinou[at]sci.hokudai.ac.jp

<Research seeds>
https://seeds.mcip.hokudai.ac.jp/jp/view/396/
https://seeds.mcip.hokudai.ac.jp/jp/view/395/
https://seeds.mcip.hokudai.ac.jp/jp/view/381/
https://seeds.mcip.hokudai.ac.jp/jp/view/119/

<Research Group Homepage>
https://sites.google.com/eis.hokudai.ac.jp/hinou

Affiliation