Staff

HINOU HiroshiProfessor

Laboratory
Laboratory of Advanced Chemical Biology
Research Theme
Fine syntheses of glycoconjugate probes, and their medicinal application
Research Keywords

organic chemistry, glycotechnology, glycomedicine, chemical biology, inhibitor, synthetic probe, mass spectrometry, microarray, infection, immunity, cancer, lectin

Overview of Research

Carbohydrates (sugar chains) are indispensable to living matter as a not only essential energy source but also signal molecules of intra- and intercellular systems. Our interests are focused on glycotechnology to elucidate and utilize the function of carbohydrates as signal molecules, and on chemical biology towards a new age of medicinal science.
To achieve these targets, we are developing innovative synthetic methods for glycoconjugates such as glycopeptides, glycolipids, and oligosaccharides. Development of probing systems using these glycoconjugates is also in progress to elucidate and apply the functions of glycans in living matter.
Inhibitors of glycosidases and glycosyltransferases are also exciting research area. Development of a new type of mechanism-based inhibitors based on protein dynamics is in progress.

Charge

Message

I’m focusing on the study of chemistry and biological function of glycoconjugates as a key probe to next-generation life sciences.

Representative Publications

Hiroshi Hinou “Aniline Derivative/DHB/Alkali Metal Matrices for Reflectron Mode MALDI-TOF and TOF/TOF MS Analysis of Unmodified Sialylated Oligosaccharides and Glycopeptides” International Journal of Mass Spectrometry 443, 109-115, 2019. DOI: org/10.1016/j.ijms.2019.06.006.

Hiroshi Hinou, Seiya Kikuchi, Rika Ochi, Kota Igarashi, Wataru Takada, Shin-Ichiro Nishimura “Synthetic glycopeptides reveal specific binding pattern and conformational change at O-mannosylated position of α-dystroglycan by POMGnT1 catalyzed GlcNAc modification” Bioorganic&Medicinal Chemistry, 27, 2822-2831, 2019. DOI: org/10.1016/j.bmc.2019.05.008

Gerard Artigas, Hiroshi Hinou, Fayna Garcia-Martin, Hans-Joachim Gabius, Shin-Ichiro Nishimura “Synthetic Mucin-like Glycopeptides as Versatile Tools to Measure Effects of Glycan Structure/Density/Position on the Interaction with Adhesion/Growth-regulatory Galectins in Arrays” Chemistry An Asian Journal, 12, 159-167, 2017. DOI: 10.1002/asia.201601420

Refer to HOKKAIDO UNIVERSITY RESEARCHERS DIRECTORY
(https://researchers.general.hokudai.ac.jp/profile/en.BoN81hZ5xVfjVZ08Md3jlg==.html)

Note

<Office Hour>
– Time: Anytime during the lecture period
– Place: Frontier-AMLS, 6F
Please contact in advance by E-mail.
E-mail: hinou[at]sci.hokudai.ac.jp

Affiliation