HIRANO YuVisiting Associate Professor

Laboratory of Biomolecular Adaptation Science
Research Theme
Development of electrochemical analysis methods for cell-based assay
Research Keywords

cell, electrochemistry, scanning electrochemical microscopy, nucleic acids, RNA, DNA

Overview of Research

I have developed novel scanning electrochemical microscopy (SECM) enabling long-term monitoring of cellular topography or activities. I am further developing a novel SECM system to carry out single-cell analysis more conveniently.


  • School of Science:
  • Graduate School of Life Science:
    Division of Life Science, Transdisciplinary Life Science Course, Biomolecular Adaptation Science (Inter-field Cooperation with AIST)

Representative Publications

Hirano, Y., and Komatsu, Y., Promotion of cytoplasmic localization of oligonucleotides by connecting cross-linked duplexes. RSC Adv., 12, 24471-24477 (2022).

Okumura, S.; Hirano, Y.; Komatsu, Y. Stable Duplex-Linked Antisense Targeting MiR-148a Inhibits Breast Cancer Cell Proliferation. Sci. Rep. 11, 11467 (2021).

Okumura, S; Hirano, Y; Maki, Y; Komatsu, Y. Analysis of time-course drug response in rat cardiomyocytes cultured on a pattern of islands. ANALYST. 143, 4083-4089, (2018)

Hirano, Y; Kojima, N; Komatsu, Y. Synthesis and Application of Interstrand Cross-Linked Duplexes by Covalently Linking a Pair of Abasic Sites. CURR. PROTOC. NUCLEIC ACID CHEM. 75, e63, (2018)

Mie, Y., Hirano, Y., Kowata, K., Nakamura, A., Yasunaga, M., Nakajima, Y. and Komatsu, Y. Function Control of Anti-microRNA Oligonucleotides Using Interstrand Cross-Linked Duplexes. Mol., Ther., Nucleic Acids, 10, 64-74 (2018).

Hirano, Y., Ikegami, M., Kowata, K., and Komatsu, Y. Bienzyme reactions on cross-linked DNA scaffolds for electrochemical analysis. Bioelectrochemistry., 113, 15-19 (2017).


<Office Hour>
Please contact me in advance by E-mail.
E-mail: yu.hirano[at]


  • National Institute of Advanced Industrial Science and Technology (AIST) Hokkaido