Laboratory of Biomolecular Adaptation Science

Research Theme
Elucidation and application of molecular functions exhibited by cold-responsive proteins / Development of functional nucleic acids and application to oligonucleotide therapeutics / Research on microorganism adaptation to cold conditions Analysis and improvement of protein functions for industrial application
Research Keywords

Antifreeze protein, Ice-binding function, Snow mold fungi, Gene expression, Biomoleculart NMR, X-ray structural analysis, Biodiversity, Cell-preservation peptide, Reporter Assay, 3D molecular structure, Gene detection, Nucleic acid drugs, Functional DNA/RNA, Molecular detection, Cell-function evaluation, Electrochemistry


Overview of Research and Education

Research Contents:

Laboratory of Biomolecular Adaptation Science(s.tsuda2018)



AIST-Hokkaido, 2-17-2-1 Tsukisamu-Higashi, Toyohira, Sapporo
s.tsuda* (Please replace * with @ when sending e-mail.)

Representative Publications

Yamauchi, A., Arai, T., Kondo, H., Sasaki, Y.C., and Tsuda, S.: An ice-binding protein from an Antarctic ascomycete is fine-tuned to bind to specific water molecules located in the prosm planes. Biomolecules, 10, 759 (2020).

Arai, T., Fukami, D., Hoshino, T., Kondo, H., and Tsuda, S.: Ice-binding proteins from the fungus Antarctomyces psychrotropicus possibly originate from two different bacteria through horizontal gene transfer. FEBS J., 286, 5, 946-962 (2019).

Azuma, N., Miyazaki, Y., Nakano, M., and Tsuda, S.: Unexpected rise of glass transition temperature of ice crystallized from antifreeze protein solution. J. Phys. Chem. Lett., 9, 4512-4515 (2018).

Mahatabuddin, S., Fukami, D., Arai,T., Nishimiya, Y., Shimizu, R., Shibazaki, C., Kondo, H., Adachi, M., and Tsuda, S.: Polypentagonal ice-like water networks emerge solely in an activity-improved variant of ice-binding protein. Proc. Natl. Acad. Sci. USA,115 (21), 5456-5461 (2018).