Study clarified that decrease of secreted α-defensin due to psychological stress causes disruption of the intestinal microbiota and the metabolites, showing previously unknown relationship between the intestine and the brain.
This research topic is related to the sustainable development goals (SDGs);
- GOOD HEALTH AND WELL-BEING
- DECENT WORK AND ECONOMIC GROWTH
Kosuke Suzuki, Kiminori Nakamura, Yu Shimizu, Yuki Yokoi, Shuya Ohira, Mizu Hagiwara, Yi Wang, Yuchi Song, Tomoyasu Aizawa, Tokiyoshi Ayabe. Decrease of α-defensin impairs intestinal metabolite homeostasis via dysbiosis in mouse chronic social defeat stress model. Scientific Reports 2021. 11: 9915. doi: 10.1038/s41598-021-89308-y