Laboratory of Molecular Device
- Research Theme
- Development of self-assembled nanoparticles for bioengineering applications
- Research Keywords
Self-organization, self-assembly, biomimetics, functional device, biosensor, DNA, protein, biomolecule, cell, molecular recognition, drug delivery system, vaccine, gold nanoparticle, surface plasmon, stimulus-response, nanocapsule
Overview of Research and Education
Bio organisms are capable of efficient energy transformation, selective synthesis of biomolecules and interactive information processing. All these processes are based on effective molecular recognition at highly organized supramolecular assemblies. This research group is concerned with the construction of hierarchical molecular devices by the combination of nanosize molecular assemblies with micro size structures derived from dissipative processes. The following themes are in progress.
1) Development of novel drug delivery system using nanostructures, 2) Control of self-assembly of nanoparticles and creation of functions, 3) Development of supersensitive gel based plasmonic biosensors, 4) Development of high efficient nanoparticle vaccine
- Charge (US):
School of Science, Biological Science course (Macromolecular Functions), Collaborative Laboratories
- Charge (GS):
Graduate School of Life Science, Division of Soft Matter, Soft Matter Materials Science
North 21 West 10, Kita-ku, Sapporo, Japan
- ijiro*poly.es.hokudai.ac.jp(Please replace ＊ with @ when sending e-mail.)
Satoru Hamajima, Hideyuki Mitomo, Takeharu Tani, Yasutaka Matsuo, Kenichi Niikura, Masayuki Naya, Kuniharu Ijiro, “Nanoscale uniformity in the active tuning of a plasmonic array using polymer gel volume change”, Nanoscale Advances, Accepted, DOI: 10.1039/C8NA00404H (2019).
Taiyu Tazaki, Koshiro Tabata, Akira Ainai, Yuki Ohara, Shintaro Kobayashi, Takafumi Ninomiya, Yasuko Orba, Hideyuki Mitomo, Tetsuo Nakano, Hideki Hasegawa, Kuniharu Ijiro, Hirofumi Sawa, Tadaki Suzuki and Kenichi Niikura, “Shape-dependent adjuvanticity of nanoparticle-conjugated RNA adjuvants for intranasal inactivated influenza vaccines”, RSC Adv., 8, 16527-16536 (2018).
Ryo Iida, Hideyuki Mitomo, Kenichi Niikura, Yasutaka Matsuo, and Kuniharu Ijiro, “Two-step assembly of thermoresponsive gold nanorods coated with a single kind of ligand”, Small, 14, 1704230 (2018). (Inside Front Cover)
Satoshi Nakamura, Hideyuki Mitomo, Miho Aizawa, Takeharu Tani, Yasutaka Mastuo, Kenichi Niikura, Andrew Pike, Masayuki Naya, Atsushi Shishido, Kuniharu Ijiro, “DNA brush-directed vertical alignment of extensive gold nanorod arrays with controlled density”, ACS Omega, 2, 2208-2213 (2017).
Jinjian Wei, Kenichi Niikura, Takeshi Higuchi, Takashi Kimura, Hideyuki Mitomo, Hiroshi Jinnai, Yasumasa Joti, Yoshitaka Bessho, Yoshinori Nishino, Yasutaka Matsuo, and Kuniharu Ijiro, “Yolk/shell assembly of gold nanoparticles by size segregation in solution”, J. Am. Chem. Soc., 138, 3274-3277 (2016).
Refer to HOKKAIDO UNIVERSITY RESEARCHERS DIRECTORY