Laboratory of Reconstructive Surgery and Rehabilitation Medicine

Functional materials for clinical application
Research Theme
To elucidate the mechanism of cartilage metabolism and tissue regeneration. / Developnent of innovative treatments for musculoskeletal diseases leading to clinical application.
Research Keywords

Orthopaedic Surgery, Joint Surgery, Regenerative Medicine, Musculoskeletal System, Animal Model, Scaffold, Cartilage, Bone, Meniscus, Biomaterials, Soft Matter, Clinical Application, Translational Research


Overview of Research and Education

Research Contents: Our laboratory aims to develop bioactive soft-matter materials as a scaffold for undifferentiated progenitor cells for the purpose of fast implementation in clinical application. By carrying out animal experiments and clinical research, which is a position as a translational research, clinical practical application of the materials will be realized.

Laboratory of Reconstructive Surgery and Rehabilitation Medicine (pdf)



Kita 14 Nishi 5, Kita-ku, Sapporo
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Representative Publications

Kentaro Homan, Tomohiro Onodera, Hisatoshi Hanamatsu, Jun-Ichi Furukawa, Daisuke Momma, Masatake Matsuoka, Norimasa Iwasaki., Articular cartilage corefucosylation regulates tissue resilience in osteoarthritis. Elife 2024/3

Onodera T, Momma D, Matsuoka M, Kondo E, Suzuki K, Inoue M, Higano M, Iwasaki N., Single-step ultra-purified alginate gel implantation in patients with knee chondral defects. Bone Joint J. 2023/8

Yamaguchi J, Onodera T, Homan K, Liang X, Matsuoka M, Miyazaki T, Yoshiaki H, Saito M, Iwasaki N., Optical coherence tomography evaluation of the spatiotemporal effects of 3D bone marrow stromal cell culture using a bioreactor. J Biomed Mater Res B Appl Biomater. 2022/08

Hosokawa Y, Onodera T, Homan K, Yamaguchi J, Kudo K, Kameda H, Sugimori H, Iwasaki N., Establishment of a New Qualitative Evaluation Method for Articular Cartilage by Dynamic T2w MRI Using a Novel Contrast Medium as a Water Tracer. Cartilage. 2022/08

Liang D, Onodera T, Hamasaki M, Hishimura R, Homan K, Xu L, Tian Y, Kanai S, Iwasaki N., Quantification of Cartilage Surface Degeneration by Curvature Analysis Using 3D Scanning in a Rabbit Model. Cartilage. 2021/12

Xu L, Urita A, Onodera T, Hishimura R, Nonoyama T, Hamasaki M, Liang D, Homan K, Gong JP, Iwasaki N., Ultrapurified Alginate Gel Containing Bone Marrow Aspirate Concentrate Enhances Cartilage and Bone Regeneration on Osteochondral Defects in a Rabbit Model. Am J Sports Med. 2021/07

Momma D, Onodera T, Kawamura D, Urita A, Matsui Y, Baba R, Funakoshi T, Kondo M, Endo T, Kondo E, Iwasaki N., Acellular Cartilage Repair Technique Based on Ultrapurified Alginate Gel Implantation for Advanced Capitellar Osteochondritis Dissecans. Orthop J Sports Med. 2021/3

Onodera T, Baba R, Kasahara Y, Tsuda T, Iwasaki N., Therapeutic effects and adaptive limits of an acellular technique by ultrapurified alginate (UPAL) gel implantation in canine osteochondral defect models. Regen Ther. 2020/02

Kim W, Onodera T, Kondo E, Terkawi MA, Homan K, Hishimura R, Iwasaki N., Which Contributes to Meniscal Repair, the Synovium or the Meniscus? An In Vivo Rabbit Model Study With the Freeze-Thaw Method. Am J Sports Med. 2020/1

Hontani K, Onodera T, Terashima M, Momma D, Matsuoka M, Baba R, Joutoku Z, Matsubara S, Homan K, Hishimura R, Xu L, Iwasaki N, Chondrogenic differentiation of mouse induced pluripotent stem cells (iPSCs) using the three-dimensional culture with ultra-purified alginate gel (UPAL gel)., Journal of biomedical materials research. Part A 2019/01

Hishimura R, Onodera T, Hontani K, Baba R, Homan K, Matsubara S, Joutoku Z, Kim W, Nonoyama T, Kurokawa T, Gong JP, Iwasaki N., Osteochondral Autograft Transplantation Technique Augmented by an Ultrapurified Alginate Gel Enhances Osteochondral Repair in a Rabbit Model., The American journal of sports medicine. 363546518817527 2019/01

Kim W, Onodera T, Kondo E, Kawaguchi Y, Terkawi MA, Baba R, Hontani K, Joutoku Z, Matsubara S, Homan K, Hishimura R, Iwasaki N, Effects of Ultra-Purified Alginate Gel Implantation on Meniscal Defects in Rabbits., The American journal of sports medicine 363546518816690 2018/12

Momma D, Onodera T, Homan K, Matsubara S, Sasazawa F, Furukawa J, Matsuoka M, Yamashita T, Iwasaki N., Coordinated existence of multiple gangliosides is required for cartilage metabolism., Osteoarthritis Cartilage 2018/11

Baba R, Onodera T, Matsuoka M, Hontani K, Joutoku Z, Matsubara S, Homan K, Iwasaki N, Bone Marrow Stimulation Technique Augmented by an Ultrapurified Alginate Gel Enhances Cartilage Repair in a Canine Model., The American journal of sports medicine 46(8) 1970-1979 2018/07