Laboratory of X-Ray Structural Biology
- Research Theme
- Structural biological elucidation regarding the functions of proteins and nucleic acid in relation to biological phenomena / Structural and functional study on translational control / Structural biology of the disease-related factors / Method development of X-ray protein crystallography
- Research Keywords
Protein, nucleic acid, translational control, signal transduction, infection regulation, disease related factor, X-ray/neutron structural biology, quantum biology, protein crystallography, computer science, protein science, biophysics
Staff
Overview of Research and Education
The elucidation of the molecular mechanisms in which converters genetic information into functional molecules like RNAs and proteins is a central subject of molecular biology. We analyze the structure and function of proteins to elucidate their reaction mechanisms and intermolecular network, by using various physical, physicochemical and biochemical methods, such as crystallography, electron microscopy, calorimetry and activity measurement. We also aim at the applications of obtained structural information to drug design and industry.
Laboratory of X-Ray Structural Biology(PDF)
Charge
- Charge (US):
School of Science, Biological Science course (Macromolecular Functions), Core Laboratories - Charge (GS):
Graduate School of Life Science, Division of Life Science, Transdisciplinary Life Science Course, Bioinformation and Molecular Sciences
Contact
- Address
-
〒060-0810
5-307, North 10 West 8, Kita-ku, Sapporo - Phone
- 011-706-4481
- Fax
- 011-706-4905
- yao*castor.sci.hokudai.ac.jp (Please replace * with @ when sending e-mail.)
Representative Publications
Selective Recent Publications
Takehito Tanzawa, Koji Kato, Dylan Girodat, Toyoyuki Ose, Yuki Kumakura, Hans-Joachim Wieden, Toshio Uchiumi, Isao Tanaka, and Min Yao, The C-terminal helix of ribosomal P stalk recognizes a hydrophobic groove of elongation factor 2 in a novel fashion, Nucleic Acids Research. 46, 3232-3244 (2018)
Meirong Chen, Koji Kato, Yume Kubo, Yoshikazu Tanaka, Yuchen Liu, Feng Long, William Whitman, Pascal Lill, Christos Gatsogiannis, Stefan Raunser, Nobutaka Shimizu, Akira Shinoda, Akiyoshi Nakamura, Isao Tanaka, and Min Yao, Structural basis for the tRNA-dependent cysteine biosynthesis, Nature Communications. 8, 1512-1532 (2017)
Shingo Nojima, Ayumi Fujishima, Koji Kato, Kayoko Ohuchi, Nobutaka Shimizu, Kento Yonezawa, Kenji Tajima and Min Yao, Crystal structure of the flexible tandem repeat domain of bacterial cellulose synthesis subunit C, Scientific Reports. 7, 13018 (2017)
Shoko Kimura, Tateki Suzuki, Meirong Chen, Koji Kato, Jian Yu, Akiyoshi Nakamura, Isao Tanaka, Min Yao, Template-dependent nucleotide addition in the reverse (3′-5′) direction by Thg1-like protein, Science Advances. 2, e1501397 (2016)
Tateki Suzuki, Akiyoshi Nakamura, Koji Kato, Dieter Soll, Isao Tanaka, Kelly Sheppard, and Min Yao, Structure of the Pseudomonas aeruginosa transamidosome reveals unique aspects of bacterial tRNA-dependent asparagine biosynthesis, Proc. Natl. Acad. Sci. USA . 112, 382-387 (2015)
Refer to HOKKAIDO UNIVERSITY RESEARCHERS DIRECTORY
(https://researchers.general.hokudai.ac.jp/profile/en.O4rpTb5EkOCSTB3go-MWrw==.html)