OSE ToyoyukiProfessor

Laboratory of Structural & Biological Chemistry
Research Theme
Protein science of signal trunsduction and natural product biosynthesis
Research Keywords

protein chemistry, structure biology, virology, signal transduction, quantum biology

Overview of Research

We focus on machinery structure, molecular-molecular interaction, and chemical reaction mechanism of signal transduction pathways related to infectious disease. In addition to normal structural biology methodology, we would like to introduce neutron diffraction to understand quantum properties of biomolecules which govern the biology world.



Our goal is interlink of quantum-organic chemistry, hydrogen atom included protein structure, and cellular biology.

Representative Publications

The measles virus V protein binding site to STAT2 overlaps that of IRF9, Yuma Nagano, Aoi Sugiyama, Madoka Kimoto, Takuya Wakahara, Yasuyo Noguchi, Xinxin Jiang, Shinya Saijo, Nobutaka Shimizu, Nana Yabuno, Min Yao, Paul Gooley, Gregory Moseley, Takashi Tadokoro, Katsumi Maenaka, Toyoyuki Ose, Virol. 94, e01169-20 (2020)

Structural comparison of the C-terminal domain of functionally divergent lyssavirus P proteins, Aoi Sugiyama, Tomo Nomai, Xinxin Jiang, Miku Minami, Min Yao, Katsumi Maenaka, Naoto Ito, Paul R Gooley, Gregory W Moseley, Toyoyuki Ose, Biochem. Biophys. Res. Commun., 529 507 – 512 (2020)

Structural Elucidation of Viral Antagonism of Innate Immunity at the STAT1 Interface, Hossain MA, Larrous F, Rawlinson SM, Zhan J, Sethi A, Ibrahim Y, Aloi M, Lieu KG, Mok YF, Griffin MDW, Ito N, Ose T, Bourhy H, Moseley GW, Gooley PR., Cell Rep. 29, 1934-1945(2019)

Structure of MHC class I-like MILL2 reveals heparan-sulfate binding and interdomain flexibility, Mizuho Kajikawa, Toyoyuki Ose, Yuko Fukunaga, Yuki Okabe, Naoki Matsumoto, Kento Yonezawa, Nobutaka Shimizu, Simon Kollnberger, Masanori Kasahara & Katsumi Maenaka, Nature Commun. 9 4330 (2018)

Solution structure of an avirulence protein, AVR-Pia, from Magnaporthe oryzae, Toyoyuki Ose, Azusa Oikawa, Yukiko Nakamura, Katsumi Maenaka, Yuya Higuchi, Yuki Satoh, Shiho Fujiwara, Makoto Demura, Teruo Sone and Masakatsu Kamiya, Biomol. NMR 63, 229-35 (2015)



<Office Hour>
– Time: Anytime during the lecture period
– Place: Science Bldg. No.5, 3F, #5-312
Please contact in advance by E-mail.
E-mail: structbio_ose[at]