Staff

NISHIMURA Shin-IchiroProfessor

Laboratory
Laboratory of Advanced Chemical Biology
Research Theme
Rational drug discovery based on a theory of dynamic epitope and innovative glycotechnology platform
Research Keywords

Chemical biology, Medicinal chemistry, Dynamic inhibition reaction, Carbohydrate-based drug, Anti-viral medicine, Reverse genomics, Biomarker discovery

Overview of Research

We establish the new concept that controls functional expression by biological molecules essential for any creatures to live. By applying this concept to create novel medical reagents, we confirm the universality of this concept. Please visit our website

Charge

Representative Publications

Villones Lareno L, Ludwig A-K., Kumeta H., Kikuchi S., Ochi R., Aizawa T., Nishimura S-I., Gabius H-J., Hinou H, “Exploring the In situ pairing of human galectins toward synthetic O-mannosylated core M1 glycopeptides of α-dystroglycan”, Sci. Rep. 12, 17800 (2022)

Otaki M., Hirane N., Natsume-Kitatani Y., Nogami Itoh M., Shindo M., Kurebayashi Y., Nishimura S-I., “Mouse tissue glycome atlas 2022 highlights inter-organ variation in major N-glycan profiles”, Sci. Rep. 12, 17804 (2022)

Shiratori K., Yokoi Y., Wakui H., Hirane N., Otaki M., Hinou H., Yoneyama T., Hatakeyama T., Kimura S., Ohyama C., Nishimura Shin-Ichiro, “Selective reaction monitoring approach using structure-defined synthetic glycopeptides for validating glycopeptide biomarkers pre-determined by bottom-up glycoproteomics” RSC Adv. 12, 21385-21393 (2022)

Pablo A. Guillen-Poza, Elena Matilde Sánchez-Fernández, Gerard Artigas, José Manuel García Fernández, Hinou H., Carmen Ortiz Mellet, Nishimura S-I., Fayna Garcia-Martin, “Amplified detection of breast cancer autoantibodies using MUC1-based Tn antigen mimics” J. Med. Chem. 63, 8524-8533 (2020)

Koide R., Hirane N., Kambe D., Yokoi Y., Otaki M., Nishimura S-I., “Antiadhesive nanosome elicits role of glycocalyx of tumor cell-derived exosomes in the organotropic cancer metastasis” Biomaterials 280, 121314

Yokoi Y., Nishimura S-I. “Effect of Site‐specific O-Glycosylation on the Structural Behavior of NOTCH1 Receptor Extracellular EGF‐like Domains 11 and 10” Chem. Eur. J. 26, 12363-12372 (2020)

Wakui H., Tanaka Y., Ose T., Matsumoto I., Kato K., Yao M., Tachibana T., Sato M., Naruchi K., García-Martín F., Hinou H., Nishimura S-I. “A straightforward approach to antibodies recognising cancer specific glycopeptidic neoepitopes” Chem. Sci. 11, 4999-5006 (2020)

Hayakawa A., Matsushita T., Yokoi Y., Wakui H., Fayna Garcia-Martin, Hinou H., Matsuoka K., Nouso H., Kamiyama T., Taketomi A, Nishimura S-I. “Impaired O-Glycosylation at Consecutive Threonine TTX Motifs in Mucins Generates Conformationally Restricted Cancer Neoepitopes” Biochemistry 59, 1221-1241 (2020)

Koide R., Nishimura S-I., “Antiadhesive nanosomes facilitate targeting of lysosomal GlcNAc salvage pathway through derailed cancer endocytosis” Angew. Chem. Int. Ed. 58, 14513-14518 (2019)

Somovilla V.J., Bermeijo I.A., Albuquerque I.S., Martínez-S. N., Castro-Lopez J., Garcia-Martin F., Companon I.., Hinou H., Nishimura S-I., Jimenez-Barbero J., Asensio J.L, Avenoza G., Busto J.H., Hurtado-Guerrero. R., Peregrina J.M., Bernardes G.J.L., Corzana F., “The use of fluoroproline in MUC1 antigen enables efficient detection of antibodies in patients with prostate cancer”, J. Am. Chem. Soc. 129, 18255-18261 (2017)

Ohyabu N, Kakiya K., Yokoi Y., Hinou H., Nishimura S-I., “Convergent solid-phase synthesis of macromolecular MUC1 models truly mimicking serum glycoprotein biomarkers of interstitial lung diseases”, J. Am. Chem. Soc. 138, 8392-8395(2016)

Refer to HOKKAIDO UNIVERSITY RESEARCHERS DIRECTORY

Note

<Office Hour>
– Time: Anytime during the lecture period
– Place: Frontier-AMLS, 6F
Please contact in advance by E-mail.
E-mail: shin[at]sci.hokudai.ac.jp

Affiliation