NISHIMURA Shin-IchiroProfessor
- Laboratory
- Laboratory of Advanced Chemical Biology
- Research Theme
- Rational drug discovery based on a theory of dynamic epitope and innovative glycotechnology platform
- Research Keywords
Chemical biology, Medicinal chemistry, Dynamic inhibition reaction, Carbohydrate-based drug, Anti-viral medicine, Reverse genomics, Biomarker discovery
Overview of Research
We establish the new concept that controls functional expression by biological molecules essential for any creatures to live. By applying this concept to create novel medical reagents, we confirm the universality of this concept. Please visit our website
Charge
- School of Science:
Biological Science course (Macromolecular Functions), Core Laboratories - Graduate School of Life Science:
Division of Life Science, Transdisciplinary Life Science Course, Biosystem and Biomolecule Control Science
Representative Publications
Villones Lareno L, Ludwig A-K., Kumeta H., Kikuchi S., Ochi R., Aizawa T., Nishimura S-I., Gabius H-J., Hinou H, “Exploring the In situ pairing of human galectins toward synthetic O-mannosylated core M1 glycopeptides of α-dystroglycan”, Sci. Rep. 12, 17800 (2022)
Otaki M., Hirane N., Natsume-Kitatani Y., Nogami Itoh M., Shindo M., Kurebayashi Y., Nishimura S-I., “Mouse tissue glycome atlas 2022 highlights inter-organ variation in major N-glycan profiles”, Sci. Rep. 12, 17804 (2022)
Shiratori K., Yokoi Y., Wakui H., Hirane N., Otaki M., Hinou H., Yoneyama T., Hatakeyama T., Kimura S., Ohyama C., Nishimura Shin-Ichiro, “Selective reaction monitoring approach using structure-defined synthetic glycopeptides for validating glycopeptide biomarkers pre-determined by bottom-up glycoproteomics” RSC Adv. 12, 21385-21393 (2022)
Pablo A. Guillen-Poza, Elena Matilde Sánchez-Fernández, Gerard Artigas, José Manuel García Fernández, Hinou H., Carmen Ortiz Mellet, Nishimura S-I., Fayna Garcia-Martin, “Amplified detection of breast cancer autoantibodies using MUC1-based Tn antigen mimics” J. Med. Chem. 63, 8524-8533 (2020)
Koide R., Hirane N., Kambe D., Yokoi Y., Otaki M., Nishimura S-I., “Antiadhesive nanosome elicits role of glycocalyx of tumor cell-derived exosomes in the organotropic cancer metastasis” Biomaterials 280, 121314
Yokoi Y., Nishimura S-I. “Effect of Site‐specific O-Glycosylation on the Structural Behavior of NOTCH1 Receptor Extracellular EGF‐like Domains 11 and 10” Chem. Eur. J. 26, 12363-12372 (2020)
Wakui H., Tanaka Y., Ose T., Matsumoto I., Kato K., Yao M., Tachibana T., Sato M., Naruchi K., García-Martín F., Hinou H., Nishimura S-I. “A straightforward approach to antibodies recognising cancer specific glycopeptidic neoepitopes” Chem. Sci. 11, 4999-5006 (2020)
Hayakawa A., Matsushita T., Yokoi Y., Wakui H., Fayna Garcia-Martin, Hinou H., Matsuoka K., Nouso H., Kamiyama T., Taketomi A, Nishimura S-I. “Impaired O-Glycosylation at Consecutive Threonine TTX Motifs in Mucins Generates Conformationally Restricted Cancer Neoepitopes” Biochemistry 59, 1221-1241 (2020)
Koide R., Nishimura S-I., “Antiadhesive nanosomes facilitate targeting of lysosomal GlcNAc salvage pathway through derailed cancer endocytosis” Angew. Chem. Int. Ed. 58, 14513-14518 (2019)
Somovilla V.J., Bermeijo I.A., Albuquerque I.S., Martínez-S. N., Castro-Lopez J., Garcia-Martin F., Companon I.., Hinou H., Nishimura S-I., Jimenez-Barbero J., Asensio J.L, Avenoza G., Busto J.H., Hurtado-Guerrero. R., Peregrina J.M., Bernardes G.J.L., Corzana F., “The use of fluoroproline in MUC1 antigen enables efficient detection of antibodies in patients with prostate cancer”, J. Am. Chem. Soc. 129, 18255-18261 (2017)
Ohyabu N, Kakiya K., Yokoi Y., Hinou H., Nishimura S-I., “Convergent solid-phase synthesis of macromolecular MUC1 models truly mimicking serum glycoprotein biomarkers of interstitial lung diseases”, J. Am. Chem. Soc. 138, 8392-8395(2016)
Refer to HOKKAIDO UNIVERSITY RESEARCHERS DIRECTORY
(https://researchers.general.hokudai.ac.jp/profile/en.qnX8FSg.EYFYAlLXrrshLw==.html)
Note
<Office Hour>
– Time: Anytime during the lecture period
– Place: Frontier-AMLS, 6F
Please contact in advance by E-mail.
E-mail: shin[at]sci.hokudai.ac.jp
Affiliation
- Faculty of Advanced Life Science, Department of Advanced Transdisciplinary Sciences, Drug Discovery Research
- Frontier Research Center for Advanced Material and Life Science, Academia-Industry Collaboration Unit