Laboratory

Laboratory of Advanced Chemical Biology

Research Theme
Rational drug discovery based on a theory of dynamic epitope and innovative glycotechnology platform
Research Keywords

Chemical biology, Medicinal chemistry, Glycomedicine, Automated glycosynthesis, Glycomics, Glycobiology, Biomarker discovery, Dynamic epitope, Glycopeptide, Antibody drug, Glycoconjugates probe, Microarray

Staff

Overview of Research and Education

Research Contents: Toward personalized medicine, our goal is to establish a promising strategy for the rational drug discovery system from disease-relevant “dynamic epitopes” based on the specific posttranslational modification of the key glycoproteins. Our new glycotechnology platform, notably glycoblotting-based high throughput glycomics and microarray displaying robust synthetic glycopeptides library, allowed for the development of epitope-defined antibodies showing potent anti-cancer activities.
At the core of our focused library construction technology, we are continuing to innovate molecular-based life technology such as microarrays and absolute quantification technology of specific key structures in life.

Laboratory of Advanced Chemical Biology (pdf)

Charge

Contact

Address
〒001-0021
N21, W11, Kita-ku, Sapporo, Hokkdido
Phone
011-706-9043
Fax
011-706-9042
Email
shin*sci.hokudai.ac.jp
hinou＊sci.hokudai.ac.jp
roger.tan＊sci.hokudai.ac.jp
(Please replace * with @ when sending e-mail.)

Representative Publications

Koide R., Hirane N., Kambe D., Yokoi Y., Otaki M., Nishimura S-I., “Antiadhesive nanosome elicits role of glycocalyx of tumor cell-derived exosomes in the organotropic cancer metastasis” Biomaterials 280, 121314

Yokoi Y., Nishimura S-I. “Effect of Site‐specific O-Glycosylation on the Structural Behavior of NOTCH1 Receptor Extracellular EGF‐like Domains 11 and 10” Chem. Eur. J. 26, 12363-12372 (2020)

Wakui H., Tanaka Y., Ose T., Matsumoto I., Kato K., Yao M., Tachibana T., Sato M., Naruchi K., García-Martín F., Hinou H., Nishimura S-I. “A straightforward approach to antibodies recognising cancer specific glycopeptidic neoepitopes” Chem. Sci. 11, 4999-5006 (2020)

Hayakawa A., Matsushita T., Yokoi Y., Wakui H., Fayna Garcia-Martin, Hinou H., Matsuoka K., Nouso H., Kamiyama T., Taketomi A, Nishimura S-I. “Impaired O-Glycosylation at Consecutive Threonine TTX Motifs in Mucins Generates Conformationally Restricted Cancer Neoepitopes” Biochemistry 59, 1221-1241 (2020)

Koide R., Nishimura S-I., “Antiadhesive nanosomes facilitate targeting of lysosomal GlcNAc salvage pathway through derailed cancer endocytosis” Angew. Chem. Int. Ed. 58, 14513-14518 (2019)

Somovilla V.J., Bermeijo I.A., Albuquerque I.S., Martínez-S. N., Castro-Lopez J., Garcia-Martin F., Companon I.., Hinou H., Nishimura S-I., Jimenez-Barbero J., Asensio J.L, Avenoza G., Busto J.H., Hurtado-Guerrero. R., Peregrina J.M., Bernardes G.J.L., Corzana F., “The use of fluoroproline in MUC1 antigen enables efficient detection of antibodies in patients with prostate cancer”, J. Am. Chem. Soc. 129, 18255-18261 (2017)

Ohyabu N, Kakiya K., Yokoi Y., Hinou H., Nishimura S-I., “Convergent solid-phase synthesis of macromolecular MUC1 models truly mimicking serum glycoprotein biomarkers of interstitial lung diseases”, J. Am. Chem. Soc. 138, 8392-8395(2016)

北大研究者総覧参照
（https://researchers.general.hokudai.ac.jp/profile/ja.qnX8FSg.EYFYAlLXrrshLw==.html）