YUYAMA KoheiSpecially Appointed Associate Professor
- Laboratory
- Laboratory of Molecular Chemical Biology (Additional Post)
Lipid Biofunction Section - Research Theme
- Exosome functions in neruodegenerative diseases
- Research Keywords
Extracellular vesicle, Exosome, Interstitial space, Waste clearance system, Amyloid-beta peptide, Alzheimer’s desease, Neurodegenerative disease, Sphingolipid
Overview of Research
Exosomes are small extracellular vesicles (40–100 nm in diameter) released from various types of cells that have recently emerged as a key player for the intercellular transport of molecules both in health and in disease conditions, including Alzheimer’s disease. Our previous studies showed that exosomes released from cultured neurons associate with amyloid-ß protein in extracellular space and are incorporated into microglia for degradation. We now study the effect of exosomal transport between neuron and microglia on waste clearance in extracellular space of brain.
Charge
- School of Science:
- Graduate School of Life Science:
Representative Publications
Refer to HOKKAIDO UNIVERSITY RESEARCHERS DIRECTORY
(https://researchers.general.hokudai.ac.jp/profile/en.3274b087de1c54f2520e17560c007669.html)
Affiliation
- Faculty of Advanced Life Science, Department of Advanced Transdisciplinary Sciences, Chemical Biology
- Frontier Research Center for Advanced Material and Life Science, Lipid Biofunction Section, Academia-Industry Collaboration Unit, Frontier Research Center for Advanced Material and Life Science
- Frontier Research Center for Advanced Material and Life Science, Academia-Industry Collaboration Unit, Lipid Biofunction Section