Staff

NISHIMURA Shin-IchiroProfessor

Laboratory
Laboratory of Advanced Chemical Biology
Research Theme
Rational drug discovery based on a theory of dynamic epitope and innovative glycotechnology platform
Research Keywords

Chemical biology, Medicinal chemistry, Dynamic inhibition reaction, Carbohydrate-based drug, Anti-viral medicine, Reverse genomics, Biomarker discovery

Overview of Research

We establish the new concept that controls functional expression by biological molecules essential for any creatures to live. By applying this concept to create novel medical reagents, we confirm the universality of this concept. Please visit our website

Charge

Representative Publications

Gebrehiwot Abrha G., Seifu Melka D., Mamo Kassaye Y., Rehan F.I., Rangappa S., Hinou H., Kamiyama T., Nishimura S-I., “Healthy human serum N-glycan profiling reveals the influence of ethnic variation on the identified cancer-relevant glycan biomarkers”, PLOS ONE 12, e0209515 (2018)

Somovilla V.J., Bermeijo I.A., Albuquerque I.S., Martínez-S. N., Castro-Lopez J., Garcia-Martin F., Companon I.., Hinou H., Nishimura S-I., Jimenez-Barbero J., Asensio J.L, Avenoza G., Busto J.H., Hurtado-Guerrero. R., Peregrina J.M., Bernardes G.J.L., Corzana F., “The use of fluoroproline in MUC1 antigen enables efficient detection of antibodies in patients with prostate cancer”, J. Am. Chem. Soc. 129, 18255-18261 (2017)

Hayakawa S., Yokoi Y., Hinou H., Nishimura S-I., “Chemical synthesis demonstrates dynamic O-glycosylation regulates folding and functional conformation of a pivotal EGF12 domain of human NOTCH1 receptor”, Biochemistry 56, 4379-4391 (2017)

Ohyabu N, Kakiya K., Yokoi Y., Hinou H., Nishimura S-I., “Convergent solid-phase synthesis of macromolecular MUC1 models truly mimicking serum glycoprotein biomarkers of interstitial lung diseases”, J. Am. Chem. Soc. 138, 8392-8395(2016)

Roger S. Tan, Naruchi K., Amano M., Hinou H., Nishimura S-I., “Rapid Endolysosomal Escape and Controlled Intracellular Trafficking of Cell Surface Mimetic Quantum-Dots-Anchored Peptides and Glycopeptides”, ACS Chem. Biol. 10, 2073-2086 (2015)

Refer to HOKKAIDO UNIVERSITY RESEARCHERS DIRECTORY
(https://researchers.general.hokudai.ac.jp/profile/en.qnX8FSg.EYFYAlLXrrshLw==.html)

Note

<Office Hour>
– Time: Anytime during the lecture period
– Place: Frontier-AMLS, 6F
Please contact in advance by E-mail.
E-mail: shin[at]sci.hokudai.ac.jp

Affiliation