Laboratory of Cell Dynamics

Cells, the Final Frontier in Science
Research Theme
Collective cell migration in 3D morphogenesis Cancer metastasis Structures and physical properties of polymeric materials and connective tissues
Research Keywords

Cell Mechanics, Collective Cell Behavior, 3D Morphogenesis, Cancer Invasion, Atomic Force Microscopy


Overview of Research and Education

Research Contents: We are interested in the behaviors of cells and tissues, especially collective cell migration, 3D morphogenesis, and tissue construction. To understand these phenomena, we utilize soft biomaterials (e.g. collagen gels, Matrigels) for cell culture to mimic biological environments and analyze the behaviors with approaches of both molecular biology and mechanobiology. Furthermore, we are using extracellular matrices of different stiffness and investigating the mechanism of cancer progression induced by substrate stiffening. We are able to contribute to improve regenerative medicine and cancer therapy with our research approaches.

Laboratory of Cell Dynamics(PDF



N10, W8, Kita-ku, Sapporo, Hokkaido
haga* (Please replace*with @ when sending e-mail.)

Representative Publications

H. Oyama, A. Nukuda, S. Ishihara, and H. Haga: Soft Surfaces Promote Astrocytic Differentiation of Mouse Embryonic Neural Stem Cells via Dephosphorylation of MRLC in the Absence of Serum, Scientific Reports, 11, 19574, 1-11 (2021).

S. Ishida-Ishihara, M. Akiyama, K. Furusawa, I. Naguro, H. Ryuno, T. Sushida, S. Ishihara, and H. Haga: Osmotic Gradients Induce Stable Dome Morphogenesis on Extracellular Matrix, Journal of Cell Science, 133, jcs243865 (2020).

Y. Kumagai, J. Nio-Kobayashi, S. Ishida-Ishihara, H. Tachibana, R. Omori, A. Enomoto, S. Ishihara, and H. Haga: The intercellular expression of type-XVII collagen, laminin-332, and integrin-β1 promote contact following during the collective invasion of a cancer cell population, Biochem. Biophys. Res. Commun., 514, 1115-1121 (2019).

S. Ishihara, K. Aoki, T. Mizutani, M. Amano, S. Nishimura, and H. Haga: Glycosphingolipid GM2 Induces Invasiveness in Irradiation-tolerant Lung Cancer Cells, Cell Structure and Function, 43, 177-185 (2018).

Koh, K. Furusawa, and H. Haga: Anisotropic Multi-channel Collagen Gel (MCCG) Guides the Growth Direction of the Neurite-like Processes of PC12 Cells, Scientific Reports, 8, 13901, 1-10 (2018).

Oyama, K. Takahashi, Y. Tanaka, H. Takemoto, and H. Haga: Long-term Culture of Human iPS Cell-derived Telencephalic Neuron Aggregates on Collagen Gel, Cell Structure and Function, 43, 85-94 (2018).

Akiyama, T. Sushida, S. Ishida, and H. Haga: Conformational Mathematical Model of Collective Cell Migrations Based on Cell Polarity, Dev. Growth Differ., 59, 471-490 (2017).