Laboratory

Laboratory of Protein Science

Protein Sciences, from production to application
Research Theme
Studies on production methods for recombinant proteins and peptides / Research on proteins and peptides using NMR spectroscopy and genetic engineering / NMR metabolomics
Research Keywords

protein science, structural biology, protein engineering, NMR, metabolome, biomarker research, biological defense, innate immunity, antimicrobial peptides, allergen, cytokines, microbiological control

Staff

Overview of Research and Education

Research Contents: Our main research targets are 1) NMR analysis of proteins and peptides, 2) development of novel production methods of heterologous proteins and peptides. Our final goals of the research is to create the artificial proteins with complete control. We also utilize NMR for metabolomics researches.

Laboratory of Protein Science(pdf)

Charge

Contact

Address
〒060-0810
N10, W8, Kita-ku, Sapporo, Hokkaido
Phone
011-706-3806
Fax
011-706-3806
Email
aizawa*sci.hokudai.ac.jp (Please replace * with @ when sending e-mail.)

Representative Publications

Sénéchal H, Šantrůček J, Melčová M, Svoboda P, Zídková J, Charpin D, Guilloux L, Shahali Y, Selva MA, Couderc R, Aizawa T, Poncet P., A new allergen family involved in pollen food-associated syndrome: Snakin/gibberellin-regulated proteins., J Allergy Clin Immunol, 141, 411-414 (2018)

Penkhrue W, Sujarit K, Kudo T, Ohkuma M, Masaki K, Aizawa T, Pathom-Aree W, Khanongnuch C, Lumyong S., Amycolatopsis oliviviridis sp. nov., a novel polylactic acid-bioplastic-degrading actinomycete isolated from paddy soil., Int J Syst Evol Microbiol, 68, 1448-1454 (2018)

Hayase E, Hashimoto D, Nakamura K, Noizat C, Ogasawara R, Takahashi S, Ohigashi H, Yokoi Y, Sugimoto R, Matsuoka S, Ara T, Yokoyama E, Yamakawa T, Ebata K, Kondo T, Hiramine R, Aizawa T, Ogura Y, Hayashi T, Mori H, Kurokawa K, Tomizuka K, Ayabe T, Teshima T., R-Spondin1 expands Paneth cells and prevents dysbiosis induced by graft-versus-host disease., J Exp Med, 214, 3507-3518 (2017)

Baek M, Kamiya M, Kushibiki T, Nakazumi T, Tomisawa S,, Abe C, Kumaki Y, Kikukawa T, Demura M, Kawano K, Aizawa T, Lipopolysaccharide-bound structure of the antimicrobial peptide cecropin P1 determined by nuclear magnetic resonance spectroscopy., J. Peptide Sci, 22, 214-21 (2016)

Ishida H, Nguyen LT, Gopal R, Aizawa T, Vogel HJ, Overexpression of Antimicrobial, Anticancer, Transmembrane Peptides in Escherichia coli through a Calmodulin-Peptide Fusion System., J Am Chem Soc, 138, 11318-26 (2016)

Refer to HOKKAIDO UNIVERSITY RESEARCHERS DIRECTORY
(https://researchers.general.hokudai.ac.jp/profile/en.YW9I3ckXtNcaTh95IUkcHw==.html)